{"id":1423,"date":"2017-01-23T09:10:43","date_gmt":"2017-01-23T08:10:43","guid":{"rendered":"http:\/\/semmelweis.hu\/patologia1\/?page_id=1423"},"modified":"2025-12-09T11:35:36","modified_gmt":"2025-12-09T10:35:36","slug":"tumorbiologia-munkacsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/patologia1\/kutatas\/tumorbiologia-munkacsoport\/","title":{"rendered":"Tumorbiol\u00f3gia \u2013 Tumormetabolizmus Munkacsoport"},"content":{"rendered":"<p style=\"text-align: justify\"><a href=\"https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6051 alignleft\" src=\"https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1-400x354.png\" alt=\"\" width=\"400\" height=\"354\" srcset=\"https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1-400x354.png 400w, https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1-768x680.png 768w, https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1-753x667.png 753w, https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1.png 785w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><\/p>\n<p>A\u00a0<strong>jel\u00e1tviteli utak szab\u00e1lyoz\u00e1si<\/strong>\u00a0zavarai hozz\u00e1j\u00e1rulnak a daganatsejtek anyagcser\u00e9j\u00e9nek megv\u00e1ltoz\u00e1s\u00e1hoz. Az\u00a0<strong>mTOR<\/strong>\u00a0(mammalian target of rapamycin) kin\u00e1z a jel\u00e1tviteli h\u00e1l\u00f3zat k\u00f6zponti elemek\u00e9nt szab\u00e1lyozza a k\u00fcl\u00f6nb\u00f6z\u0151 sejtfunkci\u00f3kat a t\u00e1panyag \u00e9s energia ell\u00e1totts\u00e1g \u00e9s egy\u00e9b faktorok f\u00fcggv\u00e9ny\u00e9ben. Megfelel\u0151 szab\u00e1lyoz\u00e1sa befoly\u00e1solja a sejtek <strong>metabolikus aktivit\u00e1s<\/strong>\u00e1t, t\u00f6bbek k\u00f6z\u00f6tt a gl\u00fck\u00f3z \u00e9s glutamin felv\u00e9tel, glikol\u00edzist, lipid anyagcser\u00e9t, oxidat\u00edv folyamatokat. Az mTOR funkci\u00f3 zavarai tumorok eset\u00e9ben j\u00f3l ismertek. Saj\u00e1t eredm\u00e9nyeink is azt mutatj\u00e1k, hogy a magas mTOR aktivit\u00e1s, k\u00fcl\u00f6n\u00f6sk\u00e9ppen, ha az mTORC2 komplexhez k\u00f6thet\u0151, szignifik\u00e1ns \u00f6sszef\u00fcgg\u00e9st mutat a rossz progn\u00f3zissal, ter\u00e1pia rezisztenci\u00e1val. Vizsg\u00e1latainkban az <strong>mTORC1 \u00e9s C2 komplexek<\/strong> szerep\u00e9t, jelent\u0151s\u00e9g\u00e9t vizsg\u00e1ljuk a tumorsejtek\u00a0<strong>ter\u00e1pi\u00e1s \u00e9rz\u00e9kenys\u00e9g\u00e9ben \u00e9s metabolikus alkalmazkod\u00e1s\u00e1ban, metabolikus plaszticit\u00e1s\u00e1ban<\/strong>\u00a0. El\u0151bbiekkel p\u00e1rhuzamosan a legk\u00fcl\u00f6nb\u00f6z\u0151bb daganat t\u00edpusok eset\u00e9ben vizsg\u00e1ljuk a daganat <strong>sejtek sz\u00f6veti \u00e9s metabolikus heterogenit\u00e1s\u00e1t, immun-mikrok\u00f6rnyezet\u00e9t<\/strong> \u00e9s ennek potenci\u00e1lis diagnosztikai \u00e9s ter\u00e1pi\u00e1s felhaszn\u00e1l\u00e1si lehet\u0151s\u00e9geit.<br \/>\nMunk\u00e1nkban a hum\u00e1n daganatok sz\u00f6veteinek jellemz\u00e9s\u00e9n t\u00fal\u00a0<em>in vitro<\/em>\u00a0\u00e9s\u00a0<em>in vivo<\/em>\u00a0modelleket is felhaszn\u00e1lunk. Az elm\u00falt \u00e9vekben a\u00a0<strong>3D bionyomtat\u00e1ssal k\u00fcl\u00f6nb\u00f6z\u0151 in vitro 3D sejtkult\u00far\u00e1k<\/strong><strong>at hoztunk l\u00e9tre, ezeket jellemezt\u00fck.<\/strong> Vizsg\u00e1latainkban a metabolikus alkalmazkod\u00e1s k\u00eds\u00e9rleti megk\u00f6zel\u00edt\u00e9s\u00e9nek t\u00f6k\u00e9letes\u00edt\u00e9se, \u00e9s ezen kereszt\u00fcl jobb daganat ellenes hat\u00e1s\u00fa szer pre-szelekci\u00f3s elj\u00e1r\u00e1sok kidolgoz\u00e1sa is c\u00e9lja munk\u00e1nknak. Term\u00e9szetesen ezekben a legk\u00fcl\u00f6nb\u00f6z\u0151bb daganatokat \u00e9rint\u0151 vizsg\u00e1latainkban nagy szerep jut molekul\u00e1ris biol\u00f3giai \u00e9s analitikai k\u00e9miai m\u00f3dszereknek, metabolitok \u00e9s feh\u00e9rj\u00e9k mennyis\u00e9gi meghat\u00e1roz\u00e1s\u00e1nak.<\/p>\n<p><div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">K\u00f6zlem\u00e9nyek<\/h2>\n<div class=\"tabcontent\">\n<br \/>\nLegjelent\u0151sebb a t\u00e9m\u00e1hoz kapcsol\u00f3d\u00f3 k\u00f6zlem\u00e9nyeink:<\/p>\n<ul>\n<li>Pet\u0151v\u00e1ri G, Moldvai D, Raffay R, Dank\u00f3 T, Sztankovics D, reszegi A, Miyaura R, Gelencs\u00e9r R, R\u00f3kusz A, Tolnai-Kriston Cs, Vilimi Zs,\u00a0 K\u00e1llai-Szab\u00f3 N, Visnovitz T,Sebesty\u00e9n A: Mimicking breast cancer tissue\u20143D bioprinted models inaccurate drug sensitivity tests. VIEW. 2025;6:20250092. https:\/\/doi.org\/10.1002\/VIW.20250092<\/li>\n<li>Moldvai D, Sztankovics D, Dank\u00f3 T, Vetl\u00e9nyi E, Pet\u0151v\u00e1ri G, M\u00e1rk \u00c1, Patonai A, V\u00e9gs\u0151 G, Piros L, Hossz\u00fa \u00c1, P\u00e1pay J, Krencz I, Sebesty\u00e9n A. Tumorigenic role of tacrolimus through mTORC1\/C2 activation in post-transplant renal cell carcinomas. Br J Cancer. 2024 Apr;130(7):1119-1130. doi: 10.1038\/s41416-024-02597-8.<\/li>\n<li>Sztankovics D, Szalai F, Moldvai D, Dank\u00f3 T, Scheich B, P\u00e1pay J, Sebesty\u00e9n A, Krencz I. Comparison of molecular subtype composition between independent sets of primary and brain metastatic small cell lung carcinoma and matched samples. Lung Cancer. 2025 Jan;199:108071. doi: 10.1016\/j.lungcan.2024.108071.<\/li>\n<li>Sztankovics D, Szalai F, Moldvai D, Dank\u00f3 T, Nagy N, P\u00e1pay J, Kho\u00f3r A, Krencz I, Sebesty\u00e9n A. Increased mTOR activity and RICTOR copy number in small cell lung carcinoma progression. Eur J Cell Biol. 2024 Dec;103(4):151468. doi:10.1016\/j.ejcb.2024.151468.<\/li>\n<li>Sebesty\u00e9n A, Sticz TB, M\u00e1rk A, et al. Activity and complexes of mTOR in diffuse large B-cell lymphomas\u2013a tissue microarray study. Mod Pathol. 2012;25(12):1623-1628. doi:10.1038\/modpathol.2012.141<\/li>\n<li>Sebesty\u00e9n A, M\u00e1rk \u00c1, Hajdu M, et al. Rapamycin can restore the negative regulatory function of transforming growth factor beta 1 in high grade lymphomas. Cytokine. 2015;73(2):219-224. doi:10.1016\/j.cyto.2015.02.024<\/li>\n<li>Sebesty\u00e9n A, Dank\u00f3 T, Sztankovics D, Moldvai D, Raffay R, Cervi C, Krencz I, Zsiros V, Jeney A, Pet\u0151v\u00e1ri G. The role of metabolic ecosystem in cancer progression &#8211; metabolic plasticity and mTOR hyperactivity in tumor tissues. Cancer Metastasis Rev. 2021 Dec;40(4):989-1033. doi: 10.1007\/s10555-021-10006-2<\/li>\n<li>Krencz I, Sztankovics D, Danko T, Sebestyen A, Khoor A. Progression and metastasis of small cell lung carcinoma: the role of the PI3K\/Akt\/mTOR pathway and metabolic alterations. Cancer Metastasis Rev. 2021 Dec;40(4):1141-1157. doi: 10.1007\/s10555-021-10012-4.<\/li>\n<li>Hujber Z, Horv\u00e1th G, Pet\u0151v\u00e1ri G, et al. GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas. J Exp Clin Cancer Res. 2018;37(1):271. 2018 Nov 7. doi:10.1186\/s13046-018-0946-5<\/li>\n<\/ul>\n<ul>\n<li>Sebesty\u00e9n A, Sticz TB, M\u00e1rk A, et al. Activity and complexes of mTOR in diffuse large B-cell lymphomas\u2013a tissue microarray study. Mod Pathol. 2012;25(12):1623-1628. doi:10.1038\/modpathol.2012.141<\/li>\n<\/ul>\n\n<\/div><h2 class=\"tabtitle\">Munkacsoport tagjai<\/h2>\n<div class=\"tabcontent\">\n\n<p>Sebesty\u00e9n Anna, DSc \u2013 kutat\u00f3professzor, a munkacsoportvezet\u0151je<\/p>\n<p>Kopper L\u00e1szl\u00f3, DSc \u2013 professzor emeritus, kor\u00e1bbi vezet\u0151<\/p>\n<p>Jeney Andr\u00e1s, DSc \u2013 professzor emeritus<\/p>\n<p>Judit P\u00e1pay, MD, PhD \u2013 egyetemi docens<\/p>\n<p>Ildik\u00f3 Krencz, MD, PhD \u2013 egyetemi tan\u00e1rseg\u00e9d, postdoc kutat\u00f3<\/p>\n<p>Moldvai Dorottya PharmD \u2013 postdoc kutat\u00f3<\/p>\n<p>Varga Vikt\u00f3ria, MD \u2013 immunol\u00f3gus-neurol\u00f3gus, PhD hallgat\u00f3<\/p>\n<p>Szalai Fatime, MD \u2013 PhD hallgat\u00f3<\/p>\n<p>Miyaura Risa, MD \u2013 PhD hallgat\u00f3<\/p>\n<p>Henrik When Olsen, MD \u2013 PhD hallgat\u00f3<\/p>\n<p>G\u00e1briel Zs\u00f3fia, Gelencs\u00e9r Rebeka, F\u00f6rch\u00e9cz N\u00f3ra, Csik\u00f3s B\u00e1lint, Orosz M\u00e1rton, Kovencz Lilla, Balk\u00e1nyi Zs\u00f3fia \u2013 egyetemi di\u00e1kk\u00f6r\u00f6s hallgat\u00f3k<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"https:\/\/semmelweis.hu\/patologia1\/files\/2020\/08\/TumorbiologiaLab1.png\"><\/a> A\u00a0jel\u00e1tviteli utak szab\u00e1lyoz\u00e1si\u00a0zavarai hozz\u00e1j\u00e1rulnak a daganatsejtek anyagcser\u00e9j\u00e9nek megv\u00e1ltoz\u00e1s\u00e1hoz. Az\u00a0mTOR\u00a0(mammalian target of rapamycin) kin\u00e1z a jel\u00e1tviteli h\u00e1l\u00f3zat k\u00f6zponti elemek\u00e9nt szab\u00e1lyozza a k\u00fcl\u00f6nb\u00f6z\u0151 sejtfunkci\u00f3kat a t\u00e1panyag \u00e9s energia ell\u00e1totts\u00e1g \u00e9s egy\u00e9b faktorok f\u00fcggv\u00e9ny\u00e9ben. Megfelel\u0151 szab\u00e1lyoz\u00e1sa befoly\u00e1solja a sejtek metabolikus aktivit\u00e1s\u00e1t, t\u00f6bbek k\u00f6z\u00f6tt a gl\u00fck\u00f3z \u00e9s glutamin felv\u00e9tel, glikol\u00edzist, lipid anyagcser\u00e9t, oxidat\u00edv folyamatokat. Az mTOR funkci\u00f3 zavarai tumorok &hellip;<\/p>\n","protected":false},"author":54,"featured_media":0,"parent":42,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-1423","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/comments?post=1423"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1423\/revisions"}],"predecessor-version":[{"id":8866,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1423\/revisions\/8866"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/42"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/media?parent=1423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/categories?post=1423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/tags?post=1423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}