{"id":1413,"date":"2015-06-22T00:09:03","date_gmt":"2015-06-21T22:09:03","guid":{"rendered":"http:\/\/semmelweis.hu\/patologia1\/?page_id=1413"},"modified":"2020-06-12T15:21:39","modified_gmt":"2020-06-12T13:21:39","slug":"lagyresz-daganat-kutatas","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/patologia1\/kutatas\/lagyresz-daganat-kutatas\/","title":{"rendered":"L\u00e1gyr\u00e9sz-daganat Kutat\u00e1s"},"content":{"rendered":"

Laborvezet\u0151: Dr. S\u00e1pi Zolt\u00e1n<\/a><\/strong>\"\"<\/a>\u00a0<\/strong><\/p>\n

A munkacsoport tev\u00e9kenys\u00e9ge \u00e9s f\u0151bb eredm\u00e9nyei:<\/strong><\/p>\n

A laborat\u00f3rium k\u00f6zponti kutat\u00e1si ter\u00fclet\u00e9t k\u00fcl\u00f6nb\u00f6z\u0151 l\u00e1gyr\u00e9sz daganatok genetikai illetve epigenetikai vizsg\u00e1latai jelentik. Epithelioid sarcom\u00e1ban k\u00edv\u00e1nja a munkacsoport tov\u00e1bbi k\u00eds\u00e9rletekkel bizony\u00edtani, hogy az SWI\/SNF kromatin remodelling komplex f\u0151 feh\u00e9rje alegys\u00e9ge \u2013 a SMARCB1 \u2013 expresszi\u00f3 veszt\u00e9s\u00e9nek okak\u00e9nt a genetikai biall\u00e9likus k\u00e1rosod\u00e1sok mellett, specifikus mikroRNS molekul\u00e1k szab\u00e1lyozta g\u00e9ncsendes\u00edt\u00e9s \u00e9s mRNS degrad\u00e1ci\u00f3 is szerepet j\u00e1tszik. Sz\u00f6vetteny\u00e9szeti sejteken, permanens transzfekci\u00f3kkal (miR-206) tervezz\u00fck vizsg\u00e1lni, hogy milyen \u00e1ltal\u00e1nos \u00e9s specifikus csendes\u00edt\u0151 effektusa van ennek a mikroRNS-nek, melyr\u0151l m\u00e1r igazoltuk, hogy szerepe van a SMARCB1 hi\u00e1nyos sarcom\u00e1k (epithelioid, synovialis sarcoma, stb) kialakul\u00e1s\u00e1ban. Az \u00e1ltalunk el\u0151\u00e1ll\u00edtott els\u0151 hum\u00e1n SYT-SSX1 kl\u00f3nozott mesenchymalis sejtvonalon v\u00e9gz\u00fcnk tov\u00e1bbi k\u00eds\u00e9rleteket, hogy felder\u00edts\u00fck a synovialis sarcoma kialakul\u00e1s\u00e1nak alapvet\u0151 pathomechanizmus\u00e1t.<\/p>\n

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Gal\u00e9ria<\/h3>\r\n\t\t\t\t\t
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3<\/span>k\u00e9p<\/div>\r\n <\/div> <\/div>\r\n \r\n\t\t\t\t\t
\"Papp<\/a><\/div>\r\n <\/span>\r\n \r\n\t\t\t\t\t
\"Mih\u00e1ly<\/a><\/div>\r\n <\/span>\r\n\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n \r\n <\/div>\r\n\r\n [\/slb_exclude]\r\n\t\n

Publik\u00e1ci\u00f3k:<\/strong><\/p>\n

1, S\u00e1pi Z, Papp G,<\/strong> Szendr\u0151i M, P\u00e1pai Z, Pl\u00f3t\u00e1r V, Krausz T, Fletcher CD. Epigenetic regulation of SMARCB1 By miR-206, -381 and -671-5p is evident in a variety of SMARCB1 immunonegative soft tissue sarcomas, while miR-765 appears specific for epithelioid sarcoma. A miRNA study of 223 soft tissue sarcomas. Genes Chromosomes Cancer. 2016 Oct;55(10):786-802. doi: 10.1002\/gcc.22379.<\/p>\n

2, Papp G<\/strong>, Krausz T, Stricker TP, Szendr\u0151i M, S\u00e1pi Z<\/strong>. SMARCB1 expression in epithelioid sarcoma is regulated by miR-206, miR-381, and miR-671-5p on Both mRNA and protein levels<\/em>. Genes Chromosomes Cancer. 2014, 53: 168-76.<\/p>\n

3, Papp G<\/strong>, Changchien YC, P\u00e9terfia B, Pecsenka L, Krausz T, Stricker TP, Khoor A, Donner L, S\u00e1pi Z<\/strong>. SMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma. <\/em>Mod Pathol. 2013, 26: 393-403.<\/p>\n

4, Changchien YC<\/strong>, T\u00e1trai P, Papp G, S\u00e1pi J, F\u00f3nyad L, Szendr\u0151i M, P\u00e1pai Z, S\u00e1pi Z<\/strong>. Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2). J Transl Med<\/em>. 2012, 10: 216.<\/p>\n

\u00a0<\/strong><\/p>\n

A munkacsoport tagjai:<\/strong><\/p>\n

Dr. S\u00e1pi Zolt\u00e1n, egyetemi tan\u00e1r
\nDr. Papp Gerg\u0151, tudom\u00e1nyos munkat\u00e1rs
\nPolg\u00e1r Zolt\u00e1nn\u00e9, szakasszisztens
\nMih\u00e1ly D\u00f3ra, TDK hallgat\u00f3
\nErd\u00e9lyi Anna, TDK hallgat\u00f3<\/p>\n","protected":false},"excerpt":{"rendered":"

Laborvezet\u0151: Dr. S\u00e1pi Zolt\u00e1n<\/a> <\/a> \u00a0 A munkacsoport tev\u00e9kenys\u00e9ge \u00e9s f\u0151bb eredm\u00e9nyei: A laborat\u00f3rium k\u00f6zponti kutat\u00e1si ter\u00fclet\u00e9t k\u00fcl\u00f6nb\u00f6z\u0151 l\u00e1gyr\u00e9sz daganatok genetikai illetve epigenetikai vizsg\u00e1latai jelentik. Epithelioid sarcom\u00e1ban k\u00edv\u00e1nja a munkacsoport tov\u00e1bbi k\u00eds\u00e9rletekkel bizony\u00edtani, hogy az SWI\/SNF kromatin remodelling komplex f\u0151 feh\u00e9rje alegys\u00e9ge \u2013 a SMARCB1 \u2013 expresszi\u00f3 veszt\u00e9s\u00e9nek okak\u00e9nt a genetikai biall\u00e9likus k\u00e1rosod\u00e1sok mellett, specifikus mikroRNS molekul\u00e1k szab\u00e1lyozta g\u00e9ncsendes\u00edt\u00e9s …<\/p>\n","protected":false},"author":54,"featured_media":0,"parent":42,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-1413","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/comments?post=1413"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1413\/revisions"}],"predecessor-version":[{"id":5622,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1413\/revisions\/5622"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/42"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/media?parent=1413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/categories?post=1413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/tags?post=1413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}