{"id":1407,"date":"2017-01-23T17:01:58","date_gmt":"2017-01-23T16:01:58","guid":{"rendered":"http:\/\/semmelweis.hu\/patologia1\/?page_id=1407"},"modified":"2017-02-26T11:06:41","modified_gmt":"2017-02-26T10:06:41","slug":"extracellularis-matrix-kutatas","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/patologia1\/kutatas\/extracellularis-matrix-kutatas\/","title":{"rendered":"Molekul\u00e1ris Patol\u00f3gia Munkacsoport"},"content":{"rendered":"

EXTRACELLUL\u00c1RIS M\u00c1TRIX KUTAT\u00c1S<\/strong><\/p>\n

(Dr. Kovalszky Ilona<\/a>, Dr. Baghy Korn\u00e9lia<\/a>)<\/p>\n

 <\/p>\n

A munkacsoport tev\u00e9kenys\u00e9ge \u00e9s f\u0151bb eredm\u00e9nyei:<\/strong><\/p>\n

Az elm\u00falt \u00e9vtizedben kutat\u00e1sok t\u00f6mege vil\u00e1g\u00edtott r\u00e1 arra a t\u00e9nyre, hogy a daganat sz\u00f6vet strom\u00e1ja nem csak egy passz\u00edv struktur\u00e1lis komponens, hanem akt\u00edvan r\u00e9szt vesz a tumorok n\u00f6veked\u00e9s\u00e9ben \u00e9s terjed\u00e9s\u00e9ben. E megfigyel\u00e9sek alapvet\u0151en \u00e1tform\u00e1lj\u00e1k a daganatok viselked\u00e9s\u00e9r\u0151l alkotott k\u00e9pet, miszerint nem felt\u00e9tlen\u00fcl el\u00e9gs\u00e9ges a tumorsejtek elpuszt\u00edt\u00e1sa a betegs\u00e9ggel val\u00f3 harc sor\u00e1n, ugyanis a tumor mikrok\u00f6rnyezete alapvet\u0151en befoly\u00e1solja annak biol\u00f3giai viselked\u00e9s\u00e9t. Munkacsoportunk imm\u00e1r 25 \u00e9ve foglalkozik az extracellul\u00e1ris m\u00e1trix proteoglycanjainak tumorbiol\u00f3gi\u00e1ban bet\u00f6lt\u00f6tt szerep\u00e9vel. Kandid\u00e1ns molekul\u00e1inkat t\u00f6bbl\u00e9pcs\u0151s k\u00eds\u00e9rleti rendszerekben, in vitro<\/em> sejtkult\u00far\u00e1kban, kokult\u00far\u00e1kban, \u00e1llatmodelleken \u00e9s beteganyagokon egyar\u00e1nt vizsg\u00e1ljuk. C\u00e9lunk a tumorok \u00e9s mikrok\u00f6rnyezet\u00fck kapcsolat\u00e1nak, v\u00e1ltoz\u00e1sainak meg\u00e9rt\u00e9se, mely ismeretekre alapozva diagnosztikai\/prognosztikai, illetve ter\u00e1pi\u00e1s elj\u00e1r\u00e1sok fejleszthet\u0151ek az orvostudom\u00e1nyban.<\/p>\n\n\n\n\n
\"ECM-1\"<\/a><\/td>\n\n

Tumorsejtek a myofibroblastok gy\u0171r\u0171j\u00e9ben. Piros: vimentin (myofibroblast); z\u00f6ld: citokeratin (tumorsejt); k\u00e9k: DAPI (sejtmag).<\/p>\n<\/td>\n<\/tr>\n

\"Agrin\"<\/a><\/td>\n\n

Az agrin immunfest\u00e9s megk\u00fcl\u00f6nb\u00f6zteti a tumort (T) a nem-tumoros sz\u00f6vett\u0151l (NT) hepatocellularis carcinom\u00e1ban. Balra: hematoxilin-eozin fest\u00e9s, Jobbra: agrin immunhisztok\u00e9mia.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/a><\/p>\n

Decorin hidrodinamikus g\u00e9ntranszfer. Az albumin prom\u00f3terrel rendelkez\u0151 decorin konstrukci\u00f3 a patk\u00e1ny m\u00e1j centr\u00e1lis v\u00e9n\u00e1i k\u00f6r\u00fcl elhelyezked\u0151 hepatocit\u00e1kban expressz\u00e1l\u00f3dik. A termel\u0151d\u0151 decorin g\u00e1tolja a k\u00e9miai hepatokarcinogenezist<\/p>\n

 <\/p>\n

Publik\u00e1ci\u00f3k:<\/strong><\/p>\n

Baghy K, T\u00e1trai P, Reg\u00f6s E, Kovalszky I. <\/u>Proteoglycans in liver cancer. WORLD JOURNAL OF GASTROENTEROLOGY 22:(1) pp. 379-393. (2016)<\/p>\n

Full\u00e1r A, Dud\u00e1s J, Ol\u00e1h L-n\u00e9, Holl\u00f3si P, Papp Z, Sobel G, Kar\u00e1szi K, Paku S, Baghy K, Kovalszky I. Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression<\/em>. BMC CANCER 15(1):256. (2015)<\/p>\n

Horvath Z, Kovalszky I, Fullar A, Kiss K, Schaff Z, Iozzo RV, Baghy K. Decorin deficiency promotes hepatic carcinogenesis<\/em>. MATRIX BIOLOGY 35: pp. 194-205. (2014)<\/p>\n

Fullar A, Baghy K, Deak F, Peterfia B, Zsak Y, Tatrai P, Schaff Z, Dudas J, Kiss I, Kovalszky I. Lack of Matrilin-2 Favors Liver Tumor Development via Erk1\/2 and GSK-3 beta Pathways In Vivo<\/em>. PLOS ONE 9:(4) Paper e93469. 11 p. (2014)<\/p>\n

Baghy K, Horvath Z, Regos E, Kiss K, Schaff Z, Iozzo RV, Kovalszky I. Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis<\/em>. FEBS JOURNAL 280:(10) pp. 2150-2164. (2013)<\/p>\n

P\u00e9terfia B, F\u00fcle T, Baghy K, Szabadkai K, Full\u00e1r A, Dobos K, Zong F, Dobra K, Holl\u00f3si P, Jeney A, Paku S, Kovalszky I. Syndecan-1 Enhances Proliferation, Migration and Metastasis of HT-1080 Cells in Cooperation with Syndecan-2<\/em>. PLOS ONE 7:(6) Paper e39474. 13 p. (2012)<\/p>\n

 <\/p>\n

A munkacsoport tagjai:<\/strong><\/p>\n

Dr. Kovalszky Ilona, egyetemi tan\u00e1r
\nDr. Baghy Korn\u00e9lia, tudom\u00e1nyos munkat\u00e1rs
\nDr. Holl\u00f3si P\u00e9ter, tudom\u00e1nyos munkat\u00e1rs
\nHorv\u00e1th Zsolt, biol\u00f3gus
\nDr. Reg\u0151s Eszter, rezidens
\nKar\u00e1szi Katalin PhD hallgat\u00f3
\nDr. Mervai Zsolt, PhD hallgat\u00f3
\nRada Krist\u00f3f, PhD hallgat\u00f3
\nReszegi Andrea PhD hallgat\u00f3
\nBozs\u00e1nyi Szabolcs TDK hallgat\u00f3<\/p>\n

Nemzetk\u00f6zi kapcsolatok:
\n<\/strong>Professor Renato Iozzo,\u00a0Thomas Jefferson University, Philadelphia, USA
\nProfessor Nikos Karamanos,\u00a0University of Patras, Greece
\nProfessor Martin G\u00f6tte,\u00a0University of M\u00fcnster, Germany
\nProfessor Alberto Passi, Insubria University, Italy<\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

EXTRACELLUL\u00c1RIS M\u00c1TRIX KUTAT\u00c1S ( Dr. Kovalszky Ilona<\/a> , Dr. Baghy Korn\u00e9lia<\/a> )   A munkacsoport tev\u00e9kenys\u00e9ge \u00e9s f\u0151bb eredm\u00e9nyei: Az elm\u00falt \u00e9vtizedben kutat\u00e1sok t\u00f6mege vil\u00e1g\u00edtott r\u00e1 arra a t\u00e9nyre, hogy a daganat sz\u00f6vet strom\u00e1ja nem csak egy passz\u00edv struktur\u00e1lis komponens, hanem akt\u00edvan r\u00e9szt vesz a tumorok n\u00f6veked\u00e9s\u00e9ben \u00e9s terjed\u00e9s\u00e9ben. E megfigyel\u00e9sek alapvet\u0151en \u00e1tform\u00e1lj\u00e1k a daganatok viselked\u00e9s\u00e9r\u0151l alkotott k\u00e9pet, miszerint nem felt\u00e9tlen\u00fcl …<\/p>\n","protected":false},"author":54,"featured_media":0,"parent":42,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-1407","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/comments?post=1407"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1407\/revisions"}],"predecessor-version":[{"id":3032,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/1407\/revisions\/3032"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/pages\/42"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/media?parent=1407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/categories?post=1407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/patologia1\/wp-json\/wp\/v2\/tags?post=1407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}