{"id":80,"date":"2024-07-15T16:07:49","date_gmt":"2024-07-15T14:07:49","guid":{"rendered":"https:\/\/semmelweis.hu\/nkl\/?page_id=80"},"modified":"2024-12-05T14:24:15","modified_gmt":"2024-12-05T13:24:15","slug":"klinikai-transzlacios-epidemiologiai-programok-modul","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/nkl\/teruletek\/klinikai-transzlacios-epidemiologiai-programok-modul\/","title":{"rendered":"Klinikai\/transzl\u00e1ci\u00f3s \u2013 epidemiol\u00f3giai programok modul"},"content":{"rendered":"<h5>A \u201eKlinikai \u2013 epidemiol\u00f3giai program\u201d sor\u00e1n az \u00faj elj\u00e1r\u00e1sok implement\u00e1ci\u00f3s lehet\u0151s\u00e9geit a bizony\u00edt\u00e9kokon alapul\u00f3 indik\u00e1tor rendszer alkalmaz\u00e1s\u00e1val a Semmelweis Egyetemen bel\u00fcl megval\u00f3sul\u00f3 kohorsz vizsg\u00e1latban (Semmelweis Study) fogjuk tesztelni. Ezen vizsg\u00e1latba \u00e1gyaz\u00f3dnak be a program seg\u00edts\u00e9g\u00e9vel kialak\u00edtand\u00f3 Eg\u00e9szs\u00e9ges \u00d6reged\u00e9s\u00e9rt Program kardiovaszkul\u00e1ris kutat\u00e1si programj\u00e1nak vizsg\u00e1latai. A program az iszk\u00e9mi\u00e1s sz\u00edvbetegs\u00e9g \u00e9s a sz\u00edvel\u00e9gtelens\u00e9g el\u0151fordul\u00e1s\u00e1nak \u00e9s hal\u00e1loz\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9t c\u00e9lz\u00f3 innovat\u00edv sz\u0171r\u00e9si, diagnosztikai \u00e9s ter\u00e1pi\u00e1s m\u00f3dszerek, szolg\u00e1ltat\u00e1sok \u00e9s term\u00e9kek kutat\u00e1s\u00e1t \u00e9s fejleszt\u00e9s\u00e9t fogja v\u00e9gezni.<\/h5>\n<p><strong>\u201eA COVID-19 fert\u0151z\u00e9s\u201d kutat\u00f3csoport<\/strong> a Nemzeti Kardiovaszkul\u00e1ris Laborat\u00f3rium klinikai\u2212epidemiol\u00f3giai programjainak r\u00e9szek\u00e9nt felt\u00e9rk\u00e9pezi a COVID-19 fert\u0151z\u00e9s potenci\u00e1lis k\u00f6z\u00e9p- \u00e9s hossz\u00fat\u00e1v\u00fa kardiovaszkul\u00e1ris hat\u00e1sait is, multimod\u00e1lis klinikai \u00e9s r\u00e9szletes ut\u00e1nk\u00f6vet\u00e9ssel. A H-UNCOVER 2020. m\u00e1jusban v\u00e9gzett reprezentat\u00edv sz\u0171r\u00e9s\u00e9nek eredm\u00e9nyei kiemelt t\u00e1rsadalmi jelent\u0151s\u00e9ggel b\u00edrtak a magyarorsz\u00e1gi els\u00f5 hull\u00e1m ut\u00e1n a t\u00e1rsadalom fert\u0151z\u00f6tts\u00e9g\u00e9nek \u00e9s \u00e1tfert\u0151z\u00f6tts\u00e9g\u00e9nek meghat\u00e1roz\u00e1s\u00e1ra, nem csup\u00e1n az aktu\u00e1lis sz\u00e1mok, de a restrikci\u00f3s szab\u00e1lyoz\u00e1sok hat\u00e9konys\u00e1g\u00e1nak igazol\u00e1s\u00e1ra.<\/p>\n<p>A tov\u00e1bbi, nagys\u00e1grendekkel nagyobb infekci\u00f3s sz\u00e1mmal zajl\u00f3 hull\u00e1mok ut\u00e1n m\u00e9g hangs\u00falyosabb a fert\u0151z\u00e9sen \u00e1tesett betegek \u00e9s az \u00e1tfert\u0151z\u00f6tts\u00e9g felm\u00e9r\u00e9se, valamint a fert\u0151z\u00e9s hossz\u00fa t\u00e1v\u00fa hat\u00e1sainak le\u00edr\u00e1sa. K\u00fcl\u00f6n\u00f6sen igaz ez olyan kiemelt t\u00e1rsadalmi csoportokra, mint az eg\u00e9szs\u00e9g\u00fcgyi dolgoz\u00f3k, orvostanhallgat\u00f3k sz\u0171r\u00e9se, amely szint\u00e9n r\u00e1vil\u00e1g\u00edthat arra, mennyiben effekt\u00edv \u00e9s pontos a v\u00e9d\u0151felszerel\u00e9sek haszn\u00e1lata a mindennapi klinikai gyakorlatban.<\/p>\n<p>Ezen fel\u00fcl a sz\u00edvizomgyullad\u00e1s \u00e9s hirtelen sz\u00edvhal\u00e1l magasabb kock\u00e1zat\u00e1val b\u00edr\u00f3, COVID-19 fert\u0151z\u00e9sen \u00e1tesett \u00e9lsportol\u00f3k k\u00f6z\u00e9p-\u00e9s hossz\u00fat\u00e1v\u00fa kardiovaszkul\u00e1ris vizsg\u00e1lata tov\u00e1bb specifik\u00e1lhatja ezen csoporton bel\u00fcl a legmagasabb rizik\u00f3csoportokat.<\/p>\n<p><strong>A kutat\u00f3csoport vezet\u0151je: Prof. Dr. V\u00e1g\u00f3 Hajnalka<\/strong><\/p>\n<p><strong>A kutat\u00f3csoport legjelent\u0151sebb publik\u00e1ci\u00f3inak el\u00e9rhet\u0151s\u00e9ge:<\/strong><\/p>\n<ul>\n<li>Escalating SARS-CoV-2 specific humoral immune response in rheumatoid arthritis patients and healthy controls<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2024.1397052\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2024.1397052\/full<\/a><\/li>\n<li>T cell immune response predicts survival in severely ill COVID-19 patients requiring venovenous extracorporeal membrane oxygenation support <br \/>\n<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2023.1179620\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2023.1179620\/full<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>A <strong>\u201eBudapest CRT study\u201d<\/strong> <strong>kutat\u00f3csoport<\/strong> a sz\u00edvel\u00e9gtelens\u00e9g egyik eszk\u00f6z\u00f6s kezel\u00e9si m\u00f3dj\u00e1nak, a kardi\u00e1lis reszinkroniz\u00e1ci\u00f3s ter\u00e1pia (CRT) sikerar\u00e1ny\u00e1nak jav\u00edt\u00e1s\u00e1t, indik\u00e1ci\u00f3s k\u00f6r\u00e9nek pontos\u00edt\u00e1s\u00e1t c\u00e9lozza meg a BUDAPEST Upgrade CRT nemzetk\u00f6zi klinikai vizsg\u00e1lat lez\u00e1r\u00e1s\u00e1val, melynek eredm\u00e9nyei alapj\u00e1n \u00faj szakmai ir\u00e1nyelvek ker\u00fclnek kidolgoz\u00e1sra. A BUDAPEST CRT upgrade study (melyben orsz\u00e1gosan 6 kardiol\u00f3giai centrum, k\u00f6zt\u00fck a szegedi Invaz\u00edv Kardiol\u00f3gia Tansz\u00e9k vesz r\u00e9szt) az els\u0151 prospekt\u00edv, nemzetk\u00f6zi, multicentrikus, randomiz\u00e1lt, kontroll\u00e1lt vizsg\u00e1lat lez\u00e1rult. Ennek a vizsg\u00e1latnak a keret\u00e9n bel\u00fcl nemzetk\u00f6zi multicentrikus, randomiz\u00e1lt, kontroll\u00e1lt vizsg\u00e1latot v\u00e9gezt\u00fcnk. A vizsg\u00e1lat els\u0151k\u00e9nt igazolta 360 pacemakerrel (PM) vagy be\u00fcltethet\u0151 kardioverter defibrill\u00e1tor (ICD) k\u00e9sz\u00fcl\u00e9kkel rendelkez\u0151 betegen a CRT upgrade hat\u00e9konys\u00e1g\u00e1t \u00e9s biztons\u00e1goss\u00e1g\u00e1t, a medi\u00e1n ut\u00e1nk\u00f6vet\u00e9si id\u0151szak alatt.<\/p>\n<p>Az eredm\u00e9nyeket az Europiai Kardiol\u00f3gus Kongresszuson bemutattuk, \u00e9s a rangos European Heart Journal\u00a0 szakmai\u00a0 akad\u00e9miai foly\u00f3iratban megjelentett\u00fck. A Budapest CRT upgrade study kutat\u00e1si eredm\u00e9nyeit felhaszn\u00e1lva a nemzetk\u00f6zi kezel\u00e9si ir\u00e1nyelvek m\u00f3dos\u00edt\u00e1sa folyamatban van.<\/p>\n<p>A vizsg\u00e1lat f\u0151 eredm\u00e9nyeinek \u00f6sszefoglal\u00e1s\u00e1val alapvet\u0151 c\u00e9lunk a jelenlegi, a CRT upgrade-re vonatkoz\u00f3 hi\u00e1nyos aj\u00e1nl\u00e1sok, az indik\u00e1ci\u00f3s k\u00f6r\u00f6k pontos\u00edt\u00e1sa, \u00e9s a szakmai ir\u00e1nyelvek kib\u0151v\u00edt\u00e9se.<\/p>\n<p><strong>A kutat\u00f3csoport vezet\u0151je: Dr. Kosztin Annam\u00e1ria<\/strong><\/p>\n<p><strong>A kutat\u00f3csoport legjelent\u0151sebb publik\u00e1ci\u00f3inak el\u00e9rhet\u0151s\u00e9ge:<\/strong><\/p>\n<ul>\n<li>Upgrading Right Ventricular Pacing to Cardiac Resynchronization in HFrEF Patients Improves Symptoms and Functional Outcomes<br \/>\n<a href=\"https:\/\/www.jacc.org\/doi\/10.1016\/j.jchf.2024.09.011\" target=\"_blank\" rel=\"noopener\">https:\/\/www.jacc.org\/doi\/10.1016\/j.jchf.2024.09.011<\/a><\/li>\n<li>Benefits of upgrading right ventricular to biventricular pacing in heart failure patients with atrial fibrillation<br \/>\n<a href=\"https:\/\/academic.oup.com\/europace\/article\/26\/7\/euae179\/7709529\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/europace\/article\/26\/7\/euae179\/7709529<\/a><\/li>\n<li>Upgrade of right ventricular pacing to cardiac resynchronization therapy in heart failure: a randomized trial<br \/>\n<a href=\"https:\/\/academic.oup.com\/eurheartj\/article\/44\/40\/4259\/7251970?login=true\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/eurheartj\/article\/44\/40\/4259\/7251970?login=true<\/a><\/li>\n<li>Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST-CRT Upgrade trial<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2609\" target=\"_blank\" rel=\"noopener\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2609<\/a><\/li>\n<\/ul>\n<p><strong>El\u0151zm\u00e9nyprojektben publik\u00e1lt, jelen projekthez szakmai tartalom tekintet\u00e9ben szorosan kapcsol\u00f3d\u00f3 cikk:<\/strong><\/p>\n<ul>\n<li>Rationale and design of the BUDAPEST-CRT Upgrade Study: a prospective, randomized, multicentre clinical trial<br \/>\n<a href=\"https:\/\/academic.oup.com\/europace\/article\/19\/9\/1549\/2952403?login=true\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/europace\/article\/19\/9\/1549\/2952403?login=true<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>A <strong>\u201eBudakal\u00e1sz Vizsg\u00e1lat\u201d kutat\u00f3csoport<\/strong> \u00e1ltal v\u00e9gzett biok\u00e9miai, genetikai \u00e9s pszichol\u00f3gia vizsg\u00e1lataink elemz\u00e9s\u00e9vel a kardiovaszkul\u00e1ris rizik\u00f3, k\u00fcl\u00f6n\u00f6s tekintettel az atherosclerosis kialakul\u00e1s\u00e1ban szerepet j\u00e1tsz\u00f3 t\u00e9nyez\u0151k multidiszciplin\u00e1ris megismer\u00e9s\u00e9t t\u0171zt\u00fck ki c\u00e9lul. A mintegy 10 \u00e9ves ut\u00e1nk\u00f6vet\u00e9ssel egyed\u00fcl\u00e1ll\u00f3 lehet\u0151s\u00e9g\u00fcnk van vizsg\u00e1lni egy hazai popul\u00e1ci\u00f3 morbidit\u00e1si \u00e9s mortalit\u00e1si adatait longitudin\u00e1lisan. Pszichol\u00f3giai kutat\u00e1saink sor\u00e1n a pszichol\u00f3giai t\u00e9nyez\u0151k \u00e9s a kardiovaszkul\u00e1ris rizik\u00f3 \u00e9s k\u00f3r\u00e1llapotok h\u00e1tter\u00e9t tudjuk vizsg\u00e1lni.<\/p>\n<p><strong>A kutat\u00f3csoport vezet\u0151je: Dr. Bagyura Zsolt Istv\u00e1n<\/strong><\/p>\n<p><strong>A kutat\u00f3csoport legjelent\u0151sebb publik\u00e1ci\u00f3inak el\u00e9rhet\u0151s\u00e9ge<\/strong><\/p>\n<ul>\n<li>Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly<br \/>\nCaucasian population sample free of manifest cardiovascular disease <br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37548881\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37548881\/<\/a><\/li>\n<li>Associations between Various Inflammatory Markers and Carotid Findings in a Voluntary Asymptomatic Population Sample<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39273602\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39273602\/<\/a><\/li>\n<li>Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease <br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38522236\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38522236\/<\/a><\/li>\n<li>PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction <br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38094682\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38094682\/<\/a><\/li>\n<li>Neutrophil-to-Lymphocyte Ratio Is an Independent Risk Factor for Coronary Artery Disease in Central Obesity<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37108560\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37108560\/<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>A <strong><u>\u201eS\u00falyos aorta \u00e9rintetts\u00e9g megel\u0151z\u00e9se Marfan-szindr\u00f3m\u00e1ban \u00e9s egy\u00e9b ritka k\u00f6t\u0151sz\u00f6veti betegs\u00e9gekben\u201d kutat\u00f3csoport<\/u><\/strong> \u00e1ltal v\u00e9gzett vizsg\u00e1lataink seg\u00edts\u00e9get ny\u00fajthatnak az aorta \u00e9rintetts\u00e9g pontosabb patomechanizmus\u00e1nak felder\u00edt\u00e9s\u00e9ben, az egyes aorta szakaszok elt\u00e9r\u0151 dilat\u00e1ci\u00f3s hajlama m\u00f6g\u00f6tt megh\u00faz\u00f3d\u00f3 okok tiszt\u00e1z\u00e1s\u00e1ban, valamint\u00a0ter\u00e1pi\u00e1s c\u00e9lpontok felismer\u00e9s\u00e9ben.<\/p>\n<p>A projekt keret\u00e9ben eg\u00e9rmodellen elv\u00e9gzett k\u00eds\u00e9rletek seg\u00edts\u00e9g\u00e9vel r\u00e9szletesen vizsg\u00e1lhat\u00f3ak az aorta biomechanikai tulajdons\u00e1gai \u00e9s meghat\u00e1rozhat\u00f3 azon, elt\u00e9r\u0151 indik\u00e1ci\u00f3val, de jelenleg is haszn\u00e1latban l\u00e9v\u0151 gy\u00f3gyszerek k\u00f6re, amelyek\u00a0hat\u00e9konyan m\u00e9rs\u00e9kelhetik a Marfan-szindr\u00f3m\u00e1sok \u00e9s egy\u00e9b k\u00f6t\u0151sz\u00f6veti betegs\u00e9gben szenved\u0151k kardiovaszkul\u00e1ris manifeszt\u00e1ci\u00f3it, illetve\u00a0megel\u0151zhetik az akut \u00e9rkatasztr\u00f3fa kialakul\u00e1s\u00e1t. A k\u00eds\u00e9rletek sor\u00e1n nyert eredm\u00e9nyek meg\u00e1gyazhatnak k\u00e9s\u0151bbi hum\u00e1n vizsg\u00e1latoknak, amelyek j\u00f3 es\u00e9llyel a Marfan-szindr\u00f3m\u00e1sok \u00e9s az egy\u00e9b k\u00f6t\u0151sz\u00f6veti betegs\u00e9ggel rendelkez\u0151k morbidit\u00e1s\u00e1nak \u00e9s mortalit\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9hez vezethetnek egy rendk\u00edv\u00fcl fiatal betegpopul\u00e1ci\u00f3ban.<\/p>\n<p>Genetikai vizsg\u00e1lataink f\u00f3kusz\u00e1ban a mut\u00e1ci\u00f3 t\u00edpusa \u00e9s a k\u00fcl\u00f6nf\u00e9le szervrendszerek manifeszt\u00e1ci\u00f3i k\u00f6z\u00f6tt fenn\u00e1ll\u00f3 kapcsolatok felt\u00e1r\u00e1sa, valamint olyan genetikai vari\u00e1ci\u00f3k azonos\u00edt\u00e1sa \u00e1ll, amelyek befoly\u00e1solhatj\u00e1k az aorta \u00e9rintetts\u00e9g megjelen\u00e9s\u00e9nek s\u00falyoss\u00e1g\u00e1t, ez\u00e1ltal jelenl\u00e9t\u00fck el\u0151re jelezheti az \u00e9letet vesz\u00e9lyeztet\u0151 akut \u00e9rkatasztr\u00f3fa kialakul\u00e1s\u00e1t.<\/p>\n<p>Tov\u00e1bb\u00e1 korszer\u0171 m\u00f3dszerekkel vizsg\u00e1ljuk a Marfan-szindr\u00f3ma kialakul\u00e1s\u00e1ban szerepet j\u00e1tsz\u00f3 fibrillin-1 feh\u00e9rje nanoszerkezet\u00e9t \u00e9s biomechanikai tulajdons\u00e1gait, amelynek r\u00e9szletes megismer\u00e9se seg\u00edthet a betegs\u00e9g patomechanizmus\u00e1nak m\u00e9lyebb felt\u00e1r\u00e1s\u00e1ban, ami ak\u00e1r \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek kidolgoz\u00e1s\u00e1ban is szerepet j\u00e1tszhat a j\u00f6v\u0151ben.<\/p>\n<p><strong>A kutat\u00f3csoport vezet\u0151je: Dr. Benke K\u00e1lm\u00e1n<\/strong><\/p>\n<p><strong>\u00a0<\/strong><strong>A kutat\u00f3csoport legjelent\u0151sebb publik\u00e1ci\u00f3inak el\u00e9rhet\u0151s\u00e9ge:<\/strong><\/p>\n<ul>\n<li><span style=\"font-size: 1rem\">\u0218ulea CM, M\u00e1rtonfalvi Z, Cs\u00e1nyi C, Haluszka D, P\u00f3los M, \u00c1gg B, Stengl R, Benke K, Szabolcs Z, Kellermayer MSZ.<br \/>\n<\/span>Nanoscale Structural Comparison of Fibrillin-1 Microfibrils Isolated from Marfan and Non-Marfan Syndrome Human Aorta. Int J Mol Sci. 2023 Apr 20;24(8):7561. doi: 10.3390\/ijms24087561.<br \/>\n<a href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7561\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7561<\/a><\/li>\n<\/ul>\n<p><strong>El\u0151zm\u00e9nyprojektben publik\u00e1lt, jelen projekthez szakmai tartalom tekintet\u00e9ben szorosan kapcsol\u00f3d\u00f3 cikkek:<\/strong><\/p>\n<ol>\n<li>Stengl R, \u00c1gg B, Szilveszter B, Benke K, Daradics N, Rusk\u00f3 B, Vattay B, Merkely B, P\u00f3los M, Szabolcs Z.<br \/>\nCase Report: Morphological Characterization and Long-Term Observation of Bilateral Sequential Internal Mammary Artery Aneurysms in a Patient With Confirmed FBN1 Mutation. Front Cardiovasc Med. 2021 Jun 16;8:697591. doi: 10.3389\/fcvm.2021.697591.<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/journals\/cardiovascular-medicine\/articles\/10.3389\/fcvm.2021.697591\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/cardiovascular-medicine\/articles\/10.3389\/fcvm.2021.697591\/full<\/a><\/li>\n<li>Stengl R, \u00c1gg B, P\u00f3los M, M\u00e1ty\u00e1s G, Szab\u00f3 G, Merkely B, Radovits T, Szabolcs Z, Benke K.<br \/>\nPotential predictors of severe cardiovascular involvement in Marfan syndrome: the emphasized role of genotype-phenotype correlations in improving risk stratification-a literature review. Orphanet J Rare Dis. 2021 May 31;16(1):245. doi: 10.1186\/s13023-021-01882-6.<br \/>\n<a href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-021-01882-6\" target=\"_blank\" rel=\"noopener\">https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-021-01882-6<\/a><\/li>\n<li>Stengl R, Bors A, \u00c1gg B, P\u00f3los M, Matyas G, Moln\u00e1r MJ, Fekete B, Csab\u00e1n D, Andrikovics H, Merkely B, Radovits T, Szabolcs Z, Benke K.<br \/>\nOptimising the mutation screening strategy in Marfan syndrome and identifying genotypes with more severe aortic involvement. Orphanet J Rare Dis. 2020 Oct 15;15(1):290. doi: 10.1186\/s13023-020-01569-4. <br \/>\n<a href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-020-01569-4\" target=\"_blank\" rel=\"noopener\">https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-020-01569-4<\/a><\/li>\n<li>P\u00f3los M, Benke K, \u00c1gg B, Stengl R, Szab\u00f3 A, Nagy \u00c1, Rusk\u00f3 B, Hedberg J, Radovits T, Sus\u00e1nszky \u00c9, Merkely B, Sz\u00e9kely A, Szabolcs Z.<br \/>\nPsychological factors affecting Marfan syndrome patients with or without cardiac surgery. Ann Palliat Med. 2020 Sep;9(5):3007-3017. doi: 10.21037\/apm-20-546. <br \/>\n<a href=\"https:\/\/apm.amegroups.org\/article\/view\/49791\/html\" target=\"_blank\" rel=\"noopener\">https:\/\/apm.amegroups.org\/article\/view\/49791\/html<\/a><\/li>\n<li>\u00c1gg B, Szilveszter B, Daradics N, Benke K, Stengl R, Kolossv\u00e1ry M, P\u00f3los M, Radovits T, Ferdinandy P, Merkely B, Maurovich-Horvat P, Szabolcs Z.<br \/>\nIncreased visceral arterial tortuosity in Marfan syndrome. Orphanet J Rare Dis. 2020 Apr 15;15(1):91. doi: 10.1186\/s13023-020-01369-w.<br \/>\n<a href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-020-01369-w\" target=\"_blank\" rel=\"noopener\">https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-020-01369-w<\/a><\/li>\n<li>Benke K, \u00c1gg B, Meienberg J, Kopps AM, Fattorini N, Stengl R, Daradics N, P\u00f3los M, Bors A, Radovits T, Merkely B, De Backer J, Szabolcs Z, M\u00e1ty\u00e1s G.<br \/>\nHungarian Marfan family with large FBN1 deletion calls attention to copy number variation detection in the current NGS era. J Thorac Dis. 2018 Apr;10(4):2456-2460. doi: 10.21037\/jtd.2018.04.40. <br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29850152\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29850152\/<\/a><\/li>\n<li>Benke K, \u00c1gg B, P\u00f3los M, Sayour AA, Radovits T, Bartha E, Nagy P, R\u00e1k\u00f3czi B, Koller \u00c1, Szokolai V, Hedberg J, Merkely B, Nagy ZB, Szabolcs Z.<br \/>\nThe effects of acute and elective cardiac surgery on the anxiety traits of patients with Marfan syndrome. BMC Psychiatry. 2017 Jul 17;17(1):253. doi: 10.1186\/s12888-017-1417-9. <br \/>\n<a href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-017-1417-9\" target=\"_blank\" rel=\"noopener\">https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-017-1417-9<\/a><\/li>\n<li>Benke K, \u00c1gg B, M\u00e1ty\u00e1s G, Szokolai V, Hars\u00e1nyi G, Szilveszter B, Odler B, P\u00f3los M, Maurovich-Horvat P, Radovits T, Merkely B, Nagy ZB, Szabolcs Z.<br \/>\nGene polymorphisms as risk factors for predicting the cardiovascular manifestations in Marfan syndrome. Role of folic acid metabolism enzyme gene polymorphisms in Marfan syndrome. Thromb Haemost. 2015 Oct;114(4):748-56. doi: 10.1160\/TH15-02-0096.<br \/>\n<a href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-017-1417-9\" target=\"_blank\" rel=\"noopener\">https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-017-1417-9<\/a><\/li>\n<li>Agg B, Benke K, Szilveszter B, P\u00f3los M, Dar\u00f3czi L, Odler B, Nagy ZB, Tarr F, Merkely B, Szabolcs Z.<br \/>\nPossible extracardiac predictors of aortic dissection in Marfan syndrome. BMC Cardiovasc Disord. 2014 Apr 11;14:47. doi: 10.1186\/1471-2261-14-47. <br \/>\n<a href=\"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/1471-2261-14-47\" target=\"_blank\" rel=\"noopener\">https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/1471-2261-14-47<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>A \u201eKlinikai \u2013 epidemiol\u00f3giai program\u201d sor\u00e1n az \u00faj elj\u00e1r\u00e1sok implement\u00e1ci\u00f3s lehet\u0151s\u00e9geit a bizony\u00edt\u00e9kokon alapul\u00f3 indik\u00e1tor rendszer alkalmaz\u00e1s\u00e1val a Semmelweis Egyetemen bel\u00fcl megval\u00f3sul\u00f3 kohorsz vizsg\u00e1latban (Semmelweis Study) fogjuk tesztelni. Ezen vizsg\u00e1latba \u00e1gyaz\u00f3dnak be a program seg\u00edts\u00e9g\u00e9vel kialak\u00edtand\u00f3 Eg\u00e9szs\u00e9ges \u00d6reged\u00e9s\u00e9rt Program kardiovaszkul\u00e1ris kutat\u00e1si programj\u00e1nak vizsg\u00e1latai. A program az iszk\u00e9mi\u00e1s sz\u00edvbetegs\u00e9g \u00e9s a sz\u00edvel\u00e9gtelens\u00e9g el\u0151fordul\u00e1s\u00e1nak \u00e9s hal\u00e1loz\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9t &hellip;<\/p>\n","protected":false},"author":102384,"featured_media":0,"parent":9,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-80","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/pages\/80","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/users\/102384"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/comments?post=80"}],"version-history":[{"count":11,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/pages\/80\/revisions"}],"predecessor-version":[{"id":315,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/pages\/80\/revisions\/315"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/pages\/9"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/media?parent=80"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/categories?post=80"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/nkl\/wp-json\/wp\/v2\/tags?post=80"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}