{"id":6249,"date":"2013-04-09T21:20:22","date_gmt":"2013-04-09T21:20:22","guid":{"rendered":"http:\/\/semmelweis.hu\/orvosi-vegytan\/?page_id=6249"},"modified":"2026-03-12T10:43:43","modified_gmt":"2026-03-12T09:43:43","slug":"med-biotech-msc","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/molekularis-biologia\/en\/students\/med-biotech-msc\/","title":{"rendered":"Medical Biotechnology MSc"},"content":{"rendered":"

P\u00e1zm\u00e1ny P\u00e9ter Catholic University<\/strong>
\nFaculty of Information Technology and Bionics<\/strong><\/p>\n

Molecular biology subject<\/strong>
\n(5 credit points, terminal examination, Prof. Mikl\u00f3s Csala; P-ITBIO-0046)<\/strong><\/p>\n

Lecturers<\/strong>: Prof. Mikl\u00f3s Csala <\/a>, Dr. \u00c9va Kereszturi<\/a>, Prof. Tam\u00e1s M\u00e9sz\u00e1ros<\/a>
\n2025\/2026 Spring semester<\/strong><\/p>\n

\n

Intro<\/h2>\n
\n
\nThe knowledge to be attained<\/b>
\nThe storage, maintenance and expression of genetic information, as well as their molecular mechanisms are fundamental topics of the course. DNA replication, DNA damage and repair, RNA synthesis and processing, protein synthesis, maturation and targeting, and different ways of regulation of gene expression are discussed. Regulation of cell cycle and apoptosis, in the light of the molecular background of tumor development is also part of the subject. Some of the lectures provide insights into molecular biology research.<\/p>\n

Midterm tests and Students’ presentation<\/b>
\nTwo oral midterm examinations are held during the semester. In each occasion, a random topic should be picked from the list and answered verbally. The student’s performance is evaluated from 1 to 5 in each of the two tests.
\nStudents who miss a test due to illness (with a medical certificate presented) will be provided with a retake opportunity within one week.<\/p>\n

Requirements for the signature<\/b>
\nThe course of the subject will not be recognized in case of more than 3 absences during the semester.<\/p>\n

Examination<\/b>
\nThe semester ends with an oral terminal examination.
\nStudents draw from two sets of topics, so the grade is based on two parts. The partial grades are offered in advance if marks of 3, 4 or 5 have been obtained at each of the two evaluations held during the term. The grade of the first oral midterm (better than 2) is counted as the first, and that of the second oral midterm (better than 2) is counted as the second partial grade. Midterm marks worse than 3 do not yield such exemptions, and the student must draw a topic from the given set at the terminal exam.<\/p>\n

What to learn for the terminal examination?<\/b>
\n– The material of all lectures during the semester.
\n– Medical Pathobiochemistry (eds. Mandl J and Machovich R) ISBN: 978 963 226 407 3
\n– Molecular Biology of the Cell (Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P) ISBN: 978-0815341055<\/p>\n

\n<\/div>

Lectures<\/h2>\n
\n
\nLocation<\/strong>: Room 134, ITK building (Pr\u00e1ter u. 50\/A)
\nDuration<\/strong>: 2 x 45 min (Mondays 9:15 – 11:00 and Wednesdays 14:15 – 16:00)<\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Date<\/th>Time<\/th>Place<\/th>Lecture<\/th>Lecturer<\/th>\n<\/tr>\n<\/thead>\n
February 9<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Basics of molecular biology<\/td>Csala<\/td>\n<\/tr>\n
February 11<\/td>14:15<\/td>ITK 134<\/FONT><\/td>DNA replication<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
February 16<\/td>9:15<\/td>ITK 134<\/FONT><\/td>DNA damage, mutation, repair<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
February 18<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Transcription<\/td>Csala<\/td>\n<\/tr>\n
February 23<\/td>9:15<\/td>ITK 134<\/FONT><\/td>RNA processing<\/td>Csala<\/td>\n<\/tr>\n
February 25<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Control of gene expression at mRNA level<\/td>Csala<\/td>\n<\/tr>\n
March 2<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Translation<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
March 4<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Control of translation<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
March 9<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Post-translational modifications<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
March 11<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Intracellular protein trafficking<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
March 16<\/td>9:15<\/td>EOK<\/FONT><\/td>ORAL MIDTERM I<\/b><\/td><\/td>\n<\/tr>\n
March 18<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Vesicular transport, endocytosis, exocytosis<\/td>Kereszturi<\/td>\n<\/tr>\n
March 23<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Protein degradation (proteasome and autophagy)<\/td>M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
March 25<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Production of recombinant
\nproteins<\/td>		M\u00e9sz\u00e1ros<\/td>\n<\/tr>\n
April 13<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Genetic polymorphism and human diseases I<\/td>Kereszturi<\/td>\n<\/tr>\n
April 15<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Genetic polymorphism and human diseases II<\/td>Kereszturi<\/td>\n<\/tr>\n
April 20<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Molecular biology of viruses I<\/td>Csala<\/td>\n<\/tr>\n
April 22<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Molecular biology of viruses II<\/td>Csala<\/td>\n<\/tr>\n
April 27<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Control of cell cycle I<\/td>Csala<\/td>\n<\/tr>\n
April 29<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Control of cell cycle II<\/td>Csala<\/td>\n<\/tr>\n
May 4<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Apoptosis I<\/td>Csala<\/td>\n<\/tr>\n
May 6<\/td>14:15<\/td>ITK 134<\/FONT><\/td>Apoptosis II<\/td>Csala<\/td>\n<\/tr>\n
May 11<\/td>9:15<\/td>ITK 134<\/FONT><\/td>Molecular background of cancer<\/td>Csala<\/td>\n<\/tr>\n
May 13<\/td>14:15<\/td>EOK<\/FONT><\/td>ORAL MIDTERM II<\/b><\/td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

\n<\/div>

Midterm 1<\/h2>\n
\n
\nTopics for the 1st midterm<\/strong><\/p>\n
    \n
  1. Structure of DNA in prokaryotes and eukaryotes, histones, topoisomerism<\/li>\n
  2. Proteins involved in prokaryotic DNA replication<\/li>\n
  3. Initiation of replication and the replication fork<\/li>\n
  4. Special features of eukaryotic DNA replication, the telomerase<\/li>\n
  5. The most important types of DNA lesion, DNA damage and mutation<\/li>\n
  6. Formation and repair of „mismatch damage”<\/li>\n
  7. Ways to repair pyrimidine (Thymine) dimer<\/li>\n
  8. Structure and function of E. coli RNA polymerase<\/li>\n
  9. Initiation and termination of transcription in prokaryotic cells<\/li>\n
  10. Initiation and termination of transcription in eukaryotic cells<\/li>\n
  11. Processing of mRNA and the structure of mature mRNA<\/li>\n
  12. Regulation of transcription in prokaryotes<\/li>\n
  13. Regulation of transcription in eukaryotes<\/li>\n
  14. Mechanisms for influencing eukaryotic gene expression (other than transcriptional control)<\/li>\n
  15. Structure and function of RNAs involved in translation<\/li>\n
  16. Mechanism of aminoacyl-tRNA formation<\/li>\n
  17. Structure and function of prokaryotic and eukaryotic ribosomes<\/li>\n
  18. Initiation of translation in prokaryotes and eukaryotes<\/li>\n
  19. Elongation and termination of translation<\/li>\n
  20. Post-translational modifications and functional consequences<\/li>\n
  21. Possible mechanisms for the control of translation<\/li>\n
  22. Eukaryotic cell organelles and the nuclear protein transport<\/li>\n
  23. Protein transport to mitochondria and the ER<\/li>\n<\/ol>\n

    \n<\/div>

    Midterm 2<\/h2>\n
    \n
    \nTopics for the 2nd midterm<\/strong><\/p>\n
      \n
    1. Intracellular proteolysis, types and mechanisms of autophagy<\/li>\n
    2. Intracellular proteolysis, ubiquitination, proteasome<\/li>\n
    3. Vesicular transport between the organelles, the role of SNARE proteins and Rab proteins<\/li>\n
    4. Vesicular transport, endocytosis and exocytosis, the role of coat-forming proteins<\/li>\n
    5. Lytic and lysogenic replication of bacteriophages<\/li>\n
    6. Grouping of animal viruses according to their replication mechanism, effect of double-stranded RNA in the eukaryotic cells<\/li>\n
    7. Replication cycle of retroviruses, acutely transforming retroviruses<\/li>\n
    8. Role of genetic variations in disease development, ways to determine genetic factors<\/li>\n
    9. Techniques for detecting and analyzing genetic polymorphisms and mutations<\/li>\n
    10. The eukaryotic cell division cycle – phases and checkpoints<\/li>\n
    11. Cyclins, cyclin-dependent kinases and their inhibitors<\/li>\n
    12. Control of cell cycle in G1 and S phases<\/li>\n
    13. Control of cell cycle in G2 and M phases<\/li>\n
    14. Handling DNA injuries and ongoing replication during the cell cycle<\/li>\n
    15. Structure and function of apoptosome, DISC, and PIDDosome<\/li>\n
    16. Types of Bcl-2 proteins and their role in apoptosis pathways of different origin<\/li>\n
    17. Properties of caspases and their role in regulating apoptosis<\/li>\n
    18. Components of the „survival signal” and its connection with the regulatory proteins of apoptosis<\/li>\n
    19. The endoplasmic reticulum stress and the UPR<\/li>\n
    20. Control of the level and activity of p53 protein<\/li>\n
    21. Effects of p53 protein on cell cycle and apoptosis<\/li>\n
    22. The concept of tumor suppressor genes, the functions of some representative tumor suppressor proteins<\/li>\n
    23. Genetic modifications leading to tumor cell formation<\/li>\n
    24. Elements of prokaryotic and eukaryotic expression vectors<\/li>\n
    25. Isolation of overexpressed proteins<\/li>\n<\/ol>\n

      \n<\/div>

      Download<\/h2>\n
      \n
      \nLecture slides are available here<\/a>.<\/p>\n

      The passwords to download pages can be obtained from the laboratory teachers personally.<\/b>
      \n<\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"

      P\u00e1zm\u00e1ny P\u00e9ter Catholic University Faculty of Information Technology and Bionics Molecular biology subject (5 credit points, terminal examination, Prof. Mikl\u00f3s Csala; P-ITBIO-0046) Lecturers: Prof. Mikl\u00f3s Csala <\/a> , Dr. \u00c9va Kereszturi<\/a> , Prof. Tam\u00e1s M\u00e9sz\u00e1ros<\/a> 2025\/2026 Spring semester The knowledge to be attained The storage, maintenance and expression of genetic information, as well as their molecular mechanisms are fundamental topics of the course. DNA replication, …<\/p>\n","protected":false},"author":183,"featured_media":0,"parent":3550,"menu_order":100,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-6249","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/pages\/6249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/users\/183"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/comments?post=6249"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/pages\/6249\/revisions"}],"predecessor-version":[{"id":8904,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/pages\/6249\/revisions\/8904"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/pages\/3550"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/media?parent=6249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/categories?post=6249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/molekularis-biologia\/wp-json\/wp\/v2\/tags?post=6249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}