{"id":1359,"date":"2018-06-18T11:54:57","date_gmt":"2018-06-18T09:54:57","guid":{"rendered":"http:\/\/semmelweis.hu\/molecularimaging\/?page_id=1359"},"modified":"2018-06-18T12:00:12","modified_gmt":"2018-06-18T10:00:12","slug":"03-2","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/molecularimaging\/03-2\/","title":{"rendered":"Neurotoxikus oligomerek amiloid k\u00f6t\u0151d\u00e9s\u00e9nek in vitro \u00e9s in vivo vizsg\u00e1lat Alzheimer modellekben"},"content":{"rendered":"<div><strong>Le\u00edr\u00e1s<br \/>\n<\/strong>Az Alzheimer betegs\u00e9g a modern vil\u00e1g egyik meghat\u00e1roz\u00f3 eg\u00e9szs\u00e9g\u00fcgyi\u00a0probl\u00e9m\u00e1ja, a hetven\u00f6t \u00e9ven t\u00fali korcsoportban el\u0151fordul\u00e1sa el\u00e9ri a\u00a015%-ot. A betegs\u00e9gben az amiloid-\u00df (A\u00df) peptidekb\u0151l fel\u00e9p\u00fcl\u0151,\u00a0oldhatatlan plakkok alakulnak ki \u00e9s rak\u00f3dnak le a k\u00f6zponti\u00a0idegrendszer extracellul\u00e1ris t\u00e9rr\u00e9szeiben. Egyre t\u00f6bb tanulm\u00e1ny mutat r\u00e1 arra, hogy maguk az amiloid plakkok rezervo\u00e1rk\u00e9nt szolg\u00e1lnak olyan\u00a0A\u00df-oligomerek sz\u00e1m\u00e1ra, amelyek direkt neurotoxikus tulajdons\u00e1gokkal\u00a0rendelkeznek. A munka c\u00e9lja, hogy megvizsg\u00e1lja, hogy a vizsg\u00e1lt N27C\u00a0neurotoxikus oligomerek k\u00e9pesek-e a m\u00e1r megl\u00e9v\u0151 amiloid plakkokhoz\u00a0k\u00f6t\u0151dni. A hallgat\u00f3 munk\u00e1ja sor\u00e1n in vitro amiloid m\u00e1trix\u00a0felhaszn\u00e1l\u00e1s\u00e1val \u2013 a munkacsoport kor\u00e1bbi eredm\u00e9nyeire t\u00e1maszkodva \u2013\u00a0meghat\u00e1rozza a k\u00f6t\u0151d\u00e9s biomechanikai tulajdons\u00e1gait. A feladat m\u00e1sodik\u00a0fel\u00e9ben Alzheimer-modell egereken in vivo k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt vizsg\u00e1lja\u00a0a jel\u00f6lt oligomer \u00a0biodisztrib\u00faci\u00f3j\u00e1t multimod\u00e1lis k\u00e9palkot\u00f3 eszk\u00f6z\u00f6k\u00a0(NanoSPECT\/CT) seg\u00edts\u00e9g\u00e9vel. A munka sor\u00e1n a hallgat\u00f3 megismeri a\u00a0legmodernebb k\u00e9palkot\u00f3 elj\u00e1r\u00e1sokat elm\u00e9letben \u00e9s gyakorlatban, r\u00e9szt\u00a0vesz az in vivo k\u00e9palkot\u00e1sban \u00e9s az eredm\u00e9nyek ki\u00e9rt\u00e9kel\u00e9s\u00e9ben.<\/div>\n<div>\n<p><strong><br \/>\nElv\u00e1r\u00e1sok<\/strong><br \/>\nInterdiszciplin\u00e1ris \u00e9rdekl\u0151d\u00e9si k\u00f6r, \u00e9rdekl\u0151d\u00e9s orvosi k\u00e9palkot\u00e1si ismeretek ir\u00e1nt.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Le\u00edr\u00e1s Az Alzheimer betegs\u00e9g a modern vil\u00e1g egyik meghat\u00e1roz\u00f3 eg\u00e9szs\u00e9g\u00fcgyi\u00a0probl\u00e9m\u00e1ja, a hetven\u00f6t \u00e9ven t\u00fali korcsoportban el\u0151fordul\u00e1sa el\u00e9ri a\u00a015%-ot. A betegs\u00e9gben az amiloid-\u00df (A\u00df) peptidekb\u0151l fel\u00e9p\u00fcl\u0151,\u00a0oldhatatlan plakkok alakulnak ki \u00e9s rak\u00f3dnak le a k\u00f6zponti\u00a0idegrendszer extracellul\u00e1ris t\u00e9rr\u00e9szeiben. Egyre t\u00f6bb tanulm\u00e1ny mutat r\u00e1 arra, hogy maguk az amiloid plakkok rezervo\u00e1rk\u00e9nt szolg\u00e1lnak olyan\u00a0A\u00df-oligomerek sz\u00e1m\u00e1ra, amelyek direkt neurotoxikus tulajdons\u00e1gokkal\u00a0rendelkeznek. A &hellip;<\/p>\n","protected":false},"author":101226,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-1359","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/pages\/1359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/users\/101226"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/comments?post=1359"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/pages\/1359\/revisions"}],"predecessor-version":[{"id":1361,"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/pages\/1359\/revisions\/1361"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/media?parent=1359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/categories?post=1359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/molecularimaging\/wp-json\/wp\/v2\/tags?post=1359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}