{"id":344,"date":"2025-05-21T12:46:58","date_gmt":"2025-05-21T10:46:58","guid":{"rendered":"https:\/\/semmelweis.hu\/mocsailab\/?page_id=344"},"modified":"2025-05-21T16:48:42","modified_gmt":"2025-05-21T14:48:42","slug":"hoxb8","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/mocsailab\/projektek\/hoxb8\/","title":{"rendered":"Neutrofilek funkcion\u00e1lis vizsg\u00e1lata a HoxB8 rendszer seg\u00edts\u00e9g\u00e9vel"},"content":{"rendered":"
A neutrofil granulocit\u00e1k r\u00f6vid \u00e9letideje, term\u00e9szete k\u00f6zvetlen g\u00e9nm\u00f3dos\u00edt\u00e1sukat nem teszi lehet\u0151v\u00e9, mellyel hat\u00e9konyan lehetne vizsg\u00e1lni a neutrofilek jelent\u0151s szerep\u00e9t az immunv\u00e1laszok kialakul\u00e1s\u00e1ban, emiatt fordultunk a HoxB8 rendszer<\/strong> fel\u00e9.<\/div>\n

A rendszer haszn\u00e1lat\u00e1val sikeresen hoztunk l\u00e9tre genetikailag m\u00f3dos\u00edtott neutrofil progenitorokat (Orosz et al., J Immunol. 2021<\/a>), melyek neutrofil funkci\u00f3beli v\u00e1ltoz\u00e1sait (migr\u00e1ci\u00f3, fagocitak\u00e9pess\u00e9g, citokintermel\u00e9s) \u00e9rett granulocit\u00e1kk\u00e1 val\u00f3 differenci\u00e1ltat\u00e1s ut\u00e1n in vitro k\u00f6r\u00fclm\u00e9nyek k\u00f6zt vizsg\u00e1lunk.<\/p>\n

A progenitorokat let\u00e1lisan besugarazott egerekbe transzplant\u00e1lva in vivo k\u00f6r\u00fclm\u00e9nyek k\u00f6zt differenci\u00e1l\u00f3dott neutrofileket hozunk l\u00e9tre, majd megfigyelj\u00fck az \u00e9rett neutrofilek funkci\u00f3beli v\u00e1ltoz\u00e1sait immunkomplex induk\u00e1lta gyulladas\u00e1sos modellekben, valamint az \u00e1llatok patog\u00e9nekkel szembeni v\u00e9dekez\u0151k\u00e9pess\u00e9g\u00e9t.<\/p>\n\r\n [slb_exclude]\r\n

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Gal\u00e9ria<\/h3>\r\n\t\t\t\t\t
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A neutrofil granulocit\u00e1k r\u00f6vid \u00e9letideje, term\u00e9szete k\u00f6zvetlen g\u00e9nm\u00f3dos\u00edt\u00e1sukat nem teszi lehet\u0151v\u00e9, mellyel hat\u00e9konyan lehetne vizsg\u00e1lni a neutrofilek jelent\u0151s szerep\u00e9t az immunv\u00e1laszok kialakul\u00e1s\u00e1ban, emiatt fordultunk a HoxB8 rendszer fel\u00e9. A rendszer haszn\u00e1lat\u00e1val sikeresen hoztunk l\u00e9tre genetikailag m\u00f3dos\u00edtott neutrofil progenitorokat ( Orosz et al., J Immunol. 2021<\/a> ), melyek neutrofil funkci\u00f3beli v\u00e1ltoz\u00e1sait (migr\u00e1ci\u00f3, fagocitak\u00e9pess\u00e9g, citokintermel\u00e9s) \u00e9rett granulocit\u00e1kk\u00e1 val\u00f3 differenci\u00e1ltat\u00e1s ut\u00e1n in vitro k\u00f6r\u00fclm\u00e9nyek …<\/p>\n","protected":false},"author":102470,"featured_media":0,"parent":104,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-344","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/344","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/users\/102470"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/comments?post=344"}],"version-history":[{"count":7,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/344\/revisions"}],"predecessor-version":[{"id":362,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/344\/revisions\/362"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/104"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/media?parent=344"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/categories?post=344"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/tags?post=344"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}