Rheumatoid arthritis and gouty arthritis are inflammatory diseases characterized by acute flare-ups as well as chronic, progressive courses, leading to significant tissue damage and joint destruction, which consequently result in decreased quality of life in the affected population.<\/p>\n
Our research group investigates the underlying cellular and molecular mechanisms involved in both the effector phase of autoimmune rheumatoid arthritis and the autoinflammatory (non-autoimmune) nature of gouty arthritis in experimental disease models. These studies may contribute to a better understanding of the pathomechanisms of these diseases, as well as the identification of new therapeutic targets. Our investigations focus on the role of tyrosine kinase signaling pathways initiated by cell surface Fc\u03b3 receptors and \u03b22-integrins, with several components of these pathways identified over the past few years.<\/p>\n
Previous publications related to the project:<\/p>\n
Futosi, K\u00e1sa et al., Arthritis Rheumatol. 2021<\/a><\/span><\/p>\n Csepregi et al., J Immunol. 2018<\/span><\/a><\/p>\n N\u00e9meth et al., Front Immunol. 2018<\/a><\/span><\/p>\n N\u00e9meth et al., Nat Commun. 2016<\/a><\/span><\/p>\n Kov\u00e1cs et al., J Exp Med. 2014<\/a><\/span><\/p>\n N\u00e9meth et al., J Immunol. 2010<\/a><\/span><\/p>\n Jakus et al., Arthritis Rheumatol. 2010<\/a><\/span>\u00a0<\/span><\/p>\n