{"id":231,"date":"2025-04-30T09:56:01","date_gmt":"2025-04-30T07:56:01","guid":{"rendered":"https:\/\/semmelweis.hu\/mocsailab\/?page_id=231"},"modified":"2025-04-30T10:12:00","modified_gmt":"2025-04-30T08:12:00","slug":"research-group","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/mocsailab\/en\/research-group\/","title":{"rendered":"Inflammatory Physiology Research Group"},"content":{"rendered":"<p style=\"text-align: justify\"><span style=\"font-size: 14pt\">The primary aim of our research group is to understand the molecular mechanisms underlying inflammatory diseases. Closely related to this, we also study the function and intracellular signaling of various cell types of hematopoietic origin. Our experiments contribute to a better understanding of these diseases and the identification of new potential therapeutic targets.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: 14pt\">Inflammatory diseases affect a significant part of the population and are often chronic diseases with limited therapeutic options. They include joint diseases such as rheumatoid arthritis and gout, as well as numerous inflammatory skin and kidney diseases. Regardless of the origin of the inflammation process (e.g., autoimmunity or autoinflammation), tissue damage is mostly mediated by cells of the innate immune system.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: 14pt\">We use transgenic approaches in in vivo model systems to study the molecular mechanisms of rheumatoid arthritis, gout, certain autoimmune blistering skin diseases and inflammatory kidney diseases (e.g. glomerulonephritis). We also examine the function and intracellular signaling of immune cells primarily responsible for tissue damage, such as neutrophils, macrophages and osteoclasts. We invest significant effort in developing new experimental methods, including human model systems and CRISPR\/Cas9-based genetic deletions.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: 14pt\">We have identified the role of several intracellular signaling molecules, including Src-family kinases, the Syk tyrosine kinase, the PLC\u03b32 phospholipase, and the CARD9 adaptor protein, in various autoimmune and autoinflammatory diseases. Inhibiting these signaling processes may facilitate the development of novel therapeutic strategies.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We investigate the molecular mechanisms underlying inflammatory diseases and the function of hematopoietic-origin cells, with the aim to identify novel therapeutic targets.<\/p>\n<p>Our primary goal is to understand the molecular basis of inflammatory conditions affecting various organs. We study autoimmune and non-autoimmune inflammatory diseases of the joints, skin, and kidneys, with particular emphasis on intracellular signaling in innate immune cells. We also investigate the molecular mechanisms of pathological bone resorption. We utilize various in vitro and in vivo models, and state-of-the-art advanced genetic tools.<\/p>\n","protected":false},"author":102470,"featured_media":85,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-231","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/users\/102470"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/comments?post=231"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/231\/revisions"}],"predecessor-version":[{"id":234,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/231\/revisions\/234"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/media\/85"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/media?parent=231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/categories?post=231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/tags?post=231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}