{"id":148,"date":"2025-03-20T23:22:36","date_gmt":"2025-03-20T22:22:36","guid":{"rendered":"https:\/\/semmelweis.hu\/mocsailab\/?page_id=148"},"modified":"2025-05-29T11:33:39","modified_gmt":"2025-05-29T09:33:39","slug":"holyagos-borbetegsegek","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/mocsailab\/projektek\/holyagos-borbetegsegek\/","title":{"rendered":"Autoimmun h\u00f3lyagos b\u0151rbetegs\u00e9gek patogenezis\u00e9nek vizsg\u00e1lata"},"content":{"rendered":"

A bullosus pemphigoid<\/strong> \u00e9s az epidermolysis bullosa acquisita<\/strong> az id\u0151s\u00f6d\u0151 popul\u00e1ci\u00f3t \u00e9rint\u0151 ritka autoimmun b\u0151rbeteges\u00e9gek, melyek jellegzetes \u00e9s igen kellemetlen t\u00fcnete a b\u0151r\u00f6n kialakul\u00f3 feszes h\u00f3lyagok<\/strong> kialakul\u00e1sa. Leggyakrabban alkalmazott ter\u00e1pi\u00e1jukat az \u00e1ltal\u00e1nos immunszupressz\u00edv szerek k\u00e9pezik, \u00edgy nagy sz\u00fcks\u00e9g van a patogenezis pontosabb megismer\u00e9s\u00e9n kereszt\u00fcl \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek azonos\u00edt\u00e1s\u00e1ra.<\/p>\n

A betegs\u00e9gek vizsg\u00e1lat\u00e1ra ma m\u00e1r sz\u00e1mos in vitro, valamint in vivo modellrendszer \u00e9rhet\u0151 el, melyek j\u00f3 lehet\u0151s\u00e9get k\u00edn\u00e1lnak a a k\u00fcl\u00f6nb\u00f6z\u0151 patogenetikai folyamatok megsimer\u00e9s\u00e9re. Kor\u00e1bbi publik\u00e1ci\u00f3inkban (Szilveszter et al., J Invest Dermatol, 2022<\/a>, Vik\u00e1r et al., J invest Dermatol, 2024<\/a>) kimutattuk az immunreceptorok jel\u00e1tvitel\u00e9ben szerepet j\u00e1tsz\u00f3 egyes feh\u00e9rj\u00e9k elengedhetetlen szerep\u00e9t, m\u00edg jelenlegi vizsg\u00e1lataink az el\u0151bbiek mellett a JAK kin\u00e1zok<\/strong>, valamint a komplement rendszer<\/strong> betegs\u00e9gben bet\u00f6lt\u00f6tt szerep\u00e9re f\u00f3kusz\u00e1lnak.<\/p>\n\r\n [slb_exclude]\r\n

\r\n
\r\n \r\n\t\t\t\t
\"\"<\/a><\/div>\r\n <\/span>\r\n\r\n <\/div>\r\n\r\n\t\t\t
\r\n\t\t\t\t
\r\n
\r\n\t\t\t\t\t

Gal\u00e9ria<\/h3>\r\n\t\t\t\t\t
\r\n\r\n\t\t\t\t\t\t
5<\/span>k\u00e9p<\/div>\r\n <\/div> <\/div>\r\n \r\n\t\t\t\t\t
\"Neutrofil<\/a><\/div>\r\n <\/span>\r\n \r\n\t\t\t\t\t
\"Dermo-epiderm\u00e1lis<\/a><\/div>\r\n <\/span>\r\n\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n
\r\n \"\"\r\n <\/a><\/div><\/span>
\r\n \"\"\r\n <\/a><\/div><\/span>\r\n <\/div>\r\n\r\n [\/slb_exclude]\r\n\t\n","protected":false},"excerpt":{"rendered":"

A bullosus pemphigoid \u00e9s az epidermolysis bullosa acquisita az id\u0151s\u00f6d\u0151 popul\u00e1ci\u00f3t \u00e9rint\u0151 ritka autoimmun b\u0151rbeteges\u00e9gek, melyek jellegzetes \u00e9s igen kellemetlen t\u00fcnete a b\u0151r\u00f6n kialakul\u00f3 feszes h\u00f3lyagok kialakul\u00e1sa. Leggyakrabban alkalmazott ter\u00e1pi\u00e1jukat az \u00e1ltal\u00e1nos immunszupressz\u00edv szerek k\u00e9pezik, \u00edgy nagy sz\u00fcks\u00e9g van a patogenezis pontosabb megismer\u00e9s\u00e9n kereszt\u00fcl \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek azonos\u00edt\u00e1s\u00e1ra. A betegs\u00e9gek vizsg\u00e1lat\u00e1ra ma m\u00e1r sz\u00e1mos in …<\/p>\n","protected":false},"author":102471,"featured_media":0,"parent":104,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-148","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/users\/102471"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/comments?post=148"}],"version-history":[{"count":8,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/148\/revisions"}],"predecessor-version":[{"id":381,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/148\/revisions\/381"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/104"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/media?parent=148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/categories?post=148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/tags?post=148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}