{"id":143,"date":"2025-03-20T23:16:47","date_gmt":"2025-03-20T22:16:47","guid":{"rendered":"https:\/\/semmelweis.hu\/mocsailab\/?page_id=143"},"modified":"2025-05-15T13:10:29","modified_gmt":"2025-05-15T11:10:29","slug":"izuleti-gyulladasok","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/mocsailab\/projektek\/izuleti-gyulladasok\/","title":{"rendered":"Autoimmun \u00e9s autoinflamm\u00e1ci\u00f3s \u00edz\u00fcleti betegs\u00e9gmodellek"},"content":{"rendered":"<div class=\"keretes w-100\">\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 14pt;\">A projekt sor\u00e1n a tirozin-kin\u00e1z jelp\u00e1ly\u00e1k autoimmun \u00edz\u00fcleti gyullad\u00e1s \u00e9s k\u00f6szv\u00e9ny kialakul\u00e1s\u00e1ban j\u00e1tszott szerep\u00e9t vizsg\u00e1ljuk.<\/span><\/strong><\/p>\n<\/div>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\">A rheumatoid arthritisz \u00e9s a k\u00f6szv\u00e9nyes \u00edz\u00fcleti gyullad\u00e1s a heveny fell\u00e1ngol\u00e1sok mellett kr\u00f3nikus, progressz\u00edv lefoly\u00e1s\u00fa gyullad\u00e1sos k\u00f3rk\u00e9pek, jelent\u0151s sz\u00f6vetk\u00e1rosod\u00e1ssal j\u00e1rnak, mely id\u0151vel az \u00edz\u00fcleti funkci\u00f3k besz\u0171k\u00fcl\u00e9s\u00e9hez \u00e9s ez\u00e1ltal az \u00e9rintett betegpopul\u00e1ci\u00f3 \u00e9letmin\u0151s\u00e9g\u00e9nek jelent\u0151s roml\u00e1s\u00e1hoz vezetnek.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt;\">Kutat\u00f3csoportunk a <strong>betegs\u00e9gek k\u00eds\u00e9rleti modellrendszereiben<\/strong> vizsg\u00e1lja mind <strong>az autoantitestek \u00e1ltal medi\u00e1lt autoimmun rheumatoid arthritisz effektor f\u00e1zis\u00e1nak<\/strong>, mind az <strong>autoinflammat\u00f3rikus jelleg\u0171<\/strong> (nem autoimmun eredet\u0171) <strong>k\u00f6szv\u00e9ny h\u00e1tter\u00e9ben \u00e1ll\u00f3 cellul\u00e1ris \u00e9s molekul\u00e1ris mechanizmusokat<\/strong>, melyek hozz\u00e1seg\u00edthetnek a betegs\u00e9gek pathomechanizmus\u00e1nak jobb meg\u00e9rt\u00e9s\u00e9hez, valamint \u00fajabb ter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1s\u00e1hoz. Vizsg\u00e1lataink f\u00f3kusz\u00e1ban a sejtfelsz\u00edni Fc\u03b3-receptorokr\u00f3l valamint \u03b22-integrinekr\u0151l indul\u00f3 tirozin-kin\u00e1z jelp\u00e1ly\u00e1k szerep\u00e9nek tanulm\u00e1nyoz\u00e1sa \u00e1ll, melynek sz\u00e1mos elem\u00e9t azonos\u00edtottuk az elm\u00falt \u00e9vekben.<\/span><\/p>\n<h5 style=\"text-align: justify;\"><span style=\"font-size: 14pt;\">Projekthez kapcsol\u00f3d\u00f3 kor\u00e1bbi publik\u00e1ci\u00f3k:<\/span><\/h5>\n<ul style=\"list-style-type: square;\">\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33645887\/\" target=\"_blank\" rel=\"noopener\">Futosi, K\u00e1sa et al., Arthritis Rheumatol. 2021<\/a><\/span><\/p>\n<\/li>\n<li>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30464050\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-size: 18.6667px;\">Csepregi et al., J Immunol. 2018<\/span><\/a><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29616043\/\" target=\"_blank\" rel=\"noopener\">N\u00e9meth et al., Front Immunol. 2018<\/a><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27032818\/\" target=\"_blank\" rel=\"noopener\">N\u00e9meth et al., Nat Commun. 2016<\/a><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25225462\/\" target=\"_blank\" rel=\"noopener\">Kov\u00e1cs et al., J Exp Med. 2014<\/a><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20675588\/\" target=\"_blank\" rel=\"noopener\">N\u00e9meth et al., J Immunol. 2010<\/a><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20201079\/\" target=\"_blank\" rel=\"noopener\">Jakus et al., Arthritis Rheumatol. 2010<\/a><\/span><span style=\"font-size: 14pt;\">\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19273622\/\" target=\"_blank\" rel=\"noopener\">Jakus et al., J Exp Med. 2009<\/a><\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>A projekt sor\u00e1n a tirozin-kin\u00e1z jelp\u00e1ly\u00e1k autoimmun \u00edz\u00fcleti gyullad\u00e1s \u00e9s k\u00f6szv\u00e9ny kialakul\u00e1s\u00e1ban j\u00e1tszott szerep\u00e9t vizsg\u00e1ljuk. A rheumatoid arthritisz \u00e9s a k\u00f6szv\u00e9nyes \u00edz\u00fcleti gyullad\u00e1s a heveny fell\u00e1ngol\u00e1sok mellett kr\u00f3nikus, progressz\u00edv lefoly\u00e1s\u00fa gyullad\u00e1sos k\u00f3rk\u00e9pek, jelent\u0151s sz\u00f6vetk\u00e1rosod\u00e1ssal j\u00e1rnak, mely id\u0151vel az \u00edz\u00fcleti funkci\u00f3k besz\u0171k\u00fcl\u00e9s\u00e9hez \u00e9s ez\u00e1ltal az \u00e9rintett betegpopul\u00e1ci\u00f3 \u00e9letmin\u0151s\u00e9g\u00e9nek jelent\u0151s roml\u00e1s\u00e1hoz vezetnek. Kutat\u00f3csoportunk a betegs\u00e9gek k\u00eds\u00e9rleti modellrendszereiben &hellip;<\/p>\n","protected":false},"author":102471,"featured_media":0,"parent":104,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-143","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/users\/102471"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":9,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/143\/revisions"}],"predecessor-version":[{"id":316,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/143\/revisions\/316"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/pages\/104"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/media?parent=143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/categories?post=143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/mocsailab\/wp-json\/wp\/v2\/tags?post=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}