Johanna Petra SZAB\u00d3, D\u00e1niel FAB\u00d3, N\u00f3ra PET\u0150, Anna S\u00c1KOVICS, R\u00f3bert B\u00d3DIZS:<\/p>\n
ROLE OF ANTERIOR THALAMIC CIRCUITRY DURING SLEEP<\/p>\n
Epilepsy Research, Volume 186, October 2022, 106999<\/p>\n
DOI: https:\/\/doi.org\/10.1016\/j.eplepsyres.2022.106999<\/a><\/p>\n <\/p>\n ABSTRACT<\/p>\n Increased attention has been paid to the structure and function of anterior nucleus of the thalamus (ANT), since deep brain stimulation (DBS) treatment for epilepsy launched a decade ago. The efficacy of the treatment on seizure count varies patient from patient and we have limited information on the predictors of better outcomes.<\/p>\n While the thalamus is considered the key brain region responsible for maintaining sleep, ANT was traditionally not involved in this function. Recent experimental and human data point to a possible role of ANT in sleep processes, although the underlying mechanisms are still ambiguous. Beside evaluating the current knowledge on sleep disturbances experienced during ANT-DBS treatment, the search for valid biomarkers primarily resides on a better understanding of sleep circuits implicating ANT and its subnuclei. Hypothetically better selectivity within the target may increase seizure outcomes and reduce psychiatric and cognitive side effects.<\/p>\n Hence, the main scope of this review is to summarize the evidence on the activity measured in the ANT during non-REM and REM sleep. Furthermore, we aim to find shared properties of sleep processes and ANT-related functions examined more thoroughly during wakefulness, such as selective attention and memory.<\/p>\n KEYWORDS: anterior nucleus of the thalamus; DBS; epilepsy; sleep<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Johanna Petra SZAB\u00d3, D\u00e1niel FAB\u00d3, N\u00f3ra PET\u0150, Anna S\u00c1KOVICS, R\u00f3bert B\u00d3DIZS: ROLE OF ANTERIOR THALAMIC CIRCUITRY DURING SLEEP Epilepsy Research, Volume 186, October 2022, 106999 DOI: https:\/\/doi.org\/10.1016\/j.eplepsyres.2022.106999<\/a> ABSTRACT Increased attention has been paid to the structure and function of anterior nucleus of the thalamus (ANT), since deep brain stimulation (DBS) treatment for epilepsy launched a …<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11128","post","type-post","status-publish","format-standard","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts\/11128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/comments?post=11128"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts\/11128\/revisions"}],"predecessor-version":[{"id":11129,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts\/11128\/revisions\/11129"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/media?parent=11128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/categories?post=11128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/tags?post=11128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}