Hal\u00e1sz P\u00e9ter, Sz\u0171cs Anna:<\/p>\n
N\u00c9ZETV\u00c1LTOZ\u00c1SOK AZ EPILEPSZIA KELETKEZ\u00c9S\u00c9R\u0150L \u00c9S MECHANIZMUS\u00c1R\u00d3L. RENDSZERALAP\u00da MEGK\u00d6ZEL\u00cdT\u00c9S<\/p>\n
Ideggy\u00f3gy\u00e1szati Szemle 2022;75(3\u20134):79\u201397.<\/p>\n
C\u00e9lkit\u0171z\u00e9s:<\/p>\n
Az epileptogenesis \u00fatjainak vizsg\u00e1lata a rendszerepilepszia-koncepci\u00f3 ment\u00e9n.<\/p>\n
M\u00f3dszerek:<\/p>\n
Irodalmi \u00e1ttekint\u00e9s \u00e9s saj\u00e1t tapasztalatok alapj\u00e1n ismertetj\u00fck a deklarat\u00edv mem\u00f3riarendszer, az alv\u00e1s\/\u00e9bred\u00e9s \u00e9s a perisylvian kommunik\u00e1ci\u00f3s rendszer epilepszi\u00e1s \u00e1talakul\u00e1s\u00e1t, majd az epileptogenesis folyamat\u00e1t bemutatjuk az agyi s\u00e9r\u00fcl\u00e9sek \u00e9s a poszttraum\u00e1s epilepszia modellj\u00e9n is.<\/p>\n
Eredm\u00e9nyek:<\/p>\n
Az ismertetett rendszer-epilepszi\u00e1k kialakul\u00e1s\u00e1ban k\u00f6z\u00f6s l\u00e9p\u00e9sek ismerhet\u0151k fel a plaszticit\u00e1s \u00e9s a NREM-alv\u00e1s alatti szinaptikus homeoszt\u00e1zis felfokoz\u00f3d\u00e1s\u00e1ban, ami egyben r\u00e1vil\u00e1g\u00edt az alv\u00e1s d\u00f6nt\u0151 szerep\u00e9re epilepszi\u00e1ban.<\/p>\n
K\u00f6vetkeztet\u00e9sek:<\/p>\n
Megk\u00eds\u00e9relj\u00fck k\u00f6rvonalazni a rendszerepilepszia-koncepci\u00f3t, \u00e9s az egym\u00e1ssal \u00f6sszef\u00fcgg\u0151 plaszticit\u00e1s \u2013 alv\u00e1si szinaptikus homeoszt\u00e1zis \u201ekisikl\u00e1sa\u201d form\u00e1j\u00e1ban r\u00e1mutatunk az epileptogenesis lehets\u00e9ges k\u00f6z\u00f6s patomechanizmus\u00e1ra.<\/p>\n
Kulcsszavak:<\/p>\n
rendszer-epilepszia, interictalis epileptiform kis\u00fcl\u00e9sek, epilepszi\u00e1s kisikl\u00e1s, alv\u00e1sf\u00fcgg\u0151 homeosztatikus szab\u00e1lyoz\u00e1s, plaszticit\u00e1s, reflexepilepszia, neuronalis h\u00e1l\u00f3zat<\/p>\n
<\/p>\n
HOW OUR VIEW OF EPILEPTOGENESIS AND MECHANISM OF EPILEPSY CHANGES? THE SYSTEM EPILEPSIES\u2019 CONCEPT<\/p>\n
Ideggy\u00f3gy\u00e1szati Szemle 2022;75(3\u20134):79\u201397.<\/p>\n
Aim:<\/p>\n
To examine the ways of epileptogenesis closely linked to the system epilepsies\u2019 concept.<\/p>\n
Methods:<\/p>\n
We follow the ways of epileptic transformation in the declarative memory-system, in the sleep\/arousal twin-systems, in the perisylvian neuronal network and in postinjury epilepsy, which we consider a general model of the epileptic transformation.<\/p>\n
Results:<\/p>\n
In the presented systems, epileptogenesis shares a similar mechanism in the form of augmentation and derailment of plasticity and sleep-related synaptic homeostasis. This highlights the central role of NREM sleep in those epilepsies.<\/p>\n
Conclusion:<\/p>\n
We try to characterize the concept of system epilepsies and suggest a shared mechanism of epileptogenesis.<\/p>\n
Keywords:<\/p>\n
Keywords: system epilepsies\u2019 concept, interictal epileptiform discharges, epileptic transformation, sleep-dependent homeostatic regulation, plasticity, reflex epilepsy, neuronal network<\/p>\n","protected":false},"excerpt":{"rendered":"
Hal\u00e1sz P\u00e9ter, Sz\u0171cs Anna: N\u00c9ZETV\u00c1LTOZ\u00c1SOK AZ EPILEPSZIA KELETKEZ\u00c9S\u00c9R\u0150L \u00c9S MECHANIZMUS\u00c1R\u00d3L. RENDSZERALAP\u00da MEGK\u00d6ZEL\u00cdT\u00c9S Ideggy\u00f3gy\u00e1szati Szemle 2022;75(3\u20134):79\u201397. C\u00e9lkit\u0171z\u00e9s: Az epileptogenesis \u00fatjainak vizsg\u00e1lata a rendszerepilepszia-koncepci\u00f3 ment\u00e9n. M\u00f3dszerek: Irodalmi \u00e1ttekint\u00e9s \u00e9s saj\u00e1t tapasztalatok alapj\u00e1n ismertetj\u00fck a deklarat\u00edv mem\u00f3riarendszer, az alv\u00e1s\/\u00e9bred\u00e9s \u00e9s a perisylvian kommunik\u00e1ci\u00f3s rendszer epilepszi\u00e1s \u00e1talakul\u00e1s\u00e1t, majd az epileptogenesis folyamat\u00e1t bemutatjuk az agyi s\u00e9r\u00fcl\u00e9sek \u00e9s a poszttraum\u00e1s epilepszia …<\/p>\n","protected":false},"author":101277,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10632","post","type-post","status-publish","format-standard","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts\/10632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/comments?post=10632"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts\/10632\/revisions"}],"predecessor-version":[{"id":10634,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/posts\/10632\/revisions\/10634"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/media?parent=10632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/categories?post=10632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/tags?post=10632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}