{"id":12293,"date":"2024-03-26T17:13:15","date_gmt":"2024-03-26T16:13:15","guid":{"rendered":"https:\/\/semmelweis.hu\/magtud\/?page_id=12293"},"modified":"2024-03-26T17:13:15","modified_gmt":"2024-03-26T16:13:15","slug":"szalardy-et-al-temporal-association-between-sleep-spindles-and-ripples-in-the-human-anterior-and-mediodorsal-thalamus","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/magtud\/szalardy-et-al-temporal-association-between-sleep-spindles-and-ripples-in-the-human-anterior-and-mediodorsal-thalamus\/","title":{"rendered":"Szal\u00e1rdy-et-al: Temporal association between sleep spindles and ripples in the human anterior and mediodorsal thalamus"},"content":{"rendered":"

Temporal association between sleep spindles and ripples in the human anterior and mediodorsal thalamus<\/strong><\/p>\n

European Journal of Neuroscience;<\/a> \u00a0Volume 59, Issue 4<\/a> p. 641-661; Special Issue Article; First published: 14 January 2024 (2024)
\nDOI: 10.1111\/ejn.16240<\/a><\/p>\n

Orsolya Szal\u00e1rdy<\/a> 1,2,\u00a0P\u00e9ter Simor<\/a> 3,4,\u00a0P\u00e9ter Przemyslaw Ujma<\/a> 1,\u00a0Zs\u00f3fia Jord\u00e1n<\/a> 5,\u00a0L\u00e1szl\u00f3 Hal\u00e1sz<\/a> 5,\u00a0Lor\u00e1nd Er\u0151ss<\/a> 5,\u00a0D\u00e1niel Fab\u00f3<\/a> 5,\u00a0R\u00f3bert B\u00f3dizs<\/a> 1<\/p>\n

1 Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary<\/p>\n

2 Institute of Cognitive Neuroscience and Psychology, Budapest, Hungary<\/p>\n

3 Institute of Psychology, ELTE, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest, Hungary<\/p>\n

4 UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN, Center for Research in Cognition and Neurosciences and UNI-ULB Neurosciences Institute, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium<\/p>\n

5 National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary<\/p>\n

 <\/p>\n

ABSTRACT<\/strong><\/p>\n

Sleep spindles are major oscillatory components of Non-Rapid Eye Movement (NREM) sleep, reflecting hyperpolarization-rebound sequences of thalamocortical neurons. Reports suggest a link between sleep spindles and several forms of high-frequency oscillations which are considered as expressions of pathological off-line neural plasticity in the central nervous system. Here we investigated the relationship between thalamic sleep spindles and ripples in the anterior and mediodorsal nuclei (ANT and MD) of epilepsy patients. Whole-night LFP from the ANT and MD were co-registered with scalp EEG\/polysomnography by using externalized leads in 15 epilepsy patients undergoing a Deep Brain Stimulation protocol. Slow (~12\u2009Hz) and fast (~14\u2009Hz) sleep spindles were present in the human ANT and MD and roughly, 20% of them were associated with ripples. Ripple-associated thalamic sleep spindles were characterized by longer duration and exceeded pure spindles in terms of spindle power as indicated by time-frequency analysis. Furthermore, ripple amplitude was modulated by the phase of sleep spindles within both thalamic nuclei. No signs of pathological processes were correlated with measures of ripple and spindle association, furthermore, the density of ripple-associated sleep spindles in the ANT showed a positive correlation with verbal comprehension. Our findings indicate the involvement of the human thalamus in coalescent spindle-ripple oscillations of NREM sleep.<\/p>\n","protected":false},"excerpt":{"rendered":"

Temporal association between sleep spindles and ripples in the human anterior and mediodorsal thalamus European Journal of Neuroscience;<\/a> \u00a0 Volume 59, Issue 4<\/a> p. 641-661; Special Issue Article; First published: 14 January 2024 (2024) DOI: 10.1111\/ejn.16240<\/a> Orsolya Szal\u00e1rdy<\/a> 1,2,\u00a0 P\u00e9ter Simor<\/a> 3,4,\u00a0 P\u00e9ter Przemyslaw Ujma<\/a> 1,\u00a0 Zs\u00f3fia Jord\u00e1n<\/a> 5,\u00a0 L\u00e1szl\u00f3 Hal\u00e1sz<\/a> 5,\u00a0 Lor\u00e1nd Er\u0151ss<\/a> 5,\u00a0 D\u00e1niel Fab\u00f3<\/a> 5,\u00a0 R\u00f3bert B\u00f3dizs<\/a> 1 1 Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary 2 Institute of Cognitive Neuroscience and Psychology, Budapest, Hungary 3 Institute …<\/p>\n","protected":false},"author":101277,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-12293","page","type-page","status-publish","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/pages\/12293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/users\/101277"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/comments?post=12293"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/pages\/12293\/revisions"}],"predecessor-version":[{"id":12294,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/pages\/12293\/revisions\/12294"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/media?parent=12293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/categories?post=12293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/magtud\/wp-json\/wp\/v2\/tags?post=12293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}