{"id":277,"date":"2025-07-03T14:08:30","date_gmt":"2025-07-03T12:08:30","guid":{"rendered":"https:\/\/semmelweis.hu\/kfipalyazat\/?page_id=277"},"modified":"2025-08-14T09:57:34","modified_gmt":"2025-08-14T07:57:34","slug":"2024-1-2-3-hu-rizont-2024-00059","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/kfipalyazat\/palyazatok\/hazai-palyazatok\/nkfih\/hu-rizont\/2024-1-2-3-hu-rizont-2024-00059\/","title":{"rendered":"2024-1.2.3-HU-RIZONT-2024-00059"},"content":{"rendered":"<p style=\"text-align: justify\"><strong>Projekt azonos\u00edt\u00f3 sz\u00e1ma:<\/strong>\u00a02024-1.2.3-HU-RIZONT-2024-00059<\/p>\n<p style=\"text-align: justify\"><strong>Projekt c\u00edme:<\/strong>\u00a0Proteomika \u00e9s Genomika a V\u00e9gst\u00e1dium\u00fa Sz\u00edvel\u00e9gtelens\u00e9gben<\/p>\n<p style=\"text-align: justify\"><strong>Projekt megval\u00f3s\u00edt\u00e1s\u00e1nak kezdete:<\/strong>\u00a02025.01.02.<\/p>\n<p style=\"text-align: justify\"><strong>Projekt fizikai befejez\u00e9s\u00e9nek hat\u00e1rideje:<\/strong>\u00a02028.01.01.<\/p>\n<p style=\"text-align: justify\"><strong>T\u00e1mogat\u00e1s \u00f6sszege:<\/strong>\u00a0400.000.000 Ft<\/p>\n<p style=\"text-align: justify\"><strong>T\u00e1mogat\u00e1s intenzit\u00e1sa:<\/strong>\u00a0100%<\/p>\n<p style=\"text-align: justify\">\u00a0<\/p>\n<p style=\"text-align: justify\"><strong>Projektr\u0151l:\u00a0<\/strong><\/p>\n<p style=\"text-align: justify\">A sz\u00edvel\u00e9gtelens\u00e9g tov\u00e1bbra is a morbidit\u00e1s \u00e9s mortalit\u00e1s vezet\u0151 oka vil\u00e1gszerte, \u00e9s jelent\u0151s hi\u00e1nyoss\u00e1gok vannak a molekul\u00e1ris mechanizmusainak meg\u00e9rt\u00e9s\u00e9ben. A PAGE-HF (Proteomika \u00e9s Genomika a V\u00e9gst\u00e1dium\u00fa Sz\u00edvel\u00e9gtelens\u00e9gben) projekt els\u0151dleges c\u00e9lja a sz\u00edvel\u00e9gtelens\u00e9g meg\u00e9rt\u00e9s\u00e9nek el\u0151seg\u00edt\u00e9se az emberi sz\u00edvizom \u00e9s sz\u00e9rum mint\u00e1k \u00e1tfog\u00f3 genomikai, transzkriptomikai \u00e9s proteomikai vizsg\u00e1lat\u00e1val. A legmodernebb technol\u00f3gi\u00e1k alkalmaz\u00e1s\u00e1val c\u00e9lunk a legnagyobb multiomikai adatb\u00e1zis l\u00e9trehoz\u00e1sa a\u00a0v\u00e9gst\u00e1dium\u00fa\u00a0sz\u00edvel\u00e9gtelens\u00e9gr\u0151l, t\u00f6bb mint 550 sz\u00e9rum \u00e9s sz\u00edvizom minta alapj\u00e1n, amelyeket t\u00f6bb mint egy \u00e9vtized alatt gy\u0171jt\u00f6tt\u00fcnk a Semmelweis Egyetem Sz\u00edv- \u00e9s \u00c9rk\u00f6zpontj\u00e1ban v\u00e9gzett sz\u00edv\u00e1t\u00fcltet\u00e9sek sor\u00e1n. Sz\u00edv\u00e1t\u00fcltet\u00e9si biobankunk m\u00e1r tartalmaz r\u00e9szletes klinikai metaadatokat \u00e9s 400 beteg teljes exomszekvenci\u00e1j\u00e1t, amelyeket az Illumina-val k\u00f6t\u00f6tt kutat\u00e1si egy\u00fcttm\u0171k\u00f6d\u00e9si meg\u00e1llapod\u00e1snak k\u00f6sz\u00f6nhet\u0151en a PAGE-HF kezdet\u00e9ig befejez\u00fcnk.<br \/>\nA Dr. Petr Kvapil (Pr\u00e1gai Alkalmazott Biotechnol\u00f3giai Int\u00e9zet, Csehorsz\u00e1g) vezet\u00e9s\u00e9vel v\u00e9gzett egy\u00fcttm\u0171k\u00f6d\u00e9s\u00fcnk lehet\u0151v\u00e9 teszi a teljes kohorsz bal kamr\u00e1j\u00e1nak transzkriptomikai m\u00e9r\u00e9seit, m\u00e9ly RNA kifejez\u00e9si adatokat biztos\u00edtva.<br \/>\nDr. Alexander Schmidt a b\u00e1zeli Biozentrum-b\u00f3l v\u00e9gzi a sz\u00e9rum, bal \u00e9s jobb kamrai mint\u00e1k proteomikai m\u00e9r\u00e9seit, meger\u0151s\u00edtve a sz\u00edvel\u00e9gtelens\u00e9g f\u0151 g\u00e9nszerepl\u0151inek transzl\u00e1ci\u00f3j\u00e1t, mik\u00f6zben t\u00f6bb ezer feh\u00e9rje kifejez\u00e9si adatait is szolg\u00e1ltatja. Prof. Oliver Schilling az Albert-Ludwigs Egyetemen, Freiburgban ny\u00fajt statisztikai elemz\u00e9si szak\u00e9rtelmet, seg\u00edt egy kereshet\u0151 kutat\u00e1si adatb\u00e1zis l\u00e9trehoz\u00e1s\u00e1ban \u00e9s kik\u00e9pzi a Semmelweis Egyetem kutat\u00f3it, lehet\u0151v\u00e9 t\u00e9ve a helyi f\u00e9lautomata mintael\u0151k\u00e9sz\u00edt\u00e9si protokollok bevezet\u00e9s\u00e9t, el\u0151seg\u00edtve a tud\u00e1stranszfert Magyarorsz\u00e1gra.<br \/>\nA PAGE-HF adatb\u00e1zis lehet\u0151v\u00e9 teszi t\u00f6bb sz\u00e1z potenci\u00e1lisan \u00faj gy\u00f3gyszer c\u00e9lpont azonos\u00edt\u00e1s\u00e1t a perif\u00e9ri\u00e1s v\u00e9r- \u00e9s sz\u00edvizom mint\u00e1k alapj\u00e1n, megalapozva a j\u00f6v\u0151beli kutat\u00e1sokat \u00e9s klinikai alkalmaz\u00e1sokat, v\u00e9gs\u0151 soron jav\u00edtva a sz\u00edvel\u00e9gtelens\u00e9ggel k\u00fczd\u0151 betegek \u00e9letmin\u0151s\u00e9g\u00e9t.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright\" src=\"https:\/\/semmelweis.hu\/kfipalyazat\/files\/2025\/07\/NKFIA_infoblokk_kerettel_program_fekvo_2019_HU.jpg\" width=\"550\" height=\"233\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Projekt azonos\u00edt\u00f3 sz\u00e1ma:\u00a02024-1.2.3-HU-RIZONT-2024-00059 Projekt c\u00edme:\u00a0Proteomika \u00e9s Genomika a V\u00e9gst\u00e1dium\u00fa Sz\u00edvel\u00e9gtelens\u00e9gben Projekt megval\u00f3s\u00edt\u00e1s\u00e1nak kezdete:\u00a02025.01.02. Projekt fizikai befejez\u00e9s\u00e9nek hat\u00e1rideje:\u00a02028.01.01. T\u00e1mogat\u00e1s \u00f6sszege:\u00a0400.000.000 Ft T\u00e1mogat\u00e1s intenzit\u00e1sa:\u00a0100% \u00a0 Projektr\u0151l:\u00a0 A sz\u00edvel\u00e9gtelens\u00e9g tov\u00e1bbra is a morbidit\u00e1s \u00e9s mortalit\u00e1s vezet\u0151 oka vil\u00e1gszerte, \u00e9s jelent\u0151s hi\u00e1nyoss\u00e1gok vannak a molekul\u00e1ris mechanizmusainak meg\u00e9rt\u00e9s\u00e9ben. A PAGE-HF (Proteomika \u00e9s Genomika a V\u00e9gst\u00e1dium\u00fa Sz\u00edvel\u00e9gtelens\u00e9gben) projekt els\u0151dleges c\u00e9lja a &hellip;<\/p>\n","protected":false},"author":102410,"featured_media":0,"parent":264,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-277","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/users\/102410"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/comments?post=277"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/277\/revisions"}],"predecessor-version":[{"id":647,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/277\/revisions\/647"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/264"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/media?parent=277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/categories?post=277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/tags?post=277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}