{"id":232,"date":"2025-07-03T13:28:08","date_gmt":"2025-07-03T11:28:08","guid":{"rendered":"https:\/\/semmelweis.hu\/kfipalyazat\/?page_id=232"},"modified":"2025-08-14T09:50:59","modified_gmt":"2025-08-14T07:50:59","slug":"2020-2-1-1-ed-2020-00031","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/kfipalyazat\/palyazatok\/hazai-palyazatok\/nkfih\/kormanyzati-onero-alap\/2020-2-1-1-ed-2020-00031\/","title":{"rendered":"2020-2.1.1-ED-2020-00031"},"content":{"rendered":"<p style=\"text-align: justify\"><strong>Projekt c\u00edme:<\/strong> Sigma-1 receptor agonist\u00e1k felhaszn\u00e1l\u00e1sa a koronav\u00edrus okozta t\u00fcd\u0151folyamatok kezel\u00e9s\u00e9re<\/p>\n<p style=\"text-align: justify\"><strong>Projektazonos\u00edt\u00f3:<\/strong> 2020-2.1.1-ED-2020-00031<\/p>\n<p style=\"text-align: justify\"><strong>Projektvezet\u0151:<\/strong> Dr. Szigeti Gyula<\/p>\n<p style=\"text-align: justify\"><strong>T\u00e1mogat\u00e1si \u00f6sszeg:<\/strong> 330 000\u00a0000 Ft<\/p>\n<p style=\"text-align: justify\"><strong>Megval\u00f3s\u00edt\u00e1si id\u0151szak:<\/strong> 2021.08.01.-2022.10.31.\u00a0<\/p>\n<p style=\"text-align: justify\">\u00a0<\/p>\n<p style=\"text-align: justify\"><strong>Projektr\u0151l:\u00a0<\/strong><\/p>\n<p style=\"text-align: justify\">K\u00f6zel 9 milli\u00f3an fert\u0151z\u0151dtek meg \u00e9s 500 000 ember vesztette \u00e9let\u00e9t a SARS-CoV-2 v\u00edrus okozta l\u00e9g\u00fati sz\u00f6v\u0151dm\u00e9nyek miatt. Akik meggy\u00f3gyulnak, azokn\u00e1l is jelent\u0151s a k\u00e9s\u0151bbi t\u00fcd\u0151hegesed\u00e9s vesz\u00e9lye. Kor\u00e1bbiakban els\u0151k\u00e9nt igazoltuk, hogy a Sigma-1 receptor (S1R) agonist\u00e1k v\u00e9d\u0151 hat\u00e1s\u00faak a gyullad\u00e1s okozta t\u00fcd\u0151hegesed\u00e9s ellen. Eredm\u00e9nyeinket az USA-ban (WO2015118365A1-2018), Izraelben (2019), K\u00edn\u00e1ban (2020), Jap\u00e1nban szabadalom v\u00e9di. Megalapozottnak l\u00e1tjuk, hogy a S1R agonista hat\u00e1s\u00fa FLUVOXAMIN \u00faj megold\u00e1s lehet a COVID-19 ter\u00e1pi\u00e1j\u00e1ban. Randomiz\u00e1lt, kett\u0151s-vak, placebo-kontroll\u00e1lt f\u00e1zis II klinikai vizsg\u00e1latban a fluvoxamin biztons\u00e1goss\u00e1g\u00e1t \u00e9s hat\u00e9konys\u00e1g\u00e1t \u00e9rt\u00e9kelj\u00fck k\u00f6z\u00e9ps\u00falyos \u00e9s s\u00falyos COVID-19 megbeteged\u00e9sben szenved\u0151 betegek (~100 f\u0151) ter\u00e1pi\u00e1j\u00e1ban. A kezel\u00e9s az akut szakban m\u00e9rs\u00e9kelheti a gyullad\u00e1sos v\u00e1laszt \u00e9s cs\u00f6kkentheti a t\u00fcd\u0151gyullad\u00e1s s\u00falyoss\u00e1g\u00e1t. Hosszabb t\u00e1von megel\u0151zheti a gyullad\u00e1s k\u00f6vetkezt\u00e9ben l\u00e9trej\u00f6v\u0151 t\u00fcd\u0151hegesed\u00e9s kialakul\u00e1s\u00e1t. Mindezek a t\u00e9nyez\u0151k a nyilv\u00e1nval\u00f3 eg\u00e9szs\u00e9g\u00fcgyi el\u0151ny\u00f6k mellett jelent\u0151sen reduk\u00e1lj\u00e1k a betegek ell\u00e1t\u00e1s\u00e1val j\u00e1r\u00f3 gazdas\u00e1gi \u00e9s t\u00e1rsadalmi terheket r\u00f6vid \u00e9s hossz\u00fa t\u00e1von egyar\u00e1nt.<\/p>\n<p style=\"text-align: justify\"><a href=\"https:\/\/semmelweis.hu\/kfipalyazat\/files\/2025\/07\/Sigma-00031_sajtokozlemeny_zaro.pdf\" target=\"_blank\" rel=\"noopener\">Z\u00e1r\u00f3 sajt\u00f3k\u00f6zlem\u00e9ny<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright\" src=\"https:\/\/semmelweis.hu\/kfipalyazat\/files\/2025\/07\/NKFIA_infoblokk_kerettel_program_fekvo_2019_HU.jpg\" width=\"550\" height=\"233\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Projekt c\u00edme: Sigma-1 receptor agonist\u00e1k felhaszn\u00e1l\u00e1sa a koronav\u00edrus okozta t\u00fcd\u0151folyamatok kezel\u00e9s\u00e9re Projektazonos\u00edt\u00f3: 2020-2.1.1-ED-2020-00031 Projektvezet\u0151: Dr. Szigeti Gyula T\u00e1mogat\u00e1si \u00f6sszeg: 330 000\u00a0000 Ft Megval\u00f3s\u00edt\u00e1si id\u0151szak: 2021.08.01.-2022.10.31.\u00a0 \u00a0 Projektr\u0151l:\u00a0 K\u00f6zel 9 milli\u00f3an fert\u0151z\u0151dtek meg \u00e9s 500 000 ember vesztette \u00e9let\u00e9t a SARS-CoV-2 v\u00edrus okozta l\u00e9g\u00fati sz\u00f6v\u0151dm\u00e9nyek miatt. Akik meggy\u00f3gyulnak, azokn\u00e1l is jelent\u0151s a k\u00e9s\u0151bbi t\u00fcd\u0151hegesed\u00e9s vesz\u00e9lye. Kor\u00e1bbiakban &hellip;<\/p>\n","protected":false},"author":102410,"featured_media":0,"parent":229,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-232","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/users\/102410"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/comments?post=232"}],"version-history":[{"count":4,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/232\/revisions"}],"predecessor-version":[{"id":625,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/232\/revisions\/625"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/229"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/media?parent=232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/categories?post=232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/tags?post=232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}