{"id":1011,"date":"2026-04-09T13:03:50","date_gmt":"2026-04-09T11:03:50","guid":{"rendered":"https:\/\/semmelweis.hu\/kfipalyazat\/?page_id=1011"},"modified":"2026-04-09T14:04:30","modified_gmt":"2026-04-09T12:04:30","slug":"2025-1-2-1-hu-rizont-2025-00011","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/kfipalyazat\/palyazatok\/hazai-palyazatok\/nkfih\/hu-rizont\/2025-2\/2025-1-2-1-hu-rizont-2025-00011\/","title":{"rendered":"2025-1.2.1-HU-RIZONT-2025-00011"},"content":{"rendered":"<p><strong>Projekt azonos\u00edt\u00f3 sz\u00e1ma:<\/strong>\u00a02025-1.2.1-HU-RIZONT-2025-00011<\/p>\n<p><strong>Projekt c\u00edme:<\/strong>\u00a0Kimenetellel \u00f6sszef\u00fcgg\u0151 biomarkerek felt\u00e1r\u00e1sa az OnkoBankban gy\u0171jt\u00f6tt szolid tumorok transzkriptomikai \u00e9s proteomikai elemz\u00e9s\u00e9vel<\/p>\n<p><strong>Projekt megval\u00f3s\u00edt\u00e1s\u00e1nak kezdete:<\/strong>\u00a02026.01.01.<\/p>\n<p><strong>Projekt fizikai befejez\u00e9s\u00e9nek hat\u00e1rideje:<\/strong>\u00a02028.12.31.<\/p>\n<p><strong>T\u00e1mogat\u00e1s \u00f6sszege:<\/strong>\u00a0400 000\u00a0000,-Ft<\/p>\n<p><strong>T\u00e1mogat\u00e1s intenzit\u00e1sa:<\/strong>\u00a0100%<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Projektr\u0151l:\u00a0<\/strong><\/p>\n<p>A daganatter\u00e1pi\u00e1ban el\u00e9rt jelent\u0151s el\u0151rel\u00e9p\u00e9sek ellen\u00e9re a colorectalis, ovarialis \u00e9s vesesejtes carcinom\u00e1ban szenved\u0151 betegek hossz\u00fa t\u00e1v\u00fa kil\u00e1t\u00e1sai tov\u00e1bbra is kedvez\u0151tlenek, f\u0151k\u00e9nt a magas relapszusr\u00e1ta, a kezel\u00e9sek toxicit\u00e1sa, valamint a sz\u00e9les k\u00f6rben alkalmazhat\u00f3 biomarkerek hi\u00e1nya miatt.<\/p>\n<p>E kritikus hi\u00e1nyoss\u00e1g \u00e1thidal\u00e1s\u00e1ra egy multidiszciplin\u00e1ris kezdem\u00e9nyez\u00e9st javasolunk, melynek c\u00e9lja \u00faj, klinikailag relev\u00e1ns biomarkerek felfedez\u00e9se \u00e9s valid\u00e1l\u00e1sa, amelyek k\u00e9pesek el\u0151re jelezni a ter\u00e1pi\u00e1s v\u00e1laszokat \u00e9s a t\u00fal\u00e9l\u00e9st ezekben a daganatt\u00edpusokban. A program k\u00f6z\u00e9ppontj\u00e1ban a Semmelweis OnkoBank \u00e1ll \u2013 a Semmelweis Egyetem koordin\u00e1l\u00e1s\u00e1val m\u0171k\u00f6d\u0151 onkol\u00f3giai biobank \u2013, amely t\u00f6bb mint 2000 betegb\u0151l sz\u00e1rmaz\u00f3, magas min\u0151s\u00e9g\u0171 tumor- \u00e9s v\u00e9rmint\u00e1t tartalmaz, r\u00e9szletes klinikai adatokkal \u00f6sszekapcsolva, bele\u00e9rtve a kezel\u00e9si el\u0151zm\u00e9nyeket, a v\u00e1laszreakci\u00f3k \u00e9rt\u00e9kel\u00e9s\u00e9t \u00e9s a hossz\u00fa t\u00e1v\u00fa ut\u00e1nk\u00f6vet\u00e9st.<\/p>\n<p>A betegekb\u0151l sz\u00e1rmaz\u00f3 mint\u00e1k \u00e1tfog\u00f3 molekul\u00e1ris profiloz\u00e1son esnek \u00e1t: transzkriptomikai anal\u00edzist v\u00e9gz\u00fcnk RNA-szekven\u00e1l\u00e1ssal, valamint kvantitat\u00edv proteomikai vizsg\u00e1latokat Prof. Schilling n\u00e9metorsz\u00e1gi laborat\u00f3rium\u00e1ban. Az \u00edgy nyert multiomikai adatokat a Semmelweis Egyetemen fejlesztett bioinformatikai eszk\u00f6z\u00f6kkel integr\u00e1ljuk a klinikai ut\u00e1nk\u00f6vet\u00e9si adatokkal annak \u00e9rdek\u00e9ben, hogy robusztus molekul\u00e1ris mint\u00e1zatokat azonos\u00edtsunk, amelyek \u00f6sszef\u00fcgg\u00e9st mutatnak a klinikai kimenetelekkel. A jel\u00f6lt biomarkerek funkcion\u00e1lis valid\u00e1l\u00e1s\u00e1t Prof. Probanza spanyolorsz\u00e1gi vezet\u00e9s\u00e9vel v\u00e9gezz\u00fck, biztos\u00edtva biol\u00f3giai relevanci\u00e1juk \u00e9s ter\u00e1pi\u00e1s potenci\u00e1ljuk meger\u0151s\u00edt\u00e9s\u00e9t preklinikai modellekben.<\/p>\n<p>A javasolt kutat\u00e1s \u00e9lvonalbeli technol\u00f3gi\u00e1kat haszn\u00e1lva klinikailag is hasznos\u00edthat\u00f3 eredm\u00e9nyeket fog szolg\u00e1ltatni a szem\u00e9lyre szabott onkol\u00f3giai ell\u00e1t\u00e1s sz\u00e1m\u00e1ra. A projekt c\u00e9lja az OnkoBank multiomikai szintre emel\u00e9se kiterjedt molekul\u00e1ris profiloz\u00e1ssal, valamint olyan ter\u00e1pi\u00e1s c\u00e9lpontok \u00e9s biomarkerek azonos\u00edt\u00e1sa, amelyek el\u0151re jelezhetik a ter\u00e1pi\u00e1s v\u00e1laszokat \u00e9s a t\u00fal\u00e9l\u00e9st t\u00f6bb daganatt\u00edpus eset\u00e9ben.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright\" src=\"https:\/\/semmelweis.hu\/kfipalyazat\/files\/2025\/07\/NKFIA_infoblokk_kerettel_program_fekvo_2019_HU.jpg\" width=\"590\" height=\"250\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Projekt azonos\u00edt\u00f3 sz\u00e1ma:\u00a02025-1.2.1-HU-RIZONT-2025-00011 Projekt c\u00edme:\u00a0Kimenetellel \u00f6sszef\u00fcgg\u0151 biomarkerek felt\u00e1r\u00e1sa az OnkoBankban gy\u0171jt\u00f6tt szolid tumorok transzkriptomikai \u00e9s proteomikai elemz\u00e9s\u00e9vel Projekt megval\u00f3s\u00edt\u00e1s\u00e1nak kezdete:\u00a02026.01.01. Projekt fizikai befejez\u00e9s\u00e9nek hat\u00e1rideje:\u00a02028.12.31. T\u00e1mogat\u00e1s \u00f6sszege:\u00a0400 000\u00a0000,-Ft T\u00e1mogat\u00e1s intenzit\u00e1sa:\u00a0100% &nbsp; Projektr\u0151l:\u00a0 A daganatter\u00e1pi\u00e1ban el\u00e9rt jelent\u0151s el\u0151rel\u00e9p\u00e9sek ellen\u00e9re a colorectalis, ovarialis \u00e9s vesesejtes carcinom\u00e1ban szenved\u0151 betegek hossz\u00fa t\u00e1v\u00fa kil\u00e1t\u00e1sai tov\u00e1bbra is kedvez\u0151tlenek, f\u0151k\u00e9nt a magas relapszusr\u00e1ta, &hellip;<\/p>\n","protected":false},"author":102410,"featured_media":0,"parent":1050,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-1011","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/1011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/users\/102410"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/comments?post=1011"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/1011\/revisions"}],"predecessor-version":[{"id":1012,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/1011\/revisions\/1012"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/pages\/1050"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/media?parent=1011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/categories?post=1011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/kfipalyazat\/wp-json\/wp\/v2\/tags?post=1011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}