{"id":172182,"date":"2026-08-04T06:00:41","date_gmt":"2026-08-04T04:00:41","guid":{"rendered":"https:\/\/semmelweis.hu\/hirek\/?p=172182"},"modified":"2026-08-04T07:46:24","modified_gmt":"2026-08-04T05:46:24","slug":"tudomanyos-hirado-31","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/hirek\/2026\/08\/04\/tudomanyos-hirado-31\/","title":{"rendered":"Tudom\u00e1nyos h\u00edrad\u00f3 31."},"content":{"rendered":"<div class=\"lead\">Tudom\u00e1nyos h\u00edrad\u00f3 c\u00edm\u0171 cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3. A cikkeket az elm\u00falt id\u0151szak megjelen\u00e9sei alapj\u00e1n a K\u00f6zponti K\u00f6nyvt\u00e1r, illetve a tudom\u00e1nyos \u00e9s innov\u00e1ci\u00f3s rektorhelyettes\u00a0v\u00e1logatta.<\/div>\n<div class=\"keretes w-100\">\n<h3>Tartalomjegyz\u00e9k<\/h3>\n<ul>\n<li><a href=\"#rendszeres\">A rendszeres fizikai aktivit\u00e1s jav\u00edtja az \u00e9letmin\u0151s\u00e9get gyullad\u00e1sos b\u00e9lbetegs\u00e9ggel \u00e9l\u0151 betegekn\u00e9l<\/a><\/li>\n<li><a href=\"#ema\">2025-ben az EMA, az FDA \u00e9s az MHRA \u00e1ltal enged\u00e9lyezett \u00faj gy\u00f3gyszerek \u2013 \u00c9ves \u00e1ttekint\u00e9s<\/a><\/li>\n<li><a href=\"#hanyinger\">A terhess\u00e9gi h\u00e1nyinger \u00e9s h\u00e1ny\u00e1s kezel\u00e9s\u00e9re alkalmazott gy\u00f3gyszeres \u00e9s nem gy\u00f3gyszeres beavatkoz\u00e1sok hat\u00e9konys\u00e1g\u00e1nak \u00f6sszehasonl\u00edt\u00e1sa: szisztematikus \u00e1ttekint\u00e9s \u00e9s h\u00e1l\u00f3zati metaanal\u00edzis<\/a><\/li>\n<li><a href=\"#enhanced\">Teljes\u00edtm\u00e9nyfokoz\u00f3 szerek versenysportban \u00e9s rekre\u00e1ci\u00f3ban: a &#8222;The Enhanced Games&#8221; sz\u00edv- \u00e9s \u00e9rrendszeri vonatkoz\u00e1sai<\/a><\/li>\n<li><a href=\"#becslesi\">A sz\u00edv-\u00e9rrendszeri kock\u00e1zat becsl\u00e9si torz\u00edt\u00e1sai<\/a><\/li>\n<li><a href=\"#rheumatoid\">A nehezen kezelhet\u0151 rheumatoid arthritis kezel\u00e9s\u00e9nek \u00faj ir\u00e1nyai: c\u00e9lzott szerek \u00e9s nem gy\u00f3gyszeres beavatkoz\u00e1sok<\/a><\/li>\n<li><a href=\"#kieges\">A ki\u00e9g\u00e9s s\u00falyoss\u00e1ga bentlak\u00e1sos demenciaell\u00e1t\u00e1sban: egy\u00e9ni terhel\u0151 t\u00e9nyez\u0151k \u00e9s int\u00e9zm\u00e9nyi szint\u0171 k\u00fcl\u00f6nbs\u00e9gek egy magyar keresztmetszeti vizsg\u00e1latban<\/a><\/li>\n<li><a href=\"#sovargas\">A GHSR-antagonista LEAP2 koncentr\u00e1ci\u00f3ja ford\u00edtott \u00f6sszef\u00fcgg\u00e9st mutat az alkohols\u00f3v\u00e1rg\u00e1ssal, \u00e9s alkoholexpoz\u00edci\u00f3 hat\u00e1s\u00e1ra megv\u00e1ltozik<\/a><\/li>\n<li><a href=\"#testedzes\">A testedz\u00e9s alv\u00e1sra gyakorolt hat\u00e1sa<\/a><\/li>\n<li><a href=\"#chatbot\">Chatbot-kapcsolati f\u00fcgg\u0151s\u00e9g \u00e9s pszich\u00f3ziskock\u00e1zat<\/a><\/li>\n<li><a href=\"#immunellenorzo\">Immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3 kezel\u00e9s okozta sz\u00edvel\u00e9gtelens\u00e9g kor\u00e1bbi sz\u00edvizomk\u00e1rosod\u00e1s eset\u00e9n<\/a><\/li>\n<li><a href=\"#sportsziv\">A mozg\u00e1sszeg\u00e9ny \u00e9letm\u00f3dt\u00f3l a sportsz\u00edvig: a kardi\u00e1lis volumetria, funkci\u00f3 \u00e9s strain \u00e1tfog\u00f3 sz\u00edv MR-vizsg\u00e1lata<\/a><\/li>\n<li><a href=\"#oregedes\">\u00c9lettel val\u00f3 el\u00e9gedetts\u00e9g mint az eg\u00e9szs\u00e9ges \u00f6reged\u00e9s kulcst\u00e9nyez\u0151je a munkahelyi k\u00f6rnyezetben<\/a><\/li>\n<\/ul>\n<\/div>\n<div><span style=\"color: #313b40;font-family: Montserrat, sans-serif;font-size: 24px;font-weight: 600\"><a id=\"rendszeres\"><\/a>A rendszeres fizikai aktivit\u00e1s jav\u00edtja az \u00e9letmin\u0151s\u00e9get gyullad\u00e1sos b\u00e9lbetegs\u00e9ggel \u00e9l\u0151 betegekn\u00e9l<\/span><\/div>\n<div>\u00a0<\/div>\n<div>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172183\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-400x259.jpg\" alt=\"\" width=\"400\" height=\"259\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-400x259.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-900x583.jpg 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-768x497.jpg 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-1536x995.jpg 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-2048x1326.jpg 2048w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/jcsm70206-fig-0001-m-753x488.jpg 753w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>A gyullad\u00e1sos b\u00e9lbetegs\u00e9ggel \u00e9l\u0151k gyakran kev\u00e9sb\u00e9 akt\u00edvak fizikailag, mint az eg\u00e9szs\u00e9ges emberek, cs\u00f6kken a csonts\u0171r\u0171s\u00e9g\u00fck, izomt\u00f6meg\u00fck \u00e9s izomerej\u00fck is \u2013 ezek mind ronthatj\u00e1k a betegs\u00e9g lefoly\u00e1s\u00e1t. Sz\u00e1mos friss tanulm\u00e1ny kimutatta, hogy a rendszeres fizikai aktivit\u00e1s jav\u00edtja mind a csonts\u0171r\u0171s\u00e9get, mind az izomt\u00f6meget \u00e9s -er\u0151t, \u00e9s kedvez\u0151en befoly\u00e1solhatja a gyullad\u00e1sos folyamatokat mozg\u00e1s sor\u00e1n felszabadul\u00f3 gyullad\u00e1scs\u00f6kkent\u0151 molekul\u00e1k seg\u00edts\u00e9g\u00e9vel.<\/p>\n<p>Kutat\u00e1sunk c\u00e9lja az volt, hogy a megl\u00e9v\u0151 tudom\u00e1nyos publik\u00e1ci\u00f3k alapj\u00e1n felm\u00e9rj\u00fck a struktur\u00e1lt testmozg\u00e1s hat\u00e1s\u00e1t gyullad\u00e1sos b\u00e9lbetegs\u00e9gben szenved\u0151 betegekn\u00e9l. A vizsg\u00e1latba 21 tanulm\u00e1nyt tudtunk bevonni, \u00f6sszesen 498 gyullad\u00e1sos b\u00e9lbetegs\u00e9ggel \u00e9l\u0151 embert. Az \u00e9letmin\u0151s\u00e9g\u00fck a rendszeresen v\u00e9gzett fizikai aktivit\u00e1s hat\u00e1s\u00e1ra szignifik\u00e1nsan javult, mely p\u00e9ld\u00e1ul azt jelenti, hogy hasi f\u00e1jdalma nem befoly\u00e1solta h\u00e9tk\u00f6znapjait, vagy teljesen megsz\u0171nt. A betegs\u00e9gaktivit\u00e1si indexek nem mutattak szignifik\u00e1ns v\u00e1ltoz\u00e1st, aminek egyik oka az lehetett, hogy olyan betegeket vontak be a vizsg\u00e1latokba, akikn\u00e9l a betegs\u00e9g nem, vagy csak enyhe t\u00fcnetek okozott aktu\u00e1lisan. Emellett mind az izomer\u0151, mind az aerob fitts\u00e9g javult. \u00d6sszefoglalva, az eddigi tanulm\u00e1nyok eredm\u00e9nyeinek \u00f6sszegz\u00e9se alapj\u00e1n a rendszeres sporttev\u00e9kenys\u00e9g jav\u00edtja betegek \u00e9letmin\u0151s\u00e9g\u00e9t \u00e9s fizikai er\u0151nl\u00e9t\u00e9t \u2013 fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban dr. M\u00fcller Katalin.<\/p>\n<\/div>\n<div class=\"keretes w-100\">\n<h6>Physical Activity Improves Quality of Life in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis<\/h6>\n<p>Emese Kaszn\u00e1r (Heim P\u00e1l National Pediatric Institute; Centre for Translational Medicine, Semmelweis University), Barbara Csendes (Centre for Translational Medicine, Semmelweis University; Institute of Genomic Medicine and Rare Disorders, Semmelweis University), Dorottya Gerg\u0151 (Centre for Translational Medicine, Semmelweis University; Department of Pharmacognosy, Semmelweis University), P\u00e9ter Hegyi (Centre for Translational Medicine, Semmelweis University; Institute for Translational Medicine, Medical School, University of P\u00e9cs; Institute of Pancreatic Diseases, Semmelweis University), R\u00e9ka T\u00f3th (Centre for Translational Medicine, Semmelweis University), Andr\u00e1s Fogarasi (Bethesda Children&#8217;s Hospital; Andr\u00e1s Pet\u0151 Faculty, Semmelweis University), Mikl\u00f3s Garami (Pediatric Center, Semmelweis University), Klementina Ocskay (Heim P\u00e1l National Pediatric Institute; Pharmaceutical Sciences and Health Technologies Division, Doctoral School, Semmelweis University), Andrea P\u00e1rniczky (Heim P\u00e1l National Pediatric Institute; Institute for Translational Medicine, Medical School, University of P\u00e9cs), Mahmoud Obeidat (Centre for Translational Medicine, Semmelweis University), Katalin Eszter M\u00fcller (Heim P\u00e1l National Pediatric Institute; Department of Family Care Methodology, Faculty of Health Sciences, Semmelweis University)<br \/>\nJournal of Cachexia, Sarcopenia and MuscleVolume 17, Issue 1 e70206<br \/>\n<a href=\"https:\/\/doi.org\/10.1002\/jcsm.70206\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/jcsm.70206<\/a><\/p>\n<\/div>\n<h3><a id=\"ema\"><\/a>2025-ben az EMA, az FDA \u00e9s az MHRA \u00e1ltal enged\u00e9lyezett \u00faj gy\u00f3gyszerek \u2013 \u00e9ves \u00e1ttekint\u00e9s<\/h3>\n<figure id=\"attachment_172184\" aria-describedby=\"caption-attachment-172184\" style=\"width: 400px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-172184\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-400x363.jpg\" alt=\"\" width=\"400\" height=\"363\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-400x363.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-881x800.jpg 881w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-768x698.jpg 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-1536x1395.jpg 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-2048x1860.jpg 2048w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/bph70376-fig-0001-m-753x684.jpg 753w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><figcaption id=\"caption-attachment-172184\" class=\"wp-caption-text\">New drugs approved in 2025 by the European Medicines Agency (EMA), U.S. Food and Drug Administration (FDA) and Medicines and Healthcare Products Regulatory Agency (MHRA) categorised by chemical\/biological category.<\/figcaption><\/figure>\n<p>A Semmelweis Egyetem vezet\u0151 szerz\u0151je nemr\u00e9giben k\u00f6z\u00f6lt egy \u00e1ttekint\u0151 tanulm\u00e1nyt azokr\u00f3l az \u00faj gy\u00f3gyszerekr\u0151l, amelyeket 2025-ben enged\u00e9lyezett az Eur\u00f3pai Gy\u00f3gyszer\u00fcgyn\u00f6ks\u00e9g (EMA), az amerikai \u00c9lelmiszer- \u00e9s Gy\u00f3gyszer\u00fcgyi Hat\u00f3s\u00e1g (FDA) \u00e9s a brit Gy\u00f3gyszer- \u00e9s Eg\u00e9szs\u00e9g\u00fcgyi Term\u00e9keket Szab\u00e1lyoz\u00f3 Hat\u00f3s\u00e1g (MHRA). A k\u00f6zlem\u00e9ny a gy\u00f3gyszertudom\u00e1nyok k\u00fcl\u00f6nb\u00f6z\u0151 ter\u00fcletein dolgoz\u00f3 kutat\u00f3k sz\u00e1m\u00e1ra egyar\u00e1nt \u00e9rdekes lehet. Az \u00e1ttekint\u00e9s j\u00f3l \u00e9rz\u00e9kelteti azt a kiemelked\u0151 innov\u00e1ci\u00f3t, amely a korszer\u0171 gy\u00f3gyszertervez\u00e9s \u00e9s -fejleszt\u00e9s h\u00e1tter\u00e9ben \u00e1ll. Az \u00faj gy\u00f3gyszerek 54 sz\u00e1zal\u00e9ka \u00faj hat\u00e1smechanizmus\u00fa a gy\u00f3gyszer-oszt\u00e1lyban els\u0151k\u00e9nt szerepl\u0151 (first-in-class, FIC) k\u00e9sz\u00edtm\u00e9ny. Tov\u00e1bbra is meghat\u00e1roz\u00f3 a feh\u00e9rje- \u00e9s antitestalap\u00fa ter\u00e1pi\u00e1k szerepe \u2013 ezek a 2025-ben enged\u00e9lyezett \u00faj gy\u00f3gyszerek mintegy egynegyed\u00e9t teszik ki \u2013, ami arra utal, hogy ez az ipar\u00e1gi trend v\u00e1ltozatlanul er\u0151s.<\/p>\n<p>Az \u00faj gy\u00f3gyszerek kevesebb mint fele c\u00e9loz meg gyakori vagy nagy n\u00e9peg\u00e9szs\u00e9g\u00fcgyi jelent\u0151s\u00e9g\u0171 betegs\u00e9geket. A j\u00f3v\u00e1hagyott k\u00e9sz\u00edtm\u00e9nyek t\u00f6bbs\u00e9ge kiel\u00e9g\u00edtetlen ter\u00e1pi\u00e1s sz\u00fcks\u00e9gleteket szolg\u00e1l ki \u00e9s\/vagy ritka betegs\u00e9gek (\u00e1rva indik\u00e1ci\u00f3k) kezel\u00e9s\u00e9re k\u00e9sz\u00fclt; ut\u00f3bbiak \u00f6nmagukban a 2025-ben enged\u00e9lyezett \u00faj gy\u00f3gyszerek 41 sz\u00e1zal\u00e9k\u00e1t adj\u00e1k. Ezek a fejleszt\u00e9sek gyakran k\u00fcl\u00f6n\u00f6sen kreat\u00edv \u00e9s innovat\u00edv megk\u00f6zel\u00edt\u00e9seken alapulnak.<\/p>\n<p>A 2025-ben enged\u00e9lyezett \u00faj gy\u00f3gyszerek \u00f6sszk\u00e9pe azt mutatja, hogy a gy\u00f3gyszeripari innov\u00e1ci\u00f3 tov\u00e1bbra is az els\u0151k\u00e9nt alkalmazott hat\u00e1smechanizmusokra, a kifinomult ter\u00e1pi\u00e1s megold\u00e1sokra \u00e9s a kiel\u00e9g\u00edtetlen orvosi sz\u00fcks\u00e9gletek kezel\u00e9s\u00e9re \u00e9p\u00fcl. A szerz\u0151k arra biztatj\u00e1k az olvas\u00f3kat, hogy a szeml\u00e9letes \u00e1br\u00e1kkal kieg\u00e9sz\u00edtett k\u00f6zlem\u00e9nyt haszn\u00e1lj\u00e1k oktat\u00e1si c\u00e9lokra \u00e9s tudom\u00e1nyos munk\u00e1juk sor\u00e1n, k\u00fcl\u00f6n\u00f6sen az orvostudom\u00e1ny valamennyi ter\u00fclet\u00e9t \u00e9rint\u0151 ter\u00e1pi\u00e1s innov\u00e1ci\u00f3k bemutat\u00e1s\u00e1hoz \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Ferdinandy P\u00e9ter.<\/p>\n<div class=\"keretes w-100\">\n<h6>Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review<\/h6>\n<p>Andreas Papapetropoulos (Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens; Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens), Stavros Topouzis (Department of Pharmacy, University of Patras), Steve P. H. Alexander (Division of Physiology, Pharmacology &amp; Neuroscience, School of Life Sciences, University of Nottingham), Miriam M. Cortese-Krott (Pharmacology, Pharmacotherapy and Clinical Pharmacy, Institute of Pharmacy, Eberhard Karls Universit\u00e4t T\u00fcbingen), Zsuzsanna Helyes (Department of Pharmacology and Pharmacotherapy, Medical School &amp; Centre for Neuroscience, University of P\u00e9cs; University of P\u00e9cs-Hungarian Research Network Chronic Pain Research Group, University of P\u00e9cs), Kirill Martemyanov (University of Florida), Claudio Mauro (College of Medicine and Health, University of Birmingham), Nithyanandan Nagercoil (Medicines and Healthcare Products Regulatory Agency), Reynold A. Panettieri Jr (Rutgers University), Hemal H. Patel (VA San Diego Healthcare System and University of California\/San Diego), Rainer Schulz (Institute of Physiology, University of Giessen), Barbara Stefanska (University of British Columbia), Gary J. Stephens (University of Reading), Nathalie Vergnolle (IRSD, Universit\u00e9 de Toulouse, INSERM, INRAE, ENVT, UPS), Xin Wang (Faculty of Biology, Medicine and Health, University of Manchester), Stephen Ward (Department of Life Sciences, University of Bath Centre for Therapeutic Innovation, University of Bath), P\u00e9ter Ferdinandy (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research and Development, Semmelweis University; Pharmahungary Group)<br \/>\nBritish Journal of PharmacologyVolume 183, Issue 9 pp. 1779-1813<br \/>\n<a href=\"https:\/\/doi.org\/10.1111\/bph.70376\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/bph.70376<\/a><\/p>\n<\/div>\n<h3><a id=\"hanyinger\"><\/a>A terhess\u00e9gi h\u00e1nyinger \u00e9s h\u00e1ny\u00e1s kezel\u00e9s\u00e9re alkalmazott gy\u00f3gyszeres \u00e9s nem gy\u00f3gyszeres beavatkoz\u00e1sok hat\u00e9konys\u00e1g\u00e1nak \u00f6sszehasonl\u00edt\u00e1sa: szisztematikus \u00e1ttekint\u00e9s \u00e9s h\u00e1l\u00f3zati metaanal\u00edzis<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-scaled.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172186\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-400x279.png\" alt=\"\" width=\"400\" height=\"279\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-400x279.png 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-900x628.png 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-768x536.png 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-1536x1071.png 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-2048x1428.png 2048w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/frivaldszky_nutrients-18-01293-g002-753x525.png 753w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>A terhess\u00e9gi h\u00e1nyinger \u00e9s h\u00e1ny\u00e1s a v\u00e1rand\u00f3s n\u0151k ak\u00e1r 80 sz\u00e1zal\u00e9k\u00e1t is \u00e9rintheti, egyes esetekben ak\u00e1r s\u00falyos sz\u00f6v\u0151dm\u00e9nyekhez vezetve. Egy \u00faj h\u00e1l\u00f3zati metaanal\u00edzis azt vizsg\u00e1lta, mely kezel\u00e9sek lehetnek a leghat\u00e9konyabbak a t\u00fcnetek enyh\u00edt\u00e9s\u00e9re.<\/p>\n<p>A kutat\u00f3k 24 klinikai vizsg\u00e1lat eredm\u00e9nyeit elemezt\u00e9k k\u00f6zlem\u00e9ny\u00fckben, \u00f6sszesen t\u00f6bb mint 3000 v\u00e1rand\u00f3s n\u0151 adatai alapj\u00e1n. A vizsg\u00e1latok gy\u00f3gyszeres \u00e9s nem gy\u00f3gyszeres m\u00f3dszereket is \u00f6sszehasonl\u00edtottak placeb\u00f3val. Hat\u00e9konynak bizonyultak B6-vitamint, antihisztamint vagy ezek kombin\u00e1ci\u00f3j\u00e1t tartalmaz\u00f3 k\u00e9sz\u00edtm\u00e9nyek (B6-vitamin, dimenhidrin\u00e1t, doxilamin-piridoxin), egyes \u00e9trendkieg\u00e9sz\u00edt\u0151k (birsalma- vagy gy\u00f6mb\u00e9r-alap\u00fa k\u00e9sz\u00edtm\u00e9nyek), egyes ill\u00f3olajok (pl. menta), alternat\u00edv gy\u00f3gy\u00e1szati m\u00f3dszerek (akupunkt\u00fara, akupressz\u00fara), valamint az el\u0151bb felsoroltak k\u00fcl\u00f6nb\u00f6z\u0151 kombin\u00e1ci\u00f3i is. A szerz\u0151k hangs\u00falyozz\u00e1k, hogy b\u00e1r sok m\u00f3dszer seg\u00edthet a t\u00fcnetek cs\u00f6kkent\u00e9s\u00e9ben, a vizsg\u00e1latok min\u0151s\u00e9ge v\u00e1ltoz\u00f3 volt, \u00e9s a mell\u00e9khat\u00e1sokr\u00f3l kev\u00e9s adat \u00e1ll rendelkez\u00e9sre. Ez\u00e9rt a kezel\u00e9sek kiv\u00e1laszt\u00e1sakor fontos az egy\u00e9ni m\u00e9rlegel\u00e9s \u00e9s a kezel\u0151orvossal val\u00f3 egyeztet\u00e9s. \u00d6sszess\u00e9g\u00e9ben a kutat\u00e1s szerint t\u00f6bb term\u00e9szetes \u00e9s gy\u00f3gyszeres lehet\u0151s\u00e9g is hat\u00e9konyan enyh\u00edtheti a terhess\u00e9gi h\u00e1nyingert \u00e9s h\u00e1ny\u00e1st \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Frivaldszky L\u0151rinc.<\/p>\n<div class=\"keretes w-100\">\n<h6>Comparative Effectiveness of Pharmacological and Non-Pharmacological Interventions for Nausea and Vomiting in Pregnancy: A Systematic Review and Network Meta-Analysis<\/h6>\n<p>L\u0151rinc Frivaldszky (Centre for Translational Medicine, Semmelweis University; MRE Bethesda Children&#8217;s Hospital; Department of Obstetrics and Gynecology, Semmelweis University), Mahmoud Obeidat (Centre for Translational Medicine, Semmelweis University), P\u00e9ter Hegyi (Centre for Translational Medicine, Semmelweis University; Institute for Translational Medicine, Medical School, University of P\u00e9cs; Institute of Pancreatic Diseases, Semmelweis University), Csongor K\u00e1rp\u00e1ti (Centre for Translational Medicine, Semmelweis University), Zolt\u00e1n Kobza (Centre for Translational Medicine, Semmelweis University), N\u00e1ndor \u00c1cs (Centre for Translational Medicine, Semmelweis University; Department of Obstetrics and Gynecology, Semmelweis University), Ferenc B\u00e1nhidy (Centre for Translational Medicine, Semmelweis University; Department of Obstetrics and Gynecology, Semmelweis University), Gergely Ag\u00f3cs (Centre for Translational Medicine, Semmelweis University), Bogl\u00e1rka Lilla Szentes (Centre for Translational Medicine, Semmelweis University), M\u00e1rton Keszthelyi (Centre for Translational Medicine, Semmelweis University; Department of Obstetrics and Gynecology, Semmelweis University)<br \/>\nNutrients. 2026 Apr 20;18(8):1293<br \/>\nDOI: <a href=\"https:\/\/www.mdpi.com\/2072-6643\/18\/8\/1293\" target=\"_blank\" rel=\"noopener\">10.3390\/nu18081293<\/a><\/p>\n<\/div>\n<h3><a id=\"enhanced\"><\/a>Teljes\u00edtm\u00e9nyfokoz\u00f3 szerek versenysportban \u00e9s rekre\u00e1ci\u00f3ban: a &#8222;The Enhanced Games&#8221; sz\u00edv- \u00e9s \u00e9rrendszeri vonatkoz\u00e1sai<\/h3>\n<figure id=\"attachment_172187\" aria-describedby=\"caption-attachment-172187\" style=\"width: 400px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-172187\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games-400x322.jpg\" alt=\"\" width=\"400\" height=\"322\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games-400x322.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games-900x725.jpg 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games-768x619.jpg 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games-1536x1238.jpg 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games-753x607.jpg 753w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/enhanced-games.jpg 1985w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><figcaption id=\"caption-attachment-172187\" class=\"wp-caption-text\">High-yield diagnostic tools and methods for cardiovascular pre-participation screening in athletes. Non-exhaustive compilation of diagnostic methods with the highest yield in TEG and non-TEG athletes. Other tools, such as nuclear imaging, invasive coronary angiography, or invasive electrophysiological studies, can also have implications in selected cases; Created using BioRender.com<\/figcaption><\/figure>\n<p>A \u201eThe Enhaned Games\u201d (TEG) egy forradalmi \u00e9s ellentmond\u00e1sos sportesem\u00e9ny \u00e9s kezdem\u00e9nyez\u00e9s, mely a klasszikus \u00e9rsportol\u00f3i verseng\u00e9s sz\u00e1mos alapvet\u00e9s\u00e9t k\u00e9rd\u0151jelezi meg. Ennek egyik pill\u00e9re egyes, az egyes\u00fclt \u00e1llamok-beli FDA (Food and Drug Adinistration) \u00e1ltal \u2013 nem teljes\u00edtm\u00e9nyn\u00f6vel\u00e9si c\u00e9lokra j\u00f3v\u00e1hagyott \u2013 teljes\u00edtm\u00e9nyfokoz\u00f3 szerek haszn\u00e1lat\u00e1nak enged\u00e9lyez\u00e9se orvosi fel\u00fcgyelet mellett. A jelenlegi bizony\u00edt\u00e9kok szerint a teljes\u00edtm\u00e9nyfokoz\u00f3 szerek kardiovaszkul\u00e1ris kock\u00e1zata jelent\u0151s lehet, ugyanakkor ezek t\u00f6bbnyire illeg\u00e1lis haszn\u00e1lathoz k\u00f6thet\u0151 esetle\u00edr\u00e1sokb\u00f3l, retrospekt\u00edv vizsg\u00e1latokb\u00f3l vagy kis esetsz\u00e1m\u00fa kohorszokb\u00f3l sz\u00e1rmaznak. Az \u00e1tlagpopul\u00e1ci\u00f3 k\u00f6r\u00e9ben is egyre nagyobb n\u00e9pszer\u0171s\u00e9ggel b\u00edr\u00f3 szerek rekre\u00e1ci\u00f3t haszn\u00e1lata miatt kulcsfontoss\u00e1g\u00fa lenne magas min\u0151s\u00e9g\u0171 tudom\u00e1nyos evidencia rendelkez\u00e9sre \u00e1ll\u00e1sa.<\/p>\n<p>Jelen irodalmi \u00e1ttekint\u00e9s a f\u0151bb szercsoportok &#8211; anabolikus-androg\u00e9n szteroidok (tesztoszteron sz\u00e1rmaz\u00e9kok), n\u00f6veked\u00e9si hormon, v\u00e9rk\u00e9pz\u00e9st serkent\u0151 szerek (pl. EPO), stimul\u00e1nsok \u2013 potenci\u00e1lis teljes\u00edtm\u00e9nyfokoz\u00f3 \u00e9s kardiovaszkul\u00e1ris hat\u00e1sait foglalja \u00f6ssze.<\/p>\n<p>Fontos, hogy a TEG nem a \u201ebiztons\u00e1gos dopping\u201d igazol\u00e1sa, hanem egy nagy kock\u00e1zat\u00fa obszerv\u00e1ci\u00f3s keretrendszer, amely szigor\u00fa sz\u0171r\u00e9s, \u00e1tl\u00e1that\u00f3s\u00e1g \u00e9s hossz\u00fa t\u00e1v\u00fa k\u00f6vet\u00e9s mellett adhat \u00e9rt\u00e9kes tudom\u00e1nyos adatokat az egyes k\u00e1ros hat\u00e1sok m\u00e9rt\u00e9k\u00e9r\u0151l \u00e9s visszaford\u00edthat\u00f3s\u00e1g\u00e1r\u00f3l \u2013 fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban dr. Juh\u00e1sz Vencel.<\/p>\n<div class=\"keretes w-100\">\n<h6>Cardiovascular Implications of the Enhanced Games: Performance Enhancing Drugs in Competition and Recreation<\/h6>\n<p>Marco Vecchiato (Sports and Exercise Medicine Division, Department of Medicine, University of Padova; Department of Theoretical and Applied Sciences, eCampus University; Sports Medicine and Cardiovascular Rehabilitation Unit, AULSS3 Noale Hospital), Stefano Palermi (Unicamillus Saint Camillus International University of Health Sciences), Mark Zamodics (Heart and Vascular Center, Semmelweis University), Mate Babity (Heart and Vascular Center, Semmelweis University), Mani Eftekhari (Foot &amp; Ankle Research and Innovation Lab [FARIL], Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School), Rohith Ryali (Foot &amp; Ankle Research and Innovation Lab [FARIL], Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School), Justin Luk (Foot &amp; Ankle Research and Innovation Lab [FARIL], Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School), Atta Taseh (Foot &amp; Ankle Research and Innovation Lab [FARIL], Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School), Soheil Ashkani-Esfahani (Foot &amp; Ankle Research and Innovation Lab [FARIL], Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School; Foot and Ankle Division, Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School), Gergo Merkely (Foot &amp; Ankle Research and Innovation Lab [FARIL], Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School; Foot and Ankle Division, Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School; Department of Orthopaedic Surgery, Mass General Brigham, Harvard Combined Orthopaedic Residency Program [HCORP], Harvard Medical School; Department of Orthopedic Surgery, Semmelweis University), Vencel Juhasz (Heart and Vascular Center, Semmelweis University; Cardiovascular Imaging Research Center, Massachusetts General Hospital &amp; Harvard Medical School)<br \/>\nSports Medicine &#8211; Open, Volume 12, article number 48 (2026)<br \/>\nDOI: <a href=\"http:\/\/dx.doi.org\/10.1186\/s40798-026-01026-9\">10.1186\/s40798-026-01026-9<\/a><\/p>\n<\/div>\n<h3><a id=\"becslesi\"><\/a>A sz\u00edv-\u00e9rrendszeri kock\u00e1zat becsl\u00e9si torz\u00edt\u00e1sai<\/h3>\n<figure id=\"attachment_172188\" aria-describedby=\"caption-attachment-172188\" style=\"width: 400px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/10.1177_21501319261442384-fig1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-172188\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/10.1177_21501319261442384-fig1-400x232.jpg\" alt=\"\" width=\"400\" height=\"232\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/10.1177_21501319261442384-fig1-400x232.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/10.1177_21501319261442384-fig1.jpg 708w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><figcaption id=\"caption-attachment-172188\" class=\"wp-caption-text\">Figure 1. Flow of misperception: discrepancies between objective and self-assessed cardiovascular risk.<\/figcaption><\/figure>\n<p>A sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek megel\u0151z\u00e9s\u00e9nek fontos eleme, hogy az emberek helyesen m\u00e9rj\u00e9k fel, \u00e9s tiszt\u00e1ban legyenek saj\u00e1t kardiovaszkul\u00e1ris kock\u00e1zatukkal. Jelen vizsg\u00e1latban 376 r\u00e9sztvev\u0151 kardiovaszkul\u00e1ris kock\u00e1zat\u00e1t meghat\u00e1roztuk Framingham score-ral. Ezt \u00f6sszevetett\u00fck a r\u00e9sztvev\u0151k saj\u00e1t meg\u00edt\u00e9l\u00e9se szerinti sz\u00edv-\u00e9rrendszeri kock\u00e1zattal. A r\u00e9sztvev\u0151k 39 sz\u00e1zal\u00e9ka re\u00e1lisan \u00edt\u00e9lte meg a kock\u00e1zat\u00e1t, 18 sz\u00e1zal\u00e9k alulbecs\u00fclte, 43 sz\u00e1zal\u00e9k pedig t\u00falbecs\u00fclte azt. \u00d6sszess\u00e9g\u00e9ben a vizsg\u00e1lt szem\u00e9lyek 61 sz\u00e1zal\u00e9ka becs\u00fclte meg rosszul kardiovaszkul\u00e1ris rizik\u00f3j\u00e1t. A f\u00e9rfi r\u00e9sztvev\u0151k 35,6 sz\u00e1zal\u00e9ka alul, m\u00edg a n\u0151k 52,5 sz\u00e1zal\u00e9ka t\u00falbecs\u00fclte saj\u00e1t kock\u00e1zat\u00e1t.<\/p>\n<p>A kock\u00e1zatukat t\u00falbecsl\u0151 r\u00e9sztvev\u0151k magasabb depresszi\u00f3pontsz\u00e1mot mutattak, m\u00edg az alulbecsl\u0151k el\u00e9gedettebbek voltak az \u00e9let\u00fckkel, \u00e9s kedvez\u0151bbnek \u00edt\u00e9lt\u00e9k meg saj\u00e1t eg\u00e9szs\u00e9gi \u00e1llapotukat. A kock\u00e1zat alulbecsl\u00e9s\u00e9nek legfontosabb prediktorai a f\u00e9rfi nem, a magasabb v\u00e9rnyom\u00e1s \u00e9s az id\u0151sebb \u00e9letkor voltak.<\/p>\n<p>Eredm\u00e9nyeink arra h\u00edvj\u00e1k fel a figyelmet, hogy a kardiovaszkul\u00e1ris rizik\u00f3faktorok sz\u00e9les k\u00f6r\u0171 ismerts\u00e9ge nem felt\u00e9tlen\u00fcl j\u00e1r egy\u00fctt a szem\u00e9lyes kock\u00e1zat pontos felismer\u00e9s\u00e9vel. Az alulbecsl\u00e9s cs\u00f6kkentheti az \u00e9letm\u00f3dv\u00e1lt\u00e1s vagy a kezel\u00e9s ir\u00e1nti motiv\u00e1ci\u00f3t, a t\u00falbecsl\u00e9s pedig indokolatlan aggodalommal t\u00e1rsulhat. A kardiovaszkul\u00e1ris prevenci\u00f3ban ez\u00e9rt a kock\u00e1zat kisz\u00e1m\u00edt\u00e1sa mellett annak \u00e9rthet\u0151, szem\u00e9lyre szabott \u00e9rtelmez\u00e9s\u00e9re \u00e9s a t\u00e9ves kock\u00e1zat\u00e9szlel\u00e9s korrekci\u00f3j\u00e1ra is sz\u00fcks\u00e9g lehet \u2013 fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban dr. Ocsovszky Zs\u00f3fia.<\/p>\n<div class=\"keretes w-100\">\n<h6>Biases in Cardiovascular Risk Perception: Psychological and Demographic Correlates: A Cross-Sectional Study in Hungary<\/h6>\n<p>Zsofia Ocsovszky (Semmelweis University), Blanka Ehrenberger (Semmelweis University), Orsolya Papp-Zipernovszky (<span style=\"font-size: 1rem\">Semmelweis University; <\/span>E\u00f6tv\u00f6s Lor\u00e1nd University), J\u00f3zsef Otohal (Semmelweis University), Alexandra Assabiny (Semmelweis University), Gergely Koplanyi (Semmelweis University), Magor Papp (Semmelweis University), \u00c9va Borenszki-Gut\u00e1si (Semmelweis University), Hajnalka Vago (Semmelweis University), Bela Merkely (Semmelweis University), Zsolt Bagyura (Semmelweis University), Marta Csabai (Semmelweis University; Karoli Gaspar University of the Reformed Church)<br \/>\nJ Prim Care Community Health. 2026 Jan-Dec:17:21501319261442384.<br \/>\nDOI: <a href=\"http:\/\/dx.doi.org\/10.1177\/21501319261442384\">10.1177\/21501319261442384<\/a><\/p>\n<\/div>\n<h3><a id=\"rheumatoid\"><\/a>A nehezen kezelhet\u0151 rheumatoid arthritis kezel\u00e9s\u00e9nek \u00faj ir\u00e1nyai: c\u00e9lzott szerek \u00e9s nem gy\u00f3gyszeres beavatkoz\u00e1sok<\/h3>\n<figure id=\"attachment_172226\" aria-describedby=\"caption-attachment-172226\" style=\"width: 400px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-172226\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra-400x362.png\" alt=\"\" width=\"400\" height=\"362\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra-400x362.png 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra-885x800.png 885w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra-768x694.png 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra-1536x1389.png 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra-753x681.png 753w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/Rheumatology_D2TRA_abra.png 1890w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><figcaption id=\"caption-attachment-172226\" class=\"wp-caption-text\">Szem\u00e9lyre szabott algoritmus a nem gy\u00f3gyszeres ter\u00e1pi\u00e1k alkalmaz\u00e1s\u00e1ra nehezen kezelhet\u0151 rheumatoid arthritisben. (Az \u00e1bra BioRender felhaszn\u00e1l\u00e1s\u00e1val k\u00e9sz\u00fclt: https:\/\/biorender.com\/zclk4l6.)<\/figcaption><\/figure>\n<p>A rheumatoid arthritis (RA) kr\u00f3nikus autoimmun betegs\u00e9g, amely a feln\u0151tt n\u00e9pess\u00e9g k\u00f6zel 1 sz\u00e1zal\u00e9k\u00e1t \u00e9rinti. Az elm\u00falt \u00e9vtizedek ter\u00e1pi\u00e1s \u00e1tt\u00f6r\u00e9sei ellen\u00e9re a betegek egy r\u00e9sz\u00e9n\u00e9l a korszer\u0171 kezel\u00e9s sem eredm\u00e9nyez megfelel\u0151 betegs\u00e9gkontrollt. 2020-ban egy eur\u00f3pai munkacsoport megalkotta az \u00fan. nehezen kezelhet\u0151 RA egys\u00e9ges defin\u00edci\u00f3j\u00e1t, amely azon betegekre vonatkozik, akiknek panaszai t\u00f6bbf\u00e9le c\u00e9lzott hat\u00e1s\u00fa gy\u00f3gyszer alkalmaz\u00e1s\u00e1t k\u00f6vet\u0151en is fennmaradnak. A kezel\u00e9si neh\u00e9zs\u00e9gek h\u00e1tter\u00e9ben k\u00fcl\u00f6nb\u00f6z\u0151 okok \u00e1llhatnak, p\u00e9ld\u00e1ul tart\u00f3s gyullad\u00e1s, magas f\u00e1jdalom\u00e9rzet, k\u00f6rnyezeti t\u00e9nyez\u0151k vagy t\u00e1rsbetegs\u00e9gek.<\/p>\n<p>\u00d6sszefoglal\u00f3 cikk\u00fcnkben jap\u00e1n munkat\u00e1rsainkkal a nehezen kezelhet\u0151 RA ter\u00e1pi\u00e1s lehet\u0151s\u00e9geir\u0151l ny\u00fajtunk \u00e1ttekint\u00e9st a friss kutat\u00e1sok t\u00fckr\u00e9ben. A ter\u00e1pi\u00e1s m\u00f3dos\u00edt\u00e1sok a nehezen kezelhet\u0151 st\u00e1tuszba l\u00e9p\u00e9st k\u00f6vet\u0151en is el\u0151ny\u00f6sek lehetnek. A biol\u00f3giai szerek mellett a c\u00e9lzott gy\u00f3gyszerek m\u00e1sik csoportj\u00e1ba tartoz\u00f3 JAK-g\u00e1tl\u00f3k kifejezetten hat\u00e9konynak t\u0171nnek ebben a betegcsoportban. A gy\u00f3gyszeres kezel\u00e9s kieg\u00e9sz\u00edt\u00e9sek\u00e9nt egy\u00e9b beavatkoz\u00e1soknak (pl. fizioter\u00e1pia, testmozg\u00e1s, pszichol\u00f3giai intervenci\u00f3k, di\u00e9ta) is fontos szerepe lehet, els\u0151sorban a gyullad\u00e1st\u00f3l f\u00fcggetlen t\u00fcnetek enyh\u00edt\u00e9s\u00e9ben. A nehezen kezelhet\u0151 csoportban ugyanakkor a hat\u00e9konys\u00e1g mellett a biztons\u00e1gi szempontokra is sz\u00fcks\u00e9ges kiemelt figyelmet ford\u00edtani. A j\u00f6v\u0151ben \u00faj kezel\u00e9si opci\u00f3k, valamint a szem\u00e9lyre szabott orvosl\u00e1s ter\u00e9n el\u00e9rt innov\u00e1ci\u00f3k jav\u00edthatj\u00e1k a kimeneteleket nehezen kezelhet\u0151 RA-ban \u2013 fogalmazott dr. Dorg\u00f3 Andr\u00e1s Mikl\u00f3s.<\/p>\n<div class=\"keretes w-100\">\n<h6>Emerging trends in the management of difficult-to-treat rheumatoid arthritis: targeted treatments and non-pharmacological interventions<\/h6>\n<p>Gy\u00f6rgy Nagy (Department of Rheumatoilogy and Immunology, Semmelweis University; Heart and Vascular Center, Semmelweis University; Departments of Genetics, Cell- and Immunbiology, Semmelweis University), Koshiro Sonomoto (Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health), Andr\u00e1s M. Dorg\u00f3 (Department of Rheumatoilogy and Immunology, Semmelweis University), Lilla Gunkl-T\u00f3th (Department of Rheumatoilogy and Immunology, Semmelweis University; Department of Pharmacology and Pharmacotherapy, University of P\u00e9cs; Chronic Pain Research Group, Hungarian Research Network \u2013 University of P\u00e9cs [HUN-REN &#8211; PTE]), Yoshiya Tanaka (Department of Molecural Targeted Therapeutics, University of Occupational and Environmental Health; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health)<br \/>\nRheumatology, Volume 65, Issue 5, May 2026, keag217<br \/>\n<a href=\"https:\/\/doi.org\/10.1093\/rheumatology\/keag217\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1093\/rheumatology\/keag217<\/a><\/p>\n<\/div>\n<h3><a id=\"kieges\"><\/a>A ki\u00e9g\u00e9s s\u00falyoss\u00e1ga bentlak\u00e1sos demenciaell\u00e1t\u00e1sban: egy\u00e9ni terhel\u0151 t\u00e9nyez\u0151k \u00e9s int\u00e9zm\u00e9nyi szint\u0171 k\u00fcl\u00f6nbs\u00e9gek egy magyar keresztmetszeti vizsg\u00e1latban<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172229\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan-400x225.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan-400x225.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan-900x506.jpg 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan-768x432.jpg 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan-1536x864.jpg 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan-753x424.jpg 753w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/baloghzoltan.jpg 1920w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>A kutat\u00e1s a demenci\u00e1val \u00e9l\u0151 szem\u00e9lyeket gondoz\u00f3 bentlak\u00e1sos int\u00e9zm\u00e9nyekben dolgoz\u00f3 \u00e1pol\u00f3k \u00e9s gondoz\u00f3k ki\u00e9g\u00e9s\u00e9nek s\u00falyoss\u00e1g\u00e1t vizsg\u00e1lta Magyarorsz\u00e1gon. A keresztmetszeti felm\u00e9r\u00e9sben 77 int\u00e9zm\u00e9ny 1254 munkat\u00e1rsa vett r\u00e9szt. A vizsg\u00e1lat c\u00e9lja annak felt\u00e1r\u00e1sa volt, hogy a munkaterhel\u00e9s, a gondoz\u00e1si neh\u00e9zs\u00e9gek, a demenci\u00e1val \u00f6sszef\u00fcgg\u0151 t\u00fcnetek \u00e9s a megk\u00fczd\u00e9si lehet\u0151s\u00e9gek mik\u00e9nt befoly\u00e1solj\u00e1k a ki\u00e9g\u00e9s kialakul\u00e1s\u00e1t.<\/p>\n<p>Az eredm\u00e9nyek szerint a r\u00e9sztvev\u0151k k\u00f6zel fele (46,4 sz\u00e1zal\u00e9k) sz\u00e1molt be a ki\u00e9g\u00e9s valamilyen jel\u00e9r\u0151l, m\u00edg minden \u00f6t\u00f6dik dolgoz\u00f3n\u00e1l s\u00falyosabb fok\u00fa ki\u00e9g\u00e9s mutatkozott. A leger\u0151sebb kock\u00e1zati t\u00e9nyez\u0151k a magas szubjekt\u00edv munkaterhel\u00e9s, a gyakori gondoz\u00e1si neh\u00e9zs\u00e9gek \u00e9s a megk\u00fczd\u00e9si lehet\u0151s\u00e9gek hi\u00e1nya voltak. Ezzel szemben a ki\u00e9g\u00e9ssel kapcsolatos kor\u00e1bbi k\u00e9pz\u00e9s \u00e9s ismeretszerz\u00e9s jelent\u0151s v\u00e9d\u0151faktornak bizonyult. A t\u00f6bbszint\u0171 elemz\u00e9s azt is kimutatta, hogy a ki\u00e9g\u00e9s k\u00fcl\u00f6nbs\u00e9geinek mintegy 21 sz\u00e1zal\u00e9ka int\u00e9zm\u00e9nyi szinten magyar\u00e1zhat\u00f3. A kutat\u00e1s r\u00e1mutat arra, hogy a demenciaell\u00e1t\u00e1sban dolgoz\u00f3k t\u00e1mogat\u00e1sa nemcsak egy\u00e9ni, hanem szervezeti feladat is. A munkaterhel\u00e9s cs\u00f6kkent\u00e9se, a megk\u00fczd\u00e9si er\u0151forr\u00e1sok b\u0151v\u00edt\u00e9se \u00e9s a c\u00e9lzott tov\u00e1bbk\u00e9pz\u00e9sek hozz\u00e1j\u00e1rulhatnak a ki\u00e9g\u00e9s megel\u0151z\u00e9s\u00e9hez \u00e9s az ell\u00e1t\u00e1s min\u0151s\u00e9g\u00e9nek jav\u00edt\u00e1s\u00e1hoz \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Balogh Zolt\u00e1n.<\/p>\n<div class=\"keretes w-100\">\n<h6>Burnout severity in residential dementia care: individual demands and institutional-level variation in a Hungarian cross-sectional study<\/h6>\n<p>Hedvig Kiss (Health Sciences Division, Doctoral College, Semmelweis University), Zolt\u00e1n Balogh (Department of Nursing, Faculty of Health Sciences, Semmelweis University), Attila P\u00e9ter Szab\u00f3 (Department of Epidemiology, Faculty of Health Sciences, University of Debrecen), Orsolya Nyilas (Institute of Applied Human Sciences, University of Ny\u00edregyh\u00e1za), P\u00e9ter Tak\u00e1cs (Department of Health Informatics, Faculty of Health Sciences, University of Debrecen)<br \/>\nBMC Nursing Volume 25, article number 432 (2026)<br \/>\nDOI: <a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12912-026-04579-y\" target=\"_blank\" rel=\"noopener\">10.1186\/s12912-026-04579-y<\/a><\/p>\n<\/div>\n<h3>A BMI \u00e9s a test\u00f6sszet\u00e9tel szerepe a kardiometabolikus kock\u00e1zat korai felismer\u00e9s\u00e9ben magyar feln\u0151ttek k\u00f6r\u00e9ben<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/BMI.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172233\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/BMI-400x220.png\" alt=\"\" width=\"400\" height=\"220\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/BMI-400x220.png 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/BMI.png 605w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>Kutat\u00e1sunk c\u00e9lja annak meghat\u00e1roz\u00e1sa volt, hogy a testt\u00f6megindex (BMI) \u00e9s a bioelektromos impedanciaanal\u00edzissel v\u00e9gzett test\u00f6sszet\u00e9tel-vizsg\u00e1lat milyen hat\u00e9konys\u00e1ggal azonos\u00edtja a kardiometabolikus kock\u00e1zatot magyar feln\u0151ttek k\u00f6r\u00e9ben.<\/p>\n<p>Az orsz\u00e1gos mobil eg\u00e9szs\u00e9g\u00fcgyi sz\u0171r\u0151programban r\u00e9szt vev\u0151 868 feln\u0151tt adatainak elemz\u00e9se sor\u00e1n azt tal\u00e1ltuk, hogy a magas v\u00e9rnyom\u00e1s, a cukorbetegs\u00e9g, a hypertriglyceridaemia \u00e9s az \u00e9relmeszesed\u00e9s kock\u00e1zata m\u00e1r a jelenleg alkalmazott WHO-hat\u00e1r\u00e9rt\u00e9kekn\u00e9l alacsonyabb BMI-\u00e9rt\u00e9kek mellett n\u00f6vekedni kezdhet. A teljes popul\u00e1ci\u00f3ban a test\u00f6sszet\u00e9teli param\u00e9terek \u00f6sszess\u00e9g\u00e9ben nem bizonyultak sz\u00e1mottev\u0151en pontosabbnak a BMI-n\u00e9l, ugyanakkor bizonyos alcsoportokban \u2013 k\u00fcl\u00f6n\u00f6sen a k\u00f6zepes BMI-tartom\u00e1nyba tartoz\u00f3 f\u00e9rfiakn\u00e1l \u2013 \u00e9rdemi t\u00f6bbletinform\u00e1ci\u00f3t ny\u00fajthatnak a kock\u00e1zat pontosabb becsl\u00e9s\u00e9hez. Eredm\u00e9nyeink alapj\u00e1n a BMI tov\u00e1bbra is egyszer\u0171, gyors \u00e9s k\u00f6lts\u00e9ghat\u00e9kony els\u0151 vonalbeli sz\u0171r\u0151eszk\u00f6z, m\u00edg a test\u00f6sszet\u00e9tel c\u00e9lzott vizsg\u00e1lata hozz\u00e1j\u00e1rulhat a szem\u00e9lyre szabott prevenci\u00f3hoz, valamint a n\u00e9peg\u00e9szs\u00e9g\u00fcgyi er\u0151forr\u00e1sok hat\u00e9konyabb \u00e9s c\u00e9lzottabb felhaszn\u00e1l\u00e1s\u00e1hoz \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Fekete M\u00f3nika \u00e9s dr. Jarecsny Tam\u00e1s.<\/p>\n<div class=\"keretes w-100\">\n<h6>Optimizing Public Health Screening: Population-Specific BMI Thresholds for Targeted Body Composition Assessment in Hungary<\/h6>\n<p>Tamas Jarecsny (Department of Neurology and Stroke, Saint John\u2019s Central Hospital of North Buda; Doctoral School, Semmelweis University), Nadim Al-Muhanna (Department of Neurology and Stroke, Saint John\u2019s Central Hospital of North Buda), Dira Rebeka Fabian (Department of Neurology and Stroke, Saint John\u2019s Central Hospital of North Buda), Roland Kosik (National Public Health and Pharmaceutical Center), Richard Schwab (MiND Brain-Gut Center), Gergo Jozsef Szollosi (Faculty of Economics and Business, University of Debrecen), Laszlo Schandl (Department of Internal Medicine-Diabetology, Saint John\u2019s Central Hospital of North Buda), Gyula Tomasics (Department of Internal Medicine-Diabetology, Saint John\u2019s Central Hospital of North Buda), Eszter Melinda Pazmandi (Doctoral School, Semmelweis University; Andr\u00e1s Pet\u0151 Faculty, Semmelweis University), Andras Folyovich (K\u00fatv\u00f6lgyi Outpatient Clinic, Saint John\u2019s Central Hospital of North Buda; Cardiovascular Medicine Research Division, Doctoral College, Semmelweis University), Ferenc Fazekas (Department of Neurology and Stroke, Saint John\u2019s Central Hospital of North Buda; Health Services Management Training Centre, Semmelweis University), Monika Fekete (Institute of Preventive Medicine and Public Health Faculty of Medicine, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Health Sciences Division, Doctoral College, Semmelweis University)<br \/>\nNutrients\u00a02026,\u00a0<em>18<\/em>(9), 1410<br \/>\n<a href=\"https:\/\/doi.org\/10.3390\/nu18091410\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/nu18091410<\/a><\/p>\n<\/div>\n<h3><a id=\"sovargas\"><\/a>A GHSR-antagonista LEAP2 koncentr\u00e1ci\u00f3ja ford\u00edtott \u00f6sszef\u00fcgg\u00e9st mutat az alkohols\u00f3v\u00e1rg\u00e1ssal, \u00e9s alkoholexpoz\u00edci\u00f3 hat\u00e1s\u00e1ra megv\u00e1ltozik<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172236\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-400x158.jpg\" alt=\"\" width=\"400\" height=\"158\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-400x158.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-900x356.jpg 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-768x304.jpg 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-1536x608.jpg 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-2048x811.jpg 2048w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/LEAP_sovargas_magyar.png-753x298.jpg 753w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>Az alkoholhaszn\u00e1lati zavar (alkoholizmus) gy\u00f3gyszeres ter\u00e1pi\u00e1j\u00e1nak eszk\u00f6zt\u00e1ra egy\u00e9rtelm\u0171en b\u0151v\u00edt\u00e9sre szorul. Egy lehets\u00e9ges \u00faj ter\u00e1pi\u00e1s c\u00e9lpont a gyomor \u00e1ltal termelt \u201e\u00e9hs\u00e9ghormon\u201d, a ghrelin \u00e9s receptora (GHSR). Hum\u00e1n vizsg\u00e1latok eredm\u00e9nyei alapj\u00e1n a ghrelin fokozza az alkohol ir\u00e1nti s\u00f3v\u00e1rg\u00e1st \u00e9s alkoholfogyaszt\u00e1st is. A m\u00e1jban expressz\u00e1lt antimikrobi\u00e1lis peptid-2-t (LEAP2) nemr\u00e9g fedezt\u00e9k fel, mint a GHSR endog\u00e9n antagonist\u00e1j\u00e1t, ez\u00e9rt arra voltunk kiv\u00e1ncsiak hogy ennek v\u00e9rszintje hogyan f\u00fcgg \u00f6ssze az alkohol ir\u00e1nti s\u00f3v\u00e1rg\u00e1ssal \u00e9s az alkoholfogyaszt\u00e1ssal. Elemz\u00e9s\u00fcnkh\u00f6z a Baltimore-i (USA) National Institute on Drug Abuse-ban v\u00e9gzett klinikai vizsg\u00e1latok mint\u00e1it haszn\u00e1ltuk fel.<\/p>\n<p>Kimutattuk, hogy min\u00e9l magasabb a LEAP-2 sz\u00e9rumszintje, ann\u00e1l alacsonyabb az alkohol ir\u00e1nti s\u00f3v\u00e1rg\u00e1s, olyan helyzetben is amikor az alkoholos italt csak l\u00e1tjuk \u00e9s szagolhatjuk, illetve akkor is amikor m\u00e1r fogyasztottunk alkoholt. Ugyanez az \u00f6sszef\u00fcgg\u00e9s nem alkoholos ital eset\u00e9ben nem volt kimutathat\u00f3. Emellett f\u00e9ny der\u00fclt arra is, hogy k\u00f6zvetlen\u00fcl alkoholos ital fogyaszt\u00e1s\u00e1t k\u00f6vet\u0151en cs\u00f6kken a LEAP-2 sz\u00e9rumszintje. Mindezek alapj\u00e1n elmondhat\u00f3, hogy a m\u00e1jban \u00e9s v\u00e9konyb\u00e9lben termel\u0151d\u0151 LEAP-2 szintje v\u00e1ltozik az alkohol hat\u00e1s\u00e1ra, illetve a s\u00f3v\u00e1rg\u00e1ssal is kapcsolatot mutat \u2013 fogalmazott dr. L\u00e9k\u00f3 Andr\u00e1s.<\/p>\n<div class=\"keretes w-100\">\n<h6>GHSR antagonist LEAP2 concentrations negatively correlate with alcohol craving and are modulated by alcohol exposure: Evidence from human and rat studies<\/h6>\n<p>Andras H. Leko (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health; Department of Psychiatry and Psychotherapy, Semmelweis University), Mehdi Farokhnia (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health), Elizabeth H. Tressler (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health; Stress and Addiction Neuroscience Unit, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; Neurobiology of Addiction Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health), Janaina C.M. Vendruscolo (Neurobiology of Addiction Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health), Lindsay A. Kryszak (Translational Analytical Core, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health), Shelley N. Jackson (Translational Analytical Core, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health), Lisa A. Farinelli (Office of the Clinical Director, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health), Olivia Jennings (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health), Zhihong Yang (Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine), Carolina L. Haass-Koffler (Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, School of Public Health, Brown University; Department of Psychiatry and Human Behavior, The Warren Alpert Medical School, Brown University; Carney Institute for Brain Science, Brown University), Leandro F. Vendruscolo (National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health; Stress and Addiction Neuroscience Unit, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health), Suthat Liangpunsakul (Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine; Roudebush Veterans Administration Medical Center), Lorenzo Leggio (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health; Translational Analytical Core, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; Office of the Clinical Director, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, School of Public Health, Brown University; Division of Addiction Medicine, Department of Medicine, School of Medicine, Johns Hopkins University; Department of Neuroscience, Georgetown University Medical Center)<br \/>\nDrug and Alcohol Dependence, Volume 284, 1 July 2026, 113176<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.drugalcdep.2026.113176\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.drugalcdep.2026.113176<\/a><\/p>\n<\/div>\n<h3><a id=\"testedzes\"><\/a>A testedz\u00e9s alv\u00e1sra gyakorolt hat\u00e1sa<\/h3>\n<figure id=\"attachment_172238\" aria-describedby=\"caption-attachment-172238\" style=\"width: 400px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-172238\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1-400x152.jpeg\" alt=\"\" width=\"400\" height=\"152\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1-400x152.jpeg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1-900x342.jpeg 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1-768x292.jpeg 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1-1536x584.jpeg 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1-753x287.jpeg 753w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/kaag025f1.jpeg 2000w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><figcaption id=\"caption-attachment-172238\" class=\"wp-caption-text\">Late-night physical activity suppresses REM sleep. Less time between physical activity and subsequent sleep was associated with increased REM latency (left, significant after FDR correction) and reduced REM percentage (right, not significant after FDR correction). The scatterplots show deviations from the individual means of sleep parameters and physical activity timing, residualized for age, sex, and day of the week. A best-fit OLS regression line, Pearson and Spearman correlations of the residualized deviations are shown. Abbreviation: FDR, false discovery rate; OLS, ordinary least squares; REM, rapid eye movement.<\/figcaption><\/figure>\n<p>Az alv\u00e1shigi\u00e9niai tan\u00e1csok gyakran javasolj\u00e1k az esti edz\u00e9s elker\u00fcl\u00e9s\u00e9t, mivel \u00e1ll\u00edt\u00f3lag rontja az alv\u00e1s min\u0151s\u00e9g\u00e9t \u2013 a tudom\u00e1nyos bizony\u00edt\u00e9kok azonban ellentmond\u00e1sosak. Kutat\u00e1sunkban azt vizsg\u00e1ltuk, hogy a fizikai aktivit\u00e1s \u00e9s annak id\u0151z\u00edt\u00e9se hogyan f\u00fcgg \u00f6ssze az alv\u00e1s min\u0151s\u00e9g\u00e9vel. A vizsg\u00e1lat sor\u00e1n 267 r\u00e9sztvev\u0151t figyelt\u00fcnk meg t\u00f6bb napon kereszt\u00fcl otthoni k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. A r\u00e9sztvev\u0151k naponta jelezt\u00e9k fizikai aktivit\u00e1sukat, \u00e9jszakai alv\u00e1suk szerkezet\u00e9t pedig egy agyi aktivit\u00e1st r\u00f6gz\u00edt\u0151 fejp\u00e1nt seg\u00edts\u00e9g\u00e9vel m\u00e9rt\u00fck. Kutat\u00e1sunk er\u0151ss\u00e9ge a nagy mintam\u00e9ret, a beavatkoz\u00e1smentes, term\u00e9szetes k\u00f6rnyezetben v\u00e9gzett megfigyel\u00e9s, tov\u00e1bb\u00e1 a kor\u00e1bbi tanulm\u00e1nyokn\u00e1l pontosabb alv\u00e1sm\u00e9r\u00e9sek.<\/p>\n<p>Eredm\u00e9nyeink alapj\u00e1n a napi fizikai aktivit\u00e1snak minim\u00e1lis hat\u00e1sa volt az alv\u00e1s min\u0151s\u00e9g\u00e9re \u00e9s szerkezet\u00e9re. Az elalv\u00e1shoz k\u00f6zel v\u00e9gzett edz\u00e9s ugyan a REM-alv\u00e1s (az \u00e1lmod\u00e1ssal \u00f6sszef\u00fcgg\u0151 alv\u00e1si f\u00e1zis) enyhe cs\u00f6kken\u00e9s\u00e9hez vezetett, de az alv\u00e1smin\u0151s\u00e9get nem befoly\u00e1solta. Ez\u00e1ltal arra k\u00f6vetkeztethet\u00fcnk, hogy a szok\u00e1sos, m\u00e9rs\u00e9kelt intenzit\u00e1s\u00fa testmozg\u00e1s nincs negat\u00edv hat\u00e1ssal az alv\u00e1sra, \u00e9s az esti edz\u00e9s is j\u00f3 v\u00e1laszt\u00e1s lehet azoknak, akiknek napk\u00f6zben nincs lehet\u0151s\u00e9ge edzeni \u2013 fogalamzott \u00f6sszefoglal\u00f3j\u00e1ban Wolf S\u00e1ra.<\/p>\n<div class=\"keretes w-100\">\n<h6>Effects of physical activity on sleep in an ecologically valid design<\/h6>\n<p>S\u00e1ra Wolf (Institute of Behavioural Sciences, Semmelweis University), R\u00f3bert B\u00f3dizs (Institute of Behavioural Sciences, Semmelweis University), P\u00e9ter Przemyslaw Ujma (Institute of Behavioural Sciences, Semmelweis University)<br \/>\nAnnals of Behavioral Medicine, Volume 60, Issue 1, 2026, kaag025<br \/>\n<a href=\"https:\/\/doi.org\/10.1093\/abm\/kaag025\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1093\/abm\/kaag025<\/a><\/p>\n<\/div>\n<h3><a id=\"chatbot\"><\/a>Chatbot-kapcsolati f\u00fcgg\u0151s\u00e9g \u00e9s pszich\u00f3ziskock\u00e1zat<\/h3>\n<p>Tanulm\u00e1nyunk azt vizsg\u00e1lja, hogy a t\u00e1rsalg\u00e1si mesters\u00e9ges intelligencia \u2013 f\u0151k\u00e9nt az \u00e9rzelmi t\u00e1mogat\u00e1sra vagy t\u00e1rsas p\u00f3tl\u00e9kk\u00e9nt haszn\u00e1lt chatbot \u2013 mik\u00e9nt v\u00e1lhat s\u00e9r\u00fcl\u00e9keny felhaszn\u00e1l\u00f3kn\u00e1l f\u00fcgg\u0151s\u00e9gszer\u0171 kapcsolati t\u00e9rr\u00e9. A chatbot el\u00e9rhet\u0151s\u00e9ge, gyors v\u00e1lasza, empatikusnak t\u0171n\u0151 jelenl\u00e9te \u00e9s \u00e1lland\u00f3 valid\u00e1ci\u00f3ja megnyugtat\u00f3 lehet, de fokozhatja az \u00e9rzelmi r\u00e1utalts\u00e1got, a t\u00e1rsas visszah\u00faz\u00f3d\u00e1st, alv\u00e1szavart \u00e9s a val\u00f3s\u00e1gtesztel\u00e9s gyeng\u00fcl\u00e9s\u00e9t.<\/p>\n<p>A klinikai esetben a chatbot kezdetben \u00f6nnyugtat\u00f3 szerepet t\u00f6lt\u00f6tt be, k\u00e9s\u0151bb azonban \u201ekapcsolati jelenl\u00e9tt\u00e9\u201d v\u00e1lt, \u00e9s paranoid \u00e9rtelmez\u00e9sekhez kapcsol\u00f3dott. A pszich\u00f3zis kialakul\u00e1s\u00e1t a szerz\u0151k nem egyetlen okra vezetik vissza, hanem s\u00e9r\u00fcl\u00e9kenys\u00e9g, mag\u00e1ny, stressz, izol\u00e1ci\u00f3, rumin\u00e1ci\u00f3 \u00e9s algoritmikusan meger\u0151s\u00edtett jelent\u00e9stulajdon\u00edt\u00e1s egy\u00fctt\u00e1ll\u00e1s\u00e1ra. A tanulm\u00e1ny \u00fajdons\u00e1ga, hogy a kock\u00e1zatot nemcsak a chatbot v\u00e1laszaiban, hanem kapcsolati \u00e9s addikci\u00f3s m\u0171k\u00f6d\u00e9s\u00e9ben l\u00e1tja. Gyakorlati \u00fczenete: r\u00e1 kell k\u00e9rdezni az intenz\u00edv chatbot-haszn\u00e1lat \u00e9rzelmi jelent\u0151s\u00e9g\u00e9re, kapcsolathelyettes\u00edt\u0151 szerep\u00e9re \u00e9s pszichotikus gondolatokkal val\u00f3 kapcsolat\u00e1ra \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Treuer Tam\u00e1s.<\/p>\n<div class=\"keretes w-100\">\n<h6>Chatbot relational dependence and psychosis risk: Conversational artificial intelligence as a potential behavioral addiction context<\/h6>\n<p>Tam\u00e1s Treuer (Department of Psychiatry and Psychotherapy, Semmelweis University), Adrienne Incze (Department of Personality and Clinical Psychology, Faculty of Humanities and Social Sciences Institute of Psychology P\u00e1zm\u00e1ny P\u00e9ter Catholic University; Doctoral School of Psychology, Theoretical Psychoanalysis Program, University of P\u00e9cs)<br \/>\nJournal of Behavioral Addictions, Volume\/Issue: Volume 15: Issue 2<br \/>\n<a href=\"https:\/\/doi.org\/10.1556\/2006.2026.00080\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1556\/2006.2026.00080<\/a><\/p>\n<\/div>\n<h3>Moldvai D et al. &#8211; A k\u00e9tdimenzi\u00f3s (2D) sejtteny\u00e9szett\u0151l a h\u00e1romdimenzi\u00f3s (3D) bionyomtatott in vitro eml\u0151daganat modellig &#8211; A tumorn\u00f6veked\u00e9s, a sz\u00f6veti strukt\u00fara \u00e9s az mTOR jel\u00e1tvitel jellegzetess\u00e9geinek \u00f6sszehasonl\u00edt\u00f3 vizsg\u00e1lata<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/sebestyenannatumor.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172239\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/sebestyenannatumor-400x332.jpg\" alt=\"\" width=\"400\" height=\"332\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/sebestyenannatumor-400x332.jpg 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/sebestyenannatumor-753x625.jpg 753w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/sebestyenannatumor.jpg 768w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>Az \u00e1llatk\u00eds\u00e9rletek helyettes\u00edt\u00e9se a legk\u00fcl\u00f6nb\u00f6z\u0151bb kutat\u00e1sokban csak megfelel\u0151 komplex betegs\u00e9g modellekkel lehets\u00e9ges. A munka a daganatos sejtek biol\u00f3giai viselked\u00e9s\u00e9t meghat\u00e1roz\u00f3 t\u00e9rbeli jellegzetess\u00e9geket vizsg\u00e1lta a hagyom\u00e1nyos 2D sejtteny\u00e9szetek \u00e9s a kialak\u00edtott, hosszabbt\u00e1von is fentarthat\u00f3, \u00faj, 3D bionyomtatott eml\u0151r\u00e1k-modellek \u00f6sszehasonl\u00edt\u00e1s\u00e1val. A bionyomtatott tumorok lassabb n\u00f6veked\u00e9se, sejt-m\u00e1trix kapcsolatai jobban t\u00fckr\u00f6zi az in vivo tumorok viselked\u00e9s\u00e9t a 2D kult\u00far\u00e1k felgyorsult oszt\u00f3d\u00e1s\u00e1val szemben. Az \u00f6sszehasonl\u00edt\u00f3 vizsg\u00e1latok jellegzetes elt\u00e9r\u00e9seket mutattak ki a tumor t\u00fal\u00e9l\u00e9s\u00e9ben kulcsfontoss\u00e1g\u00fa mTOR jelp\u00e1lya aktivit\u00e1s\u00e1ban \u00e9s a tumorsz\u00f6vetszer\u0171 strukt\u00far\u00e1k gy\u00f3gyszer\u00e9rz\u00e9kenys\u00e9gben is.<\/p>\n<p>Mindezen megfigyel\u00e9sek felh\u00edvj\u00e1k a figyelm\u00fcnket arra, hogy a k\u00fcl\u00f6nb\u00f6z\u0151 sejtfenntart\u00e1si m\u00f3dszerek nagym\u00e9rt\u00e9kben befoly\u00e1solj\u00e1k a sejtek viselked\u00e9s\u00e9t. A 3D bionyomtatott modellek pontosabban mutatj\u00e1k a daganatok val\u00f3s viselked\u00e9s\u00e9t, \u00edgy a 2D teny\u00e9szetekn\u00e9l megb\u00edzhat\u00f3bb platformot ny\u00fajtanak a daganatbiol\u00f3giai vizsg\u00e1latokhoz, preklinikai gy\u00f3gyszer hat\u00e1svizsg\u00e1latokhoz \u00e9s hat\u00e9kony gy\u00f3gyszerfejleszt\u00e9shez \u2013 fogalmazott dr. Sebesty\u00e9n Anna.<\/p>\n<div class=\"keretes w-100\">\n<h6>From 2D to 3D Bioprinted In Vitro Breast Cancer Model: A Comparative Study of Proliferation, Tissue Structure, and mTOR Signaling<\/h6>\n<p>Dorottya Moldvai (Department of Pathology and Experimental Cancer Research Semmelweis University), G\u00e1bor Pet\u0151v\u00e1ri (Department of Pathology and Experimental Cancer Research Semmelweis University), Rebeka Gelencs\u00e9r (Department of Pathology and Experimental Cancer Research Semmelweis University), D\u00e1niel Sztankovics (Department of Pathology and Experimental Cancer Research Semmelweis University), Risa Miyaura (Department of Pathology and Experimental Cancer Research Semmelweis University), Vikt\u00f3ria Varga (Department of Pathology and Experimental Cancer Research Semmelweis University), Fatime Szalai (Department of Pathology and Experimental Cancer Research Semmelweis University), Korn\u00e9lia Baghy (Department of Pathology and Experimental Cancer Research Semmelweis University), Ildik\u00f3 Krencz (Department of Pathology and Experimental Cancer Research Semmelweis University), Titanilla Dank\u00f3 (Department of Pathology and Experimental Cancer Research Semmelweis University), Anna Sebesty\u00e9n (Department of Pathology and Experimental Cancer Research Semmelweis University)<br \/>\nMedCommVolume 7, Issue 6 e70783<br \/>\n<a href=\"https:\/\/doi.org\/10.1002\/mco2.70783\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/mco2.70783<\/a><\/p>\n<\/div>\n<h3><a id=\"immunellenorzo\"><\/a>Immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3 kezel\u00e9s okozta sz\u00edvel\u00e9gtelens\u00e9g kor\u00e1bbi sz\u00edvizomk\u00e1rosod\u00e1s eset\u00e9n<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172240\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas-400x211.png\" alt=\"\" width=\"400\" height=\"211\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas-400x211.png 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas-900x474.png 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas-768x404.png 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas-753x396.png 753w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/gergelytamas.png 1379w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>Az immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3 gy\u00f3gyszerek (r\u00f6viden ICI-k) az elm\u00falt \u00e9vek egyik legnagyobb \u00e1tt\u00f6r\u00e9s\u00e9t jelentett\u00e9k a daganatos betegs\u00e9gek kezel\u00e9s\u00e9ben. Hat\u00e1smechanizmusuk a T-sejteket szab\u00e1lyoz\u00f3 immunellen\u0151rz\u0151pontok g\u00e1tl\u00e1s\u00e1n alapul, ezzel aktiv\u00e1lva a tumorellenes immunv\u00e1laszt. Azonban ezen molekul\u00e1k nem csak tumorokban tal\u00e1lhat\u00f3ak meg, hanem az immunrendszer m\u0171k\u00f6d\u00e9s\u00e9t fiziol\u00f3gi\u00e1s k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt is szab\u00e1lyozz\u00e1k, autoimmun folyamatokat megakad\u00e1lyozva. Ez magyar\u00e1zza, hogy ICI-kezel\u00e9s hat\u00e1s\u00e1ra sz\u00e1mos szervrendszert \u00e9rint\u0151 immun-medi\u00e1lt mell\u00e9khat\u00e1sok j\u00f6hetnek l\u00e9tre. Ezek k\u00f6z\u00fcl a kardiovaszkul\u00e1ris mell\u00e9khat\u00e1sok ritk\u00e1bbnak sz\u00e1m\u00edtanak, azonban potenci\u00e1lisan s\u00falyos k\u00f6vetkezm\u00e9nyekkel j\u00e1rhatnak.<\/p>\n<p>K\u00f6zlem\u00e9ny\u00fcnkben az immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3k sz\u00edvel\u00e9gtelens\u00e9get okoz\u00f3 hat\u00e1s\u00e1t vizsg\u00e1ltuk, els\u0151sorban ezen mell\u00e9khat\u00e1s kialakul\u00e1s\u00e1ban szerepet j\u00e1tsz\u00f3 rizik\u00f3faktort keresve. Ismert, hogy miokardi\u00e1lis infarktust k\u00f6vet\u0151en immun-medi\u00e1lt folyamatok jelent\u0151s szerepet j\u00e1tszanak a sz\u00edvizom \u00e1talakul\u00e1s\u00e1ban, \u00edgy felt\u00e9telezt\u00fck, hogy kor\u00e1bbi, iszk\u00e9mi\u00e1s eredet\u0171 sz\u00edvizomk\u00e1rosod\u00e1st k\u00f6vet\u0151en az ICI kezel\u00e9s sz\u00edvel\u00e9gtelens\u00e9get okoz\u00f3 hat\u00e1sa feler\u0151s\u00f6dhet. Kutat\u00e1sunk els\u0151 r\u00e9sz\u00e9ben eg\u00e9rmodellben jelent\u0151sebb funkcion\u00e1lis k\u00e1rosod\u00e1st \u00e9s gyullad\u00e1st l\u00e1ttunk ICI-kezel\u00e9st k\u00f6vet\u0151en olyan \u00e1llatok sz\u00edv\u00e9ben, melyek kor\u00e1bban sz\u00edvizomk\u00e1rosod\u00e1son estek \u00e1t. Ezen eredm\u00e9ny klinikai relevanci\u00e1j\u00e1t vizsg\u00e1lva, dr. Drobni Zs\u00f3fi\u00e1val \u00e9s dr. Tomas Neilan kutat\u00f3csoportj\u00e1val k\u00f6z\u00f6sen a Massachusetts General Hospital-ban ICI-kezel\u00e9sen \u00e1tes\u0151 tumoros betegek adatait vizsg\u00e1ltuk, az \u00fajonnan kialakult sz\u00edvel\u00e9gtelens\u00e9g rizik\u00f3faktorait elemezve. Hasonl\u00f3an \u00e1llatk\u00eds\u00e9rlet\u00fcnkh\u00f6z, a kor\u00e1bban sz\u00edvizom-iszk\u00e9mi\u00e1s esem\u00e9nyen (miokardi\u00e1lis infarktus, perkut\u00e1n vagy seb\u00e9szi revaszkulariz\u00e1ci\u00f3) \u00e1tesett betegekn\u00e9l szignifik\u00e1nsan nagyobb es\u00e9llyel alakult ki sz\u00edvel\u00e9gtelens\u00e9g ICI-kezel\u00e9st k\u00f6vet\u0151en. \u00d6sszess\u00e9g\u00e9ben adataink alapj\u00e1n az iszk\u00e9mi\u00e1s sz\u00edvbetegs\u00e9gben szenved\u0151, ICI-kezel\u00e9sben r\u00e9szes\u00fcl\u0151 tumoros betegek fokozottabb kardiovaszkul\u00e1ris ut\u00e1nk\u00f6vet\u00e9se lehet indokolt \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Gergely Tam\u00e1s.<\/p>\n<div class=\"keretes w-100\">\n<h6>Inhibition of the programmed death protein 1 immune checkpoint and the development of heart failure in the presence of prior cardiac ischaemia<\/h6>\n<p>Tam\u00e1s G Gergely (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Zs\u00f3fia D Drobni (Heart and Vascular Center, Semmelweis University; Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School), Tam\u00e1s Kov\u00e1cs (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Nabil V Sayour (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Viktoria E T\u00f3th (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), M\u00e1rton S Kocsis (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Zs\u00f3fia On\u00f3di (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), G\u00e1bor M M\u00f3rotz (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Andrea Kov\u00e1cs (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Daniel A Zlotoff (Cardiovascular Imaging Research Center [CIRC], Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School), Hannah K Gilman (Cardiovascular Imaging Research Center [CIRC], Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School), Jingyi Gong (Cardiovascular Imaging Research Center [CIRC], Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School), N\u00f3ra Fekete (Department of Genetics, Cell- and Immunobiology, Semmelweis University), \u00c9va P\u00e1llinger (Department of Genetics, Cell- and Immunobiology, Semmelweis University), Edit I Buz\u00e1s (Department of Genetics, Cell- and Immunobiology, Semmelweis University), Laura I Yousif (Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus University Medical Center), Wouter C Meijers (Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus University Medical Center), B\u00e9la Merkely (Heart and Vascular Center, Semmelweis University), Kerry L Reynolds (Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School), P\u00e9ter Ferdinandy (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; Pharmahungary Group), Tomas G Neilan (Cardiovascular Imaging Research Center [CIRC], Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School), Zolt\u00e1n V Varga (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Center for Pharmacology and Drug Research &amp; Development, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group)<br \/>\nCardiovasc Res. 2026 Jun 5;122(8):1055-1069.<br \/>\ndoi: <a href=\"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/8\/1055\/8661155\" target=\"_blank\" rel=\"noopener\">10.1093\/cvr\/cvag085<\/a><\/p>\n<\/div>\n<h3><a id=\"sportsziv\"><\/a>A mozg\u00e1sszeg\u00e9ny \u00e9letm\u00f3dt\u00f3l a sportsz\u00edvig: a kardi\u00e1lis volumetria, funkci\u00f3 \u00e9s strain \u00e1tfog\u00f3 sz\u00edv MR-vizsg\u00e1lata<\/h3>\n<p><a href=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-172241\" src=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-400x223.png\" alt=\"\" width=\"400\" height=\"223\" srcset=\"https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-400x223.png 400w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-900x502.png 900w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-768x428.png 768w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-1536x857.png 1536w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-2048x1142.png 2048w, https:\/\/semmelweis.hu\/hirek\/files\/2026\/07\/szaboliliana-753x420.png 753w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>A rendszeres, intenz\u00edv sport hat\u00e1s\u00e1ra \u00e1talakul a sz\u00edv szerkezete: a kamrai \u00fcregm\u00e9retek n\u0151nek \u00e9s a sz\u00edvizom megvastagodik. T\u00f6bbek k\u00f6z\u00f6tt ezeket a v\u00e1ltoz\u00e1sokat h\u00edvjuk \u201esportsz\u00edvnek&#8221;. A neh\u00e9zs\u00e9get az jelenti, hogy ezek a fiziol\u00f3gi\u00e1s \u00e1talakul\u00e1sok n\u00e9ha megt\u00e9veszt\u0151en hasonl\u00edtanak bizonyos sz\u00edvbetegs\u00e9gekre, ami megnehez\u00edti a diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1t.<\/p>\n<p>Kutat\u00e1sunkban 575 eg\u00e9szs\u00e9ges, 13\u201335 \u00e9v k\u00f6z\u00f6tti fiatal vizsg\u00e1ltunk sz\u00edv m\u00e1geneses rezonanci\u00e1s vizsg\u00e1lat (MR) seg\u00edts\u00e9g\u00e9vel: a mozg\u00e1sszeg\u00e9ny \u00e9letm\u00f3dot folytat\u00f3kt\u00f3l a heti n\u00e9h\u00e1ny \u00f3r\u00e1t sportol\u00f3kon \u00e1t az \u00e9lsportol\u00f3kig. A heti edz\u00e9smennyis\u00e9g n\u00f6veked\u00e9s\u00e9vel ar\u00e1nyosan emelkedtek a kamrai \u00e9s pitvari volumenek, valamint az izomt\u00f6meg, mik\u00f6zben az ejekci\u00f3s frakci\u00f3 \u00e9s a strain-\u00e9rt\u00e9kek m\u00e9rs\u00e9kl\u0151dtek. A legkifejezettebb adapt\u00e1ci\u00f3t az \u00e1ll\u00f3k\u00e9pess\u00e9gi sportol\u00f3k (p\u00e9ld\u00e1ul \u00fasz\u00f3k, evez\u0151s\u00f6k) mutatt\u00e1k. Figyelemre m\u00e9lt\u00f3 a pitvarok, els\u0151sorban a jobb pitvar fokozott \u00e9rz\u00e9kenys\u00e9ge a terhel\u00e9sre. A kutat\u00e1s f\u0151 \u00fajdons\u00e1ga, hogy \u00e9letkor, nem \u00e9s heti edz\u00e9smennyis\u00e9g szerint pontos \u201ereferencia tartom\u00e1nyokat&#8221; \u00e1ll\u00edtottunk fel. Ezek seg\u00edtenek megk\u00fcl\u00f6nb\u00f6ztetni az eg\u00e9szs\u00e9ges sportadapt\u00e1ci\u00f3t a val\u00f3di betegs\u00e9gt\u0151l, \u00edgy cs\u00f6kkentve a t\u00e9ves diagn\u00f3zisok kock\u00e1zat\u00e1t a sportol\u00f3kn\u00e1l \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Szab\u00f3 Lili\u00e1na.<\/p>\n<div class=\"keretes w-100\">\n<h6>From sedentary individuals to highly trained athletes: A comprehensive cardiovascular magnetic resonance imaging study of cardiac volumetry, function, and strain<\/h6>\n<p>Liliana Szabo (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London), Vencel Juhasz (Semmelweis University, Heart and Vascular Center; Cardiovascular Imaging Research Center (CIRC), Department of Radiology, Massachusetts General Hospital, Harvard Medical School), Dorottya Balla (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center), Zsofia Dohy (Semmelweis University, Heart and Vascular Center), Csilla Czimbalmos (Semmelweis University, Heart and Vascular Center), Ferenc I. Suhai (Semmelweis University, Heart and Vascular Center), Attila Toth (Semmelweis University, Heart and Vascular Center), Kristof Hirschberg (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center), Francesca Graziano (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua), Orsolya Kiss (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center), Emese Csulak (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center), Nora Sydo (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center), Zahra Raisi-Estabragh (William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London; Barts Heart Centre, St Bartholomew&#8217;s Hospital, Barts Health NHS Trust), Steffen E. Petersen (William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London; Barts Heart Centre, St Bartholomew&#8217;s Hospital, Barts Health NHS Trust, West Smithfield; Health Data Research UK), Bela Merkely (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center), Hajnalka Vago (Semmelweis University, Department of Sports Medicine; Semmelweis University, Heart and Vascular Center)<br \/>\nJournal of Cardiovascular Magnetic Resonance Volume 28, Issue 1, Summer 2026, 102685<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.jocmr.2026.102685\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jocmr.2026.102685<\/a><\/p>\n<\/div>\n<h3>\u00c9lettel val\u00f3 el\u00e9gedetts\u00e9g mint az eg\u00e9szs\u00e9ges \u00f6reged\u00e9s kulcst\u00e9nyez\u0151je a munkahelyi k\u00f6rnyezetben<\/h3>\n<p><a id=\"oregedes\"><\/a>Az \u00f6reged\u00e9ssel \u00f6sszef\u00fcgg\u0151 betegs\u00e9gek \u00e9s a funkcion\u00e1lis hanyatl\u00e1s n\u00f6vekv\u0151 terhe Eur\u00f3pa-szerte azt jelzi, hogy az \u00e9lettartam n\u00f6vel\u00e9se \u00f6nmag\u00e1ban nem el\u00e9g: az \u00f6reged\u00e9s folyamat\u00e1nak min\u0151s\u00e9gi jav\u00edt\u00e1sa is sz\u00fcks\u00e9ges. Ehhez olyan m\u00f3dos\u00edthat\u00f3 t\u00e9nyez\u0151k azonos\u00edt\u00e1sa fontos, amelyek befoly\u00e1solj\u00e1k a biol\u00f3giai, pszichol\u00f3giai \u00e9s funkcion\u00e1lis \u00f6reged\u00e9st. Az \u00e9lettel val\u00f3 el\u00e9gedetts\u00e9g (SWL) egyre ink\u00e1bb olyan integrat\u00edv t\u00e9nyez\u0151k\u00e9nt jelenik meg, amely \u00f6sszekapcsolja a fiziol\u00f3giai adapt\u00edv kapacit\u00e1st, a pszich\u00e9s rezilienci\u00e1t \u00e9s az eg\u00e9szs\u00e9ges \u00e9lettartamot (healthspan).<\/p>\n<p>A gerontol\u00f3gia, a pszichol\u00f3gia \u00e9s a munkaeg\u00e9szs\u00e9g\u00fcgy eredm\u00e9nyei alapj\u00e1n az SWL nemcsak kimeneti mutat\u00f3, hanem potenci\u00e1lisan m\u00f3dos\u00edthat\u00f3 meghat\u00e1roz\u00f3ja is az eg\u00e9szs\u00e9ges \u00f6reged\u00e9snek. Biol\u00f3giai, pszichol\u00f3giai \u00e9s t\u00e1rsas mechanizmusokon kereszt\u00fcl kapcsol\u00f3dik az \u00f6reged\u00e9shez, bele\u00e9rtve a kardiovaszkul\u00e1ris \u00e9s gyullad\u00e1sos folyamatokat, a pszichol\u00f3giai rezilienci\u00e1t \u00e9s a t\u00e1rsas integr\u00e1ci\u00f3t. A munkahelyi k\u00f6rnyezet kiemelt szerepet j\u00e1tszhat az SWL fejleszt\u00e9s\u00e9ben, mivel tart\u00f3san befoly\u00e1solja a stresszt, a viselked\u00e9st \u00e9s az \u00e9let \u00e9rtelmess\u00e9g\u00e9t. A Semmelweis Study \u00e9s a Semmelweis-EUniWell Workplace Health Promotion Program olyan keretet k\u00e9pvisel, amely a gerontol\u00f3gia eredm\u00e9nyeit beavatkoz\u00e1sokba ford\u00edtja, c\u00e9lzottan fejlesztve a rezilienci\u00e1t, az \u00f6nszab\u00e1lyoz\u00e1st \u00e9s az adapt\u00edv kapacit\u00e1st. Ez a megk\u00f6zel\u00edt\u00e9s hozz\u00e1j\u00e1rulhat az eg\u00e9szs\u00e9ges \u00e9lettartam n\u00f6vel\u00e9s\u00e9hez \u00e9s a munkaer\u0151 fenntarthat\u00f3s\u00e1g\u00e1hoz \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban Z\u00e1b\u00f3 Vir\u00e1g.<\/p>\n<div class=\"keretes w-100\">\n<h6>Promoting healthy aging in occupational settings: satisfaction with life as a strategic target in the Semmelweis\u2013EUniWell framework<\/h6>\n<p>Vir\u00e1g Z\u00e1b\u00f3 (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University), Andrea Lehoczki (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University), Annam\u00e1ria Buda (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Doctoral College, Health Sciences Division, Semmelweis University), P\u00e9ter Varga (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Doctoral College, Health Sciences Division, Semmelweis University), Monika Fekete (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Institute for Translational Research), Vince Fazekas-Pongor (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Institute for Translational Research), Tam\u00e1s Cs\u00edp\u0151 (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Institute for Translational Research), Kata Adonicsn\u00e9-P\u00fcski (Fodor Center for Prevention and Healthy Aging, Semmelweis University; Directorate for Strategic Organizational Development, Semmelweis University), Giorgia Giovannetti (Department of Economics and Management, University of Florence), Yura Loscalzo (Department of Health Sciences, School of Psychology, University of Florence), Marco Giannini (Department of Health Sciences, School of Psychology, University of Florence), Beatrix Busse (Department of Linguistics, University of Cologne), Miklos Kellermayer (Department of Biophysics and Radiation Biology, Semmelweis University), Iveta Nagyova (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Department of Social and Behavioural Medicine, Faculty of Medicine, PJ Safarik Universityin), Yongjie Yon (WHO Regional Office for Europe; Healthy Aging Section, European Public Health Association), R\u00f3za \u00c1d\u00e1ny (Institute of Preventive Medicine and Public Health, Semmelweis University; Fodor Center for Prevention and Healthy Aging, Semmelweis University; Institute for Translational Research; Healthy Aging Section, European Public Health Association; Department of Public Health and Epidemiology, Faculty of Medicine, HUN-REN-UD Public Health Research Group, University of Debrecen), B\u00e9la Merkely (Heart and Vascular Center, Semmelweis University), Gy\u00f6rgy Purebl (Fodor Center for Prevention and Healthy Aging, Semmelweis University; Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University), Zoltan Ungvari (Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center; International Training Program in Geroscience, Doctoral College, Health Sciences Division\/Institute of Preventive Medicine and Public Health, Semmelweis University)<br \/>\nGeroScience (2026). <br \/>\n<a href=\"https:\/\/doi.org\/10.1007\/s11357-026-02339-z\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s11357-026-02339-z<\/a><\/p>\n<\/div>\n<p>A r\u00f6vid \u00f6sszefoglal\u00f3kat a tudom\u00e1nyos publik\u00e1ci\u00f3k szerz\u0151i k\u00e9sz\u00edtett\u00e9k.<br \/>\nSzerkesztette: Szab\u00f3 \u00c1d\u00e1m<br \/>\nFot\u00f3: a publik\u00e1ci\u00f3kb\u00f3l sz\u00e1rmaz\u00f3 k\u00e9pek<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3.<\/p>\n","protected":false},"author":101751,"featured_media":102156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[161,168],"tags":[4276],"class_list":["post-172182","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tudomany","category-kiemelt","tag-tudomanyos-hirado"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/172182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/users\/101751"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/comments?post=172182"}],"version-history":[{"count":8,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/172182\/revisions"}],"predecessor-version":[{"id":172469,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/172182\/revisions\/172469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media\/102156"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media?parent=172182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/categories?post=172182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/tags?post=172182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}