{"id":138671,"date":"2024-04-17T14:00:06","date_gmt":"2024-04-17T12:00:06","guid":{"rendered":"https:\/\/semmelweis.hu\/hirek\/?p=138671"},"modified":"2024-04-18T13:02:12","modified_gmt":"2024-04-18T11:02:12","slug":"tudomanyos-hirado-19","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/hirek\/2024\/04\/17\/tudomanyos-hirado-19\/","title":{"rendered":"Tudom\u00e1nyos h\u00edrad\u00f3 19."},"content":{"rendered":"
\n

Tudom\u00e1nyos H\u00edrad\u00f3 c\u00edm\u0171 cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3. A cikkeket az elm\u00falt id\u0151szak megjelen\u00e9sei alapj\u00e1n a K\u00f6zponti K\u00f6nyvt\u00e1r, illetve a tudom\u00e1nyos \u00e9s innov\u00e1ci\u00f3s rektorhelyettes<\/strong> v\u00e1logatta.<\/p>\n<\/div>\n

A pszichi\u00e1terek ment\u00e1lis betegs\u00e9ggel \u00e9l\u0151 emberekhez val\u00f3 hozz\u00e1\u00e1ll\u00e1s\u00e1nak multicentrikus vizsg\u00e1lata Eur\u00f3pa 32 orsz\u00e1g\u00e1ban<\/h5>\n
\n
\"\"<\/a>
A mell\u00e9kelt \u00e1br\u00e1n a r\u00e9sztvev\u0151 orsz\u00e1gok \u00e9s azok az Opening Minds Stigma Scale for Health Care Providers k\u00e9rd\u0151\u00edvre adott \u00f6sszpontsz\u00e1mainak \u00e1tlagai l\u00e1that\u00f3ak. Min\u00e9l magasabb a pontsz\u00e1m, ann\u00e1l ink\u00e1bb stigmatiz\u00e1l\u00f3 attit\u0171d\u00f6t mutat. Vizsg\u00e1latunk nem tekinthet\u0151 reprezentat\u00edvnak minden orsz\u00e1gra n\u00e9zve.<\/figcaption><\/figure>
\nA ment\u00e1lis betegs\u00e9ggel \u00e9l\u0151k megb\u00e9lyegz\u00e9st\u0151l val\u00f3 f\u00e9lelme az egyik legnagyobb oka annak, hogy ment\u00e1lis t\u00fcnetek jelentkez\u00e9se eset\u00e9n nem k\u00e9rnek seg\u00edts\u00e9get az emberek. Tudom\u00e1nyos kutat\u00e1sunkban azt vizsg\u00e1ltuk, hogy a pszichi\u00e1terek hogy viszonyulnak \u00f6nbevall\u00e1suk alapj\u00e1n a ment\u00e1lis betegs\u00e9ggel \u00e9l\u0151 emberekhez, illetve hozz\u00e1\u00e1ll\u00e1sukra milyen t\u00e9nyez\u0151k vannak hat\u00e1ssal. Eur\u00f3pa 32 orsz\u00e1g\u00e1ban folyt a vizsg\u00e1lat. K\u00e9rd\u0151\u00edv\u00fcnket \u00f6sszesen 4245 f\u0151 rezidensek \u00e9s szakorvos t\u00f6lt\u00f6tte ki a gyermek \u00e9s ifj\u00fas\u00e1gpszichi\u00e1tria, valamint a feln\u0151tt pszichi\u00e1tria ter\u00fclet\u00e9r\u0151l.<\/div>\n
\u00a0<\/div>\n
A vizsg\u00e1latb\u00f3l egyr\u00e9szt kider\u00fclt, hogy a r\u00e9sztvev\u0151k k\u00f6zel k\u00e9tharmad\u00e1nak (63%) akad k\u00f6zeli ismer\u0151sei, vagy csal\u00e1dtagjai k\u00f6z\u00f6tt ment\u00e1lis betegs\u00e9ggel \u00e9l\u0151 szem\u00e9ly, tov\u00e1bb\u00e1 39%-uk ker\u00fclt m\u00e1r olyan helyzetbe, hogy saj\u00e1t ment\u00e1lis \u00e1llapota miatt k\u00e9rt seg\u00edts\u00e9get az ell\u00e1t\u00f3rendszerben.
\nEredm\u00e9nyeink azt mutatj\u00e1k, hogy azok, akik pszichoter\u00e1pi\u00e1s tev\u00e9kenys\u00e9get folytatnak, esetmegbesz\u00e9l\u0151, csoportokra j\u00e1rnak, illetve akiknek k\u00f6zvetlen munkat\u00e1rsaira nem jellemz\u0151 a p\u00e1cienseket megb\u00e9lyegz\u0151 attit\u0171d, azok \u00f6sszess\u00e9g\u00e9ben kedvez\u0151bb hozz\u00e1\u00e1ll\u00e1st tan\u00fas\u00edtanak a ment\u00e1lis betegs\u00e9ggel \u00e9l\u0151k ir\u00e1ny\u00e1ban – fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban \u0150ri Dorottya.<\/div>\n
\u00a0<\/div>\n
Attitudes of psychiatrists towards people with mental illness: a cross-sectional, multicentre study of stigma in 32 European countries
\nDorottya \u0150ri (Institute of Behavioural Sciences, Semmelweis University; Department of Mental Health, Heim P\u00e1l National Pediatric Institute), P\u00e9ter Szocsics (Department of Psychiatry and Psychotherapy, Semmelweis University), Tam\u00e1s Moln\u00e1r (Department of Psychiatry, Aladar Petz County Teaching Hospital), Lucie Bankovska Motlova (Division of Medical Psychology, 3rd Faculty of Medicine, Charles University), Olga Kazakova (Inpatient Psychiatric Department #2, Psychiatric Clinic of Minsk City), Sabrina M\u00f6rkl (Division of Medical Psychology, Psychosomatics and Psychotherapeutic Medicine, Medical University of Graz), Michael Wallies (Therapie auf Augenhoehe), Mohamed Abdulhakim (Department of Psychiatry, Vrije Universiteit Brussel), Sylvie Boivin (Department of Child and Adolescent Psychiatry, EPSM du Finist\u00e8re Sud), Krista Bruna (Admission Ward, State Psychiatric Hospital Gintermuiza), Carolina Caba\u00e7os (Psychiatry Department, Centro Hospitalar e Universit\u00e1rio de Coimbra; Institute of Psychological Medicine, Faculty of Medicine, Coimbra University; Coimbra Institute for Biomedical Imaging and Translational Research), Elvira Anna Carbone (Department of Medical and Surgical Sciences, University Magna Gr\u00e6cia of Catanzaro), Elona Dashi (Department of Neuroscience, University Hospital Center \u201cMother Theresa\u201d), Giovanni Grech (Mental Health Services, Mount Carmel Hospital), Stjepan Greguras (Division of Child and Adolescent Psychiatry and Psychotherapy, Department of Psychiatry and Psychological Medicine, University Hospital Centre Zagreb), Iva Ivanovic (Department for Child Psychiatry, Institute for Children’s Diseases, Clinical Centre of Montenegro), Kaloyan Guevara (Acute Detoxification Ward, State Psychiatric Hospital for Treatment of Drug Addiction and Alcoholism), Selay Kakar (Department of Psychiatry, Erasmus University Medical Center), Konstantinos Kotsis (Department of Psychiatry, University of Ioannina), Ida Maria Ingeholm Klinkby (Department of Child and Adolescent Psychiatry, Capital Region of Denmark), S\u00e1ndor R\u00f3zsa (Department of Personality and Health Psychology, K\u00e1roli G\u00e1sp\u00e1r University of the Reformed Church)
\neClinicalMedicine, Volume 66, 102342 (December 2023)
\n<\/span>https:\/\/doi.org\/10.1016\/j.eclinm.2023.102342<\/a><\/div>\n
\u00a0<\/div>\n
Az agykutat\u00e1s felgyors\u00edt\u00e1sa mesters\u00e9ges neur\u00e1lis h\u00e1l\u00f3k\u00a0seg\u00edts\u00e9g\u00e9vel<\/h5>\n
\"\"<\/a>A neuropatol\u00f3giai vizsg\u00e1latok egyik kih\u00edv\u00e1sa az elemz\u00e9sre ker\u00fcl\u0151 sejtek sz\u00e1m\u00e1nak a n\u00f6vel\u00e9se. Az eddig sz\u00e1zas, ezres nagys\u00e1grendr\u0151l sz\u00e1zezres, milli\u00f3s szintre t\u00f6rt\u00e9n\u0151 ugr\u00e1s nagyobb statisztikai er\u0151t biztos\u00edt, aminek seg\u00edts\u00e9g\u00e9vel felt\u00e1r\u00e1sra ker\u00fclhetnek a k\u00f3rk\u00e9pek h\u00e1tter\u00e9ben \u00e1ll\u00f3, eddig fel nem fedezett sejtt\u00edpusok. Ennek el\u00e9r\u00e9s\u00e9re mesters\u00e9ges neur\u00e1lis h\u00e1l\u00f3kat alkalmaztunk, a Faster R-CNN alap\u00fa referencia modellt egy ResNet-50 eg\u00e9sz\u00edtette ki \u00e9s a COCO adathalmazon el\u0151tan\u00edtva az asztrocita sejtek k\u00e9peivel m\u00e1r csak finomhangolni kellett a rendszert. Az adathalmazra alkalmazott gyeng\u00e9n fel\u00fcgyelt tanul\u00e1s seg\u00edts\u00e9g\u00e9vel tov\u00e1bbi, nagym\u00e9ret\u0171 k\u00e9p-adatb\u00e1zisok annot\u00e1ci\u00f3ja is j\u00f3 es\u00e9llyel elv\u00e9gezhet\u0151.<\/div>\n
\u00a0<\/div>\n
Az \u00f6sszesen 8730 darab 500×500 pixeles k\u00e9pb\u0151l \u00e1ll\u00f3 adathalmaz t\u00f6bb mint 100 ezer jel\u00f6l\u00e9st tartalmaz, melyeknek az \u00e1tvet\u00edt\u00e9s\u00e9vel tov\u00e1bbi, eddig nem vizsg\u00e1lt sejtt\u00edpusokat tartalmaz\u00f3 k\u00e9pek szegment\u00e1ci\u00f3ja val\u00f3s\u00edthat\u00f3 meg. Munk\u00e1nkat folyamatosan fejlesztj\u00fck, hogy neuronok is detekt\u00e1l\u00e1sra ker\u00fcljenek \u00e9s hogy m\u00f3dszer\u00fcnk a neurohisztol\u00f3gia \u00e9s digit\u00e1lis patol\u00f3gia mindennapos munk\u00e1j\u00e1t is el\u0151seg\u00edthesse – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Adorj\u00e1n Istv\u00e1n.<\/div>\n
\u00a0<\/div>\n
\n

Annotated dataset for training deep learning models to detect astrocytes in human brain tissue
\nAlex Olar (E\u00f6tv\u00f6s Lor\u00e1nd University, Department of Physics of Complex Systems), Teadora Tyler (Semmelweis University, Department of Anatomy, Histology and Embryology), Paulina Hoppa Semmelweis University, Department of Anatomy, Histology and Embryology), Erzs\u00e9bet Frank (Semmelweis University, Department of Anatomy, Histology and Embryology), Istv\u00e1n Csabai (E\u00f6tv\u00f6s Lor\u00e1nd University, Department of Physics of Complex Systems), Istvan Adorjan (Semmelweis University, Department of Anatomy, Histology and Embryology), P\u00e9ter Pollner (Semmelweis University, Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre)
\nScientific Data volume 11, Article number: 96 (2024)
\nhttps:\/\/doi.org\/10.1038\/s41597-024-02908-x<\/a><\/p>\n<\/div>\n

\n
Pszich\u00e9s stressz \u00e9s t\u00e1pl\u00e1lkoz\u00e1si bizonytalans\u00e1g egy magyar egyetem nemzetk\u00f6zi hallgat\u00f3i k\u00f6r\u00e9ben: poszt-pand\u00e9mi\u00e1s felm\u00e9r\u00e9s<\/h5>\n

A haz\u00e1jukt\u00f3l t\u00e1vol, m\u00e1s nyelvi \u00e9s kultur\u00e1lis, esetleg \u00e9ghajlati k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt tanul\u00f3 egyetemist\u00e1knak sz\u00e1mos probl\u00e9m\u00e1val kell szembes\u00fclni\u00fck. \u00c9let\u00fcket nagyon megnehez\u00edtette a COVID-pand\u00e9mia, amely egyfajta izol\u00e1lts\u00e1got, nehez\u00edtett lelki \u00e9s szoci\u00e1lis k\u00f6r\u00fclm\u00e9nyeket is eredm\u00e9nyezett. Ennek vizsg\u00e1lat\u00e1ra k\u00e9rd\u0151\u00edves felm\u00e9r\u00e9st v\u00e9gezt\u00fcnk a Debreceni Egyetem k\u00fclf\u00f6ldi hallgat\u00f3i k\u00f6r\u00e9ben. A felhaszn\u00e1lt, nemzetk\u00f6zileg valid\u00e1lt k\u00e9rd\u0151\u00edvekkel US Department of Agriculture Food Security Survey Module a t\u00e1pl\u00e1lkoz\u00e1si szok\u00e1saikra, m\u00edg a Depression, Anxiety and Stress Scale (DASS-21) lelki, ment\u00e1lis \u00e1llapotukra k\u00e9rdezt\u00fcnk r\u00e1.<\/p>\n

\u00d6sszesen 400 v\u00e1laszt \u00e9rt\u00e9kelt\u00fcnk. A szorong\u00e1s volt a leggyakoribb (49%), ezt k\u00f6vette a depresszi\u00f3 (42%) \u00e9s a stressz (30%), mindegyik nagyobb es\u00e9llyel a n\u0151kn\u00e9l. Depresszi\u00f3s t\u00fcnetek f\u0151leg az id\u0151sebbek (25-29 \u00e9v) k\u00f6r\u00e9ben jelentkeztek, akiknek nem volt p\u00e1rtkapcsolatuk, rosszabb eg\u00e9szs\u00e9gi \u00e1llapotban \u00e9rezt\u00e9k magukat, szobat\u00e1rssal laktak. Szorong\u00e1st panaszol\u00f3k k\u00f6r\u00e9ben is hasonl\u00f3 \u00f6sszef\u00fcgg\u00e9seket tal\u00e1ltunk, ak\u00e1rcsak a stressz meg\u00e9l\u0151k k\u00f6z\u00f6tt, gyakrabban az egy \u00e9vn\u00e9l kor\u00e1bban Magyarorsz\u00e1gra \u00e9rkezettek k\u00f6r\u00e9ben, azokn\u00e1l, akik rosszabb eg\u00e9szs\u00e9gi \u00e1llapotban voltak, komolyabb nyelvi neh\u00e9zs\u00e9geket eml\u00edtettek. Mindh\u00e1rom csoportban a t\u00e1pl\u00e1lkoz\u00e1si bizonytalans\u00e1g, az ig\u00e9nytelen \u00e9tkez\u00e9s is gyakoribb – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Rurik Imre.<\/p>\n

\n

Psychological Distress and Food Insecurity among International Students at a Hungarian University: A Post-Pandemic Survey
\nSoukaina Hilal (Department of Family and Occupational Medicine, University of Debrecen; Doctoral School of Health Sciences, University of Debrecen), L\u00e1szl\u00f3 R\u00f3bert Kolozsv\u00e1ri (Department of Family and Occupational Medicine, University of Debrecen; Doctoral School of Health Sciences, University of Debrecen), Putu Ayu Indrayathi (Department of Family and Occupational Medicine, University of Debrecen; Doctoral School of Health Sciences, University of Debrecen), Sami Najmaddin Saeed (Doctoral School of Health Sciences, University of Debrecen; Department of Public Health and Epidemiology, University of Debrecen), Imre Rurik (Doctoral School of Health Sciences, University of Debrecen; Department of Family Medicine, Semmelweis University)
\nNutrients 2024, 16(2), 241
\nhttps:\/\/doi.org\/10.3390\/nu16020241<\/a><\/p>\n<\/div>\n

A t\u00e1pl\u00e1lkoz\u00e1s szerepe menopauza id\u0151szak\u00e1ban<\/h5>\n

\"\"<\/a>A Semmelweis Egyetem kutat\u00f3i, a Magyar Dietetikusok Orsz\u00e1gos Sz\u00f6vets\u00e9ge \u00e9s az EndoCare Endokrinol\u00f3gia Centrum munkat\u00e1rsai nemzetk\u00f6zi publik\u00e1ci\u00f3k \u00e9s aj\u00e1nl\u00e1sok alapj\u00e1n \u00e1ll\u00edtott\u00e1k \u00f6ssze a menopauza k\u00f6r\u00fcli id\u0151szakot seg\u00edt\u0151 \u00e9trendet. 2030-ra 1 milli\u00e1rdn\u00e1l is t\u00f6bb n\u0151 n\u00e9zhet szembe a v\u00e1ltoz\u00f3kor kih\u00edv\u00e1saival. A menopauz\u00e1ba l\u00e9p\u0151 n\u0151k \u00e9vente \u00e1tlagosan 0,6 kil\u00f3t h\u00edznak testalkatt\u00f3l f\u00fcggetlen\u00fcl, hajlamosabbak a kardiovaszkul\u00e1ris betegs\u00e9gekre, daganatokra, inzulin rezisztenci\u00e1ra, kettes t\u00edpus\u00fa cukorbetegs\u00e9gre \u00e9s a csontritkul\u00e1s kock\u00e1zata is magasabb n\u00e1luk. A v\u00e1ltoz\u00f3kor emellett kellemetlen t\u00fcnetekkel j\u00e1r, mint h\u0151hull\u00e1mok, \u00e9jszakai izzad\u00e1s, fejf\u00e1j\u00e1s \u00e9s \u00edz\u00fcleti f\u00e1jdalom. A t\u00fcnetek intenzit\u00e1sa, gyakoris\u00e1ga \u00e9s a kr\u00f3nikus betegs\u00e9gek kialakul\u00e1s\u00e1nak kock\u00e1zata \u00e9letm\u00f3dv\u00e1lt\u00e1ssal befoly\u00e1solhat\u00f3.<\/p>\n

A perimenopauza \u00e9trendj\u00e9ben a kiegyens\u00falyozott t\u00e1pl\u00e1lkoz\u00e1s egyes aj\u00e1nl\u00e1sai hangs\u00falyosabbak, javasolt kevesebb s\u00f3 fogyaszt\u00e1s, a feh\u00e9rjebevitel cs\u00f6kkent\u00e9se \u00e9s a n\u00f6v\u00e9nyi feh\u00e9rjeforr\u00e1sok el\u0151t\u00e9rbe helyez\u00e9se, a z\u00f6lds\u00e9g- \u00e9s gy\u00fcm\u00f6lcs fogyaszt\u00e1s n\u00f6vel\u00e9se. Az id\u0151ben elkezdett \u00e9letm\u00f3dv\u00e1lt\u00e1s, a kiegyens\u00falyozott t\u00e1pl\u00e1lkoz\u00e1s cs\u00f6kkentheti \u00e9s k\u00e9sleltetheti a t\u00fcnetek \u00e9s a betegs\u00e9gek megjelen\u00e9s\u00e9t, jav\u00edtva a v\u00e1ltoz\u00f3kor\u00fa n\u0151k \u00e9letmin\u0151s\u00e9g\u00e9t – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. P\u00e1lfi Erzs\u00e9bet.<\/p>\n

\n

The Importance of Nutrition in Menopause and Perimenopause\u2014A Review
\nAliz Erd\u00e9lyi (Hungarian Dietetic Association; EndoCare Institute, Endocrinology Center), Erzs\u00e9bet P\u00e1lfi (Faculty of Health Sciences, Department of Dietetics and Nutritional Sciences, Semmelweis University), L\u00e1szl\u00f3 T\u0171\u0171 (EndoCare Institute, Endocrinology Center; School of PhD Studies, Semmelweis University), Katalin Nas (EndoCare Institute, Endocrinology Center; School of PhD Studies, Semmelweis University), Zsuzsanna Sz\u0171cs (Hungarian Dietetic Association; School of PhD Studies, Semmelweis University), Marianna T\u00f6r\u00f6k (EndoCare Institute, Endocrinology Center; Department of Obstetrics and Gynecology, Semmelweis University), Attila Jakab (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen), Szabolcs V\u00e1rb\u00edr\u00f3 (Department of Obstetrics and Gynecology, Semmelweis University; Department of Obstetrics and Gynecology, University of Szeged)
\nNutrients 2024, 16(1), 27
\nhttps:\/\/doi.org\/10.3390\/nu16010027<\/a><\/p>\n<\/div>\n

A farnezil-transzfer\u00e1z inhibitorok kombin\u00e1ci\u00f3ja az \u00faj KRAS-G12C inhibitorokkal szinergista tumorellenes hat\u00e1st eredm\u00e9nyez<\/h5>\n

\"\"<\/a>A KRAS az egyik leggyakrabban mut\u00e1ci\u00f3t elszenved\u0151 protoonkog\u00e9n, amely sz\u00e1mos rossz progn\u00f3zissal rendelkez\u0151 \u00e9s gyakori tumort\u00edpus kialakul\u00e1s\u00e1ban \u00e9s progresszi\u00f3j\u00e1ban j\u00e1tszik kulcsszerepet, mint p\u00e9ld\u00e1ul a t\u00fcd\u0151, a kolorekt\u00e1lis \u00e9s a hasny\u00e1lmirigyr\u00e1k. B\u00e1r a KRAS aktiv\u00e1l\u00f3 mut\u00e1ci\u00f3j\u00e1nak jelent\u0151s\u00e9ge \u00e9vtizedek \u00f3ta ismert, a mut\u00e1ns KRAS g\u00e1tl\u00e1sa \u00e9vtizedek \u00f3ta kih\u00edv\u00e1s el\u00e9 \u00e1ll\u00edtotta a r\u00e1kkutat\u00e1st. Mivel a kompakt feh\u00e9rj\u00e9n \u00fagy t\u0171nt, nem lehet \u201efog\u00e1st\u201d tal\u00e1lni, k\u00f6zvetett g\u00e1tl\u00e1si m\u00f3dszerekkel pr\u00f3b\u00e1lkoztak a kutat\u00f3k. A KRAS megfelel\u0151 m\u0171k\u00f6d\u00e9s\u00e9hez n\u00e9lk\u00fcl\u00f6zhetetlen a feh\u00e9rje farnezilhorgonnyal t\u00f6rt\u00e9n\u0151 sejtmembr\u00e1nhoz kapcsol\u00f3d\u00e1sa, \u00edgy az egyik leg\u00edg\u00e9retesebb pr\u00f3b\u00e1lkoz\u00e1snak az ezt g\u00e1tl\u00f3 farnezil-transzfer\u00e1z inhibitorok kifejleszt\u00e9se t\u0171nt. Azonban a sikertelen klinikai tesztek sor\u00e1n kider\u00fclt, hogy a KRAS a farnezil-transzfer\u00e1z inhibitorok jelenl\u00e9t\u00e9ben k\u00e9pes egy alternat\u00edv membr\u00e1nhorgonnyal plazmamembr\u00e1nhoz kapcsol\u00f3dni \u00e9s bet\u00f6lteni a tumort seg\u00edt\u0151 funkci\u00f3j\u00e1t. A kudarc ut\u00e1n eg\u00e9szen az elm\u00falt \u00e9vekig a KRAS c\u00e9lzott, k\u00f6zvetlen g\u00e1tl\u00e1sa lehetetlennek t\u0171nt. A k\u00f6zelm\u00faltban ugyanakkor \u2013 \u00e1tt\u00f6r\u00e9st hozva a KRAS g\u00e1tl\u00e1s\u00e1ban – sikeresen fejlesztettek specifikus inhibitorokat a mut\u00e1ns KRAS egyik t\u00edpus\u00e1ra, a KRAS G12C mut\u00e1ci\u00f3ra. Az \u00fajonnan kifejlesztett inhibitorok egy r\u00e9sz\u00e9t mostanra m\u00e1r enged\u00e9lyeztek is a KRAS-G12C mut\u00e1ns t\u00fcd\u0151r\u00e1k kezel\u00e9s\u00e9re. Ugyanakkor a tumorokban eleve jelen l\u00e9v\u0151, valamint a kezel\u00e9s sor\u00e1n kialakul\u00f3 szerzett rezisztencia miatt csak a betegek kisebb csoportja reag\u00e1l a kezel\u00e9sre, \u00edgy az \u00faj g\u00e1tl\u00f3szerek hat\u00e9konys\u00e1g\u00e1nak n\u00f6vel\u00e9s\u00e9re jelenleg sz\u00e1mos kombin\u00e1ci\u00f3s kezel\u00e9st vizsg\u00e1lnak klinikai tesztek sor\u00e1n.<\/p>\n

Munkacsoportunk a RAS feh\u00e9rj\u00e9k membr\u00e1nhorgonyz\u00f3d\u00e1s\u00e1t c\u00e9lz\u00f3 prenil\u00e1ci\u00f3-g\u00e1tl\u00f3szerek vizsg\u00e1lata sor\u00e1n figyelt fel arra a \u2013 fentebb v\u00e1zolt el\u0151zm\u00e9nyek f\u00e9ny\u00e9ben meglep\u0151 \u2013 t\u00e9nyre, hogy a KRAS G12C mut\u00e1ci\u00f3t hordoz\u00f3 sejtvonalak fokozott \u00e9rz\u00e9kenys\u00e9get mutattak a farnezil-transzfer\u00e1z inhibitorokra. Ezen eredm\u00e9ny\u00fcnk nyom\u00e1n kezdt\u00fck vizsg\u00e1lni az \u00faj, klinikai haszn\u00e1latban l\u00e9v\u0151 KRAS G12C inhibitorok kombin\u00e1ci\u00f3j\u00e1t a farnezil-transzfer\u00e1z inhibitorokkal. Vizsg\u00e1lataink sor\u00e1n a kombin\u00e1ci\u00f3s kezel\u00e9s KRAS G12C mut\u00e1ci\u00f3t hordoz\u00f3 t\u00fcd\u0151, kolorekt\u00e1lis \u00e9s hasny\u00e1lmirigyr\u00e1k tumoros sejtvonalak teny\u00e9szetein szinergista, er\u0151teljes tumorellenes hat\u00e1st mutatott. A farnezil-transzfer\u00e1z inhibitorok KRAS G12C inhibitorokat seg\u00edt\u0151 hat\u00e1s\u00e1t kimutattuk a sejtvonalakb\u00f3l k\u00e9sz\u00fclt 2D \u00e9s 3D teny\u00e9szeteken, valamint eg\u00e9rk\u00eds\u00e9rletekben is. A hat\u00e1s molekul\u00e1ris h\u00e1tter\u00e9t vizsg\u00e1lva megfigyelt\u00fck, hogy a kombin\u00e1ci\u00f3s kezel\u00e9s g\u00e1tolja a KRAS g\u00e1tl\u00e1s sor\u00e1n fell\u00e9p\u0151, rezisztenci\u00e1hoz vezet\u0151 jelens\u00e9get, a RAS jel\u00e1tviteli \u00fatvonal \u00fajraaktiv\u00e1l\u00f3d\u00e1s\u00e1t. Az \u00fajraaktiv\u00e1l\u00f3d\u00e1s g\u00e1tl\u00e1sa az ebben kulcsszerepet j\u00e1tsz\u00f3 HRAS feh\u00e9rje farnezil\u00e1ci\u00f3j\u00e1nak, valamint a jelp\u00e1lya m\u00e1s \u00e1g\u00e1ban jelen l\u00e9v\u0151 RHEB feh\u00e9rje farnezil\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1sa r\u00e9v\u00e9n val\u00f3sul meg. Vizsg\u00e1lataink nyom\u00e1n indokoltnak l\u00e1tszik a KRAS-G12C inhibitorok farnezil-transzfer\u00e1z-g\u00e1tl\u00f3kkal val\u00f3 kombin\u00e1ci\u00f3s kezel\u00e9s\u00e9nek klinikai vizsg\u00e1lata. Eredm\u00e9nyeink hasznos\u00edt\u00e1s\u00e1ra nemzetk\u00f6zi szabadalmi bejelent\u00e9s is t\u00f6rt\u00e9nt – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Baranyi Marcell.<\/p>\n

\n

Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
\nMarcell Baranyi (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University; KINETO Lab Ltd), Eszter Moln\u00e1r (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University), Luca Heged\u0171s (Department of Thoracic Surgery, University Medicine Essen – Ruhrlandklinik, University Duisburg-Essen), Zs\u00f3fia G\u00e1briel (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University; P\u00e1zm\u00e1ny P\u00e9ter Catholic University Faculty of Information Technology and Bionics), Fl\u00f3ra Gr\u00e9ta Pet\u00e9nyi (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University; P\u00e1zm\u00e1ny P\u00e9ter Catholic University Faculty of Information Technology and Bionics), Fanni Bord\u00e1s (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University; Department of Anatomy, Cell and Developmental Biology, E\u00f6tv\u00f6s Lor\u00e1nd University), Violetta L\u00e9ner (KINETO Lab Ltd), Ivan Ran\u0111elovi\u0107 (KINETO Lab Ltd; Department of Experimental Pharmacology and the National Tumor Biology Laboratory, National Institute of Oncology), Mih\u00e1ly Cserepes (KINETO Lab Ltd; Department of Experimental Pharmacology and the National Tumor Biology Laboratory, National Institute of Oncology), J\u00f3zsef T\u00f3v\u00e1ri (Department of Experimental Pharmacology and the National Tumor Biology Laboratory, National Institute of Oncology), Bal\u00e1zs Heged\u0171s (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University; Department of Thoracic Surgery, University Medicine Essen – Ruhrlandklinik, University Duisburg-Essen), J\u00f3zsef T\u00edm\u00e1r (Department of Pathology, Forensic and Insurance Medicine, Semmelweis University)
\nBritish Journal of Cancer volume 130, pages1059\u20131072 (2024)
\nhttps:\/\/doi.org\/10.1038\/s41416-024-02586-x<\/a><\/p>\n<\/div>\n

A m\u00falt parazsa: A koragyermekkori traum\u00e1k k\u00f6lcs\u00f6nhat\u00e1sa a neuroinflamm\u00e1ci\u00f3ban szerepet bet\u00f6lt\u0151 P2RX7<\/i> g\u00e9nv\u00e1ltozataival a jelenlegi szuicid kock\u00e1zati markerekben<\/h5>\n

\"\"<\/a>Sz\u00e1mos neuropszichi\u00e1triai betegs\u00e9g, k\u00f6zt\u00fck a hangulatzavarok egyik legf\u0151bb rizik\u00f3faktora a stressz. Egyre t\u00f6bb bizony\u00edt\u00e9k \u00e1ll rendelkez\u00e9sre arra vonatkoz\u00f3an, hogy a stresszorok sz\u00e1mos k\u00fcl\u00f6nf\u00e9le \u00fatvonalon, t\u00f6bbek k\u00f6z\u00f6tt az immunrendszer anom\u00e1li\u00e1in kereszt\u00fcl j\u00e1tszanak szerepet e zavarok patogenezis\u00e9ben. Kor\u00e1bbi kutat\u00e1si eredm\u00e9nyek \u00f6sszef\u00fcgg\u00e9st tal\u00e1ltak a depresszi\u00f3 \u00e9s a gyullad\u00e1sos \u00fatvonalakban fontos szerepet bet\u00f6lt\u0151 P2X7 receptorok k\u00f6z\u00f6tt. A receptort k\u00f3dol\u00f3 P2RX7 g\u00e9n egy olyan kromosz\u00f3mapoz\u00edci\u00f3ban tal\u00e1lhat\u00f3, amelyet gyullad\u00e1sos \u00e9s a pszichi\u00e1triai rendelleness\u00e9gekkel egyar\u00e1nt \u00f6sszef\u00fcgg\u00e9sbe hoztak.<\/p>\n

A hangulatzavarok \u00e9s az \u00f6ngyilkoss\u00e1g szoros kapcsolata, valamint a neuroinflamm\u00e1ci\u00f3 \u00f6ngyilkoss\u00e1gban bet\u00f6lt\u00f6tt szerep\u00e9re ir\u00e1nyul\u00f3 egyre n\u00f6vekv\u0151 figyelem ellen\u00e9re a P2RX7 g\u00e9nt ebben az \u00f6sszef\u00fcgg\u00e9sben m\u00e9g nem vizsg\u00e1lt\u00e1k. Kutat\u00f3csoportunk a P2RX7 g\u00e9nv\u00e1ltozatainak hat\u00e1s\u00e1t koragyermekkori traum\u00e1kkal, valamint k\u00f6zelm\u00faltbeli stresszorokkal val\u00f3 interakci\u00f3ban vizsg\u00e1lta a kor\u00e1bbi \u00f6ngyilkoss\u00e1gi k\u00eds\u00e9rletekre \u00e9s olyan aktu\u00e1lis szuicid kock\u00e1zati markerekre, mint a rem\u00e9nytelens\u00e9g, \u00e9s a hal\u00e1llal, illetve \u00f6ngyilkoss\u00e1ggal kapcsolatos gondolatok. A P2RX7 g\u00e9nen bel\u00fcl a vari\u00e1nsok kapcsolt \u00f6r\u00f6kl\u0151d\u00e9s\u00e9n alapul\u00f3 elj\u00e1r\u00e1s seg\u00edts\u00e9g\u00e9vel k\u00e9t olyan vari\u00e1nscsoportot azonos\u00edtottuk, melyek hat\u00e1st gyakorolnak az aktu\u00e1lis \u00f6ngyilkoss\u00e1gi gondolatokra. Gyermekkori traum\u00e1kkal val\u00f3 k\u00f6lcs\u00f6nhat\u00e1sban egy tov\u00e1bbi csoportot azonos\u00edtottunk. Eredm\u00e9nyeink tov\u00e1bbi adatokkal t\u00e1masztj\u00e1k al\u00e1, hogy a gyullad\u00e1sos immunol\u00f3giai folyamatok fontos szerepet t\u00f6ltenek be sz\u00e1mos pszichi\u00e1triai probl\u00e9ma h\u00e1tter\u00e9ben, illetve a koragyermekkori traum\u00e1k hossz\u00fat\u00e1v\u00fa hat\u00e1s\u00e1nak k\u00f6zvet\u00edt\u00e9s\u00e9ben – fogalmazott dr. Gonda X\u00e9nia.<\/p>\n

\n

Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk
\nZsuliet Kristof (Department of Psychiatry and Psychotherapy, Semmelweis University; Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine), Zsofia Gal (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University), Dora Torok (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University), Nora Eszlari (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University), Sara Sutori (National Centre for Suicide Research and Prevention (NASP), Department of Learning, Informatics, Management and Ethics, Karolinska Institutet), Beata Sperlagh (Laboratory of Molecular Pharmacology, HUN-REN Institute of Experimental Medicine), Ian M. Anderson (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester and Manchester Academic Health Sciences Centre), Bill Deakin (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester and Manchester Academic Health Sciences Centre), Gyorgy Bagdy (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University), Gabriella Juhasz (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University), Xenia Gonda (Department of Psychiatry and Psychotherapy, Semmelweis University; NAP3.0 Neuropsychopharmacology Research Group, Semmelweis University)
\nInt. J. Mol. Sci. 2024, 25(2), 865
\nhttps:\/\/doi.org\/10.3390\/ijms25020865<\/a><\/p>\n<\/div>\n

Feh\u00e9rje adatb\u00e1zis a Leishmania fajok vizsg\u00e1lat\u00e1ra<\/h5>\n

\"\"<\/a>A leishmaniasis egy s\u00falyos \u00e9letmin\u0151s\u00e9gi v\u00e1ltoz\u00e1sokat okoz\u00f3 betegs\u00e9g, melynek egyes form\u00e1i hal\u00e1lhoz vezetnek. A betegs\u00e9get a Leishmania nev\u0171 parazita terjeszti, amelyet lepkesz\u00fanyogok k\u00f6zvet\u00edtenek, \u00e9s els\u0151dleges gazd\u00e1i a gerincesek, k\u00f6zt\u00fck az ember. B\u00e1r a Leishmania fajok els\u0151sorban az Egyenl\u00edt\u0151 k\u00f6rzet\u00e9ben elhelyezked\u0151 orsz\u00e1gokban fordulnak el\u0151, a kl\u00edmav\u00e1ltoz\u00e1ssal a lepkesz\u00fanyogok \u00e9l\u0151k\u00f6rnyezete \u00e9s \u00edgy a leishmaniasis el\u0151fordul\u00e1sa is kiterjed.<\/p>\n

Fert\u0151z\u00e9skor a k\u00f3rokoz\u00f3 behatol a gazdasejtekbe, majd olyan feh\u00e9rj\u00e9ket juttat a megt\u00e1madott sejtekbe amik a k\u00f3rokoz\u00f3 n\u00f6veked\u00e9se c\u00e9lj\u00e1b\u00f3l \u00e1tprogramozzta a sejtek jel\u00e1tvitel\u00e9t feh\u00e9rje-feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1sokon kereszt\u00fcl. Ahhoz, hogy meg\u00e9rts\u00fck a fert\u0151z\u00e9s molekul\u00e1ris biol\u00f3giai h\u00e1tter\u00e9t, ismern\u00fcnk kell azokat a feh\u00e9rj\u00e9ket amelyek r\u00e9szt vesznek a t\u00e1mad\u00e1sban, valamint azokat a feh\u00e9rjemodulokat amelyek az \u00e1tprogramoz\u00e1st v\u00e9gzik. A LeishMANIAdb adatb\u00e1zis (https:\/\/leishmaniadb.ttk.hu\/) olyan k\u00eds\u00e9rletes \u00e9s bioinformatikai eredm\u00e9nyeket t\u00e1rol, amelyek a megk\u00f6nny\u00edthetik a Leishmania betegs\u00e9g vizsg\u00e1lat\u00e1t a fenti szempontok alapj\u00e1n – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Dobson L\u00e1szl\u00f3.<\/p>\n

\n

LeishMANIAdb: a comparative resource for Leishmania proteins
\nG\u00e1bor E Tusn\u00e1dy (Protein Bioinformatics Research Group, Institute of Enzymology, Research Centre for Natural Sciences; Department of Bioinformatics, Semmelweis University), Andr\u00e1s Zeke (Protein Bioinformatics Research Group, Institute of Enzymology, Research Centre for Natural Sciences), Zs\u00f3fia E K\u00e1lm\u00e1n (Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University), Marie Fatou (ICBMS UMR CNRS 5246, University Lyon; UMR CNRS 5086, University Lyon), Sylvie Ricard-Blum (ICBMS UMR CNRS 5246, University Lyon), Toby J Gibson (Structural and Computational Biology Unit, European Molecular Biology Laboratory), Laszlo Dobson (Protein Bioinformatics Research Group, Institute of Enzymology, Research Centre for Natural Sciences; Structural and Computational Biology Unit, European Molecular Biology Laboratory)
\nDatabase, Volume 2023, (2023)
\nhttps:\/\/doi.org\/10.1093\/database\/baad074<\/a><\/p>\n<\/div>\n<\/div>\n

Hospitaliz\u00e1lt id\u0151s \u00e9s fiatal SARS-CoV-2 fert\u0151z\u00f6tt, baricitinib ter\u00e1pi\u00e1ban r\u00e9szes\u00fcl\u0151 betegek m\u00e1sodlagos fert\u0151z\u00e9seinek \u00e9s hossz\u00fat\u00e1v\u00fa kimenetel\u00e9nek \u00f6sszehasonl\u00edt\u00f3 vizsg\u00e1lata<\/h5>\n

\"\"<\/a>A baricitinib a SARS-CoV-2 fert\u0151z\u00f6tt, k\u00f3rh\u00e1zban kezelt \u00e9s s\u00falyos klinikai lefoly\u00e1st mutat\u00f3 betegekn\u00e9l fell\u00e9p\u0151 citokinvihar szindr\u00f3ma egyik els\u0151vonalbeli ter\u00e1pi\u00e1ja. Centrumunkban c\u00e9lunk a baricitinib kezel\u00e9sben r\u00e9szes\u00fcl\u0151 id\u0151s \u00e9s fiatal betegek m\u00e1sodlagos fert\u0151z\u00e9seinek \u00e9s hossz\u00fat\u00e1v\u00fa kimenetel\u00e9nek \u00f6sszehasonl\u00edt\u00f3 vizsg\u00e1lata.<\/p>\n

Obszerv\u00e1ci\u00f3s, \u00f6sszehasonl\u00edt\u00f3 vizsg\u00e1latot v\u00e9gezt\u00fcnk 2020.11.28\u20132022.09.30. k\u00f6z\u00f6tt SARS-CoV-2-fert\u0151z\u00e9ssel diagnosztiz\u00e1lt, k\u00f3rh\u00e1zban kezelt \u00e9s baricitinib ter\u00e1pi\u00e1ban r\u00e9szes\u00fcl\u0151 id\u0151s (\u2265 65 \u00e9v) \u00e9s fiatal (<65 \u00e9v) betegek k\u00f6r\u00e9ben. K\u00f3rh\u00e1zi emisszi\u00f3t k\u00f6vet\u0151en kontroll vizsg\u00e1latok \u00e9s EESZT rendszer seg\u00edts\u00e9g\u00e9vel a betegek hossz\u00fat\u00e1v\u00fa kimenetel\u00e9t is regisztr\u00e1ltuk. Eredm\u00e9nyeink alapj\u00e1n id\u0151sebb betegpopul\u00e1ci\u00f3 eset\u00e9n SARS-CoV-2-fert\u0151z\u00e9s s\u00falyosabb lefoly\u00e1s\u00e1t, magasabb szekunder infekci\u00f3s r\u00e1t\u00e1t \u00e9s magasabb mortalit\u00e1st detekt\u00e1ltunk hossz\u00fat\u00e1von az immunmodul\u00e1ns ter\u00e1pia mellett – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. G\u00e1sp\u00e1r Zs\u00f3fia.<\/p>\n

\n

Secondary infections and long-term outcomes among hospitalized elderly and non-elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and treated with baricitinib: a comparative study from the national centre of Hungary
\nZs\u00f3fia G\u00e1sp\u00e1r (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest; School of PhD Studies, Semmelweis University), B\u00e1lint Gergely Szab\u00f3 (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest; School of PhD Studies, Semmelweis University; Departmental Group of Infectious Diseases, Department of Internal Medicine and Haematology, Semmelweis University), Hajnalka Andrikovics (School of PhD Studies, Semmelweis University; Laboratory of Molecular Genetics, National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest; Department of Transfusion Medicine, Semmelweis University), Andrea Cegl\u00e9di (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest), Martin Rajmon (Faculty of Medicine, Semmelweis University), Anita \u00c1brah\u00e1m (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest), Zsuzsanna V\u00e1rnai (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest), No\u00e9mi Kiss-Dala (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest; School of PhD Studies, Semmelweis University), J\u00e1nos Szl\u00e1vik (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest), J\u00e1nos Sink\u00f3 (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest; Departmental Group of Infectious Diseases, Department of Internal Medicine and Haematology, Semmelweis University), Istv\u00e1n V\u00e1lyi-Nagy (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest), Botond Lakatos (National Institute of Haematology and Infectious Diseases, Central Hospital of Southern Pest; School of PhD Studies, Semmelweis University; Departmental Group of Infectious Diseases, Department of Internal Medicine and Haematology, Semmelweis University)
\nGeroScience (2024)
\nhttps:\/\/doi.org\/10.1007\/s11357-024-01099-y<\/a><\/p>\n<\/div>\n

Virtu\u00e1lis illeszt\u00e9si m\u00f3dszer alkalmaz\u00e1sa sz\u00e1jszkennek alapj\u00e1n tervezett teljes, r\u00f6gz\u00edtett fogp\u00f3tl\u00e1sok eset\u00e9ben: A cementr\u00e9s hat\u00e1sa<\/h5>\n

\"\"<\/a>A fogorvostudom\u00e1nyban a fogp\u00f3tl\u00e1sok k\u00e9sz\u00edt\u00e9se egyre ink\u00e1bb digit\u00e1lis \u00faton t\u00f6rt\u00e9nik, amely technik\u00e1j\u00e1t r\u00f6viden CAD-CAM elj\u00e1r\u00e1snak h\u00edvunk. A CAD-CAM elj\u00e1r\u00e1s r\u00f6vid\u00edt\u00e9se a computer-aided design \u00e9s computer-aided manufacturing angol szavakb\u00f3l ered. El\u0151bbi a digit\u00e1lis tervez\u00e9sre, ut\u00f3bbi a digit\u00e1lis gy\u00e1rt\u00e1sra utal. A digit\u00e1lis munkafolyamat \u00fagy v\u00e1lik teljess\u00e9, hogy m\u00e1r a fogakkal t\u00f6rt\u00e9n\u0151 mintav\u00e9tel is digit\u00e1lis sz\u00e1jszkennerekkel t\u00f6rt\u00e9nik. Az \u00edgy k\u00e9pz\u0151d\u00f6tt digit\u00e1lis lenyomatb\u00f3l k\u00e9pz\u0151dik a digit\u00e1lis minta, ami alapj\u00e1n a CAD-CAM munkafolyamat elkezd\u0151dhet.<\/p>\n

Megjelent vizsg\u00e1ltunkban arra voltunk k\u00edv\u00e1ncsiak, hogy ha egy teljes fog\u00edvre k\u00e9sz\u00edten\u00e9nk fogp\u00f3tl\u00e1st, akkor annak pontatlans\u00e1g\u00e1ban mekkora szerepet t\u00f6lt be a digit\u00e1lis mintav\u00e9tel. A munkacsoportunk \u00e1ltal kifejlesztett vizsg\u00e1l\u00f3 m\u00f3dszer, a virtu\u00e1lis illeszt\u00e9s, amely a digit\u00e1lisan megtervezett fogp\u00f3tl\u00e1st visszailleszti a digit\u00e1lis mester mint\u00e1ra, amelyet ultrapontos ipari szkenner k\u00e9sz\u00edt az eredeti mint\u00e1r\u00f3l.
\nEzt k\u00f6vet\u0151en lem\u00e9rj\u00fck a fogp\u00f3tl\u00e1s sz\u00e9le \u00e9s a fogcsonk k\u00f6z\u00f6tti t\u00e1vols\u00e1got. Ez az \u00fan. sz\u00e9liz\u00e1r\u00f3d\u00e1s, ami meghat\u00e1rozza egy fogp\u00f3tl\u00e1s hossz\u00fat\u00e1v\u00fa sikeress\u00e9g\u00e9t. \u00daj\u00edt\u00e1sunk l\u00e9nyege, hogy a sz\u00e1jszkennel\u00e9sb\u0151l ad\u00f3d\u00f3 pontatlans\u00e1got klinikailag \u00e9rtelmezhet\u0151 m\u00e9rt\u00e9kegys\u00e9gben tudjuk m\u00e9rni. Eredm\u00e9nyeink szerint a vizsg\u00e1lt sz\u00e1jszkennerek megb\u00edzhat\u00f3an haszn\u00e1lhat\u00f3k teljes fog\u00edvre k\u00e9sz\u00fcl\u0151 fogp\u00f3tl\u00e1sok eset\u00e9n, megfelel\u0151 cementr\u00e9s kiv\u00e1laszt\u00e1s\u00e1val – fogalmaztak \u00f6sszefoglal\u00f3jukban dr. V\u00e1g J\u00e1nos \u00e9s dr. Borbola D\u00e1niel.<\/p>\n

\n

Application of the virtual-fit method for fixed complete denture cases designed on intraoral scans: Effect of cement spacing
\nJanos Vag (Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, Semmelweis University), Laszlo Romanszky (Dental Technicians, Artifex Dentis Kft.), Gyorgy Sersli (Dental Technicians, Artifex Dentis Kft.), Michael DeFee (Modern Optimized Dentistry Institute), Walter Renne (Modern Optimized Dentistry Institute), Francesco Mangano (Department of Pediatric, Preventive Dentistry and Orthodontics, Sechenov First State Medical University), Daniel Borbola (Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, Semmelweis University)
\nJournal of Dentistry Volume 141, February 2024, 104780
\nhttps:\/\/doi.org\/10.1016\/j.jdent.2023.104780<\/a><\/p>\n<\/div>\n

Immunellen\u0151rz\u0151pont molekul\u00e1k szerepe a sz\u00edvel\u00e9gtelens\u00e9gben<\/h5>\n

\"\"<\/a>Az immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3 gy\u00f3gyszerek (immune checkpoint inhibitorok, r\u00f6viden ICI-k) az elm\u00falt \u00e9vtizedben jelent\u0151s \u00e1tt\u00f6r\u00e9st hoztak az onkol\u00f3gi\u00e1ban, sz\u00e1mos daganat kezel\u00e9s\u00e9t forradalmas\u00edtott\u00e1k. Hat\u00e1smechanizmusuk a T-sejteket szab\u00e1lyoz\u00f3 immunellen\u0151rz\u0151pontok specifikus g\u00e1tl\u00e1s\u00e1n alapul, ezzel aktiv\u00e1lva a tumorellenes immunv\u00e1laszt. Azonban ezen molekul\u00e1k nem csak tumorokban expressz\u00e1l\u00f3dnak, hanem az immunrendszer fiziol\u00f3gi\u00e1s m\u0171k\u00f6d\u00e9s\u00e9t szab\u00e1lyozva sz\u00e1mos szervrendszer homeoszt\u00e1zis\u00e1nak fenntart\u00e1s\u00e1hoz sz\u00fcks\u00e9gesek. Ezt bizony\u00edtj\u00e1k az ICI kezel\u00e9s hat\u00e1s\u00e1ra l\u00e9trej\u00f6v\u0151 immunmedi\u00e1lt mell\u00e9khat\u00e1sok is, mint p\u00e9ld\u00e1ul az ICI-induk\u00e1lt sz\u00edvizomgyullad\u00e1s vagy sz\u00edvel\u00e9gtelens\u00e9g.<\/p>\n

K\u00f6zlem\u00e9ny\u00fcnkben az immunellen\u0151rz\u0151pontok kedvez\u0151tlen kardiovaszkul\u00e1ris hat\u00e1sainak lehets\u00e9ges mechanizmusait vizsg\u00e1ltuk, kiemelt figyelmet ford\u00edtva a sz\u00edvel\u00e9gtelens\u00e9g kialakul\u00e1s\u00e1ra. Ezen mell\u00e9khat\u00e1sok l\u00e9trej\u00f6tt\u00e9nek pontosabb meg\u00e9rt\u00e9se az immunellen\u0151rz\u0151pontok kardiovaszkul\u00e1ris rendszerben bet\u00f6lt\u00f6tt szerep\u00e9re is fontos adatokkal szolg\u00e1lhat, kiemelve ezen molekul\u00e1k lehets\u00e9ges gy\u00f3gyszerc\u00e9lpontk\u00e9nt val\u00f3 hasznos\u00edt\u00e1s\u00e1nak lehet\u0151s\u00e9g\u00e9t a j\u00f6v\u0151ben a sz\u00edvel\u00e9gtelens\u00e9g kezel\u00e9s\u00e9ben. Az \u00f6sszefoglal\u00f3 k\u00f6zlem\u00e9ny az egyik legrangosabb kardiovaszkul\u00e1ris szaklapban, a Nature Reviews Cardiology-ban jelent meg – \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Gergely Tam\u00e1s.<\/p>\n

\n

Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure
\nTam\u00e1s G. Gergely (Department of Pharmacology and Pharmacotherapy, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group), Zs\u00f3fia D. Drobni (Heart and Vascular Center, Semmelweis University; Division of Cardiology, Department of Medicine, Massachusetts General Hospital), Marinos Kallikourdis (Department of Biomedical Sciences, Humanitas University; Adaptive Immunity Lab, Humanitas Research Hospital IRCCS), Han Zhu (Division of Cardiovascular Medicine, Stanford University School of Medicine), Wouter C. Meijers (Erasmus MC, Cardiovascular Institute, Thorax Center, Department of Cardiology), Tomas G. Neilan (Division of Cardiology, Department of Medicine, Massachusetts General Hospital), Tienush Rassaf (Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, Medical Faculty, University Hospital Essen), P\u00e9ter Ferdinandy (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group), Zolt\u00e1n V. Varga (Department of Pharmacology and Pharmacotherapy, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group)
\nNature Reviews Cardiology (2024)
\nhttps:\/\/doi.org\/10.1038\/s41569-023-00986-9<\/a><\/p>\n<\/div>\n

Forradalmi v\u00e1ltoz\u00e1sok a prosztatar\u00e1k sz\u0171r\u00e9sben<\/h5>\n

\"\"<\/a>A Semmelweis \u00e9s a B\u00e9csi Egyetem Urol\u00f3giai Klinik\u00e1inak k\u00f6z\u00f6s kutat\u00e1sa szerint a prosztata MRI vizsg\u00e1latok \u00e1tt\u00f6r\u00e9st hozhatnak a szervezett, lakoss\u00e1gi prosztatar\u00e1k sz\u0171r\u00e9sben. A nemzetk\u00f6zi k\u00f6zrem\u0171k\u00f6d\u00e9s keret\u00e9ben l\u00e9trej\u00f6tt tanulm\u00e1nyt a rangos Egyes\u00fclt \u00c1llamokbeli tudom\u00e1nyos foly\u00f3irat, a JAMA Oncology k\u00f6z\u00f6lte \u00e1prilis elej\u00e9n. A klasszikus, kiz\u00e1r\u00f3lag PSA vizsg\u00e1laton alapul\u00f3 prosztatar\u00e1k sz\u0171r\u00e9s b\u00e1r jav\u00edtja a betegek t\u00fal\u00e9l\u00e9s\u00e9t, sz\u00e1mos sz\u00fcks\u00e9gtelen mintav\u00e9tellel \u00e9s az akt\u00edv kezel\u00e9st nem ig\u00e9nyl\u0151, kev\u00e9sb\u00e9 agressz\u00edv prosztatadaganatok sz\u00e1m\u00e1nak emelked\u00e9s\u00e9vel j\u00e1r, mely jelent\u0151s fizikai \u00e9s pszich\u00e9s terhel\u00e9st jelent a f\u00e9rfiak sz\u00e1m\u00e1ra. Mindazon\u00e1ltal az elm\u00falt \u00e9vek diagnosztikai fejl\u0151d\u00e9s\u00e9nek eredm\u00e9nyek\u00e9ppen, prosztatar\u00e1k gyan\u00faja eset\u00e9n egyre gyakrabban ker\u00fcl sor MRI-vizsg\u00e1latra a mintav\u00e9telt megel\u0151z\u0151en, valamint MRI-vez\u00e9relt biopszi\u00e1ra.<\/p>\n

A szerz\u0151k 12 tanulm\u00e1ny \u00f6sszesen 80 114 sz\u0171r\u00e9sben r\u00e9sztvev\u0151 f\u00e9rfi adat\u00e1t \u00e9rt\u00e9kelt\u00e9k ki, \u00e9s hasonl\u00edtott\u00e1k \u00f6ssze a hagyom\u00e1nyos, kiz\u00e1r\u00f3lag PSA-alap\u00fa \u00e9s az MRI-vizsg\u00e1latot haszn\u00e1l\u00f3 sz\u0171r\u0151vizsg\u00e1latok hat\u00e9konys\u00e1g\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy prosztata-MRI haszn\u00e1lat\u00e1val harmad\u00e1ra cs\u00f6kkenthet\u0151 mind a mintav\u00e9telek, mind a kev\u00e9sb\u00e9 agressz\u00edv, azonnali akt\u00edv kezel\u00e9st nem ig\u00e9nyl\u0151 prosztatadaganatok sz\u00e1ma a kiz\u00e1r\u00f3lag PSA-alap\u00fa sz\u0171r\u00e9shez k\u00e9pest. Mindemellett az MRI seg\u00edts\u00e9g\u00e9vel v\u00e9gzett biopszia n\u00e9gyszer pontosabban k\u00e9pes megtal\u00e1lni a klinikailag agressz\u00edv daganatokat. Dr. Nyir\u00e1dy P\u00e9ter, a Semmelweis Egyetem Urol\u00f3giai Klinik\u00e1j\u00e1nak igazgat\u00f3ja szerint a tanulm\u00e1ny igazolta az MRI-vizsg\u00e1latok prosztatar\u00e1k sz\u0171r\u00e9sben val\u00f3 kiemelked\u0151 hat\u00e9konys\u00e1g\u00e1t, valamint felh\u00edvta a figyelmet, hogy az Eur\u00f3pai Bizotts\u00e1g 2022-ben beemelte a prosztatar\u00e1kot a szervezett, lakoss\u00e1gi szinten sz\u0171rend\u0151 daganatok sor\u00e1ba, ez\u00e9rt haz\u00e1nkban is \u00e9rdemes lenne egy, a t\u00f6bb mint 1,1 milli\u00f3 50-70 \u00e9v k\u00f6z\u00f6tti f\u00e9rfi honfit\u00e1rsunkat c\u00e9lz\u00f3 sz\u0171r\u0151program megval\u00f3s\u00edthat\u00f3s\u00e1g\u00e1t vizsg\u00e1lni – fogalamzott \u00f6sszefoglal\u00f3j\u00e1ban dr. Fazekas Tam\u00e1s.<\/p>\n

\n

Magnetic Resonance Imaging in Prostate Cancer Screening
\nTam\u00e1s Fazekas (Comprehensive Cancer Center, Department of Urology, Medical University of Vienna; Department of Urology, Semmelweis University; Centre for Translational Medicine, Semmelweis University), Sung Ryul Shim (Department of Biomedical Informatics, College of Medicine, Konyang University), Giuseppe Basile (Unit of Urology, Urological Research Institute, Division of Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University), Michael Baboudjian (Department of Urology, Assistance Publique des H\u00f4pitaux de Marseille, North Academic Hospital), Tam\u00e1s K\u00f3i (Centre for Translational Medicine, Semmelweis University; Institute of Mathematics, Department of Stochastics, Budapest University of Technology and Economics), Mikolaj Przydacz (Department of Urology, Jagiellonian University Medical College), Mohammad Abufaraj (Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan; The National Center for Diabetes, Endocrinology and Genetics, The University of Jordan), Guillaume Ploussard (Department of Urology, La Croix du Sud Hospital), Veeru Kasivisvanathan (Division of Surgery and Interventional Science, University College London), Juan G\u00f3mez Rivas (Department of Urology, Hospital Universitario La Paz), Giorgio Gandaglia (Unit of Urology, Urological Research Institute, Division of Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University), Tibor Szarvas (Department of Urology, Semmelweis University; Department of Urology, University of Duisburg-Essen and German Cancer Consortium\u2013University Hospital Essen), Ivo G. Schoots (Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam; Department of Radiology, Netherlands Cancer Institute), Roderick C. N. van den Bergh (Department of Urology, St Antonius Hospital; Department of Urology, Erasmus MC), Michael S. Leapman (Department of Urology, Yale School of Medicine), P\u00e9ter Nyir\u00e1dy (Department of Urology, Semmelweis University; Centre for Translational Medicine, Semmelweis University), Shahrokh F. Shariat (Comprehensive Cancer Center, Department of Urology, Medical University of Vienna; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University; Department of Urology, University of Texas Southwestern Medical Center;<\/span> Department of Urology, Second Faculty of Medicine, Charles University;<\/span> Department of Urology, Weill Cornell Medical College;<\/span> Karl Landsteiner Institute of Urology and Andrology), Pawel Rajwa (Comprehensive Cancer Center, Department of Urology, Medical University of Vienna; Department of Urology, Medical University of Silesia)
\nJAMA Oncol. Published online April 5, 2024
\ndoi:10.1001\/jamaoncol.2024.0734<\/a>
\n<\/span><\/p>\n<\/div>\n

A r\u00f6vid \u00f6sszefoglal\u00f3kat a tudom\u00e1nyos publik\u00e1ci\u00f3k szerz\u0151i k\u00e9sz\u00edtett\u00e9k.
\nSzerkesztette: Szab\u00f3 \u00c1d\u00e1m
\nFot\u00f3: a publik\u00e1ci\u00f3kb\u00f3l sz\u00e1rmaz\u00f3 k\u00e9pek<\/p>\n","protected":false},"excerpt":{"rendered":"

Cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3.<\/p>\n","protected":false},"author":101751,"featured_media":102156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[161,168],"tags":[4179,2408,4276],"class_list":["post-138671","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tudomany","category-kiemelt","tag-alhonlapokra","tag-mki-alairas","tag-tudomanyos-hirado"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/138671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/users\/101751"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/comments?post=138671"}],"version-history":[{"count":8,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/138671\/revisions"}],"predecessor-version":[{"id":139053,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/138671\/revisions\/139053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media\/102156"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media?parent=138671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/categories?post=138671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/tags?post=138671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}