{"id":113469,"date":"2022-04-14T14:00:49","date_gmt":"2022-04-14T12:00:49","guid":{"rendered":"https:\/\/semmelweis.hu\/hirek\/?p=113469"},"modified":"2024-05-06T09:29:48","modified_gmt":"2024-05-06T07:29:48","slug":"tudomanyos-hirado-9","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/hirek\/2022\/04\/14\/tudomanyos-hirado-9\/","title":{"rendered":"Tudom\u00e1nyos h\u00edrad\u00f3 9."},"content":{"rendered":"
Tudom\u00e1nyos H\u00edrad\u00f3 c\u00edm\u0171 cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3. A cikkeket az elm\u00falt id\u0151szak megjelen\u00e9sei alapj\u00e1n a K\u00f6zponti K\u00f6nyvt\u00e1r, illetve dr. Szigeti Gyula innov\u00e1ci\u00f3s igazgat\u00f3 v\u00e1logatta.<\/strong><\/div>\n
Az iv\u00f3v\u00edz l\u00edtiumszintje \u00e9s a szuicid mortalit\u00e1s k\u00f6zti lehets\u00e9ges \u00f6sszef\u00fcgg\u00e9s vizsg\u00e1lata haz\u00e1nkban<\/h5>\n
\"\"<\/a>
Gender- and age-standardized SMRs for suicide; total population<\/figcaption><\/figure>\n

A l\u00edtium (Li) \u00e9vtizedek \u00f3ta a pszichi\u00e1tria ter\u00e1pi\u00e1s eszk\u00f6zt\u00e1r\u00e1nak r\u00e9sze, melyet els\u0151sorban a s\u00falyos hangulatzavarok, azaz a bipol\u00e1ris zavar \u00e9s a major depresszi\u00f3 kezel\u00e9s\u00e9ben haszn\u00e1lunk. Er\u0151s bizony\u00edt\u00e9kok sz\u00f3lnak amellett, hogy a l\u00edtium, azon t\u00fal, hogy a hangulatbetegs\u00e9gek t\u00fcneteit cs\u00f6kkenti, er\u0151s v\u00e9delmet biztos\u00edt az \u00f6ngyilkos magatart\u00e1ssal szemben ezen betegekn\u00e9l. A Li nyomelemk\u00e9nt az iv\u00f3v\u00edzben is jelen van, azonban t\u00edpusosan olyan alacsony koncentr\u00e1ci\u00f3ban, hogy naponta t\u00f6bb t\u00edzezer liternyi csapvizet kellene elfogyasztanunk ahhoz, hogy az orvosi alkalmaz\u00e1s sor\u00e1n meg\u00e1llap\u00edtott d\u00f3zist vigy\u00fck be. Ennek ellen\u00e9re sz\u00e1mos, k\u00fcl\u00f6nb\u00f6z\u0151 orsz\u00e1gokban kivitelezett, vizsg\u00e1lat szerint, az iv\u00f3v\u00edzben l\u00e9v\u0151 minim\u00e1lis Li mennyis\u00e9g is m\u00e9rs\u00e9kelni k\u00e9pes az \u00e1tlag popul\u00e1ci\u00f3 \u00f6ngyilkoss\u00e1gi kock\u00e1zat\u00e1t.<\/p>\n

Vizsg\u00e1latunkban els\u0151k\u00e9nt siker\u00fclt igazolnunk, hogy ez a hat\u00e1s haz\u00e1nkban is kimutathat\u00f3 (a vizsg\u00e1latot j\u00e1r\u00e1si szintre aggreg\u00e1lt adatokon v\u00e9gezt\u00fck el). Az eredm\u00e9nyek szerint, a Li szuicidprevenci\u00f3s hat\u00e1sa els\u0151sorban a f\u00e9rfiak k\u00f6zt mutathat\u00f3 ki, mely val\u00f3sz\u00edn\u0171leg arra vezethet\u0151 vissza, hogy \u0151k gyakrabban v\u00e1lasztanak violens elk\u00f6vet\u00e9si m\u00f3dokat, mint a n\u0151k, \u00e9s a Li antiagressz\u00edv, illetve antiimpulz\u00edv hat\u00e1sa els\u0151sorban ezeket a hal\u00e1leseteket k\u00e9pes kiv\u00e9deni \u2013 fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban dr. D\u00f6me P\u00e9ter.<\/p>\n

Investigation of the association between lithium levels in drinking water and suicide mortality in Hungary
\nBalint Izsak (National Public Health Center; Eotvos Lorand University, Doctoral School of Environmental Sciences), Anna Hidvegi (Department of Internal Medicine I, Military Hospital, Hungarian Defense Forces Medical Center), Lajos Balint (Demographic Research Institute of the Hungarian Central Statistical Office; Department of Sociology, University of P\u00e9cs), Tibor Malnasi (National Public Health Center), Marta Vargha (National Public Health Center), Tamas Pandics (National Public Health Center), Zoltan Rihmer (Department of Psychiatry and Psychotherapy, Semmelweis University; Nyiro Gyula National Institute of Psychiatry and Addictions), Peter Dome (Department of Psychiatry and Psychotherapy, Semmelweis University; Nyiro Gyula National Institute of Psychiatry and Addictions)
\nJournal of Affective Disorders, Vol. 298, Part A, pp. 540-547, 2022
\nhttps:\/\/doi.org\/10.1016\/j.jad.2021.11.041<\/a><\/div>\n

 <\/p>\n

A f\u00e1jdalomkezel\u0151 szolg\u00e1latok (Acute Pain Service) elterjedts\u00e9g\u00e9nek felm\u00e9r\u00e9se a magyar k\u00f3rh\u00e1zakban<\/h5>\n
\"\"<\/a>
Az APS teamek kialak\u00edt\u00e1si akad\u00e1lyai<\/figcaption><\/figure>\n

A m\u0171t\u00e9t ut\u00e1n kialakul\u00f3 f\u00e1jdalom jelent\u0151s terhet r\u00f3 mind a betegre, mind az eg\u00e9szs\u00e9g\u00fcgyi ell\u00e1t\u00f3rendszerre. Oper\u00e1ci\u00f3 ut\u00e1n ugyanis a betegek egy r\u00e9sze k\u00f6zepes vagy s\u00falyos f\u00e1jdalmat \u00e9l \u00e1t, amely korl\u00e1tozhatja a mindennapi tev\u00e9kenys\u00e9gek elv\u00e9gz\u00e9s\u00e9ben \u00e9s szorong\u00e1st, f\u00e9lelmet, lehangolts\u00e1got v\u00e1lthat ki, h\u00e1tr\u00e1ltatva ezzel a gy\u00f3gyul\u00e1s folyamat\u00e1t. A t\u00f6bb szakter\u00fclet k\u00e9pvisel\u0151it magukban foglal\u00f3 f\u00e1jdalomkezel\u0151 szolg\u00e1latok (Acute Pain Service, APS) olyan \u00faj ell\u00e1t\u00e1si form\u00e1t jelentenek a k\u00f3rh\u00e1zakban, amelyek seg\u00edtik a betegek f\u00e1jdalm\u00e1nak \u00e9s a kezel\u00e9ssel \u00f6sszef\u00fcgg\u0151 mell\u00e9khat\u00e1soknak a cs\u00f6kken\u00e9s\u00e9t, n\u00f6velik a betegbiztons\u00e1got \u00e9s betegel\u00e9gedetts\u00e9get. A kutat\u00e1s az APS magyarorsz\u00e1gi elterjedts\u00e9g\u00e9t, jellemz\u0151it, oktat\u00e1si \u00e9s min\u0151s\u00e9g\u00fcgyi tev\u00e9kenys\u00e9g\u00e9t, valamint a kialak\u00edt\u00e1sukat akad\u00e1lyoz\u00f3 t\u00e9nyez\u0151ket vizsg\u00e1lta.<\/p>\n

Jelenleg mind\u00f6ssze k\u00e9t k\u00f3rh\u00e1z m\u0171k\u00f6dtet f\u00e1jdalomkezel\u0151 csapatot, amelyek k\u00f6z\u00fcl az egyik orvosokb\u00f3l, a m\u00e1sik pedig aneszteziol\u00f3gus \u00e1ltal fel\u00fcgyelt eg\u00e9szs\u00e9g\u00fcgyi szakdolgoz\u00f3kb\u00f3l \u00e1ll. Tev\u00e9kenys\u00e9g\u00fck megfelel a szakirodalomban fellelhet\u0151 elv\u00e1r\u00e1soknak, min\u0151s\u00e9gi krit\u00e9riumoknak. Azokban a k\u00f3rh\u00e1zakban is elismerik a szolg\u00e1latok l\u00e9trehoz\u00e1s\u00e1nak sz\u00fcks\u00e9gess\u00e9g\u00e9t, ahol nincs APS. Kialak\u00edt\u00e1suk f\u0151 akad\u00e1lyak\u00e9nt a munkaer\u0151 \u00e9s a finansz\u00edroz\u00e1s hi\u00e1ny\u00e1t jel\u00f6lt\u00e9k meg a v\u00e1laszad\u00f3k, de fontos probl\u00e9mak\u00e9nt eml\u00edtett\u00e9k a motiv\u00e1latlans\u00e1got, a kezdem\u00e9nyez\u0151k\u00e9szs\u00e9g hi\u00e1ny\u00e1t, valamint a m\u0171t\u00e9tes szakm\u00e1k k\u00f6z\u00f6tti egy\u00fcttm\u0171k\u00f6d\u00e9s neh\u00e9zs\u00e9geit \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban Lovasi Orsolya.<\/p>\n

\n

Acute Pain Service in Hungarian hospitals
\nOrsolya Lovasi (School of PhD Studies, Semmelweis University), Judit Lam (Semmelweis University Health Services Management Training Centre), Reka Schutzmann (School of PhD Studies, Semmelweis University), Peter Gaal (Semmelweis University Health Services Management Training Centre)
\nPLoS ONE 16(9)
\nhttps:\/\/doi.org\/10.1371\/journal.pone.0257585<\/a><\/p>\n<\/div>\n

Coronaria plakk progresszi\u00f3 vizsg\u00e1lata CT angiogr\u00e1fia seg\u00edt\u00e9s\u00e9g\u00e9vel<\/h5>\n

\"\"<\/a>A koszor\u00fa\u00e9r-betegs\u00e9g egy kr\u00f3nikus \u00e9s dinamikusan el\u0151rehalad\u00f3 folyamat, melyet a plakkok m\u00e9ret\u00e9nek \u00e9s \u00f6sszet\u00e9tel\u00e9nek folyamatos v\u00e1ltoz\u00e1sa jellemez.\u00a0 A coronaria CT angiogr\u00e1fia (CTA) megb\u00edzhat\u00f3 non-invaz\u00edv modalit\u00e1s a koszor\u00fa\u00e9r atherosclerosis vizsg\u00e1lat\u00e1ra. A coronaria plakk progresszi\u00f3 a kardiovaszkul\u00e1ris esem\u00e9nyek f\u00fcggetlen prediktora, azonban defin\u00edci\u00f3ja nem egys\u00e9ges. C\u00e9lunk a koszor\u00fa\u00e9r-betegs\u00e9g s\u00falyoss\u00e1g\u00e1ra \u00e9s kiterjed\u00e9s\u00e9re jelenleg alkalmazott k\u00fcl\u00f6nb\u00f6z\u0151 defin\u00edci\u00f3k szerint a plakk-progresszi\u00f3 meghat\u00e1roz\u00e1sa volt. Emellett elemezt\u00fck, hogy mely rizik\u00f3t\u00e9nyez\u0151k befoly\u00e1solj\u00e1k a koszor\u00fa\u00e9r-betegs\u00e9g progresszi\u00f3j\u00e1t. \u00d6sszesen 115 stabil angin\u00e1s beteg coronaria CTA felv\u00e9tel\u00e9t vizsg\u00e1ltuk a V\u00e1rosmajori Sz\u00edv- \u00e9s \u00c9rgy\u00f3gy\u00e1szati Klinik\u00e1n.<\/p>\n

Eredm\u00e9nyeink alapj\u00e1n a k\u00fcl\u00f6nb\u00f6z\u0151 defin\u00edci\u00f3k alkalmaz\u00e1s\u00e1val jelent\u0151sen elt\u00e9r\u0151 m\u00e9rt\u00e9k\u0171 progresszi\u00f3t detekt\u00e1ltunk. Kiemelend\u0151, hogy a klinikumban haszn\u00e1lt \u00fan. CAD-RADS (coronary artery disease \u2013 reporting and data system) oszt\u00e1lyoz\u00e1s az esetek t\u00f6bb mint fel\u00e9ben nem azonos\u00edtotta a plakkok progresszi\u00f3j\u00e1t m\u00e1s defin\u00edci\u00f3kkal ellent\u00e9tben. Ezen fel\u00fcl a diabetes, a doh\u00e1nyz\u00e1s, a f\u00e9rfi nem \u00e9s az \u00e9letkor befoly\u00e1solta szignifik\u00e1ns m\u00e9rt\u00e9kben a coronaria plakkok progresszi\u00f3j\u00e1t \u2013 foglalta \u00f6ssze dr. Vattay Borb\u00e1la \u00e9s dr. Szilveszter B\u00e1lint.<\/p>\n

\n

CAD-RADS may underestimate coronary plaque progression as detected by serial CT angiography
\nBalint Szilveszter (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Borbala Vattay (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Melinda Bossoussou (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Milan Vecsey-Nagy (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Judit Simon (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), B\u00e9la Merkely (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), P\u00e1l Maurovich-Horvat (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University; Medical Imaging Centre, Semmelweis University), M\u00e1rton Kolossv\u00e1ry (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University)
\nEuropean Heart Journal – Cardiovascular Imaging, jeab215, 2021
\nhttps:\/\/doi.org\/10.1093\/ehjci\/jeab215<\/a><\/p>\n<\/div>\n

Egy term\u00e9szetes t\u00fal\u00e9rz\u00e9kenys\u00e9gi sert\u00e9s modell seg\u00edthet a COVID-19 mRNS vakcina \u00e1ltal kiv\u00e1ltott ritka (pszeudo) allergi\u00e1s reakci\u00f3k mechanizmus\u00e1nak meg\u00e9rt\u00e9s\u00e9ben: komplement aktiv\u00e1ci\u00f3, mint lehets\u00e9ges r\u00e9sztvev\u0151
\n– C\u00e9l: Egy hat\u00e1sos vakcina potenci\u00e1lis k\u00e1ros mell\u00e9khat\u00e1sainak enyh\u00edt\u00e9se vagy kiv\u00e9d\u00e9se<\/h5>\n

\"\"<\/a>Az \u00fajfajta mRNS-tartalm\u00fa liposz\u00f3m\u00e1s vakcin\u00e1knak, b\u00e1r kev\u00e9s esetben, de ak\u00e1r hal\u00e1los kimenetel\u0171 allergi\u00e1s hat\u00e1suk is lehet. Az \u00fan. t\u00fal\u00e9rz\u00e9kenys\u00e9gi reakci\u00f3k egyik fajt\u00e1ja a \u201eKomplement aktiv\u00e1ci\u00f3hoz kapcsolt pszeudoallergia (CARPA)\u201d. A h\u00e1zi sert\u00e9sek a jelens\u00e9g term\u00e9szetes t\u00fal\u00e9rz\u00e9kenys\u00e9gi modellj\u00e9t adj\u00e1k. A cikk szerz\u0151i a Pfizer mRNS vakcina CARPA reakci\u00f3t kiv\u00e1lt\u00f3 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k altatott sert\u00e9sen. A vakcin\u00e1t intrav\u00e9n\u00e1san, a hum\u00e1n d\u00f3zishoz k\u00e9pest 1, 2, \u00e9s 5-sz\u00f6r\u00f6s adagban adt\u00e1k, \u00e9s egy referens vegy\u00fclet, a zymosan hat\u00e1saival vetett\u00e9k \u00f6ssze. A v\u00e9rkering\u00e9si jellemz\u0151k alakul\u00e1s\u00e1t \u00e9s az EKG v\u00e1ltoz\u00e1sait k\u00f6vett\u00e9k. A v\u00e9rsejtsz\u00e1m v\u00e1ltoz\u00e1sait \u00e9s a komplement szint alakul\u00e1s\u00e1t a sert\u00e9sb\u0151l vett v\u00e9rmint\u00e1kban elemezt\u00e9k.<\/p>\n

A vizsg\u00e1lt 14 sert\u00e9sb\u0151l 6 esetben a zymosanhoz hasonl\u00f3 pulmon\u00e1lis v\u00e9rnyom\u00e1semelked\u00e9st, \u00e9s CARPA reakci\u00f3ra jellemz\u0151 v\u00e9rsejtsz\u00e1m (limfocita \u00e9s trombocita) v\u00e1ltoz\u00e1sokat tal\u00e1ltak. Egy \u00f6tsz\u00f6r\u00f6s d\u00f3zissal kezelt sert\u00e9sn\u00e9l k\u00f3ros EKG v\u00e1ltoz\u00e1s, \u00e9s \u00fajra\u00e9leszt\u00e9st ig\u00e9nyl\u0151 anafilaxi\u00e1s sokk alakult ki. In vitro vizsg\u00e1latokban a Pfizer-vakcina k\u00e9t d\u00f3zis\u00e1t 3 eg\u00e9szs\u00e9ges malac sz\u00e9rum\u00e1hoz adt\u00e1k, \u00e9s komplement feh\u00e9rj\u00e9k (C3a \u00e9s sC5b-9) termel\u0151d\u00e9s\u00e9t vizsg\u00e1lt\u00e1k. D\u00f3zisf\u00fcgg\u0151, a zymosanhoz hasonl\u00f3 komplement emel\u0151 hat\u00e1st tal\u00e1ltak. Az eredm\u00e9nyek arra utalnak, hogy a COVID-19 mRNS vakcin\u00e1k \u00e1ltali komplement aktiv\u00e1ci\u00f3 a peszudoallergi\u00e1s reakci\u00f3k kialakul\u00e1s\u00e1ban fontos szerepet j\u00e1tszhat \u2013 foglalta \u00f6ssze dr. D\u00e9zsi L\u00e1szl\u00f3.<\/p>\n

\n

A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor
\nLaszl\u00f3 Dezsi (Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University; SeroScience LCC), Tamas Meszaros (Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University; SeroScience LCC), Gergely Kozma (Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University; SeroScience LCC), Maria H-Velkei (Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University; SeroScience LCC), Csaba Zs. Olah (Department of Neurosurgery, BAZ County Central Hospital and Borsod County University Teaching Hospital), Miklos Szabo (Department of Pulmonology, BAZ County Central Hospital and Borsod County University Teaching Hospital), Zsofia Patko (Department of Radiology, BAZ County Central Hospital and Borsod County University Teaching Hospital), Tamas Fulop (TECOdevelopment GmbH), Mark Hennies (TECOdevelopment GmbH), Miklos Szebeni (Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University; SeroScience LCC), Balint Andras Barta (Heart and Vascular Center, Semmelweis University), Bela Merkely (Heart and Vascular Center, Semmelweis University), Tamas Radovits (Heart and Vascular Center, Semmelweis University), J\u00e1nos Szebeni (Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University; SeroScience LCC; Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University)
\nGeroScience, 2022
\nhttps:\/\/doi.org\/10.1007\/s11357-021-00495-y<\/a><\/p>\n<\/div>\n

Feh\u00e9rje-feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1sok h\u00e1l\u00f3zat alap\u00fa felder\u00edt\u00e9se mesters\u00e9ges intelligenci\u00e1val<\/h5>\n
\"\"<\/a>
A mesters\u00e9ges intelligencia algoritmus (generative adversarial network) v\u00e1zlatos \u00e1br\u00e1zol\u00e1sa<\/figcaption><\/figure>\n

A feh\u00e9rj\u00e9k k\u00f6z\u00f6tt l\u00e9trej\u00f6v\u0151 k\u00f6lcs\u00f6nhat\u00e1sok az \u00e9l\u0151 sejt m\u0171k\u00f6d\u00e9s\u00e9nek alapj\u00e1ul szolg\u00e1lnak, \u00edgy felder\u00edt\u00e9s\u00fck \u00e9s vizsg\u00e1latuk sz\u00e1mtalan tudom\u00e1nyter\u00fclet, mint p\u00e9ld\u00e1ul a gy\u00f3gyszerfejleszt\u00e9s kulcsfontoss\u00e1g\u00fa eszk\u00f6ze. A lehets\u00e9ges k\u00f6lcs\u00f6nhat\u00e1sok igazol\u00e1sa laborat\u00f3riumi k\u00f6rnyezetben t\u00f6rt\u00e9nik, ami egy k\u00f6lts\u00e9ges folyamat, \u00edgy fontos kutat\u00e1si ir\u00e1nny\u00e1 n\u0151tte ki mag\u00e1t azon feh\u00e9rjep\u00e1rok el\u0151rejelz\u00e9se, melyek a legnagyobb val\u00f3sz\u00edn\u0171s\u00e9ggel l\u00e9pnek k\u00f6lcs\u00f6nhat\u00e1sba a k\u00eds\u00e9rletek sor\u00e1n.<\/p>\n

Munk\u00e1nkban a k\u00f6lcs\u00f6nhat\u00e1sok megj\u00f3sl\u00e1s\u00e1hoz h\u00e1l\u00f3zatos megk\u00f6zel\u00edt\u00e9st alkalmaztunk, melyhez a feh\u00e9rj\u00e9k k\u00f6zti k\u00f6lcs\u00f6nhat\u00e1sokat egy h\u00e1l\u00f3zat \u00e9leik\u00e9nt kezelt\u00fck, magukat a feh\u00e9rj\u00e9ket pedig a h\u00e1l\u00f3zat csom\u00f3pontjaik\u00e9nt. Egy \u00edgy alkotott feh\u00e9rje-feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1s h\u00e1l\u00f3zatban a hi\u00e1nyz\u00f3 \u00e9lek felder\u00edt\u00e9se megegyezik a k\u00f6lcs\u00f6nhat\u00e1sok val\u00f3sz\u00edn\u0171s\u00e9g\u00e9nek megj\u00f3sl\u00e1s\u00e1val. K\u00f6zlem\u00e9ny\u00fcnk bemutatja, hogy erre a feladatra hogyan alkalmazhat\u00f3 egy a g\u00e9pi l\u00e1t\u00e1sban haszn\u00e1lt, neur\u00e1lis h\u00e1l\u00f3zat alap\u00fa mesters\u00e9ges intelligencia algoritmus, \u00e9s ismerteti annak haszn\u00e1lhat\u00f3s\u00e1g\u00e1t, el\u0151nyeit, h\u00e1tr\u00e1nyait, \u00f6sszevetve hasonl\u00f3 bioinformatikai megk\u00f6zel\u00edt\u00e9sekkel \u2013 foglalta \u00f6ssze Balogh Oliv\u00e9r.<\/p>\n

\n

Efficient link prediction in the protein\u2013protein interaction network using topological information in a generative adversarial network machine learning model
\nOliver M. Balogh (Cardiometabolic and MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University; Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University), Bettina Benczik (Cardiometabolic and MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group), Andras Horvath (Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University), Matyas Petervari (Cardiometabolic and MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University), P\u00e9ter Csermely (Department of Molecular Biology, Semmelweis University), Peter Ferdinandy (Cardiometabolic and MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group), Bence Agg (Cardiometabolic and MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group)
\nBMC Bioinformatics volume 23, Article number: 78, 2022
\nhttps:\/\/doi.org\/10.1186\/s12859-022-04598-x<\/a><\/p>\n<\/div>\n

Az esend\u0151s\u00e9g (frailty) magasabb hal\u00e1loz\u00e1ssal asszoci\u00e1lt COVID-19 betegekben<\/h5>\n

\"\"<\/a>K\u00f6zlem\u00e9ny\u00fcnkben a COVID-19 miatt felvett betegek esend\u0151s\u00e9ge \u00e9s a hal\u00e1loz\u00e1s, valamint intenz\u00edv oszt\u00e1lyos felv\u00e9tel k\u00f6z\u00f6tti kapcsolatot vizsg\u00e1ltuk. Az esend\u0151s\u00e9g az \u00e9let folyam\u00e1n \u00f6sszegy\u0171l\u0151 eg\u00e9szs\u00e9g k\u00e1rosod\u00e1sokb\u00f3l \u00f6sszead\u00f3d\u00f3 \u00e1llapot, mely kort\u00f3l f\u00fcggetlen\u00fcl alakul ki, egyszer\u0171en m\u00e9rhet\u0151 \u00e9s \u00edgy kock\u00e1zatbecsl\u00e9sre is alkalmazhat\u00f3 eszk\u00f6z. Esend\u0151 betegek eset\u00e9ben jelent\u0151sen emelkedett sz\u00f6v\u0151dm\u00e9nyes gy\u00f3gyul\u00e1s, valamint a hal\u00e1l kock\u00e1zata. Ez\u00e9rt a betegek szempontj\u00e1b\u00f3l kiemelked\u0151en fontos lehet a heveny betegs\u00e9g el\u0151tti esend\u0151s\u00e9g felm\u00e9r\u00e9se a megfelel\u0151 beteg\u00fat \u00e9s ell\u00e1t\u00e1s megv\u00e1laszt\u00e1s\u00e1nak c\u00e9lj\u00e1b\u00f3l. A COVID-19 pand\u00e9mia sor\u00e1n a magas betegsz\u00e1m messzemen\u0151leg t\u00falterhelte az ell\u00e1t\u00f3 rendszert, \u00edgy a megfelel\u0151 tri\u00e1zs sz\u00fcks\u00e9gess\u00e9ge m\u00e9g hatv\u00e1nyozottabban \u00e9rv\u00e9nyes\u00fclt.<\/p>\n

Kutat\u00e1saink alapj\u00e1n az esend\u0151 COVID-19 betegek hal\u00e1loz\u00e1si es\u00e9lye jelent\u0151sen magasabb a kev\u00e9sb\u00e9 esend\u0151 betegekn\u00e9l. Ez a hat\u00e1s att\u00f3l f\u00fcggetlen\u00fcl is igazol\u00f3dott, hogy az intenz\u00edv oszt\u00e1lyos felv\u00e9tel esend\u0151s\u00e9g alapj\u00e1n t\u00f6rt\u00e9nt-e. Eredm\u00e9nyeink alapj\u00e1n az intenz\u00edv oszt\u00e1lyos felv\u00e9tel esend\u0151s\u00e9gen alapul\u00f3 d\u00f6nt\u00e9si algoritmus\u00e1nak be kellene ker\u00fclnie a nemzetk\u00f6zi ir\u00e1nyelvekbe \u2013 foglalta \u00f6ssze dr. Rottler M\u00e1t\u00e9.<\/p>\n

\n

Clinical Frailty Scale (CFS) indicated frailty is associated with increased in-hospital and 30-day mortality in COVID-19 patients: a systematic review and meta-analysis
\nMate Rottler (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School; Department of Anaesthesiology and Intensive Therapy, Szent Gy\u00f6rgy University Teaching Hospital of Fej\u00e9r County; Doctoral School of Clinical Medicine, University of Szeged), Klementina Ocskay (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Centre for Translational Medicine, Semmelweis University), Zoltan Sipos (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs), Aniko Gorbe (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs), Marcell Virag (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School; Department of Anaesthesiology and Intensive Therapy, Szent Gy\u00f6rgy University Teaching Hospital of Fej\u00e9r County; Doctoral School of Clinical Medicine, University of Szeged), Peter Hegyi (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Centre for Translational Medicine, Semmelweis University; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University), Tihamer Molnar (Department of Anaesthesiology and Intensive Therapy, University of P\u00e9cs), Balint Eross (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Centre for Translational Medicine, Semmelweis University; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University), Tamas Leiner (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School; Anaesthetic Department, Hinchingbrooke Hospital, North West Anglia NHS Foundation Trust), Zsolt Molnar (Centre for Translational Medicine, Semmelweis University; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University; Doctoral School of Clinical Medicine, University of Szeged; Department of Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences; Department of Anaesthesiology and Intensive Therapy, Semmelweis University)
\nAnnals of Intensive Care volume 12, Article number: 17, 2022
\nhttps:\/\/doi.org\/10.1186\/s13613-021-00977-4<\/a><\/p>\n<\/div>\n

R\u00e9szletes, kvantitat\u00edv hisztomorfometriai-matematikai k\u00e9panal\u00edzis metodika r\u00e1gcs\u00e1l\u00f3 heresz\u00f6veten bemutatva \u00e9s lehets\u00e9ges j\u00f6v\u0151beli kutat\u00e1si perspekt\u00edv\u00e1i az Androl\u00f3gia \u00e9s a Reprodukt\u00edv Medicina ter\u00fclet\u00e9n<\/h5>\n

\"\"<\/a>Az infertilit\u00e1s vil\u00e1gszerte n\u00f6vekv\u0151 tendenci\u00e1t mutat, a term\u00e9ketlen p\u00e1rok k\u00f6zel fel\u00e9ben f\u00e9rfi okok is azonos\u00edthat\u00f3k. A here sz\u00f6vettani vizsg\u00e1lat\u00e1val \u00e9rt\u00e9kes \u00e9s fontos inform\u00e1ci\u00f3 nyerhet\u0151 a f\u00e9rfi term\u00e9kenys\u00e9g \u00e1llapot\u00e1r\u00f3l. C\u00e9lunk egy r\u00e9szletes \u00e9s k\u00f6nnyen haszn\u00e1lhat\u00f3, sz\u00e1m\u00edt\u00f3g\u00e9p-alap\u00fa, a heresz\u00f6vet jellemz\u00e9s\u00e9re, ki\u00e9rt\u00e9kel\u00e9s\u00e9re szolg\u00e1l\u00f3 kvantitat\u00edv hisztomorfometriai-matematikai k\u00e9panal\u00edzis metodika kifejleszt\u00e9se volt. Metszet-szkenner seg\u00edts\u00e9g\u00e9vel digitaliz\u00e1lt, folyamatosan nagy\u00edthat\u00f3 heresz\u00f6vet keresztmetszeteken k\u00fcl\u00f6nb\u00f6z\u0151 kvantitat\u00edv param\u00e9terek meghat\u00e1roz\u00e1sa: a teljes herekeresztmetszet, valamint a heretubulusok \u00e9s a vizsg\u00e1lt heretubulusok lumen\u00e9nek ter\u00fclet, ker\u00fclet \u00e9s \u00e1tm\u00e9r\u0151 m\u00e9r\u00e9se, heretubulusok sz\u00e1m\u00e1nak \u00e9s spermium-tartalm\u00e1nak meghat\u00e1roz\u00e1sa. A m\u00e9rt param\u00e9terek egym\u00e1shoz viszony\u00edt\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 sz\u00e1rmaztatott param\u00e9terek is le\u00edrhat\u00f3k, valamint immunhisztok\u00e9miai elj\u00e1r\u00e1ssal festett metszetek lehets\u00e9ges ki\u00e9rt\u00e9kel\u00e9si m\u00f3dszereit is tartalmazza a metodika.<\/p>\n

Metodik\u00e1nk alkalmaz\u00e1s\u00e1val jav\u00edthat\u00f3 a sz\u00f6vettani ki\u00e9rt\u00e9kel\u00e9s reproduk\u00e1lhat\u00f3s\u00e1ga, objektivit\u00e1sa, min\u0151s\u00e9ge \u00e9s a k\u00fcl\u00f6nb\u00f6z\u0151 k\u00eds\u00e9rletek eredm\u00e9nyeinek \u00f6sszehasonl\u00edthat\u00f3s\u00e1ga is lehets\u00e9ges. A j\u00f6v\u0151ben a metodika a mesters\u00e9ges intelligencia \u00e9s a g\u00e9pi tanul\u00e1s seg\u00edts\u00e9g\u00e9vel tov\u00e1bbfejleszthet\u0151, hum\u00e1n fel\u00fcgyelet mellett automatiz\u00e1lhat\u00f3, valamint sz\u00f6vettani-patol\u00f3giai diagnosztik\u00e1t alkalmaz\u00f3 egy\u00e9b orvosi szakter\u00fcleteken \u00e9s alap-, transzl\u00e1ci\u00f3s \u00e9s klinikai kutat\u00e1sokban egyar\u00e1nt alkalmazhat\u00f3 \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. Sziva R\u00e9ka Eszter.<\/p>\n

\n

Accurate Quantitative Histomorphometric-Mathematical Image Analysis Methodology of Rodent Testicular Tissue and Its Possible Future Research Perspectives in Andrology and Reproductive Medicine.
\nReka Eszter Sziva (Department of Obstetrics and Gynecology, Department of Physiology, Workgroup of Research Management, Semmelweis University), Julia Acs (Department of Obstetrics and Gynecology, Department of Physiology, Faculty of Medicine, Semmelweis University), Anna-Maria Tokes (2nd Department of Pathology, Semmelweis University), Agnes Korsos-Novak (Department of Pathology, G\u00e9za Het\u00e9nyi Hospital), Gyorgy Laszlo Nadasy (Department of Physiology, Semmelweis University), Nandor Acs (Department of Obstetrics and Gynecology, Semmelweis University), Peter Gabor Horvath (Budapest 3rd District General Practitioner; Hegyest\u0171 Bt.), Anett Szabo (Andrology Centre, Department of Urology, Semmelweis University), Haoran Ke (Department of Physiology, Faculty of Medicine, Semmelweis University), Eszter-Maria Horvath (Department of Physiology, Semmelweis University), Zsolt Kopa (Andrology Centre, Department of Urology, Semmelweis University), Szabolcs Varbiro (Department of Obstetrics and Gynecology, Workgroup of Research Management, Semmelweis University)
\nLife (Basel), 12(2):189, 2022
\nhttps:\/\/doi.org\/10.3390\/life12020189<\/a><\/p>\n<\/div>\n

A testt\u00f6megindex \u00e9s a ciszt\u00e1s fibr\u00f3zisban szenved\u0151 betegek klinikai kimeneteleinek \u00f6sszef\u00fcgg\u00e9se<\/h5>\n
\"\"<\/a>
Preferred Reporting Items for Systematic Reviews and Meta-analyses Flowchart<\/figcaption><\/figure>\n

A tanulm\u00e1ny a ciszt\u00e1s fibr\u00f3zisban szenved\u0151k k\u00f6r\u00e9ben vizsg\u00e1lja a testt\u00f6meg-index (BMI) \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 klinikai kimenetelek k\u00f6z\u00f6tti kapcsolatot.\u00a0 Az elm\u00falt k\u00e9t \u00e9vtizedben jelent\u0151sen n\u0151tt a v\u00e1rhat\u00f3 \u00e9lettartam ebben a betegs\u00e9gben (jelenleg 47 \u00e9v az USA-ban), teret engedve olyan jelens\u00e9geknek, amikkel kor\u00e1bban nem kellett sz\u00e1molni, mint p\u00e9ld\u00e1ul az elh\u00edz\u00e1s.<\/p>\n

Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a norm\u00e1lt\u00f3l magasabb BMI-hez jobb t\u00fcd\u0151funkci\u00f3 (FEV1%) \u00e9s a hasny\u00e1lmirigy m\u0171k\u00f6d\u00e9s\u00e9ben kedvez\u0151bb exocrin \u00e9s endokrin st\u00e1tusz alakul ki. A rendk\u00edv\u00fcl \u00f6sszetett metaanal\u00edzis r\u00e1mutat arra, hogy az aktu\u00e1lis t\u00e1pl\u00e1lkoz\u00e1ssal kapcsolatos aj\u00e1nl\u00e1sok (a jelenlegi 22 kg\/m2 \u00e9s 23 kg\/m2) helyett magasabb c\u00e9l BMI \u00e9rt\u00e9ket \u00edrjanak el\u0151 a CF-ben szenved\u0151 betegek sz\u00e1m\u00e1ra. Ezen eredm\u00e9nyek alapj\u00e1n \u00faj ter\u00e1pi\u00e1s strat\u00e9gia sz\u00fcks\u00e9ges a betegek t\u00e1pl\u00e1l\u00e1s\u00e1ban, mely jelent\u0151s eg\u00e9szs\u00e9gnyeres\u00e9get hozhat sz\u00e1mukra \u2013 foglalta \u00f6ssze dr. P\u00e1rniczky Andrea \u00e9s dr. Nagy Rita.<\/p>\n

\n

Association of Body Mass Index With Clinical Outcomes in Patients With Cystic Fibrosis. A Systematic Review and Meta-analysis
\nRita Nagy (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Centre for Translational Medicine, Semmelweis University; Heim P\u00e1l National Pediatric Institute), Noemi Gede (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs), Klementina Ocskay (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs), Bernadett-Miriam Dobai (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures), Alan Abada (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Department of Anaesthesiology and Intensive Therapy, Medical School, University of P\u00e9cs), Zsofia Vereczkei (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs), Piroska Pazmany (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Heim P\u00e1l National Pediatric Institute; Doctoral School of Clinical Medicine, University of Szeged), Dorottya Kato (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs), Peter Hegyi (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Centre for Translational Medicine, Semmelweis University; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University), Andrea Parniczky (Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs; Centre for Translational Medicine, Semmelweis University; Heim P\u00e1l National Pediatric Institute)
\nJAMA Netw Open, 5(3):e220740, 2022
\ndoi:10.1001\/jamanetworkopen.2022.0740<\/p>\n<\/div>\n

A r\u00f6vid \u00f6sszefoglal\u00f3kat a tudom\u00e1nyos publik\u00e1ci\u00f3k szerz\u0151i k\u00e9sz\u00edtett\u00e9k.
\nSzerkesztette: Szab\u00f3 \u00c1d\u00e1m
\nFot\u00f3: a publik\u00e1ci\u00f3kb\u00f3l sz\u00e1rmaz\u00f3 k\u00e9pek<\/p>\n","protected":false},"excerpt":{"rendered":"

Cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3.<\/p>\n","protected":false},"author":101751,"featured_media":102156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[161,168],"tags":[4179,2408,4276],"class_list":["post-113469","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tudomany","category-kiemelt","tag-alhonlapokra","tag-mki-alairas","tag-tudomanyos-hirado"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/113469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/users\/101751"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/comments?post=113469"}],"version-history":[{"count":6,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/113469\/revisions"}],"predecessor-version":[{"id":139660,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/113469\/revisions\/139660"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media\/102156"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media?parent=113469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/categories?post=113469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/tags?post=113469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}