{"id":111073,"date":"2022-02-08T06:00:01","date_gmt":"2022-02-08T05:00:01","guid":{"rendered":"https:\/\/semmelweis.hu\/hirek\/?p=111073"},"modified":"2022-02-08T10:39:56","modified_gmt":"2022-02-08T09:39:56","slug":"tudomanyos-hirado-8","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/hirek\/2022\/02\/08\/tudomanyos-hirado-8\/","title":{"rendered":"Tudom\u00e1nyos h\u00edrad\u00f3 8."},"content":{"rendered":"
Tudom\u00e1nyos H\u00edrad\u00f3 c\u00edm\u0171 cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3. A cikkeket az elm\u00falt id\u0151szak megjelen\u00e9sei alapj\u00e1n a K\u00f6zponti K\u00f6nyvt\u00e1r, illetve dr. Szigeti Gyula innov\u00e1ci\u00f3s igazgat\u00f3 v\u00e1logatta.<\/div>\n
A kr\u00f3nikus fog\u00e1gy gyullad\u00e1s \u00e9s az Alzheimer-k\u00f3r kapcsolata<\/strong><\/h5>\n

\"\"<\/a>Az Alzheimer-k\u00f3r a kognit\u00edv hanyatl\u00e1s leggyakoribb oka, ami 50 milli\u00f3 embert \u00e9rint vil\u00e1gszerte, ugyanakkor kialakul\u00e1s\u00e1nak pontos oka nem tiszt\u00e1zott. Az egyik uralkod\u00f3 elm\u00e9let az \u00fagynevezett gyullad\u00e1sos hipot\u00e9zis, miszerint a szervezetben lezajl\u00f3 kr\u00f3nikus gyullad\u00e1s olyan m\u00f3don v\u00e1ltoztatja meg az idegsz\u00f6vet m\u0171k\u00f6d\u00e9s\u00e9t, ami idegsejtelhal\u00e1st okozhat. Ebben szerepe lehet a kr\u00f3nikus fog\u00e1gy gyullad\u00e1snak (periodontitisz) is, ami a fogak t\u00e1maszt\u00f3sz\u00f6veteinek k\u00e1rosod\u00e1s\u00e1val j\u00e1r, v\u00e9g\u00fcl a fogak elveszt\u00e9s\u00e9hez vezetve.<\/p>\n

A demencia \u00e9s a fog\u00e1gy gyullad\u00e1s k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9s nem kell\u0151k\u00e9ppen tiszt\u00e1zott, mivel az eddig megjelent k\u00f6zlem\u00e9nyek a gyullad\u00e1s \u00e9s a kognit\u00edv hanyatl\u00e1s m\u00e9rt\u00e9k\u00e9nek m\u00e9r\u00e9s\u00e9re is rendk\u00edv\u00fcl k\u00fcl\u00f6nb\u00f6z\u0151 m\u00f3dszertant alkalmaznak. Ennek eld\u00f6nt\u00e9s\u00e9re teh\u00e1t olyan kutat\u00e1sok sz\u00fcks\u00e9gesek, amelyek egys\u00e9ges m\u00f3don, kvantitat\u00edvan elemzik az ok-okozati kapcsolatot. Ugyanakkor amennyiben a k\u00e9t betegs\u00e9g k\u00f6z\u00f6tti kapcsolat val\u00f3ban fenn\u00e1ll, \u00fagy felt\u00e9telezhet\u0151en a demencia kialakul\u00e1s\u00e1nak val\u00f3sz\u00edn\u0171s\u00e9ge cs\u00f6kkenthet\u0151 megfelel\u0151 sz\u00e1jhigi\u00e9nia \u00e9s fog\u00e1szati kezel\u00e9s alkalmaz\u00e1s\u00e1val \u2013 \u00f6sszegezte dr. Bata Zs\u00f3fia.<\/p>\n

\n

The Association of Periodontitis and Alzheimer\u2019s Disease: How to Hit Two Birds with One Stone
\nWerber, Tom (Faculty of Medicine, Semmelweis University), Bata, Zsofia (Department of Conservative Dentistry, Semmelweis University), Vaszine, Eniko Szabo (Department of Conservative Dentistry, Semmelweis University), \u00a0Berente, Dalida Borbala<\/a> (Faculty of Medicine, Semmelweis University; Neurocognitive Research Center, National Institute of Mental Health, Neurology and Neurosurgery), Kamondi, Anita (Neurocognitive Research Center, National Institute of Mental Health, Neurology and Neurosurgery; Department of Neurology, Semmelweis University), Horvath, Andras Attila (Neurocognitive Research Center, National Institute of Mental Health, Neurology and Neurosurgery; Department of Anatomy, Histology and Embryology, Semmelweis University)
\nJournal of Alzheimer’s Disease, vol. 84, no. 1, pp. 1-21, 2021
\ndoi.org\/10.3233\/JAD-210491<\/a><\/p>\n<\/div>\n

Gyullad\u00e1sos \u00fatvonalak jelent\u0151s\u00e9ge a sz\u00edvel\u00e9gtelens\u00e9g k\u00f3rfolyamat\u00e1ban \u00e9s kezel\u00e9s\u00e9ben<\/strong><\/h5>\n

\"\"<\/a>A kr\u00f3nikus sz\u00edvel\u00e9gtelens\u00e9g kezel\u00e9s\u00e9ben a transzplant\u00e1ci\u00f3n \u00e9s eszk\u00f6z\u00f6s beavatkoz\u00e1sokon t\u00fal t\u00f6bb gy\u00f3gyszeres kezel\u00e9si strat\u00e9gia alkalmazhat\u00f3, azonban a betegs\u00e9g hossz\u00fat\u00e1von \u00edgy is komoly fizik\u00e1lis, pszich\u00e9s \u00e9s anyagi terhet jelent a p\u00e1ciens \u00e9s a t\u00e1rsadalom sz\u00e1m\u00e1ra egyar\u00e1nt. Ismert, hogy a sz\u00edvel\u00e9gtelens\u00e9g s\u00falyosbod\u00e1sa m\u00f6g\u00f6tt gyullad\u00e1sos \u00e9s immunol\u00f3giai folyamatok is \u00e1llnak, ugyanakkor jelenleg nincs a k\u00f3rh\u00e1zi gyakorlatban olyan gyullad\u00e1scs\u00f6kkent\u0151 gy\u00f3gyszer, amely a sz\u00edvel\u00e9gtelens\u00e9g kezel\u00e9s\u00e9ben tart\u00f3san haszn\u00e1latos lenne. Kutat\u00e1sunkban sz\u00edvel\u00e9gtelen betegekb\u0151l sz\u00e1rmaz\u00f3 sz\u00edvizom mint\u00e1kon vizsg\u00e1ltunk bizonyos gyullad\u00e1sos folyamatokat, majd relev\u00e1ns \u00e1llat- \u00e9s sejtkult\u00faramodelleken meger\u0151s\u00edtett\u00fck, hogy sz\u00edvel\u00e9gtelens\u00e9g sor\u00e1n az \u00fan. AIM2 \u00e9s NLRC4 inflammasz\u00f3ma szenzorfeh\u00e9rj\u00e9k mennyis\u00e9ge, valamint az \u00e1ltaluk aktiv\u00e1l\u00f3d\u00f3 citokinek sz\u00f6veti szintje megemelkedik emberben \u00e9s patk\u00e1nymodellben egyar\u00e1nt. Az azonos\u00edtott inflammasz\u00f3ma aktiv\u00e1ci\u00f3t egy k\u00f6szv\u00e9ny ter\u00e1pi\u00e1ban \u00e9vtizedek \u00f3ta sikerrel alkalmazott gy\u00f3gyszerrel, probeneciddel g\u00e1toltuk kr\u00f3nikus sz\u00edvel\u00e9gtelens\u00e9g patk\u00e1nymodellj\u00e9ben. A probeneciddel kezelt \u00e1llatok t\u00fal\u00e9l\u00e9se \u00e9s sz\u00edvfunkci\u00f3ja javult a kontroll \u00e1llatok\u00e9hoz k\u00e9pest, \u00e9s a gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s is kimutathat\u00f3 volt.<\/p>\n

Eredm\u00e9nyeink r\u00e1mutatnak, hogy a gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1k hat\u00e9konyak lehetnek kr\u00f3nikus sz\u00edvel\u00e9gtelens\u00e9g kezel\u00e9s\u00e9ben. Emellett felh\u00edvj\u00e1k a figyelmet a m\u00e1r piacon l\u00e9v\u0151 gy\u00f3gyszerek (pl. a probenecid) \u201e\u00fajrahasznos\u00edt\u00e1s\u00e1nak\u201d lehet\u0151s\u00e9g\u00e9re, az \u00fan. gy\u00f3gyszer \u00fajrapoz\u00edcion\u00e1l\u00e1sra, amely a gy\u00f3gyszerfejleszt\u00e9s k\u00f6lts\u00e9ghat\u00e9konyabb \u00e9s alkalmank\u00e9nt biztons\u00e1gosabb form\u00e1ja lehet \u2013 fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban dr. On\u00f3di Zs\u00f3fia.<\/p>\n

\n

AIM2-driven inflammasome activation in heart failure
\nZs\u00f3fia On\u00f3di (Department of Pharmacology and Pharmacotherapy, Semmelweis University), Mih\u00e1ly Ruppert (Heart and Vascular Center, Semmelweis University), D\u00e1niel Kucsera (Department of Pharmacology and Pharmacotherapy, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group), Alex Ali Sayour (Heart and Vascular Center, Semmelweis University), Vikt\u00f3ria E T\u00f3th (Department of Pharmacology and Pharmacotherapy, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group), G\u00e1bor Koncsos (Department of Pharmacology and Pharmacotherapy, Semmelweis University), Julianna Nov\u00e1k (Department of Pharmacology and Pharmacotherapy, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group), G\u00e1bor B Brenner (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group; MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University), Andr\u00e1s Makkos (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group; MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University), Tam\u00e1s Baranyai (Department of Pharmacology and Pharmacotherapy, Semmelweis University), Zolt\u00e1n Giricz (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group), Anik\u00f3 G\u00f6rbe (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group; MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University), Przemyslaw Leszek (Department of Heart Failure and Transplantology, Cardinal Stefan Wyszy\u0144ski National Institute of Cardiology), Mariann Gy\u00f6ngy\u00f6si (Department of Cardiology, Medical University of Vienna), Iv\u00e1n G Horv\u00e1th (Heart Institute, Faculty of Medicine, University of P\u00e9cs), Iv\u00e1n G Horv\u00e1th (Heart Institute, Faculty of Medicine, University of P\u00e9cs), Rainer Schulz (Institute of Physiology, Justus Liebig University Giessen), B\u00e9la Merkely (Heart and Vascular Center, Semmelweis University), P\u00e9ter Ferdinandy (Department of Pharmacology and Pharmacotherapy, Semmelweis University; Pharmahungary Group; MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University), Tam\u00e1s Radovits (Heart and Vascular Center, Semmelweis University), Zolt\u00e1n V Varga (Department of Pharmacology and Pharmacotherapy, Semmelweis University; HCEMM-SU Cardiometabolic Immunology Research Group; Pharmahungary Group)
\nCardiovascular Research, Volume 117, Issue 13, 15 November 2021, Pages 2639\u20132651. https:\/\/doi.org\/10.1093\/cvr\/cvab202<\/a><\/p>\n<\/div>\n

Lymphoma terjed\u00e9s vizsg\u00e1lata multimodalit\u00e1s\u00fa k\u00e9palkot\u00e1s seg\u00edts\u00e9g\u00e9vel<\/strong><\/h5>\n

\"\"<\/a>Az elm\u00falt \u00e9vtizedekben az FDG PET\/CT k\u00e9palkot\u00f3 m\u00f3dszer a tumor ter\u00e1pia hat\u00e9konys\u00e1g becsl\u00e9s\u00e9nek legfontosabb eszk\u00f6z\u00e9v\u00e9 v\u00e1lt. Vizsg\u00e1lataink sor\u00e1n egerekben diff\u00faz nagy B sejtes lymphom\u00e1t (Bc-DLFL.1) vizsg\u00e1ltunk, amely a hum\u00e1n agressz\u00edv lymphoma terjed\u00e9s\u00e9nek modellje lehetett. Munk\u00e1nkban v\u00e1laszt kerest\u00fcnk a radiofarmakonok sejtek \u00e1ltali felv\u00e9tel\u00e9re, \u00e9s az \u00faj Cserenkov-k\u00e9palkot\u00e1s (CLI) alkalmazhat\u00f3s\u00e1g\u00e1ra. Vizsg\u00e1ltuk a radiofarmakonok sz\u00f6veti eloszl\u00e1s\u00e1nak inhomogenit\u00e1s\u00e1t, mivel ismert, hogy ennek nagy jelent\u0151s\u00e9ge lehet a tumor progn\u00f3zis becsl\u00e9s\u00e9ben \u00e9s a kezel\u00e9s tervez\u00e9s\u00e9ben. A CLI egy olyan k\u00e9palkot\u00f3 m\u00f3dszer, amellyel sz\u00e1mos a nukle\u00e1ris medicina sor\u00e1n haszn\u00e1latos radiofarmakon nyomon k\u00f6vethet\u0151.<\/p>\n

A cikk\u00fcnkben bemutatunk \u00e9s valid\u00e1lunk egy Cserenkov sug\u00e1rz\u00e1s alap\u00fa detektort. Eredm\u00e9nyeink el\u0151revet\u00edtik, hogy m\u0171t\u00e9t k\u00f6zben gyorsan \u00e9s hat\u00e9konyan ki tudjuk mutatni egy-egy alkalmazott radiofarmakon halmoz\u00f3d\u00e1s\u00e1t. Ez\u00e1ltal az tumor kiv\u00e9tele ut\u00e1n azonnal vizsg\u00e1lhat\u00f3v\u00e1 v\u00e1lhat a seb\u00e9szi sz\u00e9l \u00e9rintetts\u00e9ge \u00e9s a tumor inhomogenit\u00e1sa. \u00d6sszess\u00e9g\u00e9ben a preklinikai vizsg\u00e1lataink alapj\u00e1n t\u00e1mogathat\u00f3 a SPECT, a PET \u00e9s a CLI egy\u00fcttes alkalmaz\u00e1sa a klinikai onkol\u00f3giai gyakorlatban is \u2013 \u00edrta \u00f6sszefoglal\u00f3j\u00e1ban dr. M\u00e1th\u00e9 Domokos.<\/p>\n

\n

In situ lymphoma imaging in a spontaneous mouse model using the Cerenkov Luminescence of F-18 and Ga-67 isotopes
\nZsombor Ritter (Department of Nuclear Medicine, Medical School, University of P\u00e9cs), Katalin Z\u00e1mb\u00f3 (Department of Nuclear Medicine, Medical School, University of P\u00e9cs), P\u00e9ter Balogh (Department of Immunology and Biotechnology, University of P\u00e9cs), D\u00e1vid Sz\u00f6ll\u0151si (Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine), Xinkai Jia (Department of Immunology and Biotechnology, University of P\u00e9cs), \u00c1kos Bal\u00e1zs (Semmelweis University Faculty of Medicine 1st Department of Surgery), Gabriella Taba (Semmelweis University Dosimetry and Medical Physics Service), D\u00e1niel Dezs\u0151 (Department of Nuclear Medicine, Medical School, University of P\u00e9cs), Ildik\u00f3 Horv\u00e1th (Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine), Hussain Alizadeh (1St Department of Internal Medicine, University of P\u00e9cs Medical School), David Tuch (Lightpoint Medical Ltd.), Kunal Vyas (Lightpoint Medical Ltd.), Nikolett Heged\u0171s (Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine, CROmed Ltd.), Tibor Kov\u00e1cs (Institute of Radiochemistry and Radioecology, University of Pannonia), Kriszti\u00e1n Szigeti (Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine), Domokos M\u00e1th\u00e9 (Department of Biophysics and Radiation Biology, Semmelweis University Faculty of Medicine, CROmed Ltd.; In vivo Imaging Advanced Core Facility, Hungarian Center of Excellence for Molecular Medicine (HCEMM)), Erzs\u00e9bet Schmidt (Department of Nuclear Medicine, Medical School, University of P\u00e9cs)
\nScientific Reports volume 11, Article number: 24002 (2021)
\nDOI: 10.1038\/s41598-021-03505-3<\/a><\/p>\n<\/div>\n

Az ism\u00e9tl\u0151d\u0151 negat\u00edv gondolkod\u00e1s biol\u00f3gi\u00e1ja: az id\u0151perspekt\u00edva \u00e9s a fol\u00e1tfogyaszt\u00e1s szerepe<\/strong><\/h5>\n

\"\"<\/a>Az ism\u00e9tl\u0151d\u0151 (perszeverat\u00edv) negat\u00edv gondolkod\u00e1s sz\u00e1mos testi \u00e9s lelki betegs\u00e9gre (pl. depresszi\u00f3, szorong\u00e1s) hajlamos\u00edt, ez\u00e9rt biol\u00f3giai meghat\u00e1roz\u00f3ival is fontos tiszt\u00e1ban lenn\u00fcnk. Mivel a fol\u00e1t nev\u0171 B-vitamin fogyaszt\u00e1sa eg\u00e9sz \u00e9let\u00fcnk sor\u00e1n hat\u00e1ssal lehet ment\u00e1lis m\u0171k\u00f6d\u00e9s\u00fcnkre, jelen kutat\u00e1sunkban az ism\u00e9tl\u0151d\u0151 negat\u00edv gondolkod\u00e1s k\u00e9t t\u00edpus\u00e1val val\u00f3 \u00f6sszef\u00fcgg\u00e9s\u00e9t vizsg\u00e1ltuk k\u00f6z\u00e9pkor\u00fa feln\u0151ttek k\u00f6r\u00e9ben, k\u00e9rd\u0151\u00edves m\u00f3dszerrel.<\/p>\n

Eredm\u00e9nyeink szerint az el\u00e9gtelen fol\u00e1tbevitel az \u00e1ltal\u00e1nos aggodalmaskod\u00e1sra k\u00f6zvetlen\u00fcl jelent kock\u00e1zatot. Ezzel szemben egy m\u00faltbeli k\u00ednos esem\u00e9nyen val\u00f3 r\u00e1g\u00f3d\u00e1s nem k\u00f6zvetlen\u00fcl f\u00fcgg a fol\u00e1tbevitelt\u0151l, hanem a r\u00e1 hajlamos\u00edt\u00f3 g\u00e9nek f\u00fcggnek t\u0151le. El\u00e9gtelen fol\u00e1tbevitel eset\u00e9n a DNS-oszt\u00f3d\u00e1s, m\u00e9hen bel\u00fcli fejl\u0151d\u00e9s \u00e9s agyfejl\u0151d\u00e9s, valamint az immunrendszer bizonyos g\u00e9njei, el\u00e9gs\u00e9ges fol\u00e1tbevitel eset\u00e9n pedig agyi idegsejtek ingerelhet\u0151s\u00e9g\u00e9t, tanul\u00e9konys\u00e1g\u00e1t befoly\u00e1sol\u00f3 g\u00e9nek f\u00fcggnek \u00f6ssze a m\u00falton val\u00f3 r\u00e1g\u00f3d\u00e1ssal. Az \u00f6sszevont csoportban, fol\u00e1tbevitelt\u0151l f\u00fcggetlen\u00fcl, pedig olyan, \u00e1tfog\u00f3 hat\u00e1s\u00fa g\u00e9nek f\u00fcggnek vele \u00f6ssze, amelyek hat\u00e1ssal lehetnek mindezekre az elt\u00e9r\u0151 fol\u00e1t\u00e9rz\u00e9kenys\u00e9g\u0171 biol\u00f3giai r\u00e9szfolyamatokra \u2013 foglalta \u00f6ssze dr. Eszl\u00e1ri N\u00f3ra.<\/p>\n

\n

A cikk a Creative Commons „CC BY” licensze alapj\u00e1n jelent meg.
\nBiology of Perseverative Negative Thinking: The Role of Timing and Folate Intake
\nNora Eszlari (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University), Bence Bruncsics (Department of Measurement and Information Systems, Budapest University of Technology and Economics), Andras Millinghoffer (NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University; Department of Measurement and Information Systems, Budapest University of Technology and Economics), Gabor Hullam (Department of Measurement and Information Systems, Budapest University of Technology and Economics; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University), Peter Petschner (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University; Bioinformatics Center, Institute for Chemical Research, Kyoto University), Xenia Gonda (NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University; Department of Psychiatry and Psychotherapy, Semmelweis University), Gerome Breen (Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London; UK National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC)), Peter Antal (Department of Measurement and Information Systems, Budapest University of Technology and Economics), Gyorgy Bagdy (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University), John Francis William Deakin (Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester), Gabriella Juhasz (Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University; SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University)
\nNutrients 2021, 13(12), 4396.
\nhttps:\/\/doi.org\/10.3390\/nu13124396<\/a><\/p>\n<\/div>\n

Az affekt\u00edv temperamentumok, illetve s\u00falyos koszor\u00fa\u00e9r-betegs\u00e9g kapcsolata<\/strong><\/h5>\n

\"\"<\/a>Az affekt\u00edv temperamentumok (depressz\u00edv, ingerl\u00e9keny, szorong\u00f3, hipert\u00edm, ciklot\u00edm) olyan egy\u00e9ni szem\u00e9lyis\u00e9gjegyek, jellemvon\u00e1sok \u00f6sszess\u00e9ge, melyek meghat\u00e1rozz\u00e1k az egy\u00e9n \u00e9rzelmi reakci\u00f3t adott helyzetekben. Ezen temperamentumok egyfel\u0151l bizonyos pszichi\u00e1triai k\u00f3rk\u00e9pek el\u0151fut\u00e1rainak tekinthet\u0151k, m\u00e1sr\u00e9szt bizony\u00edtottan emelik egyes sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek kialakul\u00e1s\u00e1nak rizik\u00f3j\u00e1t.<\/p>\n

Keresztmetszeti vizsg\u00e1latunkba 225, a V\u00e1rosmajori Sz\u00edv- \u00e9s \u00c9rgy\u00f3gy\u00e1szati Klinik\u00e1n klinikailag indik\u00e1lt koszor\u00fa\u00e9r CTA-n \u00e1tesett mellkasi panaszos beteget vontunk be. Eredm\u00e9nyeink alapj\u00e1n mind az emelkedett koleszterin-szint, mind a gyakori hangulatingadoz\u00e1sok \u00e1ltal jellemzett ciklot\u00edm temperamentum n\u00f6velik a s\u00falyos fok\u00fa, stent be\u00fcltet\u00e9s\u00e9nek indik\u00e1ci\u00f3j\u00e1t k\u00e9pz\u0151 sz\u0171k\u00fcletek jelenl\u00e9t\u00e9nek val\u00f3sz\u00edn\u0171s\u00e9g\u00e9t. M\u00e1sfel\u0151l viszont az optimista \u00e9s extrovert\u00e1lt karakterjegyek \u00e1ltal defini\u00e1lt hipert\u00edm temperamentum protekt\u00edv hat\u00e1s\u00fanak bizonyult a s\u00falyos fok\u00fa koszor\u00fa\u00e9r-betegs\u00e9g tekint\u00e9ben a vizsg\u00e1lt popul\u00e1ci\u00f3ban. Kutat\u00e1sunk tov\u00e1bbi evidenci\u00e1t szolg\u00e1ltat a temperamentumok kedvez\u0151tlen prognosztikai szerep\u00e9t illet\u0151en, rutinszer\u0171 alkalmaz\u00e1suk tov\u00e1bb pontos\u00edthatja a betegek egy\u00e9ni sz\u00edv- \u00e9s \u00e9rrendszeri rizik\u00f3j\u00e1nak felm\u00e9r\u00e9s\u00e9t \u2013 fogalmazott \u00f6sszefoglal\u00f3j\u00e1ban dr. Vecsey-Nagy Mil\u00e1n.<\/p>\n

\n

Association between affective temperaments and severe coronary artery disease
\nMil\u00e1n Vecsey-Nagy (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), B\u00e1lint Szilveszter (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), M\u00e1rton Kolossv\u00e1ry (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Melinda Boussoussou (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Borb\u00e1la Vattay (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), Xenia Gonda (NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University; Department of Psychiatry and Psychotherapy, Semmelweis University; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group), Zolt\u00e1n Rihmer (Department of Psychiatry and Psychotherapy, Semmelweis University; Ny\u00edr\u0151 Gyula National Institute of Psychiatry and Addictions), B\u00e9la Merkely (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), P\u00e1l Maurovich-Horvat (MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University; Medical Imaging Centre, Semmelweis University), J\u00e1nos Nemcsik (Department of Family Medicine, Semmelweis University; Health Service of Zugl\u00f3 (ZESZ))
\nJournal of Affective Disorders, Volume 295, 1 December 2021, Pages 914-919.
\nhttps:\/\/doi.org\/10.1016\/j.jad.2021.08.063<\/a><\/p>\n<\/div>\n

Makrof\u00e1gok \u00e9s a v\u00e9r-b\u00e9lidegrendszer g\u00e1t k\u00f6lcs\u00f6nhat\u00e1sa a vastagb\u00e9lgyullad\u00e1sban<\/strong><\/h5>\n
\"\"<\/a>
ImageJ=1.52p
\nunit=micron<\/figcaption><\/figure>\n

Kutat\u00f3csoportunk kutat\u00e1si ter\u00fclete a b\u00e9lhez-asszoci\u00e1lt nyirokszervek \u00e9s a b\u00e9lidegrendszer fejl\u0151d\u00e9se. Embryomanipul\u00e1ci\u00f3s k\u00eds\u00e9rletekkel, p\u00e1r \u00e9vvel ezel\u0151tt kimutattuk, hogy a b\u00e9lidegrendszer ganglionjaiban kering\u00e9sb\u0151l sz\u00e1rmaz\u00f3 ny\u00falv\u00e1nyos sejtek fordulnak el\u0151. Az \u00faj sejtt\u00edpust intraganglion\u00e1ris makrof\u00e1goknak (IGM) nevezt\u00fck el, ami az enter\u00e1lis neuronokat \u00e9s gli\u00e1t k\u00f6rbefonva, a ganglionokat k\u00f6rnyezet\u00fckt\u0151l elhat\u00e1rol\u00f3 extracellul\u00e1ris m\u00e1trix membr\u00e1non bel\u00fcl helyezkednek el \u00e9s kifejezetten a k\u00f6zponti idegrendszeri microgli\u00e1hoz hasonl\u00f3 markereket expressz\u00e1lnak. Az IGM-et c\u00e9lz\u00f3 vizsg\u00e1latokkal az enter\u00e1lis ganglionok k\u00f6r\u00fcl tal\u00e1lhat\u00f3 extracellul\u00e1ris m\u00e1trix barrier szerkezet\u00e9t \u00e9s \u00e9lettani funkci\u00f3j\u00e1t k\u00edv\u00e1ntuk meg\u00e9rteni. Szuper-rezol\u00faci\u00f3s \u00e9s elektronmikroszk\u00f3pi\u00e1val kimutattuk, hogy a b\u00e9lben l\u00e9tezik egy v\u00e9r-b\u00e9lidegrendszer g\u00e1t, ami a v\u00e9r-agy g\u00e1thoz hasonl\u00f3an folyamatos gliatalp r\u00e9tegb\u0151l, m\u00e1trix feh\u00e9rj\u00e9kb\u0151l \u00e9s baz\u00e1lis membr\u00e1nb\u00f3l \u00e1ll.<\/p>\n

K\u00eds\u00e9rleteink alapj\u00e1n a feln\u0151tt egerek fluoreszcens dextr\u00e1nnal t\u00f6rt\u00e9nt felt\u00f6lt\u00e9se inform\u00e1ci\u00f3t ny\u00fajtott a v\u00e9r-b\u00e9lidegrendszer barrier permeabilit\u00e1s\u00e1r\u00f3l, amit \u00f6ssze tudtuk hasonl\u00edtani a v\u00e9r-agy g\u00e1ttal. A fluorescens dextr\u00e1n r\u00e9szecsk\u00e9k fagocit\u00f3zisa alkalmas volt a makrof\u00e1gok migr\u00e1ci\u00f3j\u00e1nak in vivo k\u00f6vet\u00e9s\u00e9re is. A makrof\u00e1gok aktivit\u00e1sa \u00e9s a barrier k\u00f6z\u00f6tti kapcsolatot DSS-induk\u00e1lt eg\u00e9r b\u00e9lgyullad\u00e1sos modellben tanulm\u00e1nyoztuk, amit az liposzom\u00e1lis clodronate-al el\u0151id\u00e9zett makrof\u00e1g depl\u00e9ci\u00f3val \u00f6tv\u00f6zt\u00fcnk. Meg\u00e1llap\u00edtottuk, hogy colitis-ben a barrier lebomlik, permeabilit\u00e1sa megn\u0151, kit\u00e9ve a b\u00e9lidegrendszer neuronjait a gyullad\u00e1sos mikromili\u0151nek. \u00d6sszefoglalva elmondhat\u00f3, hogy a b\u00e9lidegrendszert hat\u00e1rol\u00f3 extracellul\u00e1ris m\u00e1trix barrier norm\u00e1l \u00e9s patol\u00f3gi\u00e1s k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt \u00e9rz\u00e9kenyen reag\u00e1l az intesztin\u00e1lis makrof\u00e1gok jelenl\u00e9t\u00e9re \u00e9s ennek kulcsszerepe van a b\u00e9lidegrendszert \u00e9rint\u0151 gyulad\u00e1sok patomechanizmus\u00e1ban – foglalta \u00f6ssze dr. Nagy N\u00e1ndor.<\/p>\n

\n

Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation
\nDavid Dora (Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University), Szilamer Ferenczi (Institute of Experimental Medicine, Laboratory of Molecular Neuroendocrinology), Rhian Stavely (Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School), <\/span>Viktoria E. Toth (Department of Pharmacology and Pharmacotherapy, Semmelweis University; <\/span>HCEMM-SU Cardiometabolic Immunology Research Group, Semmelweis University), <\/span>Zoltan V. Varga (Department of Pharmacology and Pharmacotherapy, Semmelweis University; <\/span>HCEMM-SU Cardiometabolic Immunology Research Group, Semmelweis University),\u00a0<\/span>Tamas Kovacs (Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University),\u00a0<\/span>Ildiko Bodi (Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University),\u00a0<\/span>Ryo Hotta (Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School), <\/span>Krisztina J. Kovacs (Institute of Experimental Medicine, Laboratory of Molecular Neuroendocrinology), Allan M. Goldstein (Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School), Nandor Nagy (Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University)
\nCMGH, Vol. 12, Issue 5, pp. 1617-1641. 2021
\nDOI: https:\/\/doi.org\/10.1016\/j.jcmgh.2021.07.003<\/a><\/span><\/p>\n<\/div>\n

 <\/p>\n

A HIV-fert\u0151z\u00e9s indirekt m\u00f3don gyors\u00edthatja a koszor\u00fa\u00e9r-betegs\u00e9g progresszi\u00f3j\u00e1t. Egy longitudin\u00e1lis vizsg\u00e1lat eredm\u00e9nyei.<\/h5>\n
\n

R\u00e9g\u00f3ta ismert, hogy a HIV-fert\u0151z\u00f6ttek k\u00f6r\u00e9ben gyakoribbak a nemk\u00edv\u00e1natos kardiovaszkul\u00e1ris esem\u00e9nyek, \u00fagy mint a sz\u00edvinfarktus. Az elm\u00falt \u00e9vtizedben egyes eredm\u00e9nyek kimutatt\u00e1k, hogy HIV-fert\u0151z\u00f6ttek k\u00f6r\u00e9ben t\u00f6bb a nem-kalcifik\u00e1lt vulner\u00e1bilis plakk, amely magyar\u00e1zhatja a megn\u00f6vekedett rizik\u00f3j\u00e1t ezen betegeknek, mivel ezek k\u00e9s\u0151bb okozhatnak nemk\u00edv\u00e1natos kardiovaszkul\u00e1ris esem\u00e9nyeket. Azonban nem ismert, hogy pontosan milyen mechanizmusok \u00e1lnak ezen jelens\u00e9g h\u00e1tter\u00e9ben.<\/p>\n

Egyes vizsg\u00e1latok kimutatt\u00e1k, hogy a HIV-fert\u0151z\u00e9s f\u00fcggetlen\u00fcl megn\u00f6veli a nem-kalcifik\u00e1lt vulner\u00e1bilis plakkok sz\u00e1m\u00e1t, amely azt jelenti, hogy ezen betegeknek mindenk\u00e9pp rosszabb koszor\u00fa\u00e9r-st\u00e1tuszuk lesz mint hasonl\u00f3 nem fert\u0151z\u00f6tt t\u00e1rsukn\u00e1l. Azonban a mi longitudin\u00e1lis vizsg\u00e1latunk r\u00e1mutatott, hogy val\u00f3sz\u00edn\u0171bb, hogy a HIV potenc\u00edrozza a t\u00f6bbi rizik\u00f3faktor negat\u00edv hat\u00e1s\u00e1t, \u00edgy ha szigor\u00fabb kontroll alatt tartjuk a rizik\u00f3faktorokat, akkor elker\u00fclhet\u0151 lehet a HIV negat\u00edv hat\u00e1sa a koszor\u00fa\u00e9r-betegs\u00e9gre – foglalta \u00f6ssze dr. Kolossv\u00e1ry M\u00e1rton.<\/p>\n

\n

HIV indirectly accelerates coronary artery disease by promoting the effects of risk factors: longitudinal observational study
\nM\u00e1rton Kolossv\u00e1ry (Department of Pathology, Johns Hopkins University School of Medicine; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University), David Celentano (Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health), Gary Gerstenblith (Department of Medicine, Johns Hopkins University School of Medicine), David A. Bluemke (School of Medicine and Public Health, University of Wisconsin), Raul N. Mandler (National Institute on Drug Abuse, National Institutes of Health), Elliot K. Fishman (Department of Radiology, Johns Hopkins University School of Medicine), Sandeepan Bhatia (Institute of Human Virology, University of Maryland School of Medicine), Shaoguang Chen (Institute of Human Virology, University of Maryland School of Medicine), Shenghan Lai (Department of Pathology, Johns Hopkins University School of Medicine; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health; Department of Medicine, Johns Hopkins University School of Medicine; Department of Radiology, Johns Hopkins University School of Medicine; Institute of Human Virology, University of Maryland School of Medicine), Hong Lai (Department of Radiology, Johns Hopkins University School of Medicine; Institute of Human Virology, University of Maryland School of Medicine)
\nScientific Reports 11, 23110 (2021).
\nhttps:\/\/doi.org\/10.1038\/s41598-021-02556-w<\/a><\/p>\n<\/div>\n

 <\/p>\n<\/div>\n

A r\u00f6vid \u00f6sszefoglal\u00f3kat a tudom\u00e1nyos publik\u00e1ci\u00f3k szerz\u0151i k\u00e9sz\u00edtett\u00e9k.
\nSzerkesztette: Szab\u00f3 \u00c1d\u00e1m
\nFot\u00f3: a publik\u00e1ci\u00f3kb\u00f3l sz\u00e1rmaz\u00f3 k\u00e9pek<\/p>\n","protected":false},"excerpt":{"rendered":"

Cikksorozatunkban az egyetemhez k\u00f6thet\u0151 D1 min\u0151s\u00edt\u00e9s\u0171 tudom\u00e1nyos k\u00f6zlem\u00e9nyekr\u0151l olvashat\u00f3 r\u00f6vid \u00f6sszefoglal\u00f3.<\/p>\n","protected":false},"author":101751,"featured_media":102156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[161,168],"tags":[4276],"class_list":["post-111073","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tudomany","category-kiemelt","tag-tudomanyos-hirado"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/111073","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/users\/101751"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/comments?post=111073"}],"version-history":[{"count":8,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/111073\/revisions"}],"predecessor-version":[{"id":111302,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/posts\/111073\/revisions\/111302"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media\/102156"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/media?parent=111073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/categories?post=111073"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/hirek\/wp-json\/wp\/v2\/tags?post=111073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}