{"id":1792,"date":"2026-06-08T17:17:48","date_gmt":"2026-06-08T15:17:48","guid":{"rendered":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/?p=1792"},"modified":"2026-06-08T17:18:02","modified_gmt":"2026-06-08T15:18:02","slug":"new-publication-in-cellular-molecular-biology-letters","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/2026\/06\/08\/new-publication-in-cellular-molecular-biology-letters\/","title":{"rendered":"New Publication in Cellular &amp; Molecular Biology Letters"},"content":{"rendered":"<p style=\"text-align: justify\" data-start=\"67\" data-end=\"260\">Our study, \u201cPhosphoproteomic profiling reveals post-translational dysregulation in Huntington\u2019s disease patient-derived neurons,\u201d is now published in <em data-start=\"221\" data-end=\"259\">Cellular &amp; Molecular Biology Letters<\/em>.<\/p>\n<p style=\"text-align: justify\" data-start=\"262\" data-end=\"717\">Using directly reprogrammed neurons from Huntington\u2019s disease patients, we generated the first phosphoproteomic map of this human age-preserved neuronal model and integrated it with matched proteomic and transcriptomic datasets. The study identified widespread signaling alterations affecting RNA splicing, autophagy, and stress-response pathways, and highlighted MXRA8 as a phospho-switch candidate linked to disrupted proteostasis and autophagy.<\/p>\n<p style=\"text-align: justify\" data-start=\"719\" data-end=\"967\">This work was led by shared first authors Lea Danics and Chandramouli Muralidharan, in collaboration with partners from Semmelweis University, HCEMM, HUN-REN, Lund University, the University of Cambridge, and the University of Montreal.<\/p>\n<p style=\"text-align: justify\" data-start=\"969\" data-end=\"1032\" data-is-last-node=\"\" data-is-only-node=\"\">\ud83d\udd17 <a class=\"decorated-link\" href=\"https:\/\/link.springer.com\/article\/10.1186\/s11658-026-00948-2\" target=\"_blank\" rel=\"noopener\">https:\/\/link.springer.com\/article\/10.1186\/s11658-026-00948-2<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our study, \u201cPhosphoproteomic profiling reveals post-translational dysregulation in Huntington\u2019s disease patient-derived neurons,\u201d is now published in Cellular &amp; Molecular Biology Letters. Using directly reprogrammed neurons from Huntington\u2019s disease patients, we generated the first phosphoproteomic map of this human age-preserved neuronal model and integrated it with matched proteomic and transcriptomic datasets. The study identified widespread signaling &hellip;<\/p>\n","protected":false},"author":101875,"featured_media":1793,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1792","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts\/1792","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/users\/101875"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/comments?post=1792"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts\/1792\/revisions"}],"predecessor-version":[{"id":1794,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts\/1792\/revisions\/1794"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/media\/1793"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/media?parent=1792"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/categories?post=1792"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/tags?post=1792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}