{"id":1784,"date":"2026-05-30T08:11:48","date_gmt":"2026-05-30T06:11:48","guid":{"rendered":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/?p=1784"},"modified":"2026-05-30T08:11:48","modified_gmt":"2026-05-30T06:11:48","slug":"new-preprint","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/2026\/05\/30\/new-preprint\/","title":{"rendered":"New preprint!"},"content":{"rendered":"
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Excited to share our new bioRxiv preprint, led by the outstanding PhD student Melinda, co-supervised by Attila and Karolina:<\/p>\n

\u201cCariprazine modulates intrinsic excitability and network dynamics of hippocampal neurons in a cell-type dependent manner.\u201d<\/em><\/p>\n

This study was a truly interdisciplinary collaboration between Semmelweis University, HCEMM, HUN-REN SZTAKI, ELTE, and the Medical University of Innsbruck. By combining real-world clinical data from schizophrenia patients, multielectrode array (MEA) recordings, patch-clamp electrophysiology, computational modeling, and molecular analyses, we investigated how the antipsychotic drug cariprazine influences neuronal function and network activity.<\/p>\n

Our findings suggest that cariprazine modulates hippocampal neuronal excitability through cell-type-specific mechanisms linked to Kv1-mediated potassium currents, while largely preserving network synchronization. Importantly, the study connects these mechanistic observations with nationwide clinical outcome data, offering a translational perspective on antipsychotic drug action in schizophrenia.<\/p>\n

We are grateful to all co-authors for bringing together expertise from neuroscience, psychiatry, electrophysiology, bioinformatics, and computational biology.<\/p>\n

https:\/\/www.biorxiv.org\/content\/10.64898\/2026.05.22.727184v1<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Excited to share our new bioRxiv preprint, led by the outstanding PhD student Melinda, co-supervised by Attila and Karolina: \u201cCariprazine modulates intrinsic excitability and network dynamics of hippocampal neurons in a cell-type dependent manner.\u201d This study was a truly interdisciplinary collaboration between Semmelweis University, HCEMM, HUN-REN SZTAKI, ELTE, and the Medical University of Innsbruck. By …<\/p>\n","protected":false},"author":101875,"featured_media":1301,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts\/1784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/users\/101875"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/comments?post=1784"}],"version-history":[{"count":1,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts\/1784\/revisions"}],"predecessor-version":[{"id":1785,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/posts\/1784\/revisions\/1785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/media\/1301"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/media?parent=1784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/categories?post=1784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/hcemm-neurobiology\/wp-json\/wp\/v2\/tags?post=1784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}