{"id":75,"date":"2020-07-17T11:30:52","date_gmt":"2020-07-17T09:30:52","guid":{"rendered":"https:\/\/semmelweis.hu\/trajectome\/?page_id=75"},"modified":"2025-11-27T14:04:54","modified_gmt":"2025-11-27T13:04:54","slug":"publication","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/en\/previous-projects\/trajectome\/publication\/","title":{"rendered":"Publication"},"content":{"rendered":"
\n

Dissemination activities of the TRAJECTOME project<\/h2>\n

2025<\/h2>\n

Nagy, T., Gonda, X., Gezsi, A., Eszlari, N., Hullam, G., Gonz\u00e1lez-Colom, R., M\u00e4kinen, H., Paajanen, T., Torok, D., Gal, Z., Petschner, P., Cano, I., Kuokkanen, M., Schmidt, C. O., Van der Auwera, S., Roca, J., Antal, P., & Juhasz, G. (2025). Pharmacological profiling of major depressive disorder-related multimorbidity clusters.\u00a0European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology<\/i>,\u00a096<\/i>, 71\u201383. https:\/\/doi.org\/10.1016\/j.euroneuro.2025.05.007<\/a><\/p>\n

2024<\/h1>\n

Publications (2024)<\/h2>\n

Bonk, S., N. Eszlari, K. Kirchner, A. Gezsi, L. Garvert, M. Kuokkanen, I. Cano, H. J. Grabe, P. Antal, G. Juhasz and S. Van der Auwera (2024). &quot;Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters.&quot; Journal of Affective Disorders 359: 382-391.
\nhttps:\/\/doi.org\/10.1016\/j.jad.2024.05.126<\/a><\/p>\n

Gezsi, A., S. Van der Auwera, H. M\u00e4kinen, N. Eszlari, G. Hullam, T. Nagy, S. Bonk, R. Gonz\u00e1lez-Colom, X. Gonda, L. Garvert, T. Paajanen, Z. Gal, K. Kirchner, A. Millinghoffer, C. O. Schmidt, B. Bolgar, J. Roca, I. Cano, M. Kuokkanen, P. Antal and G. Juhasz (2024). &quot;Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.&quot; Nature Communications 15(1): 7190.
\nhttps:\/\/doi.org\/10.1038\/s41467-024-51467-7<\/a><\/p>\n

Gonz\u00e1lez-Colom, R., K. Mitra, E. Vela, A. Gezsi, T. Paajanen, Z. G\u00e1l, G. Hullam, H. M\u00e4kinen, T. Nagy, M. Kuokkanen, J. Piera-Jim\u00e9nez, J. Roca, P. Antal, G. Juhasz and I. Cano (2024). &quot;Multicentric Assessment of a Multimorbidity-Adjusted Disability Score to Stratify Depression-Related Risks Using Temporal Disease Maps: Instrument Validation Study.&quot; J Med Internet Res 26: e53162.
\nhttps:\/\/doi.org\/10.2196\/53162<\/a><\/p>\n

2023<\/h1>\n

Publications (2023)<\/h2>\n

Kevin Kirchner, Linda Garvert, Katharina Wittfeld, Sabine Ameling, Robin B\u00fclow, Henriette Meyer zu Schwabedissen, Mattias Nauck, Henry V\u00f6lzke, Hans J. Grabe, Sandra Van der Auwera; Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population; Int J Mol Sci, 2023 Jan 6;24(2):1120.
\nhttps:\/\/doi.org\/10.3390\/ijms24021120<\/a><\/p>\n

Sandra Van der Auwera, Linda Garvert, Sabine Ameling, Henry V\u00f6lzke, Matthias Nauck, Uwe V\u00f6lker, Hans J. Grabe; The interplay between micro RNAs and genetic liability to Alzheimer\u2019s Disease on memory trajectories in the general population; Psychiatry Res, 2023 May: 323:115141.
\nhttps:\/\/doi.org\/10.1016\/j.psychres.2023.115141<\/a><\/p>\n

Kristof, Z., Z. Gal, D. Torok, N. Eszlari, S. Sutori, B. Erdelyi-Hamza, P. Petschner, B. Sperlagh, I. M. Anderson, J. F. W. Deakin, G. Bagdy, G. Juhasz and X. Gonda (2023). „Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation.” Scientific Reports 13(1): 7757.
\nhttps:\/\/doi.org\/10.1038\/s41598-023-34781-w<\/a><\/p>\n

Juhasz, G., K. Gecse and D. Baksa (2023). „Towards precision medicine in migraine: Recent therapeutic advances and potential biomarkers to understand heterogeneity and treatment response.” Pharmacology & Therapeutics 250: 108523.
\nhttps:\/\/doi.org\/10.1016\/j.pharmthera.2023.108523<\/a><\/p>\n

Gal, Z., D. Torok, X. Gonda, N. Eszlari, I. M. Anderson, B. Deakin, G. Juhasz, G. Bagdy and P. Petschner (2022). „Inflammation and Blood-Brain Barrier in Depression: Interaction of CLDN5 and IL6 Gene Variants in Stress-Induced Depression.” International Journal of Neuropsychopharmacology 26(3): 189-197.
\nhttps:\/\/doi.org\/10.1093\/ijnp\/pyac079<\/a><\/p>\n

Bruncsics, B., G. Hullam, B. Bolgar, P. Petschner, A. Millinghoffer, K. Gecse, N. Eszlari, X. Gonda, D. J. Jones, S. T. Burden, P. Antal, B. Deakin, G. Bagdy and G. Juhasz (2023). „Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids.” Scientific Reports 13(1): 4976.
\nhttps:\/\/doi.org\/10.1038\/s41598-023-31495-x<\/a><\/p>\n

PhD Thesis – Rub\u00e8n Gonz\u00e1lez-Colom, Predictive Modelling for Personalised Multimorbidity Management. Faculty of Medicine, University of Barcelona. (2023)<\/p>\n

Sarah Bonk, Nora Eszlari, Kevin Kirchner, Andras Gezsi, Linda Garvert, Mikko Koukkanen, Isaac Cano, Hans J. Grabe, Peter Antal, Gabriella Juhasz, Sandra Van der Auwera; Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters; under review J Affect Disord, 2023
\nhttps:\/\/doi.org\/10.21203\/rs.3.rs-3456781\/v1<\/a><\/p>\n

Rub\u00e8n Gonz\u00e1lez-Colom, Kangkana Mitra, Emili Vela, Andras Gezsi, Teemu Paajanen, Zsofia Gal, Gabor Hullam, Hannu M\u00e4kinen, Tamas Nagy, Mikko Kuokkanen, Jordi Piera-Jim\u00e9nez, Josep Roca, Peter Antal, Gabriella Juhasz, Isaac Cano, Multicentric validation of a Multimorbidity Adjusted Disability Score to stratify depression-related risks using temporal disease maps; under review Journal of Medical Internet Research (JMIR), 2023
\nhttps:\/\/doi.org\/10.1101\/2023.09.04.23295005<\/a><\/p>\n

Andras Gezsi, Sandra Van der Auwera, Hannu M\u00e4kinen, Nora Eszlari, Gabor Hullam, Tamas Nagy, Sarah Bonk, Rub\u00e8n Gonz\u00e1lez-Colom, Xenia Gonda, Linda Garvert, Teemu Paajanen, Zsofia Gal, Kevin Kirchner, Andras Millinghoffer, Carsten\u00a0 O.\u00a0 Schmidt, Bence Bolgar, Josep Roca, Isaac Cano, Mikko Kuokkanen, Peter Antal, Gabriella Juhasz. Unique genetic and risk-factor profiles in multimorbidity clusters of depression-related disease trajectories from a study of 1.2 million subjects; under review Nature Communication, 2023
\nhttps:\/\/doi.org\/10.21203\/rs.3.rs-3199113\/v1<\/a><\/p>\n

Gabor Hullam, Zsofia Gal, Xenia Gonda, Tamas Nagy, Andras Gezsi, Isaac Cano, Sandra Van der Auwera, Mikko Kuokkanen, Peter Antal, Gabriella Juhasz. A sound mind in a sound body: a novel concept unravelling depression heterogeneity. Neuropsychopharmacologia Hungarica (under submission), Project summary paper
\nhttps:\/\/mppt.hu\/magazin\/pdf\/vol25issue4\/v25i4p183.pdf<\/a><\/p>\n

Conferences (2023)<\/h2>\n

Dobos, D., G. K\u00f6k\u00f6nyei, G. Gyebn\u00e1r, K. Gecse, E. Szab\u00f3, D. Baksa, N. Kocsel, A. Galambos, T. Zsomb\u00f3k, L. R. Koz\u00e1k and G. Juh\u00e1sz (2023). „Microstructural differences in migraine: a diffusion tensor imaging study.” Neuroscience Applied 2: 101105.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2023.101105<\/a><\/p>\n

Multicenter evaluation of a multimorbidity grouper based on temporal disease trajectories, 2nd Taul\u00ed Health Artificial Intelligence Symposium (THAIS)
\nhttps:\/\/www.tauli.cat\/hospital\/thais<\/a><\/p>\n

Torok Dora, Gecse Kinga, Hammer Angela, Nemeth Anna, Eszlari Nora, Gonda Xenia, Bagdy Gyorgy, Petschner Peter, Juhasz Gabriella – Investigating the association between polygenic risk score of depression and functional connectivity of the Nucleus Accumbens in healthy individuals: distinct role of SIRT1 (2023) – Poster presentation in Genomics of Brain Disorders ,17\u201319 May 2023, Cambridge, United Kingdom<\/p>\n

Eszlari Nora, Hullam Gabor, Gal Zsofia, Torok Dora, Nagy Tamas, Millinghoffer Andras, Baksa Daniel, Gonda Xenia, Antal Peter, Bagdy Gyorgy, Juhasz Gabriella: LncRNA or actin cytoskeleton-related genes in depression, depending on the joint pattern of sex, neuroticism, body fat, education, and stress (2023) – Poster presentation in Genomics of Brain Disorders, 17\u201319 May 2023, Cambridge, United Kingdom<\/p>\n

Tamas Nagy, Andras Gezsi, Gabor Hullam, Nora Eszlari, Peter Antal, Gabriella Juhasz: Pharmacological Characterization of Multimorbidity-Based Clusters in Depression (2023) – Presentation in PhD Scientific Days 2023 Budapest, 22-23 June 2023, Mental Health Sciences I.
\nhttps:\/\/phd.kmcongress.com\/osszefoglalo\/10141<\/a><\/p>\n

Eszlari Nora, Hullam Gabor, Gal Zsofia, Torok Dora, Nagy Tamas, Millinghoffer Andras, Baksa Daniel, Antal Peter, Bagdy Gyorgy, Juhasz Gabriella: Olfactory Receptors as a Potential Pathomechanism for Depression When No Classic Risk Factors Are Present in Women? Genomic Results from the UK Biobank Cohort (2023) – Presentation in PhD Scientific Days 2023 Budapest, 22-23 June 2023, Mental Health Sciences III.
\nhttps:\/\/phd.kmcongress.com\/osszefoglalo\/10187<\/a><\/p>\n

Erdelyi-Hamza Berta, Torok Dora, Gal Zsofia, Gyorik Dorka, Eszlari Nora, Bagdy Gyorgy, Juhasz Gabriella, Gonda Xenia: CLOCK gene plays role in the genetic background of depression after stressful life events \u2013 a GWAS study (2023) – Poster presentation in PhD Scientific Days 2023 Budapest, 22-23 June 2023, Mental Health Sciences – Posters M
\nhttps:\/\/phd.kmcongress.com\/osszefoglalo\/10182<\/a><\/p>\n

2022<\/h1>\n

Publications (2022)<\/h2>\n

Kevin Kirchner, Hartmut Brauer, Sandra Van der Auwera, Hans J. Grabe; The Impact of Resilience, Alexithymia and Subjectively Prceived Helplessness of Myocardial Infarction on the Risk of Posttraumatic Stress; J Clin Psychol Med Settings, 2022 Dec;29(4):954-962.
\nhttps:\/\/doi.org\/10.1007\/s10880-022-09857-w<\/a><\/p>\n

Sandra Van der Auwera, Sabine Ameling, Matthias Nauck, Henry V\u00f6lzke, Uwe V\u00f6lker, Hans J. Grabe; Plasma circulating micro-RNAs associated with alexithymia reflect a high overlap on neuropsychiatric outcomes; J Affect Disord, 2022 May 15:305:206-212.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0
\nhttps:\/\/doi.org\/10.1016\/j.jad.2022.03.012<\/a><\/p>\n

Sandra Van der Auwera, Johanna Klinger-K\u00f6nig, Katharina Wittfeld, Jan Terock, Anke Hannemann, Robin B\u00fclow, Matthias Nauck, Uwe V\u00f6lker, Henry V\u00f6lzke, Hans J. Grabe; The interplay between genetic variation and gene expression of the glucocorticoid receptor gene NR3C1 and blood cortisol levels on verbal memory and hippocampal volumes; Eur Arch Psychiatry Clin Neurosci, 2022 Dec,272(8):1505-1516.
\nhttps:\/\/doi.org\/10.1007\/s00406-022-01420-w<\/a><\/p>\n

Sarah Bonk, Kevin Kirchner, Sabine Ameling, Linda Garvert, Henry V\u00f6lzke, Matthias Nauck, Uwe V\u00f6lker, Hans J. Grabe, Sandra Van der Auwera; APOE \u03b54 in Depression-Associated Memory Impairment-Evidence from Genetic and MicroRNA Analyses; Biomedicines, 2022 Jun 30;10(7):1560.
\nhttps:\/\/doi.org\/10.3390\/biomedicines10071560<\/a><\/p>\n

Linda Garvert, Kevin Kirchner, Hans J. Grabe, Sandra Van der Auwera; Genome-wide gene-gene interaction of the 5-HTTLPR promotor polymorphism emphasizes the important role of neuroplasticity in depression; Prog Neuropsychopharmacol Biol Psychiatry, 2022 Dec 20:119:110614.
\nhttps:\/\/doi.org\/10.1016\/j.pnpbp.2022.110614<\/a><\/p>\n

Jan Terock, Sarah Bonk, Stefan Frenzel, Katharina Wittfeld, Linda Garvert, Norbert Hosten, Matthias Nauck, Henry V\u00f6lzke, Sandra Van der Auwera, Hans J. Grabe; Vitamin D deficit is associated with accelerated brain aging in the general population; Psychiatry Res Neuroimaging, 2022 Dec:327:111558.
\nhttps:\/\/doi.org\/10.1016\/j.pscychresns.2022.111558<\/a><\/p>\n

Annemarie Luise K\u00fchn, Stefan Frenzel, Alexander Teumer, Katharina Wittfeld, Linda Garvert, Antoine Weihs, Georg Homuth, Holger Prokisch, Robin B\u00fclow, Matthias Nauck, Uwe V\u00f6lker, Henry V\u00f6lzke, Hans J. Grabe, Sandra Van der Auwera; TREML2 Gene Expression and its Missense Variant rs3747742 associate with White Matter Hyperintensity Volume and Alzheimer\u2019s Disease-Related Brain Atrophy in the General Population; Int J Mol Sci, 2022 Nov 9;23(22):13764.\u00a0\u00a0\u00a0\u00a0\u00a0
\nhttps:\/\/doi.org\/10.3390\/ijms232213764<\/a><\/p>\n

Jambor, T., G. Juhasz and N. Eszlari (2022). „Towards personalised antidepressive medicine based on „big data”: an up-to-date review on robust factors affecting treatment response.” Neuropsychopharmacol Hung 24(1): 17-28.
\nhttps:\/\/mppt.hu\/magazin\/pdf\/vol24issue1\/v24i1p17.pdf<\/a><\/p>\n

Gonda, X., K. Gecse, Z. Gal and G. Juhasz (2022). Precision Medicine in Psychiatric Disorders. Precision Medicine in Clinical Practice. M. Hasanzad. Singapore, Springer Nature Singapore: 93-112.
\nhttps:\/\/doi.org\/10.1007\/978-981-19-5082-7_6<\/a><\/p>\n

Gecse, K., D. Dobos, C. S. Aranyi, A. Galambos, D. Baksa, N. Kocsel, E. Szab\u00f3, D. Pap, D. Vir\u00e1g, K. Lud\u00e1nyi, G. K\u00f6k\u00f6nyei, M. Emri, G. Bagdy and G. Juhasz (2022). „Association of plasma tryptophan concentration with periaqueductal gray matter functional connectivity in migraine patients.” Scientific Reports 12(1): 739.
\nhttps:\/\/doi.org\/10.1038\/s41598-021-04647-0<\/a><\/p>\n

Gecse K, \u00c9des AE, Nagy T, Demeter AK, Vir\u00e1g D, Kir\u00e1ly M, Dalmadi Kiss B, Lud\u00e1nyi K, K\u00f6rnyei Z, Denes A, et al. Citalopram Neuroendocrine Challenge Shows Altered Tryptophan and Kynurenine Metabolism in Migraine. Cells. 2022; 11(14):2258.
\nhttps:\/\/doi.org\/10.3390\/cells11142258<\/a><\/p>\n

Baksa, D., E. Szabo, N. Kocsel, A. Galambos, A. E. Edes, D. Pap, T. Zsombok, M. Magyar, K. Gecse, D. Dobos, L. R. Kozak, G. Bagdy, G. Kokonyei and G. Juhasz (2022). „Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces.” Front Hum Neurosci 16: 842426.
\nhttps:\/\/doi.org\/10.3389\/fnhum.2022.842426<\/a><\/p>\n

Daniel Baksa: THE ROLE OF CIRCADIAN RHYTHM IN MIGRAINE. Doctoral School of Mental Health Sciences Semmelweis University (2022)
\nhttp:\/\/old.semmelweis.hu\/wp-content\/phd\/phd_live\/vedes\/export\/baksadaniel.d.pdf<\/a><\/p>\n

Conferences (2022)<\/h2>\n

T\u00f6r\u00f6k, D., Z. G\u00e1l, K. Gecse, N. Eszl\u00e1ri, G. Juh\u00e1sz and P. Petschner (2022). „INVESTIGATING THE POLYGENIC SIGNAL OF MIGRAINE: COMPARISON OF DIFFERENT COHORTS.” European Neuropsychopharmacology 63: e249-e250.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2022.07.446<\/a><\/p>\n

T\u00f6r\u00f6k, D., X. Gonda, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz and P. Petschner (2022). „Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia.” European Psychiatry 65(S1): S148-S148.
\nhttps:\/\/doi.org\/10.1192\/j.eurpsy.2022.398<\/a><\/p>\n

Eszlari, N., A. Millinghoffer, G. Hullam, P. Antal, G. Bagdy and G. Juhasz (2022). „DISTINCT GENOMICS OF PERSEVERATIVE NEGATIVE THINKING IN MEN AND WOMEN: SPECIFIC ROLES OF IMMUNE PROCESSES, ION CHANNELS AND ALZHEIMER’S GENES.” European Neuropsychopharmacology 63: e258.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2022.07.461<\/a><\/p>\n

Nagy, T., G. Hullam, A. Millinghoffer, P. Antal and G. Juhasz (2022). „DIET AND STRESS EFFECT ON DEPRESSION GENETIC RISK: THE ROLE OF INTERLEUKIN-1-BETA, INTERLEUKIN-6, AND TUMOR NECROSIS FACTOR-ALPHA GENES.” European Neuropsychopharmacology 63: e265-e266.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2022.07.473<\/a><\/p>\n

Hull\u00e1m, G., T. Nagy, A. G\u00e9zsi, P. Antal and G. Juh\u00e1sz (2022). „Comparing depression comorbidity networks of different age groups.” Neuroscience Applied 1: 100173.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2022.100173<\/a><\/p>\n

Gy\u0151rik, D., D. Torok, B. Erdelyi-Hamza, Z. Gal, N. Eszlari, G. Bagdy, G. Juhasz and X. Gonda (2022). „Affective temperament polygenic risk scores predict current depression in general population pilot study.” Neuroscience Applied 1: 100772.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2022.100772<\/a><\/p>\n

Gonda, X., D. Torok, N. Eszlari, D. Gyorik, B. Erdelyi-Hamza, A. Millinghoffer, G. Bagdy and G. Juhasz (2022). „\u201cA melancholy\u2026compounded of many simples, extracted from many objects\u201d: heritability of affective temperaments suggests their role as endophenotypes for depression.” Neuroscience Applied 1: 100973.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2022.100973<\/a><\/p>\n

Gonda, X., N. Eszlari, D. Torok, Z. Gal, A. Millinghoffer, G. Breen, G. Juhasz and G. Bagdy (2022). „T54. FIRST GWAS ON AFFECTIVE TEMPERAMENTS IDENTIFIES NOVEL GENOME-WIDE SIGNIFICANT VARIANT FOR ANXIOUS TEMPERAMENT AND SUGGESTIVE VARIANTS FOR ALL FIVE AFFECTIVE TEMPERAMENTS.” European Neuropsychopharmacology 63: e197-e198.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2022.07.355<\/a><\/p>\n

Gecse, K., D. Dobos, N. K\u00e1rolyi, D. Baksa, C. S. Aranyi, M. Emri, G. K\u00f6k\u00f6nyei, G. Bagdy and G. Juhasz (2022). „Depressive symptoms are correlated with periaqueductal gray matter functional connectivity in migraine.” European Psychiatry 65(S1): S638-S638.
\nhttps:\/\/doi.org\/10.1192\/j.eurpsy.2022.1636<\/a><\/p>\n

G\u00e1l, Z., D. T\u00f6r\u00f6k, X. Gonda, N. Eszl\u00e1ri, I. M. Anderson, J. F. W. Deakin, G. Juh\u00e1sz, G. Bagdy and P. Petschner (2022). „Functional polymorphism of CLDN5 has stress mediating effect on current depressive symptoms.” Neuroscience Applied 1: 100187.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2022.100187<\/a><\/p>\n

Eszlari, N., Z. Bagyura, A. Millinghoffer, T. Nagy, G. Juhasz, P. Antal, B. Merkely and G. Bagdy (2022). „Body mass index and depressive rumination are positively associated with each other only in case of GG genotype of catenin alpha 2 gene rs13412541 variant.” European Psychiatry 65(S1): S228-S229.
\nhttps:\/\/doi.org\/10.1192\/j.eurpsy.2022.592<\/a><\/p>\n

Erdelyi-Hamza, B., D. Torok, Z. Gal, D. Gyorik, N. Eszlari, G. Bagdy, G. Juhasz and X. Gonda (2022). „Genome-wide association studies suggests clock circadian regulator gene variation is involved in the emergence of depression following recent severe stress exposure.” Neuroscience Applied 1: 100380.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2022.100380<\/a><\/p>\n

Dobos, D., K. Gecse, E. Szab\u00f3, D. Baksa, N. Kocsel, A. Galambos, T. Zsomb\u00f3k, G. K\u00f6k\u00f6nyei and G. Juh\u00e1sz (2022). „Maladaptive stress response of migraineurs is not reflected in pre-scan stress hormone levels and brain activity during emotional processing task.” Neuroscience Applied 1: 100987.
\nhttps:\/\/doi.org\/10.1016\/j.nsa.2022.100987<\/a><\/p>\n

2022 RCMAR Annual Meeting (virtual) (31 March-1 April 2022)<\/p>\n

M Kuokkanen, PJ Meikle, DC Glahn, J Blanger, JE Curran: Lipidomic Correlates of Mild Cognitive Impairment (presentation)
\nhttps:\/\/rcmar.org\/news\/2022-rcmar-annual-meeting\/<\/a><\/p>\n

Communication in scientific workshop: Health risk assessment in somatic and mental comorbidities: population-based study in Catalonia, Jornada d’agrupadors poblacionals de risc en salut – CatSalut<\/p>\n

Nagy Tam\u00e1s, Eszl\u00e1ri N\u00f3ra, Juh\u00e1sz Gabriella, Antal P\u00e9ter: Bayesian Analysis of Multi-Target Genetic Markers Using Hierarchical Phenotypic Data. Proceedings of the 29th Minisymposium of the Department of Measurement and Information Systems Budapest University of Technology and Economics, 2022
\n10.3311\/MINISY2022-004<\/a><\/p>\n

Baksa Daniel, Eszlari Nora, Torok Dora, Gonda Xenia, Juhasz Gabriella: The association of the onset order of migraine-depression comorbidity with physical and mental health status (2022) 7th Congress on Neurobiology, Psychopharmacology and Treatment Guidance, June 2-4, 2022, Virtual Congress (poster presentation)<\/p>\n

Tam\u00e1s Nagy, G\u00e1bor Hull\u00e1m, P\u00e9ter Antal, Gabriella Juh\u00e1sz – Association of Omega 3 Fatty Acid Consumption and Depression on Multiple Levels of Genetic Hierarchy (2022) PhD Scientific Days (Budapest, Hungary, 6-7 July 2022), Mental Health Sciences III.
\nhttps:\/\/phd.kmcongress.com\/osszefoglalo\/8659<\/a><\/p>\n

2021<\/h1>\n

Publications (2021)<\/h2>\n

Eszlari, N., B. Bruncsics, A. Millinghoffer, G. Hullam, P. Petschner, X. Gonda, G. Breen, P. Antal, G. Bagdy, J. F. W. Deakin and G. Juhasz (2021). „Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake.” Nutrients 13(12).
\nhttps:\/\/doi.org\/10.3390\/nu13124396<\/a><\/p>\n

Gyorik, D., N. Eszlari, Z. Gal, D. Torok, D. Baksa, Z. Kristof, S. Sutori, P. Petschner, G. Juhasz, G. Bagdy and X. Gonda (2021). „Every Night and Every Morn: Effect of Variation in CLOCK Gene on Depression Depends on Exposure to Early and Recent Stress.” Frontiers in Psychiatry 12(1465).
\nhttps:\/\/doi.org\/10.3389\/fpsyt.2021.687487<\/a><\/p>\n

Kristof, Z., N. Eszlari, S. Sutori, Z. Gal, D. Torok, D. Baksa, P. Petschner, B. Sperlagh, I. M. Anderson, J. F. W. Deakin, G. Juhasz, G. Bagdy and X. Gonda (2021). „P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.” PLoS One 16(6): e0252766.
\nhttps:\/\/doi.org\/10.1371\/journal.pone.0252766<\/a><\/p>\n

Petschner, P., D. Baksa, G. Hullam, D. Torok, A. Millinghoffer, J. F. W. Deakin, G. Bagdy and G. Juhasz (2021). „A replication study separates polymorphisms behind migraine with and without depression.” PLoS One 16(12): e0261477.
\nhttps:\/\/doi.org\/10.1371\/journal.pone.0261477<\/a><\/p>\n

Eszlari N, Bagyura Z, Millinghoffer A, Nagy T, Juhasz G, Antal P, Merkely B, Bagdy G. Catenin Alpha 2 May Be a Biomarker or Potential Drug Target in Psychiatric Disorders with Perseverative Negative Thinking. Pharmaceuticals. 2021; 14(9):850.
\nhttps:\/\/doi.org\/10.3390\/ph14090850<\/a><\/p>\n

Bokor, J., S. Sutori, D. Torok, Z. Gal, N. Eszlari, D. Gyorik, D. Baksa, P. Petschner, G. Serafini, M. Pompili, I. M. Anderson, B. Deakin, G. Bagdy, G. Juhasz and X. Gonda (2021). „Inflamed Mind: Multiple Genetic Variants of IL6 Influence Suicide Risk Phenotypes in Interaction With Early and Recent Adversities in a Linkage Disequilibrium-Based Clumping Analysis.” Frontiers in Psychiatry 12(1855).
\nhttps:\/\/doi.org\/10.3389\/fpsyt.2021.746206<\/a><\/p>\n

Conferences (2021)<\/h2>\n

G\u00e1l, Z., D. T\u00f6r\u00f6k, N. Eszl\u00e1ri, X. Gonda, G. Bagdy, G. Juh\u00e1sz and P. Petschner (2021). „P.0109 Association of foxo1 gene variants with depression and childhood stress effects in a European sample.” European Neuropsychopharmacology 53: S79-S80.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2021.10.109<\/a><\/p>\n

Gy\u0151rik, D., N. Eszlari, Z. Gal, D. Torok, D. Baksa, Z. Kristof, S. Sutori, P. Petschner, G. Juhasz, G. Bagdy and X. Gonda (2021). „P.0422 CLOCK gene variation mediates effect of early childhood adversities and recent stressors on current depressive symptoms.” European Neuropsychopharmacology 53: S306-S307.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2021.10.395<\/a><\/p>\n

Hullam, G., M. Vetro, B. Bruncsics, P. Antal and G. Juhasz (2021). „P.0102 Comorbidities of depression in men and women: a UK biobank based study.” European Neuropsychopharmacology 53: S74-S75.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2021.10.103<\/a><\/p>\n

Kristof, Z., N. Eszlari, S. Sutori, Z. Gal, D. Torok, D. Baksa, P. Petschner, B. Sperlagh, I. M. Anderson, J. F. W. Deakin, G. Juhasz, G. Bagdy and X. Gonda (2021). „P.0577 Variation in P2RX7 interacts with childhood traumas and negative life events influencing current depressive symptoms but not lifetime depression.” European Neuropsychopharmacology 53: S422-S423.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2021.10.544<\/a><\/p>\n

Eszlari, N., B. Bruncsics, A. Millinghoffer, G. Hullam, P. Petschner, X. Gonda, G. Breen, P. Antal, G. Bagdy, B. Deakin and G. Juhasz (2021). „TH7. CIRCADIAN REGULATOR ARNTL GENE ACTS ON DEPRESSIVE SYMPTOMS DIRECTLY AND INDIRECTLY THROUGH PAST-FOCUSED PERSEVERATIVE NEGATIVE THINKING.” European Neuropsychopharmacology 51: e197-e198.
\nhttps:\/\/doi.org\/10.1016\/j.euroneuro.2021.08.182<\/a><\/p>\n

Baksa D, Petschner P, Hullam G, Torok D, Millinghoffer A, Deakin WJF, Bagdy G, Juhasz G (2021) A genetic replication study of migraine with and without comorbid lifetime depression. 15th World Congress of Biological Psychiatry, 28-30 June 2021
\nhttps:\/\/www.wfsbp-congress.org\/scientific-program\/wfsbp2021-program.html<\/a><\/p>\n

Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Antal P, Bagdy G, Juhasz G (2021) Perseverative negative thinking declines with age, independently of folate intake. 15th World Congress of Biological Psychiatry, 28-30 June 2021
\nhttps:\/\/www.wfsbp-congress.org\/scientific-program\/wfsbp2021-program.html<\/a><\/p>\n

Juhasz G (2021) Big biological data, data integration and learning algorithms in deciphering major depression and its treatments. 15th World Congress of Biological Psychiatry, 28-30 June 2021. Chair of symposium \u201cBig biological data, data integration and learning algorithms in deciphering major depression and its treatments\u201d in \u201c15th World Congress of Biological Psychiatry\u201d
\nhttps:\/\/www.wfsbp-congress.org\/portal\/congress\/video-s.html?sessionId=60a6acf1891b86482e62d53d<\/a><\/p>\n

Gonda X (2021) Effects of polymorphisms depend on stress exposure: an example of the use of Bayesian learning algorithms. 15th World Congress of Biological Psychiatry, 28-30 June 2021. Speaker of symposium \u201cBig biological data, data integration and learning algorithms in deciphering major depression and its treatments\u201d in \u201c15th World Congress of Biological Psychiatry\u201d
\nhttps:\/\/www.wfsbp-congress.org\/portal\/congress\/video-s.html?sessionId=60a6acf1891b86482e62d53d<\/a><\/p>\n

Cano I (2021) Health risk assessment in somatic and mental comorbidities: population based studies in Catalonia. 15th World Congress of Biological Psychiatry, 28-30 June 2021. Speaker of symposium \u201cBig biological data, data integration and learning algorithms in deciphering major depression and its treatments\u201d in \u201c15th World Congress of Biological Psychiatry\u201d
\nhttps:\/\/www.wfsbp-congress.org\/portal\/congress\/video-s.html?sessionId=60a6acf1891b86482e62d53d<\/a><\/p>\n

van der Auwera-Palitschka S (2021) Gene-environment interactions as stratification variables behind depression. 15th World Congress of Biological Psychiatry, 28-30 June 2021. Speaker of symposium \u201cBig biological data, data integration and learning algorithms in deciphering major depression and its treatments\u201d in \u201c15th World Congress of Biological Psychiatry\u201d
\nhttps:\/\/www.wfsbp-congress.org\/portal\/congress\/video-s.html?sessionId=60a6acf1891b86482e62d53d<\/a><\/p>\n

Kirchner K, Brauer H, Van der Auwera S, Grabe HJ (2021) The Impact of Resilience, Alexithymia and Subjectively Perceived Helplessness of Myocardial Infarction on the Risk of Posttraumatic Stress (poster presentation) DGPPN 2021 (\u201cDeutsche Gesellschaft f\u00fcr Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde\u201d (24-27 November 2021))
\nhttps:\/\/www.dgppnkongress.de<\/a><\/p>\n

Internal meeting (THL), Finland<\/p>\n

Makinen H.: Temporal disease map based stratification of depression-related multimorbidities: towards quantitative investigations of patient trajectories and predictions of multi-target drug candidates (presentation)<\/p>\n

Baksa D, Petschner P, Hullam G, Torok D, Millinghoffer A, Bagdy G, Juhasz G (2021) A Genetic Study of Migraine and Comorbid Depression PhD Scientific Days 2021 Budapest, 7-8 July 2021, NE_I_L: Neurosciences I. Lectures<\/p>\n

Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Petschner P, Gonda X, Breen G, Antal P, Bagdy G, Deakin JFW, Juhasz G (2021) Circadian Clock Gene ARNTL Affects Depression Directly and Also Via Perseverative Negative Thinking PhD Scientific Days 2021 Budapest, 7-8 July 2021, MH_I_P: Mental Health Sciences I. Posters<\/p>\n

Baksa D., Petschner P., Hullam G., Torok D., Millinghoffer A., Bagdy G., Juhasz G: A genetic study of migraine and comorbid depression. (2022) Presentation in PhD Scientific Days 2021, 7-8 July 2021 Budapest, Hungary<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Dissemination activities of the TRAJECTOME project 2025 Nagy, T., Gonda, X., Gezsi, A., Eszlari, N., Hullam, G., Gonz\u00e1lez-Colom, R., M\u00e4kinen, H., Paajanen, T., Torok, D., Gal, Z., Petschner, P., Cano, I., Kuokkanen, M., Schmidt, C. O., Van der Auwera, S., Roca, J., Antal, P., & Juhasz, G. (2025). Pharmacological profiling of major depressive disorder-related multimorbidity …<\/p>\n","protected":false},"author":101145,"featured_media":0,"parent":69,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-75","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/75","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/users\/101145"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/comments?post=75"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/75\/revisions"}],"predecessor-version":[{"id":3610,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/75\/revisions\/3610"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/69"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/media?parent=75"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/categories?post=75"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/tags?post=75"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}