{"id":69,"date":"2020-07-17T10:41:44","date_gmt":"2020-07-17T08:41:44","guid":{"rendered":"https:\/\/semmelweis.hu\/trajectome\/?page_id=69"},"modified":"2025-11-27T16:18:41","modified_gmt":"2025-11-27T15:18:41","slug":"trajectome","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/en\/previous-projects\/trajectome\/","title":{"rendered":"Trajectome research group"},"content":{"rendered":"<h4><strong>Name: <\/strong>TRAJECTOME Research Group<\/h4>\n<p><strong>Title of the Project:<\/strong> Temporal disease map based stratification of depression-related multimorbidities: towards quantitative investigations of patient trajectories and predictions of multi-target drug candidates<\/p>\n<p><strong>Acronym:<\/strong> TRAJECTOME<\/p>\n<div class=\"keretes w-100\">\n<h5>Project Coordinator:<\/h5>\n<p>Semmelweis University, Department of Pharmacodynamics<strong><br \/>\n<\/strong>Dr. Gabriella Juh\u00e1sz PhD, associate professor<br \/>\nE-mail: juhasz.gabriella@semmelweis.hu<br \/>\nTel: +36 1\u00a0459 1500<\/p>\n<\/div>\n<h4><strong>Project Partners:<\/strong><\/h4>\n<ul>\n<li>Abiomics Europe Ltd., Budapest, Hungary, Dr. P\u00e9ter Antal<\/li>\n<li>The Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland, Dr. Mikko Kuokkanen<\/li>\n<li>Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) \u2013 Hospital Clinic de Barcelona, Barcelona, Spain, Dr. Josep Roca<\/li>\n<li>Department of Psychiatry, University Medicine Greifswald (UMG), Greifswald, Mecklenburg-West Pomerania, Germany, Dr. rer. med. Sandra Van der Auwera-Palitschka<\/li>\n<\/ul>\n<p><strong>Start Date of the Project:<\/strong>\u00a01 May 2020<\/p>\n<p><strong>End date of the project:<\/strong>\u00a030 April 2023<\/p>\n<hr \/>\n<p><strong><a href=\"http:\/\/www.erapermed.eu\/\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-82 alignright\" src=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/trajectome\/files\/2020\/07\/erapermed-1-400x55.png\" alt=\"\" width=\"400\" height=\"55\" srcset=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/erapermed-1-400x55.png 400w, https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/erapermed-1.png 600w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a>Call of the Project: <\/strong>ERA PerMed Joint Translational Call 2019, \u201cPersonalised Medicine: Multidisciplinary Research Towards Implementation\u201d (No. ERAPERMED2019-108)<\/p>\n<p>Additional information: <a href=\"https:\/\/erapermed.isciii.es\/\">https:\/\/erapermed.isciii.es\/<\/a><\/p>\n<hr \/>\n<p><strong>Funded by: NKFIH (contract number: 2019-2.1.7-ERA-NET-2020-00005)<\/strong><\/p>\n<p><strong>Project Budget for the consortium:<\/strong> EUR 1.115M<\/p>\n<style>\n           #page-grid .card-body > .line-clamp-box.excerpt{\n        width: inherit;\n        max-width: inherit;\n        display:flex;\n        min-height: 2.4em;\n        flex-direction: column;\n        justify-content: space-around;\n        background-color: #D6E4EA;\n        min-height: 3.4rem;\n        font-family: \"Montserrat\", sans-serif;\n    }\n\n    #page-grid a:hover .card-body > .line-clamp-box.excerpt {\n        background-color: #fff;\n        color: #313B40;\n    }\n\n    #page-grid .card-body .line-clamp-box.excerpt section{\n        max-width: inherit;\n        display: -webkit-box;\n        -webkit-line-clamp: 2;\n        -webkit-box-orient: vertical;\n        overflow: hidden;\n        text-overflow: ellipsis;\n        hyphens: auto;\n        margin: auto;\n        \n    }\n    .line-clamp-box.excerpt section, .line-clamp-box.excerpt section p{\n        font-size:0.8em;\n    }\n    \n<\/style>\n    <section id=\"page-grid\">\n        \n        <div class=\"row row-cols-1 row-cols-md-2 row-cols-lg-4 no-gutters mx-0 \">    <div class =\"col  mb-2 card-wrapper\">\n        <a class=\"d-flex flex-fill card-link-warapper m-md-1\" href=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/en\/previous-projects\/trajectome\/project-partners\/\">\n            <div class=\"card border border-secondary se-border flex-fill\">\n                <div class=\"row no-gutters mx-0 d-flex flex-nowrap flex-md-wrap align-items-center\">\n                    <div class =\"  col-5 col-md-12  d-none  d-md-none d-md-none  bg-image  card-image justify-content-center\">\n                        <img class='wp-post-image img-fluid landscape' src='https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-content\/themes\/se18\/dist\/images\/svg\/bg-image.svg' \/>\n                    <\/div>\n                    <div class=\"card-body  col flex-column  col-md-12 p-0\">\n                        <div class=\"line-clamp-box p-3\">\n                            <h5 class=\"ml-0 ml-sm-1 mt-2 align-items-center\"  >Project Partners<\/h5>\n                        <\/div>\n                        \n                    <\/div>\n                <\/div>\n\n            <\/div>\n        <\/a>\n    <\/div>    <div class =\"col  mb-2 card-wrapper\">\n        <a class=\"d-flex flex-fill card-link-warapper m-md-1\" href=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/en\/previous-projects\/trajectome\/project-summary\/\">\n            <div class=\"card border border-secondary se-border flex-fill\">\n                <div class=\"row no-gutters mx-0 d-flex flex-nowrap flex-md-wrap align-items-center\">\n                    <div class =\"  col-5 col-md-12  d-none  d-md-none d-md-none  bg-image  card-image justify-content-center\">\n                        <img class='wp-post-image img-fluid landscape' src='https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-content\/themes\/se18\/dist\/images\/svg\/bg-image.svg' \/>\n                    <\/div>\n                    <div class=\"card-body  col flex-column  col-md-12 p-0\">\n                        <div class=\"line-clamp-box p-3\">\n                            <h5 class=\"ml-0 ml-sm-1 mt-2 align-items-center\"  >Project Summary<\/h5>\n                        <\/div>\n                        \n                    <\/div>\n                <\/div>\n\n            <\/div>\n        <\/a>\n    <\/div>    <div class =\"col  mb-2 card-wrapper\">\n        <a class=\"d-flex flex-fill card-link-warapper m-md-1\" href=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/en\/previous-projects\/trajectome\/publication\/\">\n            <div class=\"card border border-secondary se-border flex-fill\">\n                <div class=\"row no-gutters mx-0 d-flex flex-nowrap flex-md-wrap align-items-center\">\n                    <div class =\"  col-5 col-md-12  d-none  d-md-none d-md-none  bg-image  card-image justify-content-center\">\n                        <img class='wp-post-image img-fluid landscape' src='https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-content\/themes\/se18\/dist\/images\/svg\/bg-image.svg' \/>\n                    <\/div>\n                    <div class=\"card-body  col flex-column  col-md-12 p-0\">\n                        <div class=\"line-clamp-box p-3\">\n                            <h5 class=\"ml-0 ml-sm-1 mt-2 align-items-center\"  >Publication<\/h5>\n                        <\/div>\n                        \n                    <\/div>\n                <\/div>\n\n            <\/div>\n        <\/a>\n    <\/div>    <div class =\"col  mb-2 card-wrapper\">\n        <a class=\"d-flex flex-fill card-link-warapper m-md-1\" href=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/en\/previous-projects\/trajectome\/media-releases-public-engagement-activities\/\">\n            <div class=\"card border border-secondary se-border flex-fill\">\n                <div class=\"row no-gutters mx-0 d-flex flex-nowrap flex-md-wrap align-items-center\">\n                    <div class =\"  col-5 col-md-12  d-none  d-md-none d-md-none  bg-image  card-image justify-content-center\">\n                        <img class='wp-post-image img-fluid landscape' src='https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-content\/themes\/se18\/dist\/images\/svg\/bg-image.svg' \/>\n                    <\/div>\n                    <div class=\"card-body  col flex-column  col-md-12 p-0\">\n                        <div class=\"line-clamp-box p-3\">\n                            <h5 class=\"ml-0 ml-sm-1 mt-2 align-items-center\"  >Media Releases, Public Engagement Activities<\/h5>\n                        <\/div>\n                        \n                    <\/div>\n                <\/div>\n\n            <\/div>\n        <\/a>\n    <\/div>        <\/div>\n    <\/section>\n<h1>About the Research<\/h1>\n<p>Depression is a commonly occurring mental disorder that usually have a chronic recurrent course throughout the life causing extensive sufferings to the patients. Previous studies suggest that depressed patients are prone to develop several other disorders, so called multimorbidities, most likely due to common biological and environmental risk factors.<\/p>\n<div class=\"fontos_div\">\n<p>The aim of the TRAJECTOME project is to investigate how these multimorbidities emerge in time in order to identify disease trajectories.<\/p>\n<\/div>\n<p>These disease trajectories will help to distinguish depressed patients with similar multimorbidity profiles and identify which specific biological, socioeconomic and lifestyle factors contribute to the development of their symptoms. By understanding these processes, the TRAJECTOME project will enable improved disease prediction and prevention in depression and also provide new insight for drug discovery to promote personalized medicine in depression related multimorbidities.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-85 size-full\" src=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1.png\" alt=\"\" width=\"2043\" height=\"795\" srcset=\"https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1.png 2043w, https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1-400x156.png 400w, https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1-1024x398.png 1024w, https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1-768x299.png 768w, https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1-1536x598.png 1536w, https:\/\/semmelweis.hu\/gyogyszerhatastan\/files\/2020\/07\/Osszefoglalo_en-1-753x293.png 753w\" sizes=\"auto, (max-width: 2043px) 100vw, 2043px\" \/><\/p>\n<p style=\"text-align: center;\"><em>Explanatory figure of the TRAJECTOME project<\/em><\/p>\n<p style=\"text-align: center;\"><em>(EraPerMed Newsletter, January, 2020,<a href=\"https:\/\/erapermed.isciii.es\/wp-content\/uploads\/2020\/02\/NEWSLETTER-3-final.pdf\">https:\/\/erapermed.isciii.es\/wp-content\/uploads\/2020\/02\/NEWSLETTER-3-final.pdf<\/a><\/em><em>)<\/em><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Depression is a commonly occurring mental disorder that usually have a chronic recurrent course throughout the life causing extensive sufferings to the patients. Previous studies suggest that depressed patients are prone to develop several other disorders, so called multimorbidities, most likely due to common biological and environmental risk factors. The aim of the TRAJECTOME project is to investigate how these multimorbidities emerge in time in order to identify disease trajectories.<\/p>\n","protected":false},"author":101145,"featured_media":3588,"parent":2549,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-69","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/69","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/users\/101145"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/comments?post=69"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/69\/revisions"}],"predecessor-version":[{"id":3612,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/69\/revisions\/3612"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/pages\/2549"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/media\/3588"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/media?parent=69"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/categories?post=69"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszerhatastan\/wp-json\/wp\/v2\/tags?post=69"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}