{"id":1927,"date":"2023-11-27T17:15:59","date_gmt":"2023-11-27T16:15:59","guid":{"rendered":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/?page_id=1927"},"modified":"2025-06-13T09:50:32","modified_gmt":"2025-06-13T07:50:32","slug":"adme-fizkem-kutatocsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/kutatas-2\/adme-fizkem-kutatocsoport\/","title":{"rendered":"ADME-Fizk\u00e9m Kutat\u00f3csoport"},"content":{"rendered":"<p><img decoding=\"async\" class=\"aligncenter wp-image-1673 size-full\" src=\"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/files\/2025\/03\/ADME-fizkem_2025-scaled.jpg\" height=\"420\" \/><\/p>\n<h3><strong>Kutat\u00e1si ter\u00fcletek:<\/strong><\/h3>\n<ul style=\"list-style-type: square\">\n<li>gy\u00f3gyszer- \u00e9s biomolekul\u00e1k r\u00e9szecske-specifikus sav-b\u00e1zis tulajdons\u00e1gainak \u00e9s lipofilit\u00e1s\u00e1nak jellemz\u00e9se, ciklodextrin komplexeik vizsg\u00e1lata<\/li>\n<li>gy\u00f3gyszerformul\u00e1ci\u00f3k kis t\u00e9rfogat\u00fa szimult\u00e1n kiold\u00f3d\u00e1s-felsz\u00edv\u00f3d\u00e1s vizsg\u00e1lata, biokevivalencia vizsg\u00e1lat\u00e1nak el\u0151rejelz\u00e9se<\/li>\n<li>gy\u00f3gyszerhat\u00f3anyagok termodinamikai \u00e9s kinetikai oldhat\u00f3s\u00e1g\u00e1nak meghat\u00e1roz\u00e1sa, val\u00f3s idej\u0171 kiold\u00f3d\u00e1s vizsg\u00e1lata<\/li>\n<li>gy\u00f3gyszerjel\u00f6lt vegy\u00fcletek \u00e9s formul\u00e1ci\u00f3k in vitro sz\u00f6vetspecifikus permeabilit\u00e1si (GIT-, BBB-, b\u0151r-, m\u00e1j-, sz\u00edv-PAMPA) folyamatinak vizsg\u00e1lata<\/li>\n<li>\n<p>in vitro HTS-, MTS-gy\u00f3gyszermetabolizmus modellek kidolgoz\u00e1sa, hat\u00f3anyagjel\u00f6lt molekul\u00e1k metabolikus stabilit\u00e1s vizsg\u00e1lata<\/p>\n<\/li>\n<\/ul>\n<h3><strong>TDK\/szakdolgozat t\u00e9m\u00e1k:<\/strong><\/h3>\n<hr \/>\n<h5>Dr. Angi Erzs\u00e9bet R\u00e9ka (adjunktus):<\/h5>\n<ul>\n<li>Naz\u00e1lisan alkalmazhat\u00f3 GnRH anal\u00f3g hat\u00f3anyag hat\u00e9konys\u00e1g\u00e1nak n\u00f6vel\u00e9se ciklodextrin alap\u00fa formul\u00e1ci\u00f3val<\/li>\n<li>Intesztin\u00e1lis gy\u00f3gyszermetabolizmus vizsg\u00e1lata nanopartikul\u00e1ris hordoz\u00f3kra r\u00f6gz\u00edtett enzimek alkalmaz\u00e1s\u00e1val <strong>(munkav\u00e9gz\u00e9s a BME-n is)<\/strong><\/li>\n<\/ul>\n<hr \/>\n<h5>Dr. Balogh Gy\u00f6rgy Tibor (egyetemi tan\u00e1r):<\/h5>\n<ul>\n<li>\u00daj szem\u00e9szeti formul\u00e1ci\u00f3k fejleszt\u00e9se \u00e9s vizsg\u00e1lata in vitro \u00e9s ex vivo rendszerekben<\/li>\n<li>Szil\u00e1rd formul\u00e1ci\u00f3s lehet\u0151s\u00e9gek a szem\u00e9szetben <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<li>Optikailag akt\u00edv hat\u00f3anyagok felsz\u00edv\u00f3d\u00e1s\u00e1nak vizsg\u00e1lata<\/li>\n<\/ul>\n<hr \/>\n<h5>Dr. B\u00e1rdos Vivien (Ph.D. hallgat\u00f3):<\/h5>\n<ul>\n<li>Plate alap\u00fa k\u00eds\u00e9rlettervez\u0151 modell fejleszt\u00e9se (t\u00e1rst\u00e9mavezet\u0151: Dr. Szoll\u00e1th Rita)<\/li>\n<li>Neurodegenerat\u00edv betegs\u00e9gek (ALS, Parkinson, Alzheimer) gy\u00f3gyszereinek k\u00e9mi\u00e1ja <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span> (t\u00e1rst\u00e9mavezet\u0151: Dr. Szoll\u00e1th Rita)<\/li>\n<li>Izomm\u0171k\u00f6d\u00e9sre hat\u00f3 szerek gy\u00f3gyszer\u00e9szi k\u00e9mi\u00e1ja <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<\/ul>\n<hr \/>\n<h5>Herr Dominika (Ph.D. hallgat\u00f3):<\/h5>\n<ul>\n<li>C\u00e9lzott hat\u00f3anyaglead\u00f3 rendszerek fejleszt\u00e9se a r\u00e1kkutat\u00e1sban <strong>(munkav\u00e9gz\u00e9s a Cyclolab Kft.-n\u00e9l)<\/strong> (t\u00e1rst\u00e9mavezet\u0151: Dr. Balogh Gy\u00f6rgy Tibor)<\/li>\n<\/ul>\n<h5>Dr. Maz\u00e1k K\u00e1roly (egyetemi docens):<\/h5>\n<ul>\n<li>M\u00e9r\u0151lemez alap\u00fa UV-pH titr\u00e1l\u00e1sos m\u00f3dszerek fejleszt\u00e9se gy\u00f3gyszer-makromolekula k\u00f6lcs\u00f6nhat\u00e1sok vizsg\u00e1lat\u00e1ra<\/li>\n<li>Pszichoakt\u00edv triciklusos vegy\u00fcletek ciklodextrin komplexeinek vizsg\u00e1lata spektroszk\u00f3piai m\u00f3dszerekkel<\/li>\n<li>Gy\u00f3gyszermolekul\u00e1k neveinek etimol\u00f3gi\u00e1ja <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<li>A csontanyagcser\u00e9re hat\u00f3 szerek gy\u00f3gyszer\u00e9szi k\u00e9mi\u00e1ja <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<li>A proton\u00e1l\u00f3d\u00e1s hat\u00e1sa gy\u00f3gyszer- \u00e9s biomolekul\u00e1k ciklodextrin komplexeinek stabilit\u00e1s\u00e1ra <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<li>Az Eur\u00f3pai Uni\u00f3 esszenci\u00e1lis gy\u00f3gyszerlist\u00e1ja a gy\u00f3gyszer\u00e9szi k\u00e9mia szemsz\u00f6g\u00e9b\u0151l <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<\/ul>\n<hr \/>\n<h5>Moh\u00e1csi Zsombor (Ph.D hallgat\u00f3):<\/h5>\n<ul>\n<li>Axi\u00e1lis ligandumok hat\u00e1sa metalloporfirin alap\u00fa biomimetikus rendszerre (t\u00e1rst\u00e9mavezet\u0151: Dr. Balogh Gy\u00f6rgy Tibor)<\/li>\n<\/ul>\n<hr \/>\n<h5>Stifter-Mursits Marcell (Ph.D. hallgat\u00f3):<\/h5>\n<ul>\n<li>Ciklodextrin-hat\u00f3anyag k\u00f6lcs\u00f6nhat\u00e1s sz\u00e1m\u00edt\u00f3g\u00e9pes el\u0151rejelz\u00e9se <span style=\"color: #ff6600\">(irodalmaz\u00e1s,<\/span> <strong>Python programoz\u00e1s) <\/strong>(t\u00e1rst\u00e9mavezet\u0151: Dr. Mirzahosseini Arash)<\/li>\n<\/ul>\n<hr \/>\n<h5>Dr. Szoll\u00e1th Rita (Ph.D. hallgat\u00f3):<\/h5>\n<ul>\n<li>N\u0151gy\u00f3gy\u00e1szati betegs\u00e9gek (Endometri\u00f3zis, PCOS, stb) diagnosztik\u00e1ja, gy\u00f3gyszerei, gy\u00f3gyszereinek k\u00e9mi\u00e1ja <span style=\"color: #ff6600\">(irodalmaz\u00e1s)<\/span><\/li>\n<\/ul>\n<hr \/>\n<h5>Dr. Vincze Anna (tan\u00e1rseg\u00e9d):<\/h5>\n<ul>\n<li>In vitro plate alap\u00fa permeabilit\u00e1si modell optim\u00e1l\u00e1sa szem\u00e9szeti formul\u00e1ci\u00f3k tesztel\u00e9s\u00e9re<\/li>\n<li>Hat\u00f3anyag felsz\u00edv\u00f3d\u00e1s modellez\u00e9se horizont\u00e1lis \u00e9s vertik\u00e1lis diff\u00fazi\u00f3s cell\u00e1kban<\/li>\n<\/ul>\n<hr \/>\n<h3><strong>PhD t\u00e9m\u00e1k:<\/strong><\/h3>\n<ul style=\"list-style-type: square\">\n<li><a class=\"link\" href=\"https:\/\/doktori.hu\/index.php?menuid=195&amp;lang=HU&amp;tk_ID=247438\">Ciklodextrin alap\u00fa c\u00e9lzott hat\u00f3anyaglead\u00f3 rendszerek fejleszt\u00e9se<\/a><\/li>\n<\/ul>\n<h3><strong>Friss k\u00f6zlem\u00e9nyek:<\/strong><\/h3>\n<ol>\n<li>\n<p><span style=\"font-size: 14pt\"><strong>Alaa Malik, S\u00e1ndor Hosztafi, Anna Vincze, Andr\u00e1s M\u00e1rton,M\u00e1rta Kraszni,Gy\u00f6rgy T. Balogh, B\u00e9la Nosz\u00e1l, K\u00e1roly Maz\u00e1k<\/strong> (<strong>2024<\/strong>): Characterization of Opioid Agonist Morphine Derivatives with Emphasis on Medicinal Chemistry. <em>ChemM<\/em><em>ed<\/em><em>Chem<\/em> Paper: e202400654.<br \/>\n<\/span>DOI:<a href=\"https:\/\/doi.org\/10.1002\/cmdc.202400654\">10.1002\/cmdc.202400654<\/a><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt\">David Klari\u0107, \u017deljka Soldin, <strong>Anna Vincze, Rita Szoll\u00e1th, Gy\u00f6rgy T. Balogh,<\/strong> Maro Jug, Nives Gali\u0107 (<strong>2024<\/strong>): Biopharmaceutical Characterization and Stability of Nabumetone\u2013Cyclodextrins Complexes Prepared by Grinding.\u00a0<em>Pharmaceutics\u00a0<\/em>16:12 Paper: 1493.<br \/>\n<\/span>DOI:<a href=\"https:\/\/doi.org\/10.3390\/pharmaceutics16121493\">10.3390\/pharmaceutics16121493<\/a><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt\">Gerg\u0151 D. T\u00f3th, Nikolett K\u00e1llai-Szab\u00f3, Mil\u00e9na Lengyel, K\u00e1roly S\u00fcvegh, Ferenc Ender, G\u00e1bor Katona,\u00a0\u00a0Adrienn Kazsoki, Rom\u00e1na Zelk\u00f3, Istv\u00e1n Antal,\u00a0<strong>Gy\u00f6rgy T. Balogh,<\/strong> Di\u00e1na Balogh-Weiser (<strong>2023<\/strong>): Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies.\u00a0<em>J. Mol. Liquids<\/em><\/span><span style=\"font-size: 1rem\"><span style=\"font-size: 14pt\"> 389 Paper: 122819.<br \/>\n<\/span><\/span>DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.molliq.2023.122819\">10.1016\/j.molliq.2023.122819<\/a><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt\"><strong>Anna Vincze<\/strong>, R\u00e9ka Facsk\u00f3, M\u00e1ria Budai-Sz\u0171cs, G\u00e1bor Katona, Benj\u00e1min Gyarmati, Anita Csorba, Rom\u00e1na Zelk\u00f3, Zolt\u00e1n Zs. Nagy, Lajos Szente, <strong>Gy\u00f6rgy T. Balogh<\/strong> (<\/span><strong style=\"font-size: 14pt\">2023<\/strong><span style=\"font-size: 14pt\">): Cyclodextrin-enabled nepafenac eye drops with improved absorption open a new therapeutic window. <\/span><em style=\"font-size: 14pt\">Carbohydrate Polymers, <\/em><span style=\"font-size: 14pt\">310, 120717<br \/>\n<\/span><span style=\"font-size: 14pt\">DOI:<\/span><a class=\"anchor doi anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2023.120717\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.carbpol.2023.120717<\/span><\/a><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14pt\">Anita R\u00e1cz, <strong>Anna Vincze, Gy\u00f6rgy T. Balogh<\/strong> (<strong>2023<\/strong>): Extending the limitations in the prediction of PAMPA permeability with machine learning algorithms. <em>Eur. J. Pharm. Sci<\/em>, 188, 106514<br \/>\n<\/span><span style=\"font-size: 14pt\">DOI:<a class=\"anchor doi anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.ejps.2023.106514\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.ejps.2023.106514<\/span><\/a><\/span><\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Kutat\u00e1si ter\u00fcletek: gy\u00f3gyszer- \u00e9s biomolekul\u00e1k r\u00e9szecske-specifikus sav-b\u00e1zis tulajdons\u00e1gainak \u00e9s lipofilit\u00e1s\u00e1nak jellemz\u00e9se, ciklodextrin komplexeik vizsg\u00e1lata gy\u00f3gyszerformul\u00e1ci\u00f3k kis t\u00e9rfogat\u00fa szimult\u00e1n kiold\u00f3d\u00e1s-felsz\u00edv\u00f3d\u00e1s vizsg\u00e1lata, biokevivalencia vizsg\u00e1lat\u00e1nak el\u0151rejelz\u00e9se gy\u00f3gyszerhat\u00f3anyagok termodinamikai \u00e9s kinetikai oldhat\u00f3s\u00e1g\u00e1nak meghat\u00e1roz\u00e1sa, val\u00f3s idej\u0171 kiold\u00f3d\u00e1s vizsg\u00e1lata gy\u00f3gyszerjel\u00f6lt vegy\u00fcletek \u00e9s formul\u00e1ci\u00f3k in vitro sz\u00f6vetspecifikus permeabilit\u00e1si (GIT-, BBB-, b\u0151r-, m\u00e1j-, sz\u00edv-PAMPA) folyamatinak vizsg\u00e1lata in vitro HTS-, MTS-gy\u00f3gyszermetabolizmus modellek kidolgoz\u00e1sa, hat\u00f3anyagjel\u00f6lt &hellip;<\/p>\n","protected":false},"author":102300,"featured_media":0,"parent":1915,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[23],"tags":[],"class_list":["post-1927","page","type-page","status-publish","hentry","category-kutatas"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/pages\/1927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/users\/102300"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/comments?post=1927"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/pages\/1927\/revisions"}],"predecessor-version":[{"id":2784,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/pages\/1927\/revisions\/2784"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/pages\/1915"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/media?parent=1927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/categories?post=1927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/gyogyszereszi-kemia\/wp-json\/wp\/v2\/tags?post=1927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}