{"id":2368,"date":"2024-01-11T15:22:18","date_gmt":"2024-01-11T14:22:18","guid":{"rendered":"https:\/\/semmelweis.hu\/esk\/?p=2368"},"modified":"2025-12-11T15:23:04","modified_gmt":"2025-12-11T14:23:04","slug":"influenza-vedooltas-eredmenyesseg-europaban-a-2022-2023-szezon-eredmenyei-a-vebis-alapellatasban-vegzett-tobbkozpontu-vizsgalatabol","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/esk\/2024\/01\/11\/influenza-vedooltas-eredmenyesseg-europaban-a-2022-2023-szezon-eredmenyei-a-vebis-alapellatasban-vegzett-tobbkozpontu-vizsgalatabol\/","title":{"rendered":"Influenza v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9g Eur\u00f3p\u00e1ban: A 2022-2023. szezon eredm\u00e9nyei a VEBIS* alapell\u00e1t\u00e1sban v\u00e9gzett t\u00f6bbk\u00f6zpont\u00fa vizsg\u00e1lat\u00e1b\u00f3l"},"content":{"rendered":"

A 2022-2023-as l\u00e9g\u00fati szezon Eur\u00f3p\u00e1ban kezdetben az influenza A(H3N2) v\u00edrusok dominanci\u00e1j\u00e1val indult, melyet k\u00e9s\u0151bb a magasabb A(H1N1)pdm09 \u00e9s influenza B v\u00edrusok cirkul\u00e1ci\u00f3ja k\u00f6vetett. A szezon sor\u00e1n a VEBIS h\u00e1ziorvosi h\u00e1l\u00f3zat\u00e1ban a v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9get (VE) multicentrikus, teszt-negat\u00edv m\u00f3dszertannal becs\u00fclt\u00fck meg.<\/p>\n

A h\u00e1l\u00f3zatunkban r\u00e9sztvev\u0151 h\u00e1ziorvosok l\u00e9g\u00fati mint\u00e1kat \u00e9s adatokat gy\u0171jt\u00f6ttek azokt\u00f3l a betegekt\u0151l, akik akut l\u00e9g\u00fati megbeteged\u00e9s t\u00fcneteivel kerest\u00e9k fel a rendel\u0151t. A VE-t az influenzav\u00edrusokkal szemben \u00f6sszes\u00edtetten, valamint az influenza (al)t\u00edpusok \u00e9s kl\u00e1dok szerint becs\u00fclt\u00fck. Az adatokat \u00e9letkor, az olt\u00e1sok c\u00e9lcsoportja, valamint az olt\u00e1s \u00f3ta eltelt id\u0151 f\u00fcggv\u00e9ny\u00e9ben vizsg\u00e1ltuk, statisztikai m\u00f3dszerek alkalmaz\u00e1s\u00e1val.<\/p>\n

A vizsg\u00e1lat sor\u00e1n \u00f6sszesen 38\u202f058 beteget vontunk be, k\u00f6z\u00fcl\u00fck 3786 influenza A(H3N2), 1548 influenza A(H1N1)pdm09 \u00e9s 3275 influenza B eset volt.<\/p>\n

Az influenza A(H3N2) eset\u00e9ben a VE az \u00f6sszes\u00edtett korcsoportban 36% volt (95% CI: 25\u201345), m\u00edg az egyes korcsoportokban \u00e9s olt\u00e1si c\u00e9lcsoportokban m\u00e9rt VE 30% \u00e9s 52% k\u00f6z\u00f6tt v\u00e1ltozott. Az A(H3N2) 2b kl\u00e1d elleni VE-t 38%-nak (95% CI: 25\u201349) becs\u00fclt\u00fck.<\/p>\n

Az influenza A(H1N1)pdm09 ellen m\u00e9rt \u00f6sszes\u00edtett VE m\u00e9rs\u00e9kelt volt (46%; 95% CI: 35\u201356), a korcsoportok \u00e9s olt\u00e1si c\u00e9lcsoportok szerinti \u00e9rt\u00e9ke 29% \u00e9s 59% k\u00f6z\u00f6tt mozgott. A H1N1 influenzav\u00edrus 5a.2a kl\u00e1dja elleni VE k\u00f6zepes m\u00e9rt\u00e9k\u0171 volt (56%; 95% CI: 46\u201365), m\u00edg a 5a.2a.1 kl\u00e1d ellen enn\u00e9l is magasabb, 79% (95% CI: 64\u201388) volt.<\/p>\n

Az influenza B elleni VE magasabb, mintegy 76% (95% CI: 70\u201381) volt. Korcsoportok szerint: A 0\u201314 \u00e9vesekn\u00e9l 84%, a 15\u201364 \u00e9vesekn\u00e9l 72%, az v\u00e9d\u0151olt\u00e1sok c\u00e9lcsoportj\u00e1ban pedig 71%-nak m\u00e9rt\u00fck. Az influenza B v\u00edrus hemagglutinin g\u00e9nj\u00e9nek 197-es poz\u00edci\u00f3j\u00e1n mut\u00e1ci\u00f3t hordoz\u00f3 t\u00f6rzsek ellen sz\u00e1m\u00edtott VE 79% (95% CI: 73\u201385), m\u00edg a mut\u00e1ci\u00f3 n\u00e9lk\u00fcli t\u00f6rzsek ellen m\u00e9rt VE 90% (95% CI: 85\u201394) volt.<\/p>\n

A 2022\u20132023-as szezon v\u00e9g\u00e9n a VEBIS h\u00e1ziorvosi h\u00e1l\u00f3zat\u00e1ban gy\u0171jt\u00f6tt adatok szerint a v\u00e9d\u0151olt\u00e1sok magas szint\u0171 v\u00e9delmet ny\u00fajtottak a gyermekekn\u00e9l \u00e9s az influenza B ellen, m\u00edg az influenza A(H1N1)pdm09 \u00e9s A(H3N2) elleni v\u00e9delem m\u00e9rs\u00e9keltebbnek bizonyult.<\/p>\n

    \n
  1. \u00e1bra: Az influenza elleni v\u00e9d\u0151olt\u00e1s eredm\u00e9nyess\u00e9g Eur\u00f3p\u00e1ban: A 2022-2023. szezon eredm\u00e9nyei a VEBIS alapell\u00e1t\u00e1sban v\u00e9gzett multicentrikus vizsg\u00e1lat\u00e1b\u00f3l<\/strong><\/span><\/li>\n<\/ol>\n

    \"\"<\/p>\n

    Forr\u00e1s: Influenza Resp Viruses, Volume: 18, Issue: 1, First published: 10 January 2024, DOI: (10.1111\/irv.13243) publik\u00e1ci\u00f3 1. \u00e1br\u00e1ja alapj\u00e1n SE ESK saj\u00e1t szerkeszt\u00e9s<\/span><\/p>\n

     <\/p>\n

    Influenza vaccine effectiveness in Europe: Results from the 2022\u20132023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study<\/strong><\/h3>\n

    Marine Maurel <\/em>(Epiconcept, Paros, France)
    \nFrancisco Pozo <\/em>(National Centre for Microbiology, Institute of Health Carlos III, Madrid, Spain)
    \nBeatrix Oroszi <\/em>(National Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest),
    \nGerg\u0151 T\u00fari <\/em>(National Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest),
    \nand the VEBIS study team<\/p>\n

    Abstract<\/strong><\/h5>\n

    Background:<\/p>\n

    Influenza A(H3N2) viruses dominated early in the 2022\u20132023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test\u2010negative study.<\/p>\n

    Materials and Methods:<\/p>\n

    Primary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We measured VE against any influenza, influenza (sub)type and clade, by age group, by influenza vaccine target group and by time since vaccination, using logistic regression.<\/p>\n

    Results:<\/p>\n

    We included 38\u2009058 patients, of which 3786 were influenza A(H3N2), 1548 influenza A(H1N1)pdm09 and 3275 influenza B cases. Against influenza A(H3N2), VE was 36% (95% CI: 25\u201345) among all ages and ranged between 30% and 52% by age group and target group. VE against influenza A(H3N2) clade 2b was 38% (95% CI: 25\u201349). Overall, VE against influenza A(H1N1)pdm09 was 46% (95% CI: 35\u201356) and ranged between 29% and 59% by age group and target group. VE against influenza A(H1N1)pdm09 clade 5a.2a was 56% (95% CI: 46\u201365) and 79% (95% CI: 64\u201388) against clade 5a.2a.1. VE against influenza B was 76% (95% CI: 70\u201381); overall, 84%, 72% and 71% were among 0\u201314\u2010year\u2010olds, 15\u201364\u2010year\u2010olds and those in the influenza vaccination target group, respectively. VE against influenza B with a position 197 mutation of the hemagglutinin (HA) gene was 79% (95% CI: 73\u201385) and 90% (95% CI: 85\u201394) without this mutation.<\/p>\n

    Conclusion:<\/p>\n

    The 2022\u20132023 end\u2010of\u2010season results from the VEBIS network at primary care level showed high VE among children and against influenza B, with lower VE against influenza A(H1N1)pdm09 and A(H3N2).<\/p>\n

    * Vaccine Effectiveness, Burden and Impact Studies<\/span><\/p>\n

    Maurel M, Pozo F, P\u00e9rez-Gimeno G, Buda S, S\u00e8ve N, Oroszi B, Hooiveld M, Gomez V, Domegan L, Mart\u00ednez-Baz I, Ili\u0107 M, Carnahan AS, Mihai ME, Mart\u00ednez A, Goerlitz L, Enouf V, Horv\u00e1th JK, Dijkstra F, Rodrigues AP, Bennett C, Trobajo-Sanmart\u00edn C, Mlinari\u0107 I, Latorre-Margalef N, Ivanciuc A, Lopez A, D\u00fcrrwald R, Falchi A, T\u00fari G, Meijer A, Melo A, O’Donnell J, Castilla J, Vu\u010dina VV, Hagey TS, Lazar M, Kaczmarek M, Bacci S, Kissling E; VEBIS study team. Influenza vaccine effectiveness in Europe: Results from the 2022-2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study. Influenza Other Respir Viruses. 2024 Jan 10;18(1):e13243. doi: 10.1111\/irv.13243. PMID: 38204584; PMCID: PMC10777262.<\/span><\/p>\n

    https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10777262\/<\/strong><\/a><\/p>\n

     <\/p>\n

    K\u00e9sz\u00edtette az \"\"\u00a0<\/em><\/span><\/p>\n

    \"\"<\/em>RRF-2.3.1-21-2022-00006\u00a0<\/span><\/span><\/p>\n

    \"\"<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

    A 2022-2023-as l\u00e9g\u00fati szezon Eur\u00f3p\u00e1ban kezdetben az influenza A(H3N2) v\u00edrusok dominanci\u00e1j\u00e1val indult, melyet k\u00e9s\u0151bb a magasabb A(H1N1)pdm09 \u00e9s influenza B v\u00edrusok cirkul\u00e1ci\u00f3ja k\u00f6vetett. A szezon sor\u00e1n a VEBIS h\u00e1ziorvosi h\u00e1l\u00f3zat\u00e1ban a v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9get (VE) multicentrikus, teszt-negat\u00edv m\u00f3dszertannal becs\u00fclt\u00fck meg. A h\u00e1l\u00f3zatunkban r\u00e9sztvev\u0151 h\u00e1ziorvosok l\u00e9g\u00fati mint\u00e1kat \u00e9s adatokat gy\u0171jt\u00f6ttek azokt\u00f3l a betegekt\u0151l, akik akut l\u00e9g\u00fati megbeteged\u00e9s t\u00fcneteivel …<\/p>\n","protected":false},"author":102284,"featured_media":2369,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-2368","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cikk-osszefoglalok"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts\/2368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/users\/102284"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/comments?post=2368"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts\/2368\/revisions"}],"predecessor-version":[{"id":2371,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts\/2368\/revisions\/2371"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/media\/2369"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/media?parent=2368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/categories?post=2368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/tags?post=2368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}