{"id":1454,"date":"2024-07-06T11:38:42","date_gmt":"2024-07-06T09:38:42","guid":{"rendered":"https:\/\/semmelweis.hu\/esk\/?p=1454"},"modified":"2024-09-25T14:34:13","modified_gmt":"2024-09-25T12:34:13","slug":"az-influenza-elleni-vedooltas-eredmenyesseg-becslesehez-alkalmazott-klinikai-esetdefiniciok-hatasanak-vizsgalata-az-alapellatasban-a-2022-23-as-szezon-vegi-vebis-multicentrikus-europai-vizsgalat-ered","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/esk\/2024\/07\/06\/az-influenza-elleni-vedooltas-eredmenyesseg-becslesehez-alkalmazott-klinikai-esetdefiniciok-hatasanak-vizsgalata-az-alapellatasban-a-2022-23-as-szezon-vegi-vebis-multicentrikus-europai-vizsgalat-ered\/","title":{"rendered":"Az influenza elleni v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9g becsl\u00e9s\u00e9hez alkalmazott klinikai esetdefin\u00edci\u00f3k hat\u00e1s\u00e1nak vizsg\u00e1lata az alapell\u00e1t\u00e1sban: a 2022-23-as szezon v\u00e9gi VEBIS multicentrikus eur\u00f3pai vizsg\u00e1lat eredm\u00e9nyei"},"content":{"rendered":"

Az influenza v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9gi vizsg\u00e1latokban alkalmazott Eur\u00f3pai Uni\u00f3s esetdefin\u00edci\u00f3k<\/em><\/p>\n

\"\"<\/p>\n

A h\u00e1ziorvosok r\u00e9szv\u00e9tel\u00e9vel zajl\u00f3 influenza v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9gi (IVE) vizsg\u00e1latokba a p\u00e1ciensek bev\u00e1logat\u00e1s\u00e1ra elt\u00e9r\u0151 klinikai defin\u00edci\u00f3k alkalmazhat\u00f3k, egyr\u00e9szt az Eur\u00f3pai Uni\u00f3 (EU) akut l\u00e9g\u00fati megbeteged\u00e9s (ARI) szerinti esetdefin\u00edci\u00f3, valamint az EU influenzaszer\u0171 megbeteged\u00e9s (ILI) esetdefin\u00edci\u00f3 (ez ut\u00f3bbi r\u00e9szhalmaza az ARI esetdefin\u00edci\u00f3j\u00e1nak) (\u00e1bra).<\/p>\n

A jelen tanulm\u00e1nyban az alapell\u00e1t\u00e1sban v\u00e9gzett VEBIS* eur\u00f3pai multicentrikus vizsg\u00e1lat 2022-23 szezonv\u00e9gi adatait vizsg\u00e1ltuk meg, miszerint a k\u00fcl\u00f6nb\u00f6z\u0151 klinikai esetdefin\u00edci\u00f3k alkalmaz\u00e1sa befoly\u00e1solja-e az influenza v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9g\u00e9t. A vizsg\u00e1lat keret\u00e9ben logisztikus regresszi\u00f3val elemezt\u00fck az influenza \u00e9s influenza (al)vari\u00e1nsai elleni v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9g\u00e9t 0-14, 15-64, \u226565 \u00e9ves korcsoportok, valamint az influenzaolt\u00e1s c\u00e9lcsoportja szerinti bont\u00e1sban. A betegek bev\u00e1logat\u00e1shoz kiz\u00e1r\u00f3lag azokat a helysz\u00edneket vett\u00fck figyelembe, ahol az ARI esetdefin\u00edci\u00f3t haszn\u00e1lt\u00e1k.<\/p>\n

Az IVE becsl\u00e9sek \u00f6sszehasonl\u00edt\u00e1s\u00e1t a k\u00e9t esetdefin\u00edci\u00f3 (ARI \u00e9s ILI) szerinti csoportban v\u00e9gezt\u00fck. Az elemz\u00e9sbe bevont \u00f6sszes ARI eset 90%-a az ILI esetdefin\u00edci\u00f3nak is megfeleltehet\u0151 volt (ARI: 24\u00a0319 p\u00e1ciens, ILI: 21\u00a0804 p\u00e1ciens). A teljes vizsg\u00e1lati popul\u00e1ci\u00f3ban az influenza (al)vari\u00e1nsok szerinti VE legfeljebb 2%-ban t\u00e9rt el az ILI \u00e9s ARI betegk\u00f6r k\u00f6z\u00f6tt. Az eredm\u00e9nyek azt jelzik, hogy a 2022-23-as influenzaszezonban a VE-t jelent\u0151sen nem befoly\u00e1solta az elt\u00e9r\u0151 klinikai esetdefin\u00edci\u00f3 alkalmaz\u00e1sa a toborz\u00e1s sor\u00e1n.<\/p>\n

*VEBIS: Vaccine Effectiveness, Burden and Impact Studies<\/span><\/p>\n

Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe <\/strong><\/span><\/h3>\n


\n<\/u><\/strong><\/span>Marine Maurel<\/em> (Epiconcept),
\n<\/em>Esther Kissling <\/em>(Epiconcept),
\n<\/em>Beatrix Oroszi <\/em>(National Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest),
\n<\/em>Gerg\u0151 T\u00fari <\/em>(National Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest),
\n<\/em>Judit Krisztina\u00a0Horv\u00e1th <\/em>(National Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest)
\n<\/em>and VEBIS study team<\/em><\/p>\n

Abstract
\n<\/u><\/strong><\/span>For studies of influenza vaccine effectiveness (IVE) in the primary care setting, different clinical definitions may be used for patient recruitment, such as the European Union (EU) acute respiratory illness (ARI) and the EU influenza-like illness case (ILI) definitions (the latter includes a subset of patients meeting the EU ARI case definition) (Figure).<\/p>\n

Our research analyzes the 2022-23 end-of-season data from the VEBIS* European multicentre study in primary care setting to determine how various clinical definitions impact influenza vaccine effectiveness. We used logistic regression to measure vaccination effectiveness against influenza and influenza (sub)variants by age groups 0-14, 15-64, \u226565 years and by influenza vaccine target group. We only considered study sites that used the ARI case definition for patient selection.<\/p>\n

The IVE estimates were compared for the two groups according to each case definition (ARI and ILI). There was 90% overlap between patients meeting the EU ARI and the EU ILI (ARI: 24,319 patients, ILI: 21,804 patients). According to our results, the effectiveness of the influenza vaccine was 2% or less different between ILI and ARI patients. \u00a0The results indicate that the VE estimates in the 2022-23 influenza season did not differ significantly when using a different clinical definition for recruitment.<\/p>\n

*VEBIS: Vaccine Effectiveness, Burden and Impact Studies<\/span><\/p>\n

Vaccine. Published online May 3, 2024. doi:10.1016\/j.vaccine.2024.04.060
\nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X24004973?via%3Dihub<\/a>\u00a0<\/p>\n

K\u00e9sz\u00edtette az \"\"\u00a0<\/em><\/p>\n

RRF-2.3.1-21-2022-00006 Eg\u00e9szs\u00e9gbiztons\u00e1g Nemzeti Laborat\u00f3rium projekt <\/em><\/span>\"\"<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

Az influenza v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9gi vizsg\u00e1latokban alkalmazott Eur\u00f3pai Uni\u00f3s esetdefin\u00edci\u00f3k A h\u00e1ziorvosok r\u00e9szv\u00e9tel\u00e9vel zajl\u00f3 influenza v\u00e9d\u0151olt\u00e1s-eredm\u00e9nyess\u00e9gi (IVE) vizsg\u00e1latokba a p\u00e1ciensek bev\u00e1logat\u00e1s\u00e1ra elt\u00e9r\u0151 klinikai defin\u00edci\u00f3k alkalmazhat\u00f3k, egyr\u00e9szt az Eur\u00f3pai Uni\u00f3 (EU) akut l\u00e9g\u00fati megbeteged\u00e9s (ARI) szerinti esetdefin\u00edci\u00f3, valamint az EU influenzaszer\u0171 megbeteged\u00e9s (ILI) esetdefin\u00edci\u00f3 (ez ut\u00f3bbi r\u00e9szhalmaza az ARI esetdefin\u00edci\u00f3j\u00e1nak) (\u00e1bra). A jelen tanulm\u00e1nyban az alapell\u00e1t\u00e1sban v\u00e9gzett VEBIS* …<\/p>\n","protected":false},"author":102284,"featured_media":1597,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-1454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cikk-osszefoglalok"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts\/1454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/users\/102284"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/comments?post=1454"}],"version-history":[{"count":6,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts\/1454\/revisions"}],"predecessor-version":[{"id":1598,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/posts\/1454\/revisions\/1598"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/media\/1597"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/media?parent=1454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/categories?post=1454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/esk\/wp-json\/wp\/v2\/tags?post=1454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}