{"id":44532,"date":"2025-05-07T11:00:25","date_gmt":"2025-05-07T09:00:25","guid":{"rendered":"https:\/\/semmelweis.hu\/english\/?p=44532"},"modified":"2025-11-26T10:27:54","modified_gmt":"2025-11-26T09:27:54","slug":"more-aspirin-doesnt-mean-better-protection-against-preeclampsia-study-finds","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/english\/2025\/05\/more-aspirin-doesnt-mean-better-protection-against-preeclampsia-study-finds\/","title":{"rendered":"More Aspirin Doesn\u2019t Mean Better Protection Against Preeclampsia, Study Finds"},"content":{"rendered":"
Taking a higher dose of aspirin during pregnancy doesn\u2019t offer better protection against preeclampsia than a lower dose, according to a new study by Semmelweis University<\/a> that found no clear link between increasing the dose and reducing the chances of developing the condition. Starting the therapy early, irrespective of the dose, has a greater potential to reduce the risk, the authors confirm.<\/div>\n

Preeclampsia, a serious complication of pregnancy that causes high blood pressure and excess protein in urine, affects about five percent of pregnancies and is the leading cause of maternal death among all pregnancy-related conditions associated with high blood pressure.<\/p>\n

It can develop in one out of every twenty pregnancies in healthy mothers, with the risk increasing with older maternal age, multiple pregnancies (twins), previous history of high blood pressure, obesity and\/or during a first pregnancy. Aspirin (active ingredient) is a common preventive treatment for preeclampsia, typically in daily doses ranging from 25 to 100 mg.\u00a0<\/p>\n

\n

To find out whether increasing the dose would be more effective, the researchers at Semmelweis university reviewed data from nearly 55,000 pregnant women.<\/p>\n<\/div>\n

\u201cWe wanted to see if there\u2019s any benefit to giving higher doses of aspirin\u201d, says first author Bal\u00e1zs Komor\u00f3czy of the Department of Obstetrics and Gynecology, Semmelweis University.<\/p>\n

\u201cOur aim was to study the largest population possible and compare different dosage ranges, regardless of\u00a0 known risk factors\u201d, he adds.<\/p>\n

\n

In the group that received the 100 mg dose, the most commonly used in practice, the incidence of preeclampsia was reduced by 60%.<\/p>\n<\/div>\n

However, increasing the dose to 150 mg did not necessarily lead to a greater reduction in risk.<\/p>\n

\u201cWe could not establish a clear correlation between dosage and efficacy\u201d, the researcher notes.<\/p>\n

\"\"<\/a>When deciding on preventive treatment, physicians assess individual risk factors. \u201cAspirin being a blood thinner, the main concern is an increased risk of bleeding\u201d, says Komor\u00f3czy adding that this often discourages routine administration.<\/p>\n

While the study did observe slightly higher rates of bleeding among the women involved, the increase did not reach statistical significance. \u201cThis suggests the difference may be due to chance\u201d, said Komor\u00f3czy.<\/p>\n

The timing of aspirin therapy is more important than dosage. For optimal effectiveness, it is advised to start treatment early, ideally between the 12th and 15th weeks of pregnancy.<\/p>\n

\"\"\u201cPreeclampsia and pregnancy-induced hypertension generally develop around the 20th week in individuals prone to developing this condition\u201d, says corresponding author N\u00e1ndor \u00c1cs, director of the Department of Obstetrics and Gynecology, Semmelweis University. If high blood pressure (\u2265140\/90 mmHg) is measured on multiple occasions earlier than that, it is considered chronic hypertension.<\/p>\n

Though preeclampsia is widely researched, most studies focus on specific subgroups. Comparisons between different aspirin doses (rather than versus placebo) are rare. \u201cFuture research should further compare higher doses to established effective ones, but current data on this is limited\u201d, Komor\u00f3czy notes.<\/p>\n

Preeclampsia: Its exact cause is unknown. Symptoms may include upper abdominal pain, headache, changes in the vision (like seeing flashing lights), nausea, and vomiting. The most serious maternal complication is eclampsia, which involves seizures and kidney dysfunction. For the baby, it can cause fetal growth restriction, and in severe cases, stillbirth\/preterm birth.<\/div>\n

Zs\u00f3fia V\u00e9gh<\/p>\n

Photo: Semmelweis University – B\u00e1lint Barta, Attila Kov\u00e1cs; Cover photo (illustration): iStock by Getty Images – AndreyPopov<\/p>\n","protected":false},"excerpt":{"rendered":"

The researchers could not establish a clear correlation between dosage and efficacy.<\/p>\n","protected":false},"author":102059,"featured_media":44533,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[129,270,286],"tags":[261],"class_list":["post-44532","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-other","category-x-nyitolap","tag-press"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/44532","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/users\/102059"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/comments?post=44532"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/44532\/revisions"}],"predecessor-version":[{"id":46650,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/44532\/revisions\/46650"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/media\/44533"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/media?parent=44532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/categories?post=44532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/tags?post=44532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}