{"id":3549,"date":"2013-09-20T14:39:22","date_gmt":"2013-09-20T12:39:22","guid":{"rendered":"http:\/\/semmelweis-egyetem.hu\/english\/?p=3549"},"modified":"2015-12-10T16:03:27","modified_gmt":"2015-12-10T15:03:27","slug":"depression-and-personalised-treatment-dr-gyorgy-bagdys-academic-research-team","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/english\/2013\/09\/depression-and-personalised-treatment-dr-gyorgy-bagdys-academic-research-team\/","title":{"rendered":"Depression and personalised treatment \u2013 Dr. Gy\u00f6rgy Bagdy\u2019s academic research team"},"content":{"rendered":"

The Neuropsychopharmacological and Neurochemical research team, which was established on July 1st<\/sup> by Dr. Gy\u00f6rgy Bagdy, focuses on improving the possibilities of treating depression. The research project\u2019s title is: The Examination of the Role of Environmental and Inheritable Factors in the Emergence of Human Depression through Genomical and Picture Imaging Methods<\/em>.<\/p>\n

\"Dr.<\/a>,,In practice this means that from our daily problems and from the stress that affects us, through the visualized process of our brains, we get all the way to the level of molecules so that then we may build a satisfactory model for certain groups of people and situations that may be used in clinical practice and therapy.\u201c \u2013 explained Professor Gy\u00f6rgy Bagdy, director of the Department of Parmacodynamics.<\/p>\n

The choice of the topic is justified by the frequency of the occurrence of depression which \u2013 according to the predictions of WHO \u2013 will be the most burdening illness regarding the quality of life in middle and high income economies by 2030. Despite the fact that we possess effective antidepressants, only 50% of the patients show improvement after the first treatment, and an estimated of 1\/3 of them don\u2019t get better even after the fourth treatment. The treatment may even increase distress in a small group of patients. The topic\u2019s saddening actuality is emphasised by the fact that the economic crisis \u2013 as an environmental factor \u2013 has further aggravated the situation. Thus, for example, the decades-long tendency of decreasing number of suicides in Europe has halted. \u201cIt is our aim to be able to determine who suffers from serious mood swings due to environmental factors and what kind of alternative and medicinal treatment possibilities we may offer to that person.\u201d<\/p>\n

Professor Bagdy and his team are not new to this subject: they have already dealt with this topic as one of the most successful members of a big international syndicate supported by the EU between 2004 and 2009. Apart from genotypically extendable samples, they now possess a databank of several thousand people that contains personality traits, environmental factors and response strategies used in stressful situations; all thanks to their project. As a result, numerous scientific articles were born that encouraged serious debate. Thus, Dr. Gy\u00f6rgy Bagdy and his team were the first to write about the connection between serotonergic system and the endocannabinoid CB1 receptor. Also, they have identified many of the unknown effects and side-effects of numerous antidepressants that are currently in use.<\/p>\n

\"Dr.<\/a><\/p>\n

\u201cOn one hand, one of our main goals is to predict the effects of the currently used antidepressants, on the other hand we wish to identify new therapeutic targets\u201d \u2013 answered Dr. Gy\u00f6rgy Bagdy when we asked him what they would like to achieve at the end of the 5 year period supported by the Hungarian Academy of Sciences. As he explained, the precise knowledge of the symptoms may help in planning the treatment in some cases, but we still haven\u2019t identified the right biological markers which would predict the effects and side-effects of antidepressants even though these would provide guidance in creating personalised treatment. The professor also stressed that along with the medications used today to treat depression we would also need to develop medications with completely different underlying system of effects. This process has to be preceded by and based on the identification of neurobiological pathways and their protein components which all play a part in the emergence of human depression.<\/p>\n

In accordance with the application guidelines, the team consists of young scientists: doctors, pharmacists, biologists, psychologists and bioinformaticians. \u00a0The majority of them are researchers, who have obtained qualification in a laboratory \u2013 or they will in the near future \u2013 and whose skills and commitment toward science were observed by the professor beforehand.<\/p>\n

Dr. Gy\u00f6rgy Bagdy has mentioned by name \u2013 among others \u2013 Dr. Gabriella Juh\u00e1sz, who finished at Szent\u00e1gothai J\u00e1nos Doctoral School of Neurosciences following which she worked with Dr. Bagdy at a European consortium already in the employment of the partner in Manchester. The neurologist \u2013 who is one of the leading teachers of the Department of Pharmacodynamics \u2013 has presented results in the fields of genetics and pharmaco- and functional MRI. Dr. X\u00e9nia Gonda is also a member of the team who obtained the scientific qualification in 2009 on top of her two other diplomas and by now she has become an internationally renowned expert of the personality traits and temperaments that play a part in the development of depression. Dr. Judit Laz\u00e1ry \u2013 also part of the team \u2013 was awarded the Junior Pr\u00edma award in 2012. The prospective psychiatrist presented the \u2018mood-creating genes\u2019 to the audience at the Kutat\u00f3i Szalon event (Researchers\u2019 Salon) in April.<\/p>\n

The Hungarian Academy of Sciences stated in May that it only supports 15 research groups in 7 universities throughout the country. Semmelweis University won two applications: Dr. Veronika \u00c1d\u00e1m, director of the Department of Medical Biochemistry and Dr. Gy\u00f6rgy Bagdy, director of the Department of Pharmacodynamics received support from the Academy to create research groups.\u00a0<\/p>\n

P\u00e1lma Dobozi
Translated by: Bonif\u00e1c Makkai<\/p>\n","protected":false},"excerpt":{"rendered":"

The Neuropsychopharmacological and Neurochemical research team, which was established on July 1st by Dr. Gy\u00f6rgy Bagdy, focuses on improving the possibilities of treating depression. The research project\u2019s title is: The Examination of the Role of Environmental and Inheritable Factors in the Emergence of Human Depression through Genomical and Picture Imaging Methods. <\/a> ,,In practice this means …<\/p>\n","protected":false},"author":203,"featured_media":3551,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13,2],"tags":[],"class_list":["post-3549","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/3549","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/users\/203"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/comments?post=3549"}],"version-history":[{"count":3,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/3549\/revisions"}],"predecessor-version":[{"id":6831,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/3549\/revisions\/6831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/media\/3551"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/media?parent=3549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/categories?post=3549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/tags?post=3549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}