{"id":27528,"date":"2021-08-12T09:00:12","date_gmt":"2021-08-12T07:00:12","guid":{"rendered":"https:\/\/semmelweis.hu\/english\/?p=27528"},"modified":"2021-08-12T16:58:54","modified_gmt":"2021-08-12T14:58:54","slug":"breakthrough-in-treating-a-rare-childhood-disorder-at-semmelweis-university","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/english\/2021\/08\/breakthrough-in-treating-a-rare-childhood-disorder-at-semmelweis-university\/","title":{"rendered":"Breakthrough in treating a rare childhood disorder at Semmelweis University"},"content":{"rendered":"<div class=\"lead\">4 children were among the first patients in Hungary to undergo a new biological therapy at the 1st and 2nd Department of Pediatrics of Semmelweis University. New therapeutic option has recently been developed to treat growth disorder and bone deformity in children.<\/div>\n<p>There are approximately 20-25 children in Hungary suffering from hypophosphatemia, a rare genetic disorder linked to the X chromosome which causes the kidney to lose phosphate due to the increased level of a hormone. <\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-27529 alignright\" src=\"https:\/\/semmelweis.hu\/english\/files\/2021\/08\/RS10949_KA-20110722-IMG_5259-scr-753x497-1-400x264.jpg\" alt=\"\" width=\"400\" height=\"264\" srcset=\"https:\/\/semmelweis.hu\/english\/files\/2021\/08\/RS10949_KA-20110722-IMG_5259-scr-753x497-1-400x264.jpg 400w, https:\/\/semmelweis.hu\/english\/files\/2021\/08\/RS10949_KA-20110722-IMG_5259-scr-753x497-1-203x135.jpg 203w, https:\/\/semmelweis.hu\/english\/files\/2021\/08\/RS10949_KA-20110722-IMG_5259-scr-753x497-1.jpg 753w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/> &#8220;The most common symptoms affect the structure and strength of bones and teeth, causing pain, growth abnormalities, and rachitis characterized by bone deformity. A new biological therapy has\u00a0 recently been developed, which uses an antibody targeting the phosphate excreting hormone.&#8221;, said Dr. Gy\u00f6rgy Reusz and dr. Andr\u00e1s Szab\u00f3, the two professors from the 1st and 2nd Departments of Pediatrics responsible for the treatment. <\/p>\n<p>4 pediatric patients were the first in Hungary to receive this brand new and effective drug treatment as part of a biological therapy at Semmelweis University. One of the children showed visible signs of this rare disease: his lower limbs were moderately bent, which would have caused a severe deformity affecting the ability of walking by adolescence without treatment. However, the disease can be successfully treated with biological therapy.\u00a0<\/p>\n<div class=\"fontos_div\">\n<p>The drug containing the active substance burosumab has been successfully started in children without complications who will need to continue the therapy until they reach adolescence, when skeletal growth stops.<\/p>\n<\/div>\n<p>According to Dr. Attila Szab\u00f3, Director of the 1st Department of Pediatrics, the treatment of more children is going to be started at Semmelweis University in the following days.<\/p>\n<p>Orsolya D\u00e1vid<br \/>\nPhoto (illustration): Attila Kov\u00e1cs \u2013 Semmelweis University<\/p>\n<p>Translation: Norbert Luk\u00e1cs<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new biological therapy has been recently developed to treat growth disorder and bone deformity in children.<\/p>\n","protected":false},"author":101920,"featured_media":27529,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[129,13,2],"tags":[215,31,121],"class_list":["post-27528","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-science","category-news","tag-healing","tag-health-care","tag-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/27528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/users\/101920"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/comments?post=27528"}],"version-history":[{"count":5,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/27528\/revisions"}],"predecessor-version":[{"id":27545,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/posts\/27528\/revisions\/27545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/media\/27529"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/media?parent=27528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/categories?post=27528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/english\/wp-json\/wp\/v2\/tags?post=27528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}