{"id":24171,"date":"2024-01-20T15:07:36","date_gmt":"2024-01-20T14:07:36","guid":{"rendered":"https:\/\/semmelweis.hu\/emk\/?p=24171"},"modified":"2024-12-18T15:23:59","modified_gmt":"2024-12-18T14:23:59","slug":"biologiai-alapokon-nyugvo-mely-tanulas-segithet-az-eletkorral-osszefuggo-allapotok-kockazatertekeleseben","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/emk\/2024\/01\/20\/biologiai-alapokon-nyugvo-mely-tanulas-segithet-az-eletkorral-osszefuggo-allapotok-kockazatertekeleseben\/","title":{"rendered":"Biol\u00f3giai alapokon nyugv\u00f3 m\u00e9ly tanul\u00e1s seg\u00edthet az \u00e9letkorral \u00f6sszef\u00fcgg\u0151 \u00e1llapotok kock\u00e1zat\u00e9rt\u00e9kel\u00e9s\u00e9ben"},"content":{"rendered":"<p style=\"text-align: justify\"><span style=\"font-weight: 400\">Az <strong>\u00f6reged\u00e9s<\/strong>t gyakran jellemzi a k\u00e1rosod\u00e1sok folyamatos felhalmoz\u00f3d\u00e1sa, ami ami a kr\u00f3nikus betegs\u00e9gek egyik f\u0151 kock\u00e1zati t\u00e9nyez\u0151je. Az epigenetikai (a g\u00e9nm\u0171k\u00f6d\u00e9st szab\u00e1lyoz\u00f3) mechanizmusok, bele\u00e9rtve a DNS-metil\u00e1ci\u00f3t, szerepet j\u00e1tszhatnak az \u00f6reged\u00e9s folyamat\u00e1ban, azonban azokat a kulcsfontoss\u00e1g\u00fa funkci\u00f3kat \u00e9s biol\u00f3giai folyamatokat, amelyek befoly\u00e1solhatj\u00e1k az \u00f6reged\u00e9st, m\u00e9g mindig nem \u00e9rtj\u00fck teljesen, mely funkci\u00f3k \u00e9s biol\u00f3giai folyamatok befoly\u00e1solj\u00e1k azt.\u00a0<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">Az <\/span><b>epigenetikus \u00f3r\u00e1k<\/b><span style=\"font-weight: 400\">nak nevezett \u00e9letkor-el\u0151rejelz\u0151k pontosan meg tudj\u00e1k becs\u00fclni az szervezet biol\u00f3giai \u00e9letkor\u00e1t a sejt DNS-metil\u00e1ci\u00f3ja alapj\u00e1n, de modelljeik csak csak r\u00e9szben magyar\u00e1zz\u00e1k az \u00f6reged\u00e9st szab\u00e1lyoz\u00f3 kulcsfontoss\u00e1g\u00fa biol\u00f3giai folyamatok m\u00f6g\u00f6tt megh\u00faz\u00f3d\u00f3 el\u0151rejelz\u0151 algoritmust.\u00a0<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">A<\/span><b> Scientific Reports<\/b><span style=\"font-weight: 400\"> foly\u00f3iratban 2024 janu\u00e1rj\u00e1ban megjelent tanulm\u00e1ny, amelynek t\u00e1rsszerz\u0151je az EMK docense, <\/span><b>dr. Palla Gergely<\/b><span style=\"font-weight: 400\">, bemutatja a <strong>XAI-AGE<\/strong>-t, amely egy biol\u00f3giailag megalapozott, t\u00f6bb sz\u00f6vett\u00edpust vizsg\u00e1l\u00f3 m\u00e9ly neur\u00e1lis h\u00e1l\u00f3zati modell a <strong>biol\u00f3giai \u00e9letkor pontos el\u0151rejelz\u00e9s\u00e9re<\/strong>. <\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">A XAI-AGE fel\u00fclm\u00falja az els\u0151 gener\u00e1ci\u00f3s \u00e9letkor-el\u0151rejelz\u0151ket, \u00e9s a deep learningen (m\u00e9ly tanul\u00e1son) alapul\u00f3 modellekhez hasonl\u00f3 eredm\u00e9nyeket \u00e9r el, mik\u00f6zben lehet\u0151s\u00e9get ad arra, hogy k\u00f6zvetlen\u00fcl a modellb\u0151l k\u00f6vetkeztess\u00fcnk az \u00fatvonalak \u00e9s m\u00e1s absztrakt biol\u00f3giai folyamatok aktivit\u00e1s\u00e1ra. \u00cdgy k\u00e9pesek lesz\u00fcnk jobban \u00e1tl\u00e1tni azokat a kronol\u00f3giai \u00e9letkoron fel\u00fcli tov\u00e1bbi inform\u00e1ci\u00f3kat, amelyek seg\u00edthetnek az <strong>\u00e9letkorral \u00f6sszef\u00fcgg\u0151 \u00e1llapotok kock\u00e1zat\u00e9rt\u00e9kel\u00e9s\u00e9ben<\/strong>.<\/span><\/p>\n<div class=\"fontos_div w-100\">\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">A teljes cikk el\u00e9rhet\u0151 ezen a linken: <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-50495-5\" target=\"_blank\" rel=\"noopener\"><strong>Biologically informed deep learning for explainable epigenetic clocks<\/strong><\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Az \u00f6reged\u00e9st gyakran jellemzi a k\u00e1rosod\u00e1sok folyamatos felhalmoz\u00f3d\u00e1sa, ami ami a kr\u00f3nikus betegs\u00e9gek egyik f\u0151 kock\u00e1zati t\u00e9nyez\u0151je. Az epigenetikai (a g\u00e9nm\u0171k\u00f6d\u00e9st szab\u00e1lyoz\u00f3) mechanizmusok, bele\u00e9rtve a DNS-metil\u00e1ci\u00f3t, szerepet j\u00e1tszhatnak az \u00f6reged\u00e9s folyamat\u00e1ban, azonban azokat a kulcsfontoss\u00e1g\u00fa funkci\u00f3kat \u00e9s biol\u00f3giai folyamatokat, amelyek befoly\u00e1solhatj\u00e1k az \u00f6reged\u00e9st, m\u00e9g mindig nem \u00e9rtj\u00fck teljesen, mely funkci\u00f3k \u00e9s biol\u00f3giai folyamatok befoly\u00e1solj\u00e1k azt.\u00a0 &hellip;<\/p>\n","protected":false},"author":102350,"featured_media":24173,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[529,527,531],"class_list":["post-24171","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek","tag-deep-learning","tag-epigenetika","tag-scientific-reports"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/posts\/24171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/users\/102350"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/comments?post=24171"}],"version-history":[{"count":4,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/posts\/24171\/revisions"}],"predecessor-version":[{"id":24176,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/posts\/24171\/revisions\/24176"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/media\/24173"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/media?parent=24171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/categories?post=24171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/emk\/wp-json\/wp\/v2\/tags?post=24171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}