{"id":4146,"date":"2019-07-10T15:53:32","date_gmt":"2019-07-10T13:53:32","guid":{"rendered":"http:\/\/semmelweis.hu\/elettan\/?page_id=4146"},"modified":"2021-07-22T16:08:59","modified_gmt":"2021-07-22T14:08:59","slug":"chronophysiology-lab","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/elettan\/kutatas\/chronophysiology-lab\/","title":{"rendered":"Chronophysiology lab"},"content":{"rendered":"

Lab members:<\/em><\/h3>\n

Dr. Krisztina K\u00e1ldi (PI)
\nDr. Krisztina Ella
\n\u00c1gnes S\u0171dy
\nAnita Sz\u0151ke
\nOrsolya S\u00e1rk\u00e1ny
\nZs\u00f3fia B\u00far<\/p>\n

\"\"<\/a><\/p>\n

The circadian time-keeping system enhances the adaptive ability of the organism by preparing it to the periodical changes in the environment, and on the other hand, allows temporal separation of otherwise conflicting biochemical activities (e.g<\/em>. catabolic and anabolic processes). Endogenous time measuring is organized at the cellular level and almost all mammalian cells harbour self-sustained circadian oscillators. Coherent time-measuring at the level of the whole organism needs synchronization of these cellular oscillators. The suprachiasmatic nucleus is considered as the master pacemaker, that drives peripheral oscillators by neuronal and humoral mechanisms.<\/p>\n

Circadian rhythm disturbances are associated with an increased risk of severe health problems, including cardiovascular diseases, metabolic syndrome, diabetes mellitus, various malignancies and psychiatric diseases such as mood disorders. In the modern society the risk for circadian misalignment is increasing due to the growing demand of shift work and intense exposure to artificial light during the late evening hours. Moreover, a large portion of the society is affected by social jetlag, the disruption of the circadian rhythm by sleeping at different times on workdays and during the weekend.<\/p>\n

Our research group is interested in a broad field of chronobiology research including the examination of molecular clock functions, studying circadian control of the immune system and exploring human behavioural rhythms.<\/strong><\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

Publications<\/strong><\/h3>\n

S\u0171dy \u00c1R, Ella K, B\u00f3dizs R and K\u00e1ldi K
\nAssociation of Social Jetlag With Sleep Quality and Autonomic Cardiac Control During Sleep in Young Healthy Men
\n<\/em>Front. Neurosci. 13:950, 2019<\/p>\n

Ella K, M\u00f3csai A, K\u00e1ldi K
\nCircadian regulation of neutrophils: Control by a cell-autonomous clock or systemic factors?
\n<\/em>Eur J Clin Invest. 2018;e12965.<\/p>\n

Gy\u00f6ngy\u00f6si N, Sz\u00f6ke A, Ella K, K\u00e1ldi K
\nThe small G protein RAS2 is involved in the metabolic compensation of the circadian clock in the circadian model Neurospora crassa
\n<\/em>Biol. Chem. 292:14929-14939, 2017<\/p>\n

Ella K , Cs\u00e9p\u00e1nyi-K\u00f6mi R , K\u00e1ldi K
\nCircadian regulation of human peripheral neutrophils
\n<\/em>BRAIN BEHAVIOR AND IMMUNITY 57:209-221, 2016<\/p>\n

Gy\u00f6ngy\u00f6si N, K\u00e1ldi K
\nInterconnections of Reactive Oxygen Species Homeostasis and Circadian Rhythm in Neurospora crassa
\n<\/em>ANTIOXIDANTS AND REDOX SIGNALING 20: 3007-3023, 2014<\/p>\n

Haraszti R\u00c1, Ella K, Gy\u00f6ngy\u00f6si N, Roenneberg T, K\u00e1ldi K
\nSocial jetlag negatively correlates with academic performance in undergraduates
\n<\/em>Chronobiol Int 31:603-12, 2014<\/p>\n

Gy\u00f6ngy\u00f6si N, Nagy D, Makara K, Ella K, K\u00e1ldi K
\nReactive oxygen species can modulate circadian phase and period in Neurospora crassa
\n<\/em>FREE RADICAL BIOLOGY AND MEDICINE 58: pp. 134-143, 2013<\/p>\n

Ruisanchez E, Cselenyak A, Papp RS, Nemeth T, K\u00e1ldi K, Sandor P, Benyo Z
\nPerivascular expression and potent vasoconstrictor effect of dynorphin a in cerebral arteries
\n<\/em>PLOS ONE 7:(5) p. e37798, 2012<\/p>\n

* Malzahn E, * Ciprianidis S, * K\u00e1ldi K (*joint first authors), Schafmeier T, Brunner M
\nPhotoadaptation in Neurospora by Competitive Interaction of Activating and Inhibitory LOV Domains
\n<\/em>CELL 142:(5) pp. 762-772., 2010<\/p>\n

Brunner M, K\u00e1ldi K
\nInterlocked feedback loops of the circadian clock of Neurospora crassa
\n<\/em>MOLECULAR MICROBIOLOGY 68:(2) pp. 255-262., 2008<\/p>\n

Kozma-Bognar L, K\u00e1ldi K
\nSynchronization of the Fungal and the Plant Circadian Clock by Light
\n<\/em>CHEMBIOCHEM 9:(16) pp. 2565-2573., 2008<\/p>\n

K\u00e1ldi K, Gonzalez BH, Brunner M
\nTranscriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output
\n<\/em>EMBO Rep 7: 199-204, 2006<\/p>\n

Schafmeier T, K\u00e1ldi K, Diernfellner A, Mohr C and Brunner M
\nPhosphorylation dependent maturation of Neurospora circadian clock protein from a nuclear repressor towards a cytoplasmic activator
\n<\/em>Genes Dev. 20: 297-306, 2006<\/p>\n

Sirokmany G, Szidonya L, K\u00e1ldi K, Gaborik Z, Ligeti E, Geiszt M
\nSec14 Homology Domain Targets p50RhoGAP to Endosomes and Provides a Link between Rab and Rho GTPases
\n<\/em>Biol. Chem. 281: 6096-6105, 2006<\/p>\n

*Schafmeier T, *Haase A, *K\u00e1ldi K (*joint first authors), Scholz J, Fuchs M, Brunner M
\nTranscriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor
\n<\/em>Cell 122: 235-246, 2005<\/p>\n

Rada B K, Geiszt M, Kaldi K, Timar C, Ligeti E
\nDual role of phagocytic NADPH oxidase in bacterial killing
\n<\/em>Blood 104: 2947-2953, 2004<\/p>\n

Horv\u00e1th B, Hrab\u00e1k A, K\u00e1ldi K, S\u00e1ndor P and Beny\u00f3 Z
\nContribution of the heme oxigenase pathway to the maintenance of the hypothalamic blood flow during diminished NO synthesis
\n<\/em>Cereb. Blood Flow Metab. 23: 653-657, 2003<\/p>\n

K\u00e1ldi K, Kalocsai A, Rada BK, Mezo G, Molnar GZ, Bathori G, Ligeti E
\nDegranulation and superoxide production depend on cholesterol in PLB-985 cells<\/em>, Biochem. Biophys.
\nRes. Commun. 310:1241-1246, 2003<\/p>\n

Lacza, L. D\u00e9zsi, K. K\u00e1ldi, E.M. Horv\u00e1th, P. S\u00e1ndor and Z. Beny\u00f3
\nProstacyclin-mediated compensatory mechanism in the coronary circulation during acute NO synthase blockade
\n<\/em>Life Sci 73: 1141-1149, 2003<\/p>\n

K\u00e1ldi K, Szeberenyi J, Rada BK, Kovacs P, Geiszt M, Mocsai A, Ligeti E
\nContribution of phopholipase D and a brefeldin A sensitive ARF to chemoattractant induced superoxide production and secretion of human neutrophils
\n<\/em>Leuk. Biol. 71: 695-700, 2002<\/p>\n

Lacza, K. K\u00e1ldi, K. K\u00f6vecs, C. G\u00f6rlach, Z. Nagy, P. S\u00e1ndor, Z. Beny\u00f3 and M. Wahl
\nInvolvement of prostanoid release in the mediation of UTP-induced cerebrovascular contraction in the rat
\n<\/em>Brain Res. 896: 169-174, 2001<\/p>\n

*Donzeau M, *K\u00e1ldi K (*joint first authors), Adam A, Paschen S, Wanner G, Guiard B, Bauer MF, Neupert W, Brunner M
\nThe preprotein translocase component Tim23 links the inner and outer mitochondrial membranes
\n<\/em>Cell 101: 401-412, 2000<\/p>\n

\u00a0Paschen SA, Rothbauer U, K\u00e1ldi K, Bauer MF, Neupert W and Brunner M
\nThe role of the TIM8-13 complex in the import of Tim23 into mitochondria
\n<\/em>EMBO J. 19:6392-6400, 2000<\/p>\n

Geiszt M, Szeber\u00e9nyi J, K\u00e1ldi K and Ligeti E
\nRole of different Ca2+ sources in the superoxid e production of human neutrophil granulocytes
\n<\/em>Free Rad Biol Med 26:1092-1099, 1999<\/p>\n

K\u00e1ldi K and Neupert W
\nProtein translocation into mitochondria
\n<\/em>Biofactors 8: 221-224, 1998<\/p>\n

K\u00e1ldi K, Bauer MF, Sirrenberg C, Neupert W, Brunner M
\nBiogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix targeted preproteins
\n<\/em>EMBO J. 17:1569-76, 1998<\/p>\n

K\u00e1ldi K, Sz\u00e1szi K, Koncz G, Suszt\u00e1k K and Ligeti E
\nArachidonic acid activatable electrogenic H+ transport in the absence of cytochrome b558 in human T lymphocytes
\n<\/em>FEBS Lett. 381:156-160, 1996<\/p>\n

Suszt\u00e1k K, K\u00e1ldi K, Kapus A and Ligeti E
\nLigands of purinergic receptors stimulate electrogenic H+-transport of neutrophils
\n<\/em>FEBS Lett. 375:79-82, 1995<\/p>\n

Geiszt M, K\u00e1ldi K, Szeber\u00e9nyi J and Ligeti E
\nThapsigargin inhibits calcium entry into human neutrophil granulocytes
\n<\/em>Biochem. J. 305:525-528, 1995<\/p>\n

K\u00e1ldi K, Szaszi K, Susztak K, Kapus A, Ligeti E
\nLymphocytes posses an electrogenic H+ transporting pathway in their plasma membrane
\n<\/em>Biochem. J. 301:329-334, 1994<\/p>\n

K\u00e1ldi K, Diestelkotter P, Stenbeck G, Auerbach S, Jakle U, Magert HJ, Wieland FT, Just WW
\nMembrane topology of the 22 kDa integral peroxisomal membrane protein
\n<\/em>FEBS Lett. 315:217-222, 1993<\/p>\n

Kapus, K. Sz\u00e1szi, K. K\u00e1ldi, E. Ligeti and A. Fony\u00f3
\nIs the mitochondrial Ca2+ uniporter a voltage-modulated transport pathway?
\n<\/em>FEBS Lett. 282: 61-64, 1991<\/p>\n

Kapus, K. Sz\u00e1szi, K. K\u00e1ldi, E. Ligeti and A. Fony\u00f3
\nRuthenium red inhibits mitochondrial Na+ and K+ uniports induced by magnesium removal
\n<\/em>Biol. Chem. 265: 18063-18066, 1990<\/p>\n","protected":false},"excerpt":{"rendered":"

Lab members: Dr. Krisztina K\u00e1ldi (PI) Dr. Krisztina Ella \u00c1gnes S\u0171dy Anita Sz\u0151ke Orsolya S\u00e1rk\u00e1ny Zs\u00f3fia B\u00far <\/a> The circadian time-keeping system enhances the adaptive ability of the organism by preparing it to the periodical changes in the environment, and on the other hand, allows temporal separation of otherwise conflicting biochemical activities (e.g. catabolic and anabolic …<\/p>\n","protected":false},"author":133,"featured_media":0,"parent":17,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-4146","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/4146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/users\/133"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/comments?post=4146"}],"version-history":[{"count":6,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/4146\/revisions"}],"predecessor-version":[{"id":5413,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/4146\/revisions\/5413"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/17"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/media?parent=4146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/categories?post=4146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/tags?post=4146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}