{"id":2863,"date":"2017-09-06T09:46:11","date_gmt":"2017-09-06T07:46:11","guid":{"rendered":"http:\/\/semmelweis.hu\/elettan\/?page_id=2863"},"modified":"2021-09-06T16:31:58","modified_gmt":"2021-09-06T14:31:58","slug":"hirek","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/elettan\/nvkp-palyazat\/hirek\/","title":{"rendered":"H\u00cdREK – NVKP"},"content":{"rendered":"

\"\"<\/a><\/p>\n

SAJT\u00d3K\u00d6ZLEM\u00c9NYEK<\/span><\/b><\/span><\/p>\n

2021. j\u00fanius 21-\u00e9n \u201eF\u00f3kuszban az atherosclerosis: \u00daj ter\u00e1pi\u00e1s c\u00e9lpontok \u00e9s gy\u00f3gyszerjel\u00f6ltek azonos\u00edt\u00e1sa\u201d c\u00edm\u0171 projektz\u00e1r\u00f3 hibrid konferenci\u00e1t tartottunk.<\/a><\/p>\n

\u00a02018.06.20.\u00a0<\/p>\n

\u00a0Atheroslerosis<\/b> \u2013 \u00faj ter\u00e1pi\u00e1s c\u00e9lpontok \u00e9s gy\u00f3gyszerjel\u00f6ltek azonos\u00edt\u00e1sa<\/b>\u00a0<\/p>\n

\u00a0Az elm\u00falt 60 \u00e9v tudom\u00e1nyos eredm\u00e9nyei \u00e9s gy\u00f3gyszerfejleszt\u00e9sei ellen\u00e9re \u00e9vtizedek \u00f3ta vil\u00e1gszerte az atherosclerosis okozta megbeteged\u00e9sek vezetik a hal\u00e1loki statisztik\u00e1kat. Ennek oka, hogy az atherosclerosis kialakul\u00e1s\u00e1nak okair\u00f3l, a betegs\u00e9g lefoly\u00e1s\u00e1t meghat\u00e1roz\u00f3 t\u00e9nyez\u0151kr\u0151l m\u00e9g sok mindent nem tudunk. A Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, \u00c9lettani Int\u00e9zet, a Nemzeti Agr\u00e1rkutat\u00e1si \u00e9s Innov\u00e1ci\u00f3s K\u00f6zpont \u2013 Mez\u0151gazdas\u00e1gi Biotechnol\u00f3giai Kutat\u00f3int\u00e9zet, valamint az ImmunoGenes Kft. \u00e1ltal alkotott konzorcium kutat\u00e1sa ezekre a k\u00e9rd\u00e9sekre keresi a v\u00e1laszt.\u00a0<\/p>\n

\u00a0A Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Alap finansz\u00edroz\u00e1s\u00e1nak seg\u00edts\u00e9g\u00e9vel kialak\u00edtott konzorcium azt t\u0171zte ki c\u00e9lj\u00e1ul, hogy innovat\u00edv, molekul\u00e1ris biol\u00f3giai, immunol\u00f3giai \u00e9s g\u00e9ntechnol\u00f3giai m\u00f3dszereket alkalmaz\u00f3 kutat\u00e1ssal, p\u00e1ciens mint\u00e1k anal\u00edzis\u00e9vel, valamint a kutat\u00e1si eredm\u00e9nyek transzl\u00e1ci\u00f3j\u00e1val k\u00f6zelebb jusson az atherosclerosis h\u00e1tter\u00e9ben \u00e1ll\u00f3 folyamatok megismer\u00e9s\u00e9hez \u00e9s gy\u00f3gyszeres befoly\u00e1sol\u00e1s\u00e1hoz. A fejleszt\u00e9s a Nemzeti Versenyk\u00e9pess\u00e9gi \u00e9s Kiv\u00e1l\u00f3s\u00e1gi Program NVKP_16-1-2016-0039 azonos\u00edt\u00f3 sz\u00e1m\u00fa p\u00e1ly\u00e1zat\u00e1nak keret\u00e9n bel\u00fcl h\u00e1rom \u00e9v alatt val\u00f3sul meg 2017. janu\u00e1r 1. \u00e9s 2019. december 31. k\u00f6z\u00f6tt a Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Alap 941,02 milli\u00f3 forintos t\u00e1mogat\u00e1s\u00e1val, amelyb\u0151l a Semmelweis Egyetem \u00c9lettani Int\u00e9zete 799,999 milli\u00f3 forinttal, az ImmunoGenes Kft. 56,200 milli\u00f3 forinttal, a Nemzeti Agr\u00e1rkutat\u00e1si \u00e9s Innov\u00e1ci\u00f3s K\u00f6zpont pedig 84,816 milli\u00f3 forinttal r\u00e9szesedik. A projekt k\u00f6lts\u00e9gvet\u00e9s\u00e9hez tartozik tov\u00e1bbi 14 milli\u00f3 forint, mellyel \u2013 saj\u00e1ter\u0151k\u00e9nt \u2013 az ImmunoGenes Kft. j\u00e1rul hozz\u00e1 a kutat\u00e1shoz.\u00a0<\/p>\n

A konzorcium vezet\u0151je Dr. Hunyady L\u00e1szl\u00f3 egyetemi tan\u00e1r, az MTA rendes tagja, a Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, \u00c9lettani Int\u00e9zet igazgat\u00f3ja. Klinikai ter\u00fcleten k\u00f6zrem\u0171k\u00f6dik a\u00a0 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, \u00c9rseb\u00e9szeti Tansz\u00e9k, Angiol\u00f3giai Tansz\u00e9ki Csoport vezet\u0151je, Dr. J\u00e1rai Zolt\u00e1n habilit\u00e1lt doktor, c. egyetemi tan\u00e1r, belgy\u00f3gy\u00e1sz angiol\u00f3gus, kardiol\u00f3gus. profilvezet\u0151 f\u0151orvos. A projektben a konzorciumi partnereket Dr. B\u0151sze Zsuzsanna, a Nemzeti Agr\u00e1rkutat\u00e1si \u00e9s Innov\u00e1ci\u00f3s K\u00f6zpont Mez\u0151gazdas\u00e1gi Biotechnol\u00f3giai Kutat\u00f3int\u00e9zete genomikai f\u0151oszt\u00e1ly\u00e1nak vezet\u0151je, valamint Dr. Kacskovics Imre egyetemi tan\u00e1r, az MTA doktora, az Immunogenes Kft \u00fcgyvezet\u0151je k\u00e9pviseli.\u00a0\u00a0<\/p>\n

A t\u00e1mogat\u00e1s elnyer\u00e9s\u00e9vel 8-10 kutat\u00f3i poz\u00edci\u00f3 biztos\u00edt\u00e1s\u00e1ra, meg\u0151rz\u00e9s\u00e9re volt m\u00f3d, \u00e9s mindemellett majd ugyanennyi \u00faj kutat\u00f3i \u00e9s asszisztensi munkahely l\u00e9trehoz\u00e1s\u00e1ra ny\u00edlt lehet\u0151s\u00e9g.\u00a0<\/p>\n

A projektr\u0151l b\u0151vebben a honlapunkon<\/a> olvashatnak.<\/p>\n

Dr. <\/b>Hunyady<\/b> L\u00e1szl\u00f3<\/b>\u00a0<\/p>\n

projektvezet\u0151
\nSemmelweis Egyetem, \u00c9lettani Int\u00e9zet
\n1094 Budapest, T\u0171zolt\u00f3 utca 37-47.\u00a0
\nhunyady.laszlo@med.semmelweis-univ.hu<\/a>\u00a0
\n(m\u00e1solatban szilagyi.anna@med.semmelweis-univ.hu<\/a>)\u00a0<\/p>\n

\u00c1TVETT\u00c9K:<\/span>
\n<\/strong><\/p>\n

\u00a0WebORVOS Online Eg\u00e9szs\u00e9g\u00fcgyi Magazin<\/a><\/p>\n

PharmaOnline<\/a><\/p>\n

SE EOK<\/a><\/p>\n

INTERJ\u00daK<\/span><\/b><\/p>\n

Interj\u00fa Dr. Geiszt Mikl\u00f3s vezet\u0151 kutat\u00f3val<\/a><\/p>\n

KAPCSOL\u00d3D\u00d3 MEGJELEN\u00c9SEK<\/span><\/b><\/p>\n

Konzorciumunk elnyerte a Nemzeti versenyk\u00e9pess\u00e9gi \u00e9s kiv\u00e1l\u00f3s\u00e1gi program t\u00e1mogat\u00e1s\u00e1t<\/a>\u00a0az Egyetem 7 m\u00e1sik p\u00e1ly\u00e1zat\u00e1val egy\u00fctt<\/a>, ezzel hozz\u00e1j\u00e1rult az Egyetem p\u00e1ly\u00e1zati sikereihez<\/a>.<\/p>\n

PUBLIK\u00c1CI\u00d3S LISTA<\/span><\/strong><\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Sorsz\u00e1m<\/th>C\u00edm<\/th>Dokumentum t\u00edpusa<\/th>Impaktfaktor<\/th>\n<\/tr>\n<\/thead>\n
1.<\/td>Gene targeting experiments in rabbits for agricultural and medical research<\/a><\/td>7th International Congress On Rabbit Biotechnology, 2017 \u2013 el\u0151ad\u00e1s absztrakt<\/td>nincs<\/td>\n<\/tr>\n
2.<\/td>Organ Specific Induction of Lymphatic Growth with Nanoparticle-Encapsulated Nucleoside-Modified VEGFC mRNA (VEGFC mRNA-LNP) Complexes In Vivo<\/a><\/td>Lymphatic Forum 2017: Exploring the Lymphatic Continuum \u2013 sz\u00f3beli el\u0151ad\u00e1s<\/td>nincs<\/td>\n<\/tr>\n
3.<\/td>Postnatal remodeling of meningeal lymphatics coincides with the beginning of the drainage of macromolecules from the Central Nervous System<\/a><\/td>Lymphatic Forum 2017: Exploring the Lymphatic Continuum \u2013 poszter prezent\u00e1ci\u00f3<\/td>nincs<\/td>\n<\/tr>\n
4.<\/td>Heterologous phosphorylation\u2013induced formation of a stability lock permits regulation of inactive receptors by \u2013arrestins<\/a><\/td>J. Biol. Chem. (2018) 293(3) 876 \u2013892 \u2013 tudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>4,125<\/td>\n<\/tr>\n
5.<\/td>GFP transgenic animals in biomedical research: a review of potential disadvantages.<\/a><\/td>Physiol Res. 2019 Aug 29;68(4):525-530. Epub 2019 Jul 25.
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
6.<\/td>Importance of Fc Receptor \u03b3-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis<\/a><\/td>Front. Immunol., 25 February 2019
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
7.<\/td>Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling<\/a><\/td>J Clin Invest. 2019;129(11):4912\u20134921.
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
8.<\/td>Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels<\/a><\/td>Front. Immunol., 14 January 2020
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
9.<\/td>Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases<\/a><\/td>Front. Immunol., 09 August 2019
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
10.<\/td>Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage<\/a><\/td> J Clin Invest. 2019 Apr 4
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
11.<\/td>Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K\/K Embryos With Impaired Motor Functions Including Fetal reathing Movements in Preparation of the Developing Lung for Inflation at Birth <\/a><\/td>Front Bioeng Biotechnol. 2020; 8
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
12.<\/td>Lymphoangiocrine signals promote cardiac growth and repair<\/a><\/td>Nature. 2020 Dec;588(7839)
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
13.<\/td>Pyrophosphate therapy prevents trauma-induced calcification in the mouse model of neurogenic heterotopic ossification<\/a><\/td>J Cell Mol Med. 2020 Oct;24(20)
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
14.<\/td>In Vivo Functions of Mouse Neutrophils Derived from HoxB8-Transduced Conditionally Immortalized Myeloid Progenitors<\/a><\/td>J Immunol January 15, 2021, 206 (2)
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
15.<\/td>Neutrophil phospholipase C\u03b32 drives autoantibody-induced arthritis through the generation of the inflammatory microenvironment<\/td>Arthritis Rheumatol 2021 (in press)<\/td>-<\/td>\n<\/tr>\n
16.<\/td>Phospholipase C\u03b32 is essential for a mouse model of epidermolysis bullosa acquisita<\/td>Submitted 17 Dec 2020
\n
\n<\/td>		-<\/td>\n<\/tr>\n
17.<\/td>Fluorescence-based real-time analysis of osteoclast development
\n
\n<\/td>		Under preparation in Jan 2021<\/td>-<\/td>\n<\/tr>\n
18.<\/td>The Creation of a Multiallele Knockout Genotype in Rabbit Using CRISPR\/Cas9 and Its Application in Translational Medicine<\/a><\/td>Appl. Sci. 2020, 10(23)
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
19.<\/td>Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema<\/a><\/td>NATURE COMMUNICATIONS (2021)
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
20.<\/td>Mechanosensation and Mechanotransduction by Lymphatic Endothelial Cells Act as Important Regulators of Lymphatic Development and Function<\/a><\/td>Int. J. Mol. Sci. 2021
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n
21.<\/td>Disruption of the NOX5 Gene Aggravates Atherosclerosis in Rabbits<\/a><\/td>Circulation Research. 2021
\ntudom\u00e1nyos k\u00f6zlem\u00e9ny<\/td>		-<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

<\/a> SAJT\u00d3K\u00d6ZLEM\u00c9NYEK 2021. j\u00fanius 21-\u00e9n \u201eF\u00f3kuszban az atherosclerosis: \u00daj ter\u00e1pi\u00e1s c\u00e9lpontok \u00e9s gy\u00f3gyszerjel\u00f6ltek azonos\u00edt\u00e1sa\u201d c\u00edm\u0171 projektz\u00e1r\u00f3 hibrid konferenci\u00e1t tartottunk.<\/a> \u00a02018.06.20.\u00a0 \u00a0Atheroslerosis \u2013 \u00faj ter\u00e1pi\u00e1s c\u00e9lpontok \u00e9s gy\u00f3gyszerjel\u00f6ltek azonos\u00edt\u00e1sa\u00a0 \u00a0Az elm\u00falt 60 \u00e9v tudom\u00e1nyos eredm\u00e9nyei \u00e9s gy\u00f3gyszerfejleszt\u00e9sei ellen\u00e9re \u00e9vtizedek \u00f3ta vil\u00e1gszerte az atherosclerosis okozta megbeteged\u00e9sek vezetik a hal\u00e1loki statisztik\u00e1kat. Ennek oka, hogy az atherosclerosis kialakul\u00e1s\u00e1nak okair\u00f3l, a betegs\u00e9g lefoly\u00e1s\u00e1t meghat\u00e1roz\u00f3 t\u00e9nyez\u0151kr\u0151l m\u00e9g sok mindent nem tudunk. A Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, \u00c9lettani Int\u00e9zet, …<\/p>\n","protected":false},"author":133,"featured_media":0,"parent":2848,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-2863","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/2863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/users\/133"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/comments?post=2863"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/2863\/revisions"}],"predecessor-version":[{"id":5475,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/2863\/revisions\/5475"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/pages\/2848"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/media?parent=2863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/categories?post=2863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/elettan\/wp-json\/wp\/v2\/tags?post=2863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}