{"id":16545,"date":"2025-01-23T15:36:27","date_gmt":"2025-01-23T14:36:27","guid":{"rendered":"https:\/\/semmelweis.hu\/corefacility\/?page_id=16545"},"modified":"2026-01-20T14:20:04","modified_gmt":"2026-01-20T13:20:04","slug":"la-reims","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/corefacility\/home\/la-reims\/","title":{"rendered":"LA-REIMS \u2013 Pharmacokinetic and chemical screening using MS based imaging system"},"content":{"rendered":"<div class=\"keretes\" style=\"width: 40% !important;border-left: 6px solid #4d9de0 !important\">\n<p><strong>Head of Core Facility<br \/>\n<\/strong>Gy\u00f6rgy Tibor Balogh Prof. Dr.\u00a0<br \/>\nIstv\u00e1n M\u00e1ndity Dr.<\/p>\n<p><strong>Core Facility Address<br \/>\n<\/strong>Department of Pharmaceutical Chemistry<br \/>\nH-1092 Budapest, <br \/>\nH\u0151gyes Endre u. 7-9.<\/p>\n<p><strong>Contact E-mail<br \/>\n<\/strong><a href=\"mailto:la-reims.medchem@semmelweis.hu\">la-reims.medchem@semmelweis.hu<\/a><\/p>\n<p><strong>Number of staff<br \/>\n<\/strong>5<\/p>\n<p><strong>Quality Control<br \/>\n<\/strong>ISO9001<strong><br \/>\n<\/strong><\/p>\n<\/div>\n<h4><strong>What we offer<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li>Chemical imaging reveals molecular spatial distribution in tissues, organs, and biological samples.<\/li>\n<li>Enables mapping of biomarkers, drugs, metabolites, and chemical fingerprints (lipidomic, metabolomic).<\/li>\n<li>Supports drug distribution studies and novel formulation development.<\/li>\n<li>Aids identification of disease states and tumor margins.<\/li>\n<li>High-throughput REIMS autosampler provides mass spectra within seconds per sample.<\/li>\n<li>Molecular fingerprints reveal trends linked to sample conditions or history.<\/li>\n<li>Compatible with solutions, solids, and heterogeneous sample types.\n<\/li>\n<\/ul>\n<h4><strong>Why work with us<\/strong><\/h4>\n<p style=\"text-align: justify\">High-resolution mass spectrometry based chemical imaging offers the accurate visualization of molecular distribution within samples, which a valuable tool for biomedical research, clinical diagnostic and sample charaterization.\u00a0<\/p>\n<h4><strong>Our equipment<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li>\u00a0Waters Xevo G2-XS QToF Mass Spectrometer with a custom-built AmbiMass Prototype Imaging Setup\u00a0<\/li>\n<li>Confocal Raman Imaging\u00a0<\/li>\n<li>Cryostat Microtome\u00a0<\/li>\n<li>Waters Xevo G2-XS QToF Mass Spectrometer with a custom-built AmbiMass Automatic Wellplate Reader Prototype Setup<\/li>\n<\/ul>\n<h4><strong>References<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li><a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2023-p2g9h-v2\">https:\/\/doi.org\/10.26434\/chemrxiv-2023-p2g9h-v2\u00a0<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ebiom.2020.103017\">https:\/\/doi.org\/10.1016\/j.ebiom.2020.103017<\/a>\u00a0<\/li>\n<li><a href=\"https:\/\/doi.org\/10.1002\/rcm.8525\">https:\/\/doi.org\/10.1002\/rcm.8525\u00a0<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.talanta.2020.121043\">https:\/\/doi.org\/10.1016\/j.talanta.2020.121043<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Head of Core Facility Gy\u00f6rgy Tibor Balogh Prof. Dr.\u00a0 Istv\u00e1n M\u00e1ndity Dr. Core Facility Address Department of Pharmaceutical Chemistry H-1092 Budapest, H\u0151gyes Endre u. 7-9. Contact E-mail <a href=\"mailto:la-reims.medchem@semmelweis.hu\">la-reims.medchem@semmelweis.hu<\/a> Number of staff 5 Quality Control ISO9001 What we offer Chemical imaging reveals molecular spatial distribution in tissues, organs, and biological samples. Enables mapping of biomarkers, drugs, metabolites, &hellip;<\/p>\n","protected":false},"author":102026,"featured_media":0,"parent":14502,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,37],"tags":[],"class_list":["post-16545","page","type-page","status-publish","hentry","category-core-facility","category-medicinal-chemistry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/users\/102026"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/comments?post=16545"}],"version-history":[{"count":4,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16545\/revisions"}],"predecessor-version":[{"id":16602,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16545\/revisions\/16602"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/14502"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/media?parent=16545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/categories?post=16545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/tags?post=16545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}