{"id":16534,"date":"2025-01-23T15:06:04","date_gmt":"2025-01-23T14:06:04","guid":{"rendered":"https:\/\/semmelweis.hu\/corefacility\/?page_id=16534"},"modified":"2026-01-20T14:09:54","modified_gmt":"2026-01-20T13:09:54","slug":"chiral-separation-for-drug-discovery","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/corefacility\/home\/chiral-separation-for-drug-discovery\/","title":{"rendered":"Chiral separation for drug discovery"},"content":{"rendered":"<div class=\"keretes\" style=\"width: 40% !important;border-left: 6px solid #4d9de0 !important\">\n<p><strong>Head of Core Facility<br \/>\n<\/strong>Gy\u00f6rgy Tibor Balogh Prof. Dr.\u00a0<br \/>\nIstv\u00e1n M\u00e1ndity Dr.<\/p>\n<p><strong>Core Facility Address<br \/>\n<\/strong>Department of Pharmaceutical Chemistry<br \/>\nH-1092 Budapest, <br \/>\nH\u0151gyes Endre u. 7-9.<\/p>\n<p><strong>Contact E-mail<br \/>\n<\/strong><a href=\"mailto:chiral.medchem@semmelweis.hu\">chiral.medchem@semmelweis.hu<\/a> <\/p>\n<p><strong>Staff<br \/>\n<\/strong>5<\/p>\n<p><strong>Quality Control<br \/>\n<\/strong>ISO9001<\/p>\n<\/div>\n<h4><strong>What we offer<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li>Separation of chiral molecule isomers (diastereomers or enantiomers) and optimalization of experimental design and conditions.<\/li>\n<li>Chiral enantioseparation using HPLC or CE methods, optionally using cyclodextrin binding as chiral separator.<\/li>\n<li>Docking studies, CD\/FI measurements and NMR\/UV titrimetry to characterize cyclodextrin complexation.<\/li>\n<\/ul>\n<h4><strong>Why work with us<\/strong><\/h4>\n<p style=\"text-align: justify\">In our core facility enantioseparation using reverse-phase chiral columns is a reliable and versatile tool for chiral analysis in polar organic mode. The use of cyclodextrins as a tool for separation provides an efficient means of rapid method optimalization complemented with binding characterization.\u00a0<\/p>\n<h4><strong>Our equipment<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li>\u00a0Agilent 1260 HPLC system with DAD detector<\/li>\n<li>Agilent 7100 CE system with DAD detector<\/li>\n<li>JASCO HPLC with ELSD detector<\/li>\n<li>Waters HPLC-MS system<\/li>\n<li>More than 20 chiral HPLC columns\u00a0<\/li>\n<li>Jasco UV-VIS spectrophotometer\u00a0<\/li>\n<li>Jasco j815 CD spectrometer (CD\/UV\/FI parallel measurement)<\/li>\n<\/ul>\n<h4><strong>References<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41598-023-41941-5\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41598-023-41941-5<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.3390\/sym16010017\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/sym16010017<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.3390\/ijms25052697\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/ijms25052697<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Head of Core Facility Gy\u00f6rgy Tibor Balogh Prof. Dr.\u00a0 Istv\u00e1n M\u00e1ndity Dr. Core Facility Address Department of Pharmaceutical Chemistry H-1092 Budapest, H\u0151gyes Endre u. 7-9. Contact E-mail <a href=\"mailto:chiral.medchem@semmelweis.hu\">chiral.medchem@semmelweis.hu<\/a> Staff 5 Quality Control ISO9001 What we offer Separation of chiral molecule isomers (diastereomers or enantiomers) and optimalization of experimental design and conditions. Chiral enantioseparation using HPLC or &hellip;<\/p>\n","protected":false},"author":102026,"featured_media":0,"parent":14502,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,37],"tags":[52,51],"class_list":["post-16534","page","type-page","status-publish","hentry","category-core-facility","category-medicinal-chemistry","tag-spectrometer","tag-spectrophotometer"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/users\/102026"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/comments?post=16534"}],"version-history":[{"count":4,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16534\/revisions"}],"predecessor-version":[{"id":16600,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16534\/revisions\/16600"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/14502"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/media?parent=16534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/categories?post=16534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/tags?post=16534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}