{"id":16530,"date":"2025-01-23T14:57:59","date_gmt":"2025-01-23T13:57:59","guid":{"rendered":"https:\/\/semmelweis.hu\/corefacility\/?page_id=16530"},"modified":"2026-01-20T13:58:40","modified_gmt":"2026-01-20T12:58:40","slug":"ex-vivo-in-vitro-studies-of-ophthalmic-preparations","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/corefacility\/home\/ex-vivo-in-vitro-studies-of-ophthalmic-preparations\/","title":{"rendered":"Ex vivo \/ In vitro studies of ophthalmic preparations"},"content":{"rendered":"<div class=\"keretes\" style=\"width: 40% !important;border-left: 6px solid #4d9de0 !important\">\n<p><strong>Head of Core Facility<br \/>\n<\/strong>Gy\u00f6rgy Tibor Balogh Prof. Dr.\u00a0<br \/>\nIstv\u00e1n M\u00e1ndity Dr.<\/p>\n<p><strong>Core Facility Address<br \/>\n<\/strong>Department of Pharmaceutical Chemistry<br \/>\nH-1092 Budapest, <br \/>\nH\u0151gyes Endre u. 7-9.<\/p>\n<p><strong>Contact E-mail<br \/>\n<\/strong><a href=\"mailto:ex-vivo.medchem@semmelweis.hu\">ex-vivo.medchem@semmelweis.hu<\/a> <\/p>\n<p><strong>Staff<br \/>\n<\/strong>5<\/p>\n<p><strong>Quality Control<br \/>\n<\/strong>ISO9001<\/p>\n<\/div>\n<h4><strong>What we offer<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li>Ex vivo penetration studies with porcine eye, in vitro across corneal permeability studies.<\/li>\n<li>PAMPA assays.<\/li>\n<li>Dissolution kinetics assays.<\/li>\n<li>Physicochemical characterization of ophthalmic formulations \u2013 viscosity, mucoadhesivity, osmolarity and pH, chemical stability, zeta-potential analysis.<\/li>\n<\/ul>\n<h4><strong>Why work with us<\/strong><\/h4>\n<p style=\"text-align: justify\">The core facility provides a comprehensive suite of advanced research services, from basic physicochemical characterisations to sophisticated in vitro and ex vivo efficacy and safety assessments of ophthalmic preparations\/drugs, ensuring thorough evaluation and informed decision-making in the selection and advancement of promising candidates for preclinical and clinical development stages.\u00a0<\/p>\n<h4><strong>Our equipment<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li>\u03bcFLUX with Rainbow UV probes (Pion Inc.)\u00a0<\/li>\n<li>Beckman Coulter Biomek FX Dual Arm System Robot\u00a0<\/li>\n<li>Proprietary, in-house developed systems to investigate absorption<\/li>\n<li>Zeta potential analyzer<\/li>\n<\/ul>\n<h4><strong>References<\/strong><\/h4>\n<ul style=\"list-style-type: square\">\n<li><a href=\"https:\/\/doi.org\/10.1002\/chem.201704205\">https:\/\/doi.org\/10.1002\/chem.201704205\u00a0<\/a><\/li>\n<li><a href=\"http:\/\/dx.doi.org\/10.1016\/j.ejps.2016.10.034\">http:\/\/dx.doi.org\/10.1016\/j.ejps.2016.10.034\u00a0<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.3390\/pharmaceutics15010278\">https:\/\/doi.org\/10.3390\/pharmaceutics15010278\u00a0<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1002\/chem.201704205\">https:\/\/doi.org\/10.1002\/chem.201704205\u00a0<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.molliq.2022.120781\">https:\/\/doi.org\/10.1016\/j.molliq.2022.120781<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Head of Core Facility Gy\u00f6rgy Tibor Balogh Prof. Dr.\u00a0 Istv\u00e1n M\u00e1ndity Dr. Core Facility Address Department of Pharmaceutical Chemistry H-1092 Budapest, H\u0151gyes Endre u. 7-9. Contact E-mail <a href=\"mailto:ex-vivo.medchem@semmelweis.hu\">ex-vivo.medchem@semmelweis.hu<\/a> Staff 5 Quality Control ISO9001 What we offer Ex vivo penetration studies with porcine eye, in vitro across corneal permeability studies. PAMPA assays. Dissolution kinetics assays. Physicochemical characterization &hellip;<\/p>\n","protected":false},"author":102026,"featured_media":0,"parent":14502,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,37],"tags":[],"class_list":["post-16530","page","type-page","status-publish","hentry","category-core-facility","category-medicinal-chemistry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/users\/102026"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/comments?post=16530"}],"version-history":[{"count":3,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16530\/revisions"}],"predecessor-version":[{"id":16595,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/16530\/revisions\/16595"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/pages\/14502"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/media?parent=16530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/categories?post=16530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/corefacility\/wp-json\/wp\/v2\/tags?post=16530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}