{"id":201,"date":"2020-06-03T15:47:38","date_gmt":"2020-06-03T13:47:38","guid":{"rendered":"https:\/\/semmelweis.hu\/gyermekklinika1\/?page_id=201"},"modified":"2026-01-30T15:55:29","modified_gmt":"2026-01-30T14:55:29","slug":"neonatologiai-kutatocsoport","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/bokayklinika\/kutatas\/neonatologiai-kutatocsoport\/","title":{"rendered":"Neonatol\u00f3giai kutat\u00f3csoport"},"content":{"rendered":"<div class=\"keretes\">\n<p><strong>Munkacsoport tagjai<\/strong><\/p>\n<ul>\n<li>Prof. Dr. Szab\u00f3 Mikl\u00f3s egyetemi tan\u00e1r<\/li>\n<li>Dr. Jermendy \u00c1gnes habilit\u00e1lt egyetemi adjunktus<\/li>\n<li>Dr. M\u00e9der \u00dcn\u0151ke egyetemi adjunktus<\/li>\n<li>Dr. Kov\u00e1cs Kata egyetemi tan\u00e1rseg\u00e9d<\/li>\n<li>Dr. Szakm\u00e1r Enik\u0151 egyetemi tan\u00e1rseg\u00e9d<\/li>\n<li>Dr. Barta Hajnalka tudom\u00e1nyos munkat\u00e1rs<\/li>\n<li>Dr. K\u0151v\u00e1ri Eszter klinikai szakorvos<\/li>\n<li>Dr. Dobi Mariann klinikai szakorvos<\/li>\n<li>Dr. Sz\u00e1sz Barbara klinikai szakorvos<\/li>\n<li>Dr. Csek\u0151 Anna klinikai szakorvos, PhD hallgat\u00f3<\/li>\n<li>Dr. Cziniel M\u00f3nika klinikai szakorvos, PhD hallgat\u00f3<\/li>\n<li>Dr. Mahdi Leina klinikai szakorvos<\/li>\n<li>Dr. Andorka Csilla szakorvos jel\u00f6lt<\/li>\n<li>Dr. Balog Vera PhD hallgat\u00f3<\/li>\n<li>Dr. Trinh Sarolta PhD hallgat\u00f3<\/li>\n<li>Dr. Pekli-T\u00f3th Fanni klinikai szakorvos, PhD hallgat\u00f3<\/li>\n<li>Dr. Kerekes Ram\u00f3na PhD hallgat\u00f3<\/li>\n<li>Dr. Bogner Luca Laura PhD hallgat\u00f3<\/li>\n<li>Dr. Barra Magdolna PhD hallgat\u00f3<\/li>\n<li>Dr. Tarj\u00e1nyi Eszter PhD hallgat\u00f3<\/li>\n<li>Dr. Varga Zsuzsanna klinikai szakpszichol\u00f3gus<\/li>\n<li>Nagy Eszter klinikai szakpszichol\u00f3gus<\/li>\n<li>Bod\u00f3cs D\u00f3ra klinikai szakpszichol\u00f3gus, PhD hallgat\u00f3<\/li>\n<li>L\u00f6kk\u00f6s Emma logop\u00e9dus<\/li>\n<li>Kapros Andrea szak\u00e1pol\u00f3<\/li>\n<li>Sz\u00e9kelyi Andrea szak\u00e1pol\u00f3<\/li>\n<li>F\u00fcl\u00f6p Ivett adminisztr\u00e1tor<\/li>\n<li>Dunain\u00e9 Gregor \u00c9va adminisztr\u00e1tor<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"#a_kutatocsoportrol\">A kutat\u00f3csoportr\u00f3l<\/a><br \/>\n<a href=\"#perinatalis_asphyxia\">Perinat\u00e1lis asphyxia<\/a><br \/>\n<a href=\"#fejlodestamogato_kezelesek_koraszulottekben\">Fejl\u0151d\u00e9st\u00e1mogat\u00f3 kezel\u00e9sek korasz\u00fcl\u00f6ttekben<\/a><br \/>\n<a href=\"#fejlodesneurologiai_utankovetes,_gondozas\">Fejl\u0151d\u00e9sneurol\u00f3giai ut\u00e1nk\u00f6vet\u00e9s, gondoz\u00e1s<\/a><br \/>\n<a href=\"#ujszulott_aneszteziai_vizsgalatok\">\u00dajsz\u00fcl\u00f6tt aneszt\u00e9ziai vizsg\u00e1latok<\/a><br \/>\n<a href=\"#palyazati_tamogatasok\">P\u00e1ly\u00e1zati t\u00e1mogat\u00e1sok<\/a><br \/>\n<a href=\"#neonatology_research_group_pediatric_center_energy\">In English<\/a><\/p>\n<p><a name=\"a_kutatocsoportrol\"><\/a><\/p>\n<h3><strong>A kutat\u00f3csoportr\u00f3l<\/strong><\/h3>\n<p>Kutat\u00e1saink k\u00f6z\u00e9ppontj\u00e1ban az intenz\u00edv ter\u00e1pi\u00e1t ig\u00e9nyl\u0151 pathol\u00f3gi\u00e1s \u00fajsz\u00fcl\u00f6ttek ell\u00e1t\u00e1s\u00e1nak jav\u00edt\u00e1sa \u00e1ll. A kedvez\u0151bb fejl\u0151d\u00e9sneurol\u00f3giai kimenetel el\u00e9r\u00e9s\u00e9re \u00fagy gondoljuk, hogy \u00fajsz\u00fcl\u00f6ttek k\u00f6r\u00e9ben is fontos a szem\u00e9lyre szabott medicina elveinek alkalmaz\u00e1sa. C\u00e9lunk a klinikai gyakorlatban alkalmazott ter\u00e1pi\u00e1s elj\u00e1r\u00e1sok finomhangol\u00e1sa, kieg\u00e9sz\u00edt\u0151 intervenci\u00f3s lehet\u0151s\u00e9gek vizsg\u00e1lata, a folyamatos, nem-invaz\u00edv monitoroz\u00e1s \u00e1ltal szolg\u00e1ltatott adatok mesters\u00e9ges-intelligencia alap\u00fa elemz\u00e9se a kimentel jav\u00edt\u00e1s\u00e1ra. Klinikai kutat\u00e1saink sor\u00e1n h\u00e1rom nagyobb betegcsoporttal foglalkozunk: a perinat\u00e1lis asphyxi\u00e1t \u00e1t\u00e9lt \u00fajsz\u00fcl\u00f6ttekkel, az intenz\u00edv oszt\u00e1lyon kezelt korasz\u00fcl\u00f6ttekkel, valamint a seb\u00e9szi beavatkoz\u00e1st ig\u00e9nyl\u0151 \u00fajsz\u00fcl\u00f6ttekkel.<\/p>\n<p>Kutat\u00e1si eredm\u00e9nyeinkkel szeretn\u00e9nk seg\u00edteni az \u00e9vente haz\u00e1nkban intenz\u00edv oszt\u00e1lyon kezelt mintegy 6000 \u00fajsz\u00fcl\u00f6tt kedvez\u0151bb kimenetel\u00e9t, \u00e9s rem\u00e9lj\u00fck, hogy tapasztalataink a nemzetk\u00f6zi gyakorlatra is hat\u00e1ssal lehetnek.<\/p>\n<p><a name=\"perinatalis_asphyxia\"><\/a><\/p>\n<h3><strong>Perinat\u00e1lis asphyxia<\/strong><\/h3>\n<p>A perinatalis asphyxia \u00e9s a k\u00f6vetkezm\u00e9nyesen kialakul\u00f3 hypoxi\u00e1s ischaemi\u00e1s encephalopathia (HIE) vil\u00e1gszerte 2 milli\u00f3 \u00fajsz\u00fcl\u00f6tt hal\u00e1l\u00e1t vagy maradand\u00f3 idegrendszeri k\u00e1rosod\u00e1s\u00e1t okozza \u00e9vente. Mai napig a HIE egyetlen kezel\u00e9si m\u00f3dja az enyhe teljestest-hypothermia, \u00edgy \u00e9rthet\u0151 m\u00f3don a kieg\u00e9sz\u00edt\u0151 ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek vizsg\u00e1lata a kutat\u00e1sok el\u0151ter\u00e9ben \u00e1ll, k\u00fcl\u00f6n\u00f6s tekintettel a szupport\u00edv ter\u00e1pia optimaliz\u00e1l\u00e1s\u00e1ra.<\/p>\n<p>Munkacsoportunk egy <strong>eur\u00f3pai viszonylatban is kiemelked\u0151 adatb\u00e1zist<\/strong> hozott l\u00e9tre, mintegy 900 asphyxi\u00e1s \u00fajsz\u00fcl\u00f6tt klinikai adatainak, k\u00e9palkot\u00f3 vizsg\u00e1latainak \u00e9s fejl\u0151d\u00e9sneurol\u00f3giai teszteredm\u00e9nyeinek sturkt\u00far\u00e1lt rendszerez\u00e9s\u00e9re, kutathat\u00f3s\u00e1g\u00e1ra [1]. Kimutattuk, hogy a <strong>hypothermi\u00e1s kezel\u00e9s m\u00e1r a sz\u00fcl\u00e9szeten biztons\u00e1gosan megkezdhet\u0151, \u00e9s a neonat\u00e1lis transzport sor\u00e1n biztons\u00e1ggal folytathat\u00f3<\/strong>, mindezzel el\u0151seg\u00edtve a h\u0171t\u00e9s korai ind\u00edt\u00e1s\u00e1t, ami a kimenetel szempontj\u00e1b\u00f3l bizony\u00edtottan kedvez\u0151 hat\u00e1s\u00fa [2].<\/p>\n<p>Vizsg\u00e1ltuk a kering\u00e9sstabiliz\u00e1ci\u00f3 jav\u00edt\u00e1s\u00e1nak lehet\u0151s\u00e9geit. Kimutattuk, hogy <strong>asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek 25%-n\u00e1l relat\u00edv hypadrenia \u00e1ll fenn<\/strong>, amely a kering\u00e9si instabilit\u00e1s egyik k\u00f3roka lehet, \u00edgy a kortizolp\u00f3tl\u00e1s alkalmaz\u00e1sa oki ter\u00e1piak\u00e9nt mer\u00fcl fel [3]. A <strong>\u201eCORTISoL\u201d elnevez\u00e9s\u0171 klinikai tanulm\u00e1nyunk<\/strong> sor\u00e1n placebo-kontrolla\u0301lt, randomiza\u0301lt, ketto\u030bs-vak elrendeze\u0301sben teszteltu\u0308k az alacsony do\u0301zisu\u0301 hydrocortison hata\u0301sa\u0301t, a rutinszeru\u030ben alkalmazott dopamin keringe\u0301sta\u0301mogata\u0301s mellett. Eredm\u00e9nyeink szerint a <strong>hydrocortison p\u00f3tl\u00e1sban r\u00e9szes\u00fcl\u0151 betegek nagyobb h\u00e1nyada \u00e9rte el az 5 Hgmm-nyi art\u00e9ri\u00e1s k\u00f6z\u00e9pnyom\u00e1s emelked\u00e9st<\/strong> a placebo csoporthoz k\u00e9pest, cs\u00f6kkenthet\u0151 volt a kering\u00e9st\u00e1mogat\u00e1s hossza, kumulat\u00edv d\u00f3zisa [4]. Ezek alapj\u00e1n a hypotensios betegekn\u00e9l a hydrocortison els\u0151k\u00e9nt v\u00e1lasztand\u00f3 gy\u00f3gyszer lehet.<\/p>\n<p>Hypothermi\u00e1s kezel\u00e9sben r\u00e9szes\u00fcl\u0151 \u00fajsz\u00fcl\u00f6ttekn\u00e9l folyamatos nem-invaz\u00edv hemodinamikai monitoroz\u00e1st v\u00e9gezt\u00fcnk. Id\u0151soros adatok elemz\u00e9s\u00e9vel kimutattuk, hogy a kedvez\u0151 fejl\u0151d\u00e9sneurol\u00f3giai kimenettel rendelkez\u0151 betegek sz\u00edvfrekvenci\u00e1ja alacsonyabb, ver\u0151t\u00e9rfogata pedig magasabb, \u00edgy hasonl\u00f3 perct\u00e9rfogattal rendelkeznek, mint a rossz kimenetel\u0171 betegek. <strong>A sz\u00edvfrekvencia h\u0171t\u00e9s alatt a kimenetel f\u00fcggetlen prediktor\u00e1<\/strong>nak bizonyult [5].<\/p>\n<p>Ugyanezen betegpopul\u00e1ci\u00f3ban vizsg\u00e1ltuk a l\u00e9legeztet\u00e9si param\u00e9terek, a <strong>ventill\u00e1ci\u00f3 szorosabb kontrollj\u00e1nak lehet\u0151s\u00e9g\u00e9t<\/strong> [6]. Igazoltuk, hogy <strong>hypothermi\u00e1s kezel\u00e9s a v\u00e9r alacsony sz\u00e9ndioxid-tenzi\u00f3 (hypocapnia) f\u00fcggetlen rizik\u00f3faktora<\/strong>, ami ronthatja a neurol\u00f3giai kimenetelt [7], a hosszabb hypocapni\u00e1ban t\u00f6lt\u00f6tt id\u0151 s\u00falyosabb koponya-MR elt\u00e9r\u00e9sekkel j\u00e1r egy\u00fctt [8]. A hypocapnia elker\u00fcl\u00e9s\u00e9re vizsg\u00e1ltuk az alacsony koncentr\u00e1ci\u00f3j\u00fa (5%) <strong>CO2-bel\u00e9legeztet\u00e9s biztons\u00e1goss\u00e1g\u00e1t a \u201eHENRIC\u201d tanulm\u00e1nyban<\/strong>. Kimutattuk, hogy a betegek a vizsg\u00e1lati ido\u030b 95%-ban az elo\u030bre meghata\u0301rozott permissz\u00edv hypercapnia tartoma\u0301nyban voltak, jelent\u0151s mell\u00e9khat\u00e1sok n\u00e9lk\u00fcl [9].<\/p>\n<p>Legut\u00f3bbi eredm\u00e9nyeink szerint, <strong>az amplit\u00fad\u00f3 integr\u00e1lt electroencephalogram (aEEG) longitudin\u00e1lis \u00e9rt\u00e9kel\u00e9s\u00e9vel<\/strong> a h\u0171t\u00e9ses kezel\u00e9s ideje alatt az asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek <strong>neurol\u00f3giai kimenetel\u00e9t nagy pontoss\u00e1ggal el\u0151re lehet jelezni<\/strong> [10]. Ennek el\u0151seg\u00edt\u00e9s\u00e9re egy <strong>online el\u00e9rhet\u0151 predikci\u00f3s eszk\u00f6zt (HOPE tool)<\/strong> hoztunk l\u00e9tre [11].<\/p>\n<p>Mindemellett igazoltuk, hogy a <strong>sz\u00fcl\u0151i iskol\u00e1zotts\u00e1g \u00e9s korai kognit\u00edv fejl\u0151d\u00e9s szoros kapcsolatot mutat<\/strong> k\u00f6z\u00e9ps\u00falyos asphyxi\u00e1t \u00e1t\u00e9lt \u00fajsz\u00fcl\u00f6ttekben. A sz\u00fcl\u0151k, els\u0151sorban az \u00e9desanya iskolai v\u00e9gzetts\u00e9g\u00e9nek hat\u00e1sa a 2 \u00e9ves kori kognit\u00edv fejl\u0151d\u00e9si kimenetre \u00f6sszem\u00e9rhet\u0151 az \u00fajsz\u00fcl\u00f6tt kori MRI-n l\u00e1tott elt\u00e9r\u00e9sekkel (Barkovich score szerint) [12].<\/p>\n<p>Adataink alapj\u00e1n az asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek intenz\u00edv ter\u00e1pi\u00e1s kezel\u00e9se \u00e9s korai fejleszt\u00e9se szem\u00e9lyre szabott\u00e1 v\u00e1lhat, optimaliz\u00e1lhat\u00f3.<\/p>\n<p>Leg\u00fajabban indult vizsg\u00e1latunk az <strong>F-NEO-BRIGHT Study<\/strong> (Feasibility of NEOnatal-intranasal BReast milk, Impact on brain Growth in HIE Therapy) avagy az <strong>orrba cseppentett anyatej megval\u00f3s\u00edthat\u00f3s\u00e1gi vizsg\u00e1lata<\/strong> hypoxi\u00e1s ischaemi\u00e1s encephalopathi\u00e1s \u00fajsz\u00fcl\u00f6ttekben. A kutat\u00e1sr\u00f3l b\u0151vebben <a href=\"https:\/\/semmelweis.hu\/bokayklinika\/files\/2025\/10\/NEO-BRIGHT-kutatasi-osszefoglalo.pdf\" target=\"_blank\" rel=\"noopener\">itt<\/a> tudnak olvasni, a sz\u00fcl\u0151i t\u00e1j\u00e9koztat\u00f3 <a href=\"https:\/\/semmelweis.hu\/bokayklinika\/files\/2025\/10\/NEO-BRIGHT-szuloi-tajekoztato.pdf\" target=\"_blank\" rel=\"noopener\">itt<\/a> \u00e9rhet\u0151 el. (NCT06747260)<\/p>\n<p>Ezen vizsg\u00e1lat tapasztalatait felhaszn\u00e1lva kezd\u0151d\u00f6tt a <strong>NEO-BRIGHT Study<\/strong>, amely a biztons\u00e1goss\u00e1gi \u00e9s megval\u00f3s\u00edthat\u00f3s\u00e1gi kutat\u00e1s alapj\u00e1n, 2025 \u00f3ta, prospekt\u00edv, randomiz\u00e1lt klinikai tanulm\u00e1ny keret\u00e9ben vizsg\u00e1lja az <strong>orrba cseppentett friss anyatej hat\u00e1s\u00e1t a k\u00f6zponti idegrendszer regener\u00e1ci\u00f3j\u00e1ra<\/strong> \u00e9s a hossz\u00fat\u00e1v\u00fa fejl\u0151d\u00e9sneurol\u00f3giai kimenetelre. A kutat\u00e1sr\u00f3l b\u0151vebben <a href=\"https:\/\/semmelweis.hu\/bokayklinika\/files\/2025\/10\/NEO-BRIGHT-kutatasi-osszefoglalo.pdf\" target=\"_blank\" rel=\"noopener\">itt<\/a> tudnak olvasni, a sz\u00fcl\u0151i t\u00e1j\u00e9koztat\u00f3 <a href=\"https:\/\/semmelweis.hu\/bokayklinika\/files\/2025\/10\/NEO-BRIGHT-szuloi-tajekoztato.pdf\" target=\"_blank\" rel=\"noopener\">itt<\/a> \u00e9rhet\u0151 el. (NCT 06746532)<\/p>\n<p><a name=\"fejlodestamogato_kezelesek_koraszulottekben\"><\/a><\/p>\n<h3><strong>Fejl\u0151d\u00e9st\u00e1mogat\u00f3 kezel\u00e9sek korasz\u00fcl\u00f6ttekben<\/strong><\/h3>\n<p><span class=\"TextRun SCXW55335348 BCX0\" lang=\"HU-HU\" xml:lang=\"HU-HU\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW55335348 BCX0\">Kor<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">a<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">sz\u00fcl\u00f6tt betegeink k\u00f6r\u00e9ben els\u0151sorban a <\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">min\u0151s\u00e9gi t\u00fal\u00e9l\u00e9s\u00e9t jav\u00edt\u00f3 m\u00f3dszerek vizsg\u00e1lat\u00e1val foglalkoztunk. Kimutattuk, hogy az \u00e9desany\u00e1val kialak\u00edtott b\u0151r-b\u0151r kontaktus (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW55335348 BCX0\">kenguruz\u00e1s<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">), majd az anyai \u00e9nekhang <\/span><\/span><strong><span class=\"TextRun SCXW55335348 BCX0\" lang=\"HU-HU\" xml:lang=\"HU-HU\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW55335348 BCX0\">hat\u00e1s\u00e1ra az agyi sz\u00f6veti <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW55335348 BCX0\">oxigeniz\u00e1ci\u00f3<\/span><\/span> <span class=\"TextRun SCXW55335348 BCX0\" lang=\"HU-HU\" xml:lang=\"HU-HU\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW55335348 BCX0\">javul<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\"> \u00e9s<\/span><\/span> <\/strong><span class=\"TextRun SCXW55335348 BCX0\" lang=\"HU-HU\" xml:lang=\"HU-HU\" data-contrast=\"auto\"><strong><span class=\"NormalTextRun SCXW55335348 BCX0\">az auton\u00f3m idegrendszeri stabilit\u00e1s fokoz\u00f3dni l\u00e1tszik<\/span><\/strong><span class=\"NormalTextRun SCXW55335348 BCX0\">. <\/span><\/span><span class=\"TextRun SCXW55335348 BCX0\" lang=\"HU-HU\" xml:lang=\"HU-HU\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW55335348 BCX0\">Mindezek alapj\u00e1n a zeneter\u00e1pia a kenguru-m\u00f3dszerrel kombin\u00e1lva egy k\u00f6lts\u00e9ghat\u00e9kony, sz\u00e9les k\u00f6rben alkalmazhat\u00f3 lehet\u0151s\u00e9g a korasz\u00fcl\u00f6ttekn\u00e9l, amellyel a klinikai \u00e1llapot r\u00f6vidt\u00e1von el\u0151ny\u00f6sen befoly\u00e1solhat\u00f3<\/span> <span class=\"NormalTextRun SCXW55335348 BCX0\">[<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">1<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">3<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">]<\/span><span class=\"NormalTextRun SCXW55335348 BCX0\">.<\/span><\/span><\/p>\n<p><a name=\"fejlodesneurologiai_utankovetes,_gondozas\"><\/a><\/p>\n<h3><strong>Fejl\u0151d\u00e9sneurol\u00f3giai ut\u00e1nk\u00f6vet\u00e9s, gondoz\u00e1s<\/strong><\/h3>\n<p>Klinik\u00e1nkon 2018 \u00f3ta interdiszciplin\u00e1ris fej\u0151d\u00e9sneurol\u00f3giai ambulanci\u00e1t m\u0171k\u00f6dtet\u00fcnk, ahol t\u00f6bb szakma szempontrendszere &#8211; gyermekneurol\u00f3gia, gy\u00f3gytorna, gy\u00f3gypedag\u00f3gia, kondukt\u00edv pedag\u00f3gia, pszichol\u00f3gia &#8211; szerint k\u00f6vetj\u00fck \u00e9s gondozzuk a PIC oszt\u00e1lyon kezelt gyermekeket. M\u00e1r a hazaad\u00e1s el\u0151tt betan\u00edtjuk az otthon v\u00e9gezhet\u0151 neurohabilit\u00e1ci\u00f3s tr\u00e9ninget (oktat\u00f3 vide\u00f3k a <a href=\"https:\/\/www.facebook.com\/rizikoujszulottek\" target=\"_blank\" rel=\"noopener\">Rizik\u00f3 \u00fajsz\u00fcl\u00f6ttek ut\u00f3gondoz\u00e1sa Facebook oldalon<\/a>) \u00e9s a tov\u00e1bbiakban is seg\u00edt\u00fcnk eld\u00f6nteni, hogy sz\u00fcks\u00e9g van-e int\u00e9zm\u00e9nyi fejleszt\u00e9sre, \u00e9s ha igen, pontosan milyen m\u00f3dszerrel \u00e9s heti h\u00e1ny \u00f3r\u00e1ban. Meghat\u00e1rozott id\u0151pontokban fejl\u0151d\u00e9spszichol\u00f3giai teszteket (Bayley III., WPPSI) v\u00e9gz\u00fcnk, melyekkel objektiviz\u00e1lhat\u00f3 a gyermekek pszichomotoros fejl\u0151d\u00e9se. Ezeket az adatokat struktur\u00e1lt adatb\u00e1zisban is kezelj\u00fck, ezek tudom\u00e1nyos feldolgoz\u00e1sa folyamatosan zajlik.<\/p>\n<p>2025 janu\u00e1rj\u00e1ban hivatalosan is megjelent a Rizik\u00f3 \u00fajsz\u00fcl\u00f6ttek ut\u00f3gondoz\u00e1s\u00e1r\u00f3l sz\u00f3l\u00f3 <a href=\"https:\/\/jogkodex.hu\/doc\/9941074\" target=\"_blank\" rel=\"noopener\">eg\u00e9szs\u00e9g\u00fcgyi szakmai ir\u00e1nyelv<\/a>, melynek sz\u00fcl\u0151t\u00e1j\u00e9kozatat\u00f3 fejezet\u00e9t sorst\u00e1rs sz\u00fcl\u0151k \u00edrt\u00e1k. Az ir\u00e1nyelv angol nyelv\u0171 kivonata ppt form\u00e1tumban <a href=\"https:\/\/unisemmelweis-my.sharepoint.com\/:p:\/g\/personal\/jermendy_agnes_semmelweis_hu\/IQCPbIX_Z7JdRItWsMMeNVsiAZvx0XrLaMKxXR9hOym7Q9c\" target=\"_blank\" rel=\"noopener\">ide kattintva<\/a> el\u00e9rhet\u0151.<\/p>\n<p><a name=\"ujszulott_aneszteziai_vizsgalatok\"><\/a><\/p>\n<h3><strong>\u00dajsz\u00fcl\u00f6tt aneszt\u00e9ziai vizsg\u00e1latok<\/strong><\/h3>\n<p>Seb\u00e9szeti ell\u00e1t\u00e1st ig\u00e9nyl\u0151 betegeink k\u00f6r\u00e9ben a <strong>multimodalis (MM) nem-invaz\u00edv monitoroz\u00e1s lehet\u0151s\u00e9geit vizsg\u00e1ltuk a gyermekaneszt\u00e9zia sor\u00e1n<\/strong>, agyi oxigeniz\u00e1ci\u00f3s \u00e9s hemodinamikai monitorral kieg\u00e9sz\u00edtve a rutinszer\u0171en alkalmazott betegmonitor-rendszert. A sz\u00e1mos eszk\u00f6z \u00f6sszehangol\u00e1s\u00e1t \u00e9s a nagy mennyis\u00e9g\u0171 inform\u00e1ci\u00f3 val\u00f3s-idej\u0171 \u00e9rt\u00e9kel\u00e9s\u00e9t biom\u00e9rn\u00f6ki \u00e9s informatikai seg\u00edts\u00e9ggel oldottuk meg. Vizsg\u00e1latunk eredm\u00e9nyei szerint az \u00fajsz\u00fcl\u00f6ttek aneszt\u00e9zi\u00e1ja sor\u00e1n az agyi oxigeniz\u00e1ci\u00f3-cs\u00f6kken\u00e9s gyakori jelens\u00e9g [14], h\u00e1tter\u00e9ben hypotensios esem\u00e9nyek mellett hypocapnia el\u0151fordul\u00e1sa is gyakori [15]. Eredm\u00e9nyeink el\u0151seg\u00edtik a <strong>neuroprotekci\u00f3-f\u00f3kusz\u00fa aneszt\u00e9zi\u00e1t<\/strong> \u00fajsz\u00fcl\u00f6ttekben, korai intervenci\u00f3t tesznek lehet\u0151v\u00e9, n\u00f6velve a betegbiztons\u00e1got \u00e9s jav\u00edtva a kimenetelt.<\/p>\n<p>Korasz\u00fcl\u00f6ttek k\u00f6r\u00e9ben vizsg\u00e1ltuk a k\u00fcl\u00f6nb\u00f6z\u0151 l\u00e9g\u00fatbiztos\u00edt\u00e1sra alkalmas eszk\u00f6z\u00f6k hat\u00e1s\u00e1t \u00e1ltal\u00e1nos aneszt\u00e9zia sor\u00e1n, a r\u00f6vidt\u00e1v\u00fa kimenetelre, l\u00e9zeres szem\u00e9szeti beavatkoz\u00e1sok kapcs\u00e1n. Azt tal\u00e1ltuk, hogy laryngealis maszk haszn\u00e1lata a tests\u00falyt\u00f3l \u00e9s a kor\u00e1bbi g\u00e9pi l\u00e9legeztet\u00e9s hossz\u00e1t\u00f3l f\u00fcggetlen\u00fcl cs\u00f6kkenti a posztoperat\u00edv l\u00e9gz\u00e9st\u00e1mogat\u00e1s sz\u00fcks\u00e9gess\u00e9g\u00e9t, az endotrachealis tubushoz k\u00e9pest. Eredm\u00e9ny\u00fcnk fontos v\u00e1ltoz\u00e1st hozhat a korasz\u00fcl\u00f6ttek l\u00e9g\u00fatbiztos\u00edt\u00e1s\u00e1ban, kisebb m\u0171t\u00e9ti beavatkoz\u00e1sok sor\u00e1n [16].<\/p>\n<h5><b><span data-contrast=\"auto\">Bibliogr\u00e1fia<\/span><\/b><\/h5>\n<ol>\n<li>Kovacs K, Szakmar E, Meder U, Kolossvary M, Bagyura Z, Lamboy L, Elo Z, Szabo A, Szabo M, Jermendy A: Ter\u00e1pi\u00e1s hypothermia alkalmaz\u00e1sa az asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek kezel\u00e9s\u00e9ben &#8211; egy hazai neonatol\u00f3giai centrum eredm\u00e9nyei. Orv Hetilap 2017; 158:331-339.<\/li>\n<li>Szakmar E, Kovacs K, Meder U, Nagy A, Szell A, Bundzsity B, Somogyvari Z, Szabo AJ, Szabo M, Jermendy A: Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy. Pediatr Crit Care Med 2017; 18:1159-1165.<\/li>\n<li>Kovacs K, Szakmar E, Meder U, Cseko A, Szabo AJ, Szabo M, Jermendy A: Serum cortisol levels in asphyxiated infants with hypotension. Early Hum Dev 2018; 120:40-45.<\/li>\n<li>Kovacs K, Szakmar E, Meder U, Szakacs L, Cseko A, Vatai B, Szabo AJ, McNamara PJ, Szabo M, Jermendy A: A randomized controlled study of low-dose hydrocortisone versus placebo in dopamine-treated hypotensive neonates undergoing hypothermia treatment for hypoxic-ischemic encephalopathy. J Pediatr 2019; 211:13-19.<\/li>\n<li>Balog V, Vatai B, Kovacs K, Szabo AJ, Szabo M, Jermendy A: Time series analysis of non-invasive hemodynamic monitoring data in neonates with hypoxic-ischaemic encephalopathy. Frontiers in Pediatrics 2023 in press<\/li>\n<li>Szakmar E, Jermendy A, El-Dib M: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy. J Perinatol. 2019; 39:763-773.<\/li>\n<li>Szakmar E, Kovacs K, Meder U, Bokodi G, Szell A, Somogyvari Z, Szabo AJ, Szabo M, Jermendy A: Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls. Acta Paediatr 2018; 107:1902-1908.<\/li>\n<li>Szakmar E, Munster C, El-Shibiny H, Jermendy A, Inder T, El-Dib M. Hypocapnia in early hours of life is associated with brain injury in moderate to severe neonatal encephalopathy. J Perinatol. 2022 Jul;42(7):892-897.<\/li>\n<li>Szakmar E, Kovacs K, Meder U, Bokodi G, Andorka C, Lakatos A, Szabo AJ, Belteki G, Szabo M, Jermendy A. Neonatal encephalopathy therapy optimization for better neuroprotection with inhalation of CO2: the HENRIC feasibility and safety trial. Pediatr Res 2020; 87:1025-1032.<\/li>\n<li>Meder U, Cseko AJ, Szakacs L, Balogh CD, Szakmar E, Andorka C, Kovacs K, Dobi M, Brandt FA, Szabo M, Szabo AJ, Jermendy A. Longitudinal Analysis of Amplitude-Integrated Electroencephalography for Outcome Prediction in Hypoxic-Ischemic Encephalopathy. J Pediatr. 2022 Jul; 246:19-25.e5.<\/li>\n<li><a href=\"https:\/\/suneonatalgroup.shinyapps.io\/aeegpredictiontool\/\" target=\"_blank\" rel=\"noopener\">https:\/\/suneonatalgroup.shinyapps.io\/aeegpredictiontool\/<\/a><\/li>\n<li>Varga Zs, Andorka Cs, Pataki M, Meder U, Szakmar E, Szabo AJ, Szabo M, Jermendy A: The role of parental education level in the cognitive outcome of infants with neonatal encephalopathy. Acta Paed 2023 in press<\/li>\n<li>Meder U, Tarjanyi E, Kovacs K, Szakmar E, Cseko AJ, Hazay T, Belteki G, Szabo M, Jermendy A. Cerebral oxygenation in preterm infants during maternal singing combined with skin-to-skin care. Pediatr Res 2021; 90:809-814.<\/li>\n<li>Balog V, Trinh S, Barra M, Szabo M, Hauser B, Jermendy A. Cerebral oxygenation changes in neonates under anesthesia. NBBC 15th International Newborn Brain Conference, Cork 2024.<\/li>\n<li>Bogner LL, Trinh S, Balog V, Szabo M, Hauser B, Jermendy A. Neurointensive monitoring during neonatal anesthesia: synchronous cerebral oxygenation and mean arterial pressure changes. NBBC 15th International Newborn Brain Conference, Cork 2024.<\/li>\n<li>Trinh S, Tovishazi Gy, Katai L, Bogner L, Maka E, Balog V, Szabo M, Szabo AJ, Gal J, Jermendy A, Hauser B: Airway management may influence postoperative ventilation need in preterm infants after laser eye treatment. Pediatr Res. 2025; 97:341-347.<\/li>\n<\/ol>\n<p><a name=\"palyazati_tamogatasok\"><\/a><\/p>\n<h3><strong>P\u00e1ly\u00e1zati t\u00e1mogat\u00e1sok<\/strong><\/h3>\n<p><b><span data-contrast=\"auto\">Dr. Szab\u00f3 Mikl\u00f3s:<\/span><\/b><\/p>\n<p><span data-contrast=\"auto\">2022-2026: Idegtudom\u00e1nyi Nemzeti Labor RRF-2.3.1-21-2022-00011<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559740&quot;:360}\"><strong>Dr.<\/strong> <\/span><b style=\"font-size: 1rem\"><span data-contrast=\"none\">Jermendy \u00c1gnes:<\/span><\/b><\/p>\n<p><span data-contrast=\"none\">2016-2019: MTA Pr\u00e9mium Posztdoktori \u00d6szt\u00f6nd\u00edj t\u00e1mogat\u00e1s (PPD460004)<\/span><br \/>\n<span data-contrast=\"none\">2018-2021: FIKP Neurol\u00f3gia T\u00e9mater\u00fclet, Asphyxia munkacsoport<\/span><br \/>\n<span data-contrast=\"none\">2020-2024: OTKA FK_20 (135222)<\/span><br \/>\n<span data-contrast=\"none\">2021-2025: Felfedez\u0151, klinikai \u00e9s kognit\u00edv idegtudom\u00e1nyi kutat\u00e1sok a Semmelweis Egyetemen (TKP2021-EGA-25), Neonatol\u00f3gia Kutat\u00f3csoport<\/span><br \/>\n<span data-contrast=\"none\">2020-2023 MTA Bolyai \u00f6szt\u00f6nd\u00edj<\/span><br \/>\n<span data-contrast=\"none\">2020, 2021, 2022: \u00daNKP Bolyai+ \u00f6szt\u00f6nd\u00edj<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2025-2029: NKFIH Starting Grant (150900)<\/span><br \/>\n\u00a0<br \/>\n<b><span data-contrast=\"none\">Dr. Kov\u00e1cs Kata:<\/span><\/b><\/p>\n<p><span data-contrast=\"none\">2019:\u202f\u00daNKP-19-3-III-SE-10<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2019: SE STIA19<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2021: ESPR Young Investigator Start-up Grant<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2021: <\/span><span data-contrast=\"none\">NTP- Nemzet Fiatal Tehets\u00e9gei\u00e9rt \u00d6szt\u00f6nd\u00edj<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2022: NTP- Nemzet Fiatal Tehets\u00e9gei\u00e9rt \u00d6szt\u00f6nd\u00edj<\/span><br \/>\n<span data-contrast=\"none\">2022-2025: OTKA PD_22 (142288)<\/span><br \/>\n\u00a0<br \/>\n<b><span data-contrast=\"none\">Dr. Szakm\u00e1r Enik\u0151:<\/span><\/b><\/p>\n<p><span data-contrast=\"none\">2018: Roszt\u00f3czy \u00f6szt\u00f6nd\u00edj<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2018:\u202f\u00daNKP-18-3-III-SE-3<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2019: ESPR Young Investigator Start-up Grant<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2021: \u00daNKP-21-4-II-SE-12<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2022: NTP- Nemzet Fiatal Tehets\u00e9gei\u00e9rt \u00d6szt\u00f6nd\u00edj<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2022:\u202fMagyar Tehets\u00e9gseg\u00edt\u0151 Szervezetek Sz\u00f6vets\u00e9g\u00e9nek d\u00edja<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2022: Newborn Brain Society Trainee Award<\/span><br \/>\n\u00a0<br \/>\n<b><span data-contrast=\"none\">Dr. Trinh Sarolta:<\/span><\/b><\/p>\n<p><span data-contrast=\"none\">2021: SE Innov\u00e1ci\u00f3s d\u00edj<br \/>\n<\/span><span data-contrast=\"none\">2023: Semmelweis Egyetem STIA-POC p\u00e1ly\u00e1zat<\/span><span data-ccp-props=\"{}\"><br \/>\n<\/span><span data-contrast=\"none\">2023: <\/span><span data-contrast=\"auto\">\u00daNKP-23-3-II-SE-71<\/span><br \/>\n\u00a0<br \/>\n<b><span data-contrast=\"none\">Dr. Balog Vera:<\/span><\/b><\/p>\n<p><span data-contrast=\"none\">2022: NTP- Nemzet Fiatal Tehets\u00e9gei\u00e9rt \u00d6szt\u00f6nd\u00edj<\/span><\/p>\n<p><span data-ccp-props=\"{}\"><strong>Dr.<\/strong> <\/span><b style=\"font-size: 1rem\"><span data-contrast=\"none\">Bogner Luca:<\/span><\/b><\/p>\n<p><span data-contrast=\"none\">2024: EK\u00d6P-2024-232<\/span><\/p>\n<hr \/>\n<div>\u00a0<\/div>\n<p><a name=\"neonatology_research_group_pediatric_center_energy\"><\/a><\/p>\n<h3><strong>Neonatology Research Group, Pediatric Center: \u201ceNeRGy\u201d<\/strong><\/h3>\n<p>Our research is dedicated to advancing the care of critically ill neonates requiring intensive therapy after birth. To optimize neurodevelopmental outcomes, we emphasize the application of personalized medicine principles. Our objectives include refining therapeutic strategies currently employed in clinical practice, exploring adjunctive interventional approaches, and applying artificial intelligence\u2013based analyses to data obtained from continuous, non-invasive monitoring in order to improve patient outcomes.<\/p>\n<p>Our clinical research primarily targets three major neonatal populations: infants with perinatal asphyxia, preterm infants, and neonates undergoing surgical interventions.<\/p>\n<p>Through these efforts, we aim to improve outcomes for the approximately 6,000 newborns admitted to intensive care units annually in Hungary, with the expectation that our findings will also inform and influence international practice.<\/p>\n<h3><strong>Perinatal Asphyxia<\/strong><\/h3>\n<p>Perinatal asphyxia and the resulting hypoxic-ischemic encephalopathy (HIE) cause the death or permanent neurological deficit of 2 million newborns worldwide each year. To date, the only available treatment for HIE is mild whole-body hypothermia, so it is understandable that research mainly focuses on investigating complementary therapeutic options, especially optimizing supportive therapy.<\/p>\n<p>Our group has created an outstanding database, containing structured clinical data, imaging studies, and neurodevelopmental test results of about 900 asphyxiated newborns [1]. We demonstrated that hypothermia treatment can be safely initiated already at obstetric units and continued during neonatal transport, supporting early initiation of cooling, which is proven to improve outcomes [2].<\/p>\n<p>We examined ways to improve circulatory stabilization. We showed that 25% of newborns with HIE have relative hypadrenia, which may cause circulatory instability, suggesting cortisol replacement as a causal therapy [3]. In our \u201cCORTISoL\u201d clinical study, we tested the effect of low-dose hydrocortisone in a placebo-controlled, randomized, double-blind design, in addition to routinely used dopamine circulatory support. Our results showed that a higher proportion of patients receiving hydrocortisone achieved a 5 mmHg increase in mean arterial pressure compared to placebo, and the duration and cumulative dose of circulatory support were reduced [4]. Thus, in hypotensive patients, hydrocortisone may be considered as first-line therapy.<\/p>\n<p>In hypothermia-treated newborns, we performed continuous non-invasive hemodynamic monitoring. Time-series data analysis showed that patients with favorable neurodevelopmental outcomes had lower heart rates and higher stroke volumes, resulting in similar cardiac output compared to those with poor outcomes. Heart rate during cooling proved to be an independent predictor of outcome [5].<\/p>\n<p>We also investigated the possibility of stricter control of ventilation parameters in this patient population [6]. We confirmed that hypothermia treatment is an independent risk factor for low carbon dioxide tension (hypocapnia), which may worsen neurological outcomes [7]. Longer periods of hypocapnia were associated with more severe brain MRI abnormalities [8]. To prevent hypocapnia, we examined the safety of inhaled low-concentration CO\u2082 (5%) in the \u201cHENRIC\u201d study. We demonstrated that patients remained in the predetermined permissive hypercapnia range for 95% of the study time, without significant side effects [9].<\/p>\n<p>Our latest results show that longitudinal evaluation of amplitude-integrated electroencephalography (aEEG) during hypothermia treatment allows highly accurate prediction of neurological outcomes in asphyxiated newborns [10]. To support this, we developed an online prediction tool (HOPE tool) [11].<\/p>\n<p>We also showed that parental education is closely linked to early cognitive development in infants with moderate asphyxia. The impact of parents\u2019 &#8211; particularly the mother\u2019s -education level on 2-year cognitive outcomes is comparable to neonatal MRI abnormalities (according to Barkovich score) [12].<\/p>\n<p>Based on our data, intensive care and early developmental interventions for asphyxiated newborns can become personalized and optimized.<\/p>\n<p>Most recently, our study F-NEO-BRIGHT (Feasibility of NEOnatal-intranasal BReast milk, Impact on brain Growth in HIE Therapy) was launched to test the feasibility of intranasal administration of breast milk in newborns with hypoxic-ischemic encephalopathy (NCT06747260). Building on this feasibility and safety study, the NEO-BRIGHT Study has been ongoing since 2025, a prospective, randomized clinical trial investigating the effects of intranasally administered fresh breast milk on central nervous system regeneration and long-term neurodevelopmental outcomes (NCT06746532).<\/p>\n<h3><strong>Developmental Care in Premature Infants<\/strong><\/h3>\n<p>In our preterm infant population, we focused on methods that improve quality of survival. We demonstrated that skin-to-skin contact with the mother (kangaroo care), followed by maternal singing, improves cerebral tissue oxygenation and enhances autonomic nervous system stability. Based on these findings, music therapy combined with kangaroo care represents a cost-effective, widely applicable intervention in preterm infants, with short-term clinical benefits [13].<\/p>\n<h3><strong>Neurodevelopmental follow-up and care<\/strong><\/h3>\n<p>In 2018, our clinic has opened an interdisciplinary neurodevelopmental follow-up outpatient service, where children treated in our Neonatal\/Perinatal Intensive Care (NICU\/PIC) unit are monitored and cared for using the integrated perspectives of multiple disciplines &#8211; pediatric neurology, physiotherapy, special education, conductive education, and psychology. Before discharge, we train families in a home-based neurorehabilitation program (instructional videos are available on the <a href=\"https:\/\/www.facebook.com\/rizikoujszulottek\" target=\"_blank\" rel=\"noopener\">Rizik\u00f3 \u00fajsz\u00fcl\u00f6ttek ut\u00f3gondoz\u00e1sa Facebook page<\/a>). Thereafter, we continue to support families in determining whether institution-based developmental therapy is needed and, if so, which method is most appropriate and at what weekly intensity (hours per week). At predefined time points, we perform standardized developmental and psychological assessments (e.g., Bayley-III and WPPSI) to objectively evaluate children\u2019s psychomotor development. These data are maintained in a structured database, and their scientific analysis is ongoing.<\/p>\n<p>In January 2025, the national healthcare professional guideline on follow-up care for high-risk newborns was officially published. The parent information chapter was written by peer parents. An English-language summary of the guideline is available in PowerPoint format <a href=\"https:\/\/unisemmelweis-my.sharepoint.com\/:p:\/g\/personal\/jermendy_agnes_semmelweis_hu\/IQCPbIX_Z7JdRItWsMMeNVsiAZvx0XrLaMKxXR9hOym7Q9c\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\n<h3><strong>Neonatal Anesthesia Studies<\/strong><\/h3>\n<p>In newborns requiring surgical care, we investigated the possibilities of multimodal (MM) non-invasive monitoring during pediatric anesthesia, adding cerebral oxygenation and hemodynamic monitoring to the routinely used patient monitoring system. Coordinating multiple devices and real-time evaluation of large data volumes was achieved with biomedical engineering and IT support. Our results showed that cerebral oxygenation decreases are a frequent phenomenon during neonatal anesthesia [14], with hypotensive events and hypocapnia being common underlying factors [15]. These findings support neuroprotection-focused anesthesia in neonates, enabling early intervention, increasing patient safety, and improving outcomes.<\/p>\n<p>In premature infants, we studied the effect of various airway management devices during general anesthesia for laser ophthalmic interventions. We found that the use of a laryngeal mask reduced the need for postoperative respiratory support compared to endotracheal intubation, regardless of body weight and previous ventilation duration. This result could lead to significant changes in airway management of preterm infants during minor surgical procedures [16].<\/p>\n<h5><strong>Bibliography<\/strong><\/h5>\n<ol>\n<li><span data-contrast=\"none\">Kovacs K, Szakmar E, Meder U, Kolossvary M, Bagyura Z, Lamboy L, Elo Z, Szabo A, Szabo M, Jermendy A: Ter\u00e1pi\u00e1s hypothermia alkalmaz\u00e1sa az asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttek kezel\u00e9s\u00e9ben &#8211; egy hazai neonatol\u00f3giai centrum eredm\u00e9nyei. Orv Hetilap 2017; 158:331-339.<\/span><\/li>\n<li><span data-contrast=\"none\">Szakmar E, Kovacs K, Meder U, Nagy A, Szell A, Bundzsity B, Somogyvari Z, Szabo AJ, Szabo M, Jermendy\u202fA: Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy. Pediatr Crit Care Med 2017; 18:1159-1165.<\/span><\/li>\n<li><span data-contrast=\"none\">Kovacs K, Szakmar E, Meder U, Cseko A, Szabo AJ, Szabo M, Jermendy A:\u202fSerum cortisol levels in asphyxiated infants with hypotension. Early Hum Dev 2018; 120:40-45.<\/span><\/li>\n<li><span data-contrast=\"none\">Kovacs K, Szakmar E, Meder U, Szakacs L, Cseko A, Vatai B, Szabo AJ, McNamara PJ, Szabo M, Jermendy A: A randomized controlled study of low-dose hydrocortisone versus placebo in dopamine-treated hypotensive neonates undergoing hypothermia treatment for hypoxic-ischemic encephalopathy. J Pediatr 2019; 211:13-19.<\/span><\/li>\n<li><span data-contrast=\"auto\">Balog V, Vatai B, Kovacs K, Szabo AJ, Szabo M, Jermendy A: Time series analysis of non-invasive hemodynamic monitoring data in neonates with hypoxic-ischaemic encephalopathy. Frontiers in Pediatrics 2023<\/span><i><span data-contrast=\"auto\"> in press<\/span><\/i><\/li>\n<li><span data-contrast=\"none\">Szakmar E, Jermendy A, El-Dib M: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy. J Perinatol. 2019; 39:763-773.<\/span><\/li>\n<li><span data-contrast=\"none\">Szakmar E, Kovacs K, Meder U, Bokodi G, Szell A, Somogyvari Z, Szabo AJ, Szabo M, Jermendy A: Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls. Acta Paediatr 2018; 107:1902-1908.<\/span><\/li>\n<li><span data-contrast=\"none\">Szakmar E, Munster C, El-Shibiny H, Jermendy A, Inder T, El-Dib Hypocapnia in early hours of life is associated with brain injury in moderate to severe neonatal encephalopathy. J Perinatol. 2022 Jul;42(7):892-897.<\/span><\/li>\n<li><span data-contrast=\"none\">Szakmar E, Kovacs K, Meder U, Bokodi G, Andorka C, Lakatos A, Szabo AJ, Belteki G, Szabo M, Jermendy Neonatal encephalopathy therapy optimization for better neuroprotection with inhalation of CO2: the HENRIC feasibility and safety trial. Pediatr Res 2020; 87:1025-1032.<\/span><\/li>\n<li><span data-contrast=\"none\">Meder U, Cseko AJ, Szakacs L, Balogh CD, Szakmar E, Andorka C, Kovacs K, Dobi M, Brandt FA, Szabo M, Szabo AJ, Jermendy Longitudinal Analysis of Amplitude-Integrated Electroencephalography for Outcome Prediction in Hypoxic-Ischemic Encephalopathy. J Pediatr. 2022 Jul; 246:19-25.e5.<\/span><\/li>\n<li><a href=\"https:\/\/suneonatalgroup.shinyapps.io\/aeegpredictiontool\/\"><span data-contrast=\"none\">https:\/\/suneonatalgroup.shinyapps.io\/aeegpredictiontool\/<\/span><\/a><\/li>\n<li><span data-contrast=\"auto\">Varga Zs, Andorka Cs, Pataki M, Meder U, Szakmar E, Szabo AJ, Szabo M, Jermendy A: The role of parental education level in the cognitive outcome of infants with neonatal encephalopathy. Acta Paed 2023 <\/span><i><span data-contrast=\"auto\">in press<\/span><\/i><\/li>\n<li><span data-contrast=\"none\">Meder U, Tarjanyi E, Kovacs K, Szakmar E, Cseko AJ, Hazay T, Belteki G, Szabo M, Jermendy Cerebral oxygenation in preterm infants during maternal singing combined with skin-to-skin care. Pediatr Res 2021; 90:809-814.<\/span><\/li>\n<li><span data-contrast=\"auto\">Balog V, Trinh S, Barra M, Szabo M, Hauser B, Jermendy A. Cerebral oxygenation changes in neonates under anesthesia. NBBC 15th International Newborn Brain Conference, Cork 2024.\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Bogner LL, Trinh S, Balog V, Szabo M, Hauser B, Jermendy A. Neurointensive monitoring during neonatal anesthesia: synchronous cerebral oxygenation and mean arterial pressure changes. NBBC 15th International Newborn Brain Conference, Cork 2024.<\/span><\/li>\n<li><span data-contrast=\"none\">Trinh<\/span> <span data-contrast=\"none\">S, Tovishazi<\/span> <span data-contrast=\"none\">Gy, Katai<\/span> <span data-contrast=\"none\">L, Bogner<\/span> <span data-contrast=\"none\">L, Maka E, Balog<\/span> <span data-contrast=\"none\">V, Szabo M, Szabo AJ, Gal<\/span> <span data-contrast=\"none\">J, Jermendy A, Hauser B: <\/span><span data-contrast=\"auto\">Airway management may influence postoperative ventilation need in preterm infants after laser eye treatment.<\/span> <span data-contrast=\"auto\">Pediatr Res. 2025; 97:341-347.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Munkacsoport tagjai Prof. Dr. Szab\u00f3 Mikl\u00f3s egyetemi tan\u00e1r Dr. Jermendy \u00c1gnes habilit\u00e1lt egyetemi adjunktus Dr. M\u00e9der \u00dcn\u0151ke egyetemi adjunktus Dr. Kov\u00e1cs Kata egyetemi tan\u00e1rseg\u00e9d Dr. Szakm\u00e1r Enik\u0151 egyetemi tan\u00e1rseg\u00e9d Dr. Barta Hajnalka tudom\u00e1nyos munkat\u00e1rs Dr. K\u0151v\u00e1ri Eszter klinikai szakorvos Dr. Dobi Mariann klinikai szakorvos Dr. Sz\u00e1sz Barbara klinikai szakorvos Dr. Csek\u0151 Anna klinikai szakorvos, PhD &hellip;<\/p>\n","protected":false},"author":101740,"featured_media":0,"parent":15,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-201","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/pages\/201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/users\/101740"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/comments?post=201"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/pages\/201\/revisions"}],"predecessor-version":[{"id":7937,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/pages\/201\/revisions\/7937"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/media?parent=201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/categories?post=201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bokayklinika\/wp-json\/wp\/v2\/tags?post=201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}