{"id":13186,"date":"2021-04-26T15:15:31","date_gmt":"2021-04-26T13:15:31","guid":{"rendered":"https:\/\/semmelweis.hu\/biokemia\/?page_id=13186"},"modified":"2026-01-22T12:58:08","modified_gmt":"2026-01-22T11:58:08","slug":"csanady-lab","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/biokemia\/en\/research\/csanady-lab\/","title":{"rendered":"Ion channel division"},"content":{"rendered":"<h4>What are we studying?<\/h4>\n<p style=\"text-align: justify\">Our lab studies structure and function of ion channels: transmembrane protein pores which allow passage of some type of inorganic ion across a biological membrane. Our studies are focused on two target proteins, the CFTR chloride channel\u00a0and the TRPM2 cation channel. Our experimental approaches include real-time recording of ionic currents of single ion channel proteins and of large channel populations using the patch-clamp technique, kinetic analysis of current time courses, site-directed mutagenesis, protein biochemistry and structural methods, as well as mathematical modeling.<\/p>\n<h4>How do we research?<\/h4>\n<ul>\n<li>Molecular mechanism of CFTR channel gating by ATP binding and hydrolysis<\/li>\n<li>Molecular mechanism of CFTR channel activation by cAMP-dependent protein kinase<\/li>\n<li>Molecular pathology of CFTR mutations associated with cystic fibrosis<\/li>\n<li>Pharmacological profiling of mutant CFTR channels<\/li>\n<li>Molecular evolution of the TRPM2 channel<\/li>\n<li>Molecular mechanism of TRPM2 channel gating by ADP ribose, Ca2+ and phosphatydil-inositol-bisphosphate<\/li>\n<\/ul>\n<h4>Current research projects<\/h4>\n<ul>\n<li>Molecular mechanisms of CFTR activation by protein kinase A<\/li>\n<li>Structure-function, molecular evolution, and pharmacological modulation of the CFTR and TRPM2 ion channel-enzymes<\/li>\n<\/ul>\n<h4>Staff members and publications<\/h4>\n<ul>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10015499&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">L\u00e1szl\u00f3 Csan\u00e1dy<\/a>, professor<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10003430&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Be\u00e1ta T\u00f6r\u0151csik<\/a>, associate professor<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10020191&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Andr\u00e1s Sz\u00f6ll\u0151si<\/a>, senior research associate<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10052053&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Iordan Iordanov<\/a>, research associate<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10024493&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Bal\u00e1zs T\u00f3th<\/a>, research associate<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10034486&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">\u00c1d\u00e1m Bart\u00f3k<\/a>, research associate<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10037593&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Mih\u00e1lyi Csaba<\/a>, research associate<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078526&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">\u00c1d\u00e1m T\u00f3th<\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10088874&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Oliv\u00e9r Z\u00e1voti<\/a><\/li>\n<li>Kriszti\u00e1n B\u00e1lint, research assistant<\/li>\n<\/ul>\n<h4>PhD students<\/h4>\n<ul>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10088874&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">Oliv\u00e9r Z\u00e1voti<\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078526&amp;cond=category.mtid;eq;1&amp;labelLang=en&amp;size=100\">\u00c1d\u00e1m T\u00f3th<\/a><\/li>\n<li><span data-olk-copy-source=\"MessageBody\">Krist\u00f3f Asztalos<\/span><\/li>\n<\/ul>\n<h4>TDK students<\/h4>\n<ul>\n<li><span data-olk-copy-source=\"MessageBody\">T\u00f3th Petra Lili<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>What are we studying? Our lab studies structure and function of ion channels: transmembrane protein pores which allow passage of some type of inorganic ion across a biological membrane. Our studies are focused on two target proteins, the CFTR chloride channel\u00a0and the TRPM2 cation channel. Our experimental approaches include real-time recording of ionic currents of &hellip;<\/p>\n","protected":false},"author":101604,"featured_media":0,"parent":378,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13186","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/users\/101604"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/comments?post=13186"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13186\/revisions"}],"predecessor-version":[{"id":14125,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13186\/revisions\/14125"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/378"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/media?parent=13186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/categories?post=13186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/tags?post=13186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}