{"id":13177,"date":"2021-04-26T15:05:15","date_gmt":"2021-04-26T13:05:15","guid":{"rendered":"https:\/\/semmelweis.hu\/biokemia\/?page_id=13177"},"modified":"2026-01-22T12:54:25","modified_gmt":"2026-01-22T11:54:25","slug":"csanady-labor","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/biokemia\/kutatas\/csanady-labor\/","title":{"rendered":"Ioncsatorna r\u00e9szleg"},"content":{"rendered":"<h4>Mit kutatunk?<\/h4>\n<p style=\"text-align: justify\">Csoportunk ioncsatorn\u00e1k szerkezet\u00e9t, molekul\u00e1ris m\u0171k\u00f6d\u00e9s\u00e9t vizsg\u00e1lja. Az ioncsatorn\u00e1k transzmembr\u00e1n feh\u00e9rje p\u00f3rusok, amelyek lehet\u0151v\u00e9 teszik egy adott t\u00edpus\u00fa szervetlen ion \u00e1tjut\u00e1s\u00e1t a membr\u00e1non. Kutat\u00e1saink k\u00e9t ioncsatorn\u00e1t c\u00e9loznak: a CFTR kloridion csatorn\u00e1t \u00e9s a TRPM2 kationcsatorn\u00e1t. K\u00eds\u00e9rleti m\u00f3dszereink k\u00f6z\u00e9 tartozik egyedi csatorna feh\u00e9rj\u00e9k illetve nagy csatorna popul\u00e1ci\u00f3k ion\u00e1ramainak regisztr\u00e1l\u00e1sa patch-clamp technik\u00e1val, az \u00e1ramg\u00f6rb\u00e9k kinetikai elemz\u00e9se, c\u00e9lzott mutagenezis, feh\u00e9rje-biok\u00e9miai \u00e9s szerkezeti m\u00f3dszerek, illetve matematikai modellez\u00e9s.<\/p>\n<h4>Hogyan kutatunk?<\/h4>\n<ul>\n<li>CFTR csatorna ATP-f\u00fcgg\u0151 kapuz\u00e1si mechanizmusa<\/li>\n<li>cAMP-dependens protein kin\u00e1z CFTR csatorn\u00e1t aktiv\u00e1l\u00f3 mechanizmusa<\/li>\n<li>Cisztikus fibr\u00f3zist okoz\u00f3 CFTR mut\u00e1ci\u00f3k molekul\u00e1ris patol\u00f3gi\u00e1ja<\/li>\n<li>Mut\u00e1ns CFTR csatorn\u00e1k farmakol\u00f3giai jellemz\u00e9se<\/li>\n<li>TRPM2 csatorna molekul\u00e1ris evol\u00faci\u00f3ja<\/li>\n<li>TRPM2 csatorna kapuz\u00e1sa, ADP rib\u00f3z, Ca<sup>2+<\/sup> \u00e9s foszfatidil-inozitol-biszfoszf\u00e1t-f\u00fcgg\u0151 aktiv\u00e1ci\u00f3<\/li>\n<\/ul>\n<h4>Aktu\u00e1lis kutat\u00e1si projektek<\/h4>\n<ul>\n<li>Molecular mechanisms of CFTR activation by protein kinase A<\/li>\n<li>Structure-function, molecular evolution, and pharmacological modulation of the CFTR and TRPM2 ion channel-enzymes<\/li>\n<li>K\u00f3rtani jelent\u0151s\u00e9g\u0171 ioncsatorna-enzimek szerkezete, m\u0171k\u00f6d\u00e9se, \u00e9s gy\u00f3gyszertana<\/li>\n<li>TRPM2: szerkezett\u0151l a funkci\u00f3ig<\/li>\n<\/ul>\n<h4>Munkat\u00e1rsaink \u00e9s k\u00f6zlem\u00e9nyeink<\/h4>\n<ul>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10015499&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Csan\u00e1dy L\u00e1szl\u00f3<\/a>, MD, PhD, DSc<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10003430&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">T\u00f6r\u0151csik Be\u00e1ta<\/a>, MD, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10020191&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Sz\u00f6ll\u0151si Andr\u00e1s<\/a>, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10052053&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Iordanov Iordan<\/a>, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10024493&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">T\u00f3th Bal\u00e1zs<\/a>, MD, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10034486&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Bart\u00f3k \u00c1d\u00e1m<\/a>, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10037593&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Mih\u00e1lyi Csaba<\/a>, MD, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078526&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">T\u00f3th \u00c1d\u00e1m<\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10088874&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Z\u00e1voti Oliv\u00e9r<\/a><\/li>\n<li>B\u00e1lint Kriszti\u00e1n<\/li>\n<\/ul>\n<h4>PhD-hallgat\u00f3k<\/h4>\n<ul>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10088874&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Z\u00e1voti Oliv\u00e9r<\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078526&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">T\u00f3th \u00c1d\u00e1m<\/a><\/li>\n<li><span data-olk-copy-source=\"MessageBody\">Asztalos Krist\u00f3f<\/span><\/li>\n<\/ul>\n<h4>TDK-hallgat\u00f3k<\/h4>\n<ul>\n<li><span data-olk-copy-source=\"MessageBody\">T\u00f3th Petra Lili<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Mit kutatunk? Csoportunk ioncsatorn\u00e1k szerkezet\u00e9t, molekul\u00e1ris m\u0171k\u00f6d\u00e9s\u00e9t vizsg\u00e1lja. Az ioncsatorn\u00e1k transzmembr\u00e1n feh\u00e9rje p\u00f3rusok, amelyek lehet\u0151v\u00e9 teszik egy adott t\u00edpus\u00fa szervetlen ion \u00e1tjut\u00e1s\u00e1t a membr\u00e1non. Kutat\u00e1saink k\u00e9t ioncsatorn\u00e1t c\u00e9loznak: a CFTR kloridion csatorn\u00e1t \u00e9s a TRPM2 kationcsatorn\u00e1t. K\u00eds\u00e9rleti m\u00f3dszereink k\u00f6z\u00e9 tartozik egyedi csatorna feh\u00e9rj\u00e9k illetve nagy csatorna popul\u00e1ci\u00f3k ion\u00e1ramainak regisztr\u00e1l\u00e1sa patch-clamp technik\u00e1val, az \u00e1ramg\u00f6rb\u00e9k kinetikai elemz\u00e9se, &hellip;<\/p>\n","protected":false},"author":101604,"featured_media":0,"parent":53,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13177","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/users\/101604"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/comments?post=13177"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13177\/revisions"}],"predecessor-version":[{"id":14124,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13177\/revisions\/14124"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/53"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/media?parent=13177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/categories?post=13177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/tags?post=13177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}