{"id":13173,"date":"2021-04-26T15:04:00","date_gmt":"2021-04-26T13:04:00","guid":{"rendered":"https:\/\/semmelweis.hu\/biokemia\/?page_id=13173"},"modified":"2026-01-22T12:30:24","modified_gmt":"2026-01-22T11:30:24","slug":"kraszimir-labor","status":"publish","type":"page","link":"https:\/\/semmelweis.hu\/biokemia\/kutatas\/kraszimir-labor\/","title":{"rendered":"Hemoszt\u00e1zis r\u00e9szleg"},"content":{"rendered":"<h4><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-14053\" src=\"https:\/\/semmelweis.hu\/biokemia\/files\/2025\/10\/krasimir_group_2025-400x284.png\" alt=\"\" width=\"894\" height=\"635\" srcset=\"https:\/\/semmelweis.hu\/biokemia\/files\/2025\/10\/krasimir_group_2025-400x284.png 400w, https:\/\/semmelweis.hu\/biokemia\/files\/2025\/10\/krasimir_group_2025-1024x726.png 1024w, https:\/\/semmelweis.hu\/biokemia\/files\/2025\/10\/krasimir_group_2025-768x545.png 768w, https:\/\/semmelweis.hu\/biokemia\/files\/2025\/10\/krasimir_group_2025-753x534.png 753w, https:\/\/semmelweis.hu\/biokemia\/files\/2025\/10\/krasimir_group_2025.png 1280w\" sizes=\"auto, (max-width: 894px) 100vw, 894px\" \/><\/h4>\n<h4>Mit kutatunk?<\/h4>\n<p style=\"text-align: justify\">A <em>Hemoszt\u00e1zis r\u00e9szleg<\/em> a vezet\u0151 hal\u00e1lok, a sz\u00edv- \u00e9s agy\u00e9r-betegs\u00e9gek h\u00e1tter\u00e9ben \u00e1ll\u00f3 atherothrombosis molekul\u00e1ris aspektusaival foglalkozik. A k\u00f3ros alvad\u00e1si folyamatok patomechanizmus\u00e1nak vizsg\u00e1lata mellett f\u0151 c\u00e9ljaink k\u00f6z\u00f6tt szerepel a patol\u00f3gi\u00e1s v\u00e9rr\u00f6g\u00f6k felold\u00e1s\u00e1ban haszn\u00e1latos prote\u00e1zok enzimol\u00f3giai jellemz\u00e9se, illetve az \u00e9rfali komponensek \u00e9s a v\u00e9rsejtek intravaszkul\u00e1ris trombusok stabiliz\u00e1l\u00e1s\u00e1ban bet\u00f6lt\u00f6tt szerep\u00e9nek megismer\u00e9se. Kutat\u00e1saink t\u00e1vlati c\u00e9lja a jelenleg el\u00e9rhet\u0151n\u00e9l magasabb hat\u00e9konys\u00e1g\u00fa trombol\u00edtikus ter\u00e1pi\u00e1k fejleszt\u00e9se, illetve az ehhez sz\u00fcks\u00e9ges molekul\u00e1ris c\u00e9lpontok azonos\u00edt\u00e1sa. <em>In vitro<\/em> technik\u00e1k sor\u00e1t alkalmazva (p\u00e1szt\u00e1z\u00f3 elektronmikroszk\u00f3pia, immunofluoreszcens konfok\u00e1lis mikroszk\u00f3pia, rheometria, turbidimetria, surface plasmon rezonancia, mikrokalorimetria) jellemezz\u00fck a hemosztatikus faktorok k\u00f6lcs\u00f6nhat\u00e1sait, az izol\u00e1lt fibrin \u00e9s plazmaalvad\u00e9k szerkezet\u00e9t \u00e9s mechanikai, valamint k\u00e9miai stabilit\u00e1s\u00e1t.<\/p>\n<h4>Hogyan kutatunk?<\/h4>\n<p><strong>Sz\u00f6vetek, \u00e9rfal szintj\u00e9n:<\/strong><\/p>\n<ul>\n<li>immunfluoreszcens mikroszk\u00f3pia, AFM, SEM<\/li>\n<\/ul>\n<p><strong>Sejtek, szupramolekul\u00e1ris komplexek szintj\u00e9n:<\/strong><\/p>\n<ul>\n<li>\u00e1raml\u00e1si kamra, ELISA, AFM, SEM<\/li>\n<\/ul>\n<p><strong>Molekul\u00e1k szintj\u00e9n:<\/strong><\/p>\n<ul>\n<li>SPR, FRET, LSM, turbidimetria, kolorimetri\u00e1s \u00e9s fluoreszcens m\u00e9r\u00e9sek<\/li>\n<\/ul>\n<p><strong>Elm\u00e9leti szinten:<\/strong><\/p>\n<ul>\n<li>sztochasztikus \u00e9s determinisztikus szimul\u00e1ci\u00f3k<\/li>\n<\/ul>\n<h4>Kik vagyunk?<\/h4>\n<p style=\"text-align: justify\">Dr. Kolev Kraszimir csoportvezet\u0151 egyetemi oktat\u00f3i \u00e9s kutat\u00f3i tev\u00e9kenys\u00e9ge 1991 \u00f3ta a Semmelweis Egyetem Biok\u00e9miai Tansz\u00e9k\u00e9hez k\u00f6t\u0151dik. A tromb\u00f3zis \u00e9s hemoszt\u00e1zis ter\u00fclet\u00e9n v\u00e9gzett kutat\u00e1sainak eredm\u00e9nyess\u00e9g\u00e9t igazolja a hazai \u00e9s nemzetk\u00f6zi elismerts\u00e9ge (k\u00e9t cikluson \u00e1t eln\u00f6ke volt a Magyar Thrombosis \u00e9s Haemostasis T\u00e1rsas\u00e1gnak, t\u00e1rseln\u00f6ke a Nemzetk\u00f6zi Thrombosis \u00e9s Haemostasis T\u00e1rsas\u00e1g Fibrinol\u00edzis albizotts\u00e1g\u00e1nak, ill. jelenleg is a Nemzetk\u00f6zi Fibrinol\u00edzis \u00e9s Proteol\u00edzis T\u00e1rsas\u00e1g eln\u00f6ks\u00e9gi tagja). Az oktat\u00f3i \u00e9s kutat\u00f3i tev\u00e9kenys\u00e9g\u00e9nek sikeress\u00e9g\u00e9t f\u00e9mjelzik az iskolateremt\u0151 hat\u00e1sk\u00e9nt sz\u00e1mon tartott t\u00e9mavezet\u00e9s\u00e9vel PhD fokozatot szerzett doktoranduszok, akik jelenlegi munkacsoportj\u00e1ban vagy k\u00fclf\u00f6ldi kutat\u00f3helyeken hasznos\u00edtj\u00e1k vezet\u00e9s\u00e9vel elsaj\u00e1t\u00edtott gondolkod\u00e1sm\u00f3dot \u00e9s k\u00e9szs\u00e9geket.<\/p>\n<h4>Aktu\u00e1lis kutat\u00e1si projektek<\/h4>\n<ul>\n<li>Trombusok mechanikai \u00e9s litikus stabilit\u00e1s\u00e1nak unortodox molekul\u00e1ris \u00e9s szerkezeti determin\u00e1nsai<\/li>\n<li>The interplay of neutrophil extracellular traps and hemostasis in thrombosis, thrombolysis and hematological malignancies<\/li>\n<li>Neutrofil extracellul\u00e1ris csapd\u00e1k a daganatokhoz kapcsol\u00f3d\u00f3 tromb\u00f3zisban<\/li>\n<\/ul>\n<h4>Munkat\u00e1rsaink \u00e9s k\u00f6zlem\u00e9nyeink<\/h4>\n<ul>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10000059&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Kraszimir Kolev<\/a>, MD, PhD, DSc<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10010953&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Komorowicz Erzs\u00e9bet<\/a>, MD, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10021854&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Anna Tanka-Salamon<\/a>, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10015070&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">L\u00e1szl\u00f3 Beinrohr<\/a>, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10051354&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Veronika Judit Farkas<\/a>, MD, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10014812&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">L\u00e1szl\u00f3 Szab\u00f3<\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10021387&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Erzs\u00e9bet T\u00f3th Mar\u00f3thyn\u00e9<\/a>, PhD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078213&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Bar\u00e1th Barbara<\/a>, PhD<\/li>\n<li>Gy\u00f6rgyi Oravecz<\/li>\n<li>Kriszti\u00e1n B\u00e1lint<\/li>\n<\/ul>\n<h4>PhD-hallgat\u00f3k<\/h4>\n<ul>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10095692&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\"><span data-olk-copy-source=\"MessageBody\">Csik\u00f3s Petra<\/span><\/a><\/li>\n<li><span data-olk-copy-source=\"MessageBody\">Guzmits Korn\u00e9lia<\/span><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10088873&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\"><span data-olk-copy-source=\"MessageBody\">Major Fanni<\/span><\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078693&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Raska Alexandra<\/a>, MD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10085359&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Balog Vir\u00e1g Kata<\/a><\/li>\n<\/ul>\n<h4>TDK-hallgat\u00f3k<\/h4>\n<ul>\n<li>Moln\u00e1r Krist\u00f3f<\/li>\n<li>Csik\u00f3s Petra<\/li>\n<li>Guzmits Korn\u00e9lia<\/li>\n<li>Kov\u00e1cs Bence Gy\u00f6rgy<\/li>\n<li><span data-olk-copy-source=\"MessageBody\">Becsei Bogl\u00e1rka<\/span><\/li>\n<\/ul>\n<h4><span lang=\"HU\">&#8222;HUNGARIAN CENTRE OF EXCELLENCE FOR MOLECULAR MEDICINE&#8221; \u00d6N\u00c1LL\u00d3 KUTAT\u00d3CSOPORT<\/span><\/h4>\n<ul>\n<li><span lang=\"HU\"><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10020190&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Wohner Nikolett<\/a>, MD, PhD, HCEMM csoportvezet\u0151<\/span><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10078693&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Raska Alexandra<\/a>, MD<\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10085359&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\">Balog Vir\u00e1g Kata<\/a><\/li>\n<li><a href=\"https:\/\/m2.mtmt.hu\/api\/publication?cond=authors;in;10095692&amp;cond=category.mtid;eq;1&amp;labelLang=hu&amp;size=100\"><span data-olk-copy-source=\"MessageBody\">Csik\u00f3s Petra<\/span><\/a><\/li>\n<li>Moln\u00e1r Krist\u00f3f<\/li>\n<\/ul>\n<h4>Jelent\u0151s nemzetk\u00f6zi egy\u00fcttm\u0171k\u00f6d\u0151ink<\/h4>\n<ul>\n<li><a href=\"https:\/\/www.nibsc.org\/about_us\/staff_profiles\/dr_colin_longstaff.aspx\">Colin Longstaff<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Kiril_Tenekedjiev\">Kiril Tenekedjiev<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Mit kutatunk? A Hemoszt\u00e1zis r\u00e9szleg a vezet\u0151 hal\u00e1lok, a sz\u00edv- \u00e9s agy\u00e9r-betegs\u00e9gek h\u00e1tter\u00e9ben \u00e1ll\u00f3 atherothrombosis molekul\u00e1ris aspektusaival foglalkozik. A k\u00f3ros alvad\u00e1si folyamatok patomechanizmus\u00e1nak vizsg\u00e1lata mellett f\u0151 c\u00e9ljaink k\u00f6z\u00f6tt szerepel a patol\u00f3gi\u00e1s v\u00e9rr\u00f6g\u00f6k felold\u00e1s\u00e1ban haszn\u00e1latos prote\u00e1zok enzimol\u00f3giai jellemz\u00e9se, illetve az \u00e9rfali komponensek \u00e9s a v\u00e9rsejtek intravaszkul\u00e1ris trombusok stabiliz\u00e1l\u00e1s\u00e1ban bet\u00f6lt\u00f6tt szerep\u00e9nek megismer\u00e9se. Kutat\u00e1saink t\u00e1vlati c\u00e9lja a jelenleg &hellip;<\/p>\n","protected":false},"author":101604,"featured_media":0,"parent":53,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-13173","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/users\/101604"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/comments?post=13173"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13173\/revisions"}],"predecessor-version":[{"id":14118,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/13173\/revisions\/14118"}],"up":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/pages\/53"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/media?parent=13173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/categories?post=13173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/biokemia\/wp-json\/wp\/v2\/tags?post=13173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}