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Biochemistry 3 – medical – 2018/2019



  • Tuesday 13:10-14:20 Szent-Györgyi Albert lecture hall
  • Thursday 08:00-09:10 Szent-Györgyi Albert lecture hall

Lecturers: Tretter, László MD, PhD, DSc; Kolev, Kraszimir MD, PhD, DSc; Csanády, László MD, PhD, DSc; Törőcsik, Beáta MD, PhD

Week Date Topic
01 2019.02.05 Metabolism of red blood cells. Red blood cell enzymopathies
  2019.02.07 Metabolism of muscle and heart
02 2019.02.12 Metabolic characteristics of brain and adipose tissue. Metabolism of lymphocytes and intestinal epithel cells
  2019.02.14 Reseach Students’ Conference
03 2019.02.19 The starving-feed cyclus and its regulation. Regulattion of hepatocyte metabolism in starvation
  2019.02.21 ChREBP signal transduction. The role of the SREBP, mTOR and PPAR system in the regulation of metabolism
 04 2019.02.26 AMP kinase, PGC1-a, HIF, p53. The role of thyroid hormones 
  2019.02.28 Na+,K+ ATP-ase. The permeability of cell membranes, P-type ATP-ase. Structure of Na+,K+ ATP-ase, Na+,K+ ATP-ase isoforms. Regulation. Secondary active transports. Na-H exchange 
05 2019.03.05 Chemical neurotransmission. Cholinergic neurotransmission. Biosynthesis of acetylcholine. receptors, acetylcholine esterase. Molecular mechanism of exocytosis
  2019.03.07 Noradrenerg neurotransmission. Synthesis and metabolism of norepinephrine. Synaptic uptake.
06 2019.03.12 Adrenerg receptors. Molecular mechanism of epinephrine and norepinephrine on various organs
  2019.03.14 Dopaminergic and serotoninergic neurotransmission. Synthesis, transporters, receptors. Biochemistry of Parkinson disease
07 2019.03.19 Glutamatergic neurotransmission
  2019.03.21 NO: Regulatory role of NO. Nitric oxide synthase. Guanylate cyclase. Molecular effects of nitric oxide
08  2019.03.26 General properties of ion channels. Methods for studying ion channels. Molecular mechanisms of gating and permeation. Structure of K+ channels. (LCs)
  2019.03.28 Molecular diversity of ion channels. Voltage-gated K+ channels. ATP-sensitive K+ channels. Voltage-gated Cl- channels. The CFTR chloride channel. The nicotinic Acetylcholine Receptor. (LCS)
09 2019.04.02 General overview of blood clot formation and elimination. Fibrinogen and fibrin. Prothrombin activation and regulation of thrombin activity. Triggers of blood clotting, amplification of the initiation. (KK)
  2019.04.04 Inhibitors  of blood coagulation and  negative feedback mechanisms  (KK)
10 2019.04.09 Fibrinolysis. Activation of plasminogen. Inhibitors of plasmin  (KK)
  2019.04.11 Cellular elements of the haemostatic system. Platelets and von Willebrand factor  (KK)
    Spring break, Eastern
11 2019.04.23 Neutrophils and endothelial cells in haemostasis.  (KK)
  2019.04.25 Haemodynamical and biochemical interactions in haemostasis  (KK)
12 2019.04.30 Faculty Day (FD)
  2019.05.02 The role of endothelial dysfunction in atherosclerosis. LDL oxidation and   pattern-recognition receptors (TLR, scavenger receptors). Cholesterol induced pyroptosis   (KK)
13 2019.05.07 Effect of cholesterol on  atherosclerotic  plaque formation. Risk factors of atherosclerosis related to cholesterol homeostasis (diabetes, hypertriglyceridemia). Biochemical background of atherosclerosis, prevention)
  2019.05.09 Signaltransduction-1: Therapeutic targeting of signal transduction pathways (TB)
14 2019.05.14 Signaltransduction-2: Cytokine signaling. Jak-STAT pathway. Calcium signaling. Nuclear receptors. (TB)
  2019.05.16 Signaltransduction-3: Wnt signal transduction pathways. Frizzled/Arrow/LRP receptors, Dsh, axin, APC proteins, GSK3, CK1α protein kinases, protein phosphatases (PP2A) and the ubiquitin system. Notch receptor signaling (TB)


Laboratory and seminar lessons in spring semester of the 2018/2019 academic year

Day Time Group Lab teacher
Monday 08:00-10:10 EM01 Bak, J dr.  
Monday 08:00-10:10 EM07 Komorowicz, J. dr  
Monday 10:40-12:50 EM05 Tóth, E. dr  
Monday 10:40-12:50 EM09 Bartha, K. dr  
Monday 13:20-15:30 EM14 Kolev, K. prof  
Monday 13:20-15:30 EM15 Törőcsik, B. dr  
Wednesday 11:00-13:10 EM08 Margittai, É. dr  
Wednesday 11:00-13:10 EM10 Chinopoulos, C. dr  
Thursday 10:40-12:50 EM03 Kolev, K. prof  
Thursday 10:40-12:50 EM13 Dóczi, J. dr  
Thursday 13:20-15:30 EM04 Léránt, I. dr
Thursday 13:20-15:30 EM12 Mészáros, N. dr  
Friday 08:00-10:10 EM11 Törőcsik, B. dr  
Friday 10:20-12:30 EM02 Müllner, N. dr  
Friday 10:20-12:30 EM06 Komáry, Zs. dr  

Laboratory lessons

Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)

01 2019.02.04→ The isoenzyme profile of lactate-dehydrogenase (laboratory lesson)
02 2019.02.11→ Metabolism of excercise  (seminar) 
03 2019.02.18→ Acute and chronic liver disease (seminar)
04 2019.02.25→ Determination of transaminase enzyme activity. Determination of serum creatine kinase activity (laboratory lesson)
05 2019.03.04→ Extracellular matrix (seminar)
06 2019.03.11-14 Metabolism of tumors (seminar)
07 2019.03.18→ The K+, Na+ transport ATP-ase (laboratory lesson) 
08 2019.03.25→ Metabolism of human nervous system (seminar) 
09 2019.04.01→ Determination of blood glucose level; In vitro determination of hemoglobin 1Ac (laboratory lessons)
10 2019.04.08→ Haemostatic abnormalities -1 (seminar) 
    SPRING BREAK – EASTER 15. April – 22. April
11 2019.04.23→ Experimental models of blood coagulation (laboratory lesson)
12 2019.04.29→ Haemostatic abnormalities -2 (seminar) 
13 2019.05.06→ Investigation of microsomal drug mebatolism (laboratory lesson)
14 2019.05.13→ Research of specific literature of Biochemistry. Presentation of research at our department – Consultation


Recommended books

  • Harper’s Illustrated Biochemistry (30th edition)
  • Powerpoint files of lectures 
  • Consultation manual 
  • Students’ own notes
  • Ask your laboratory teacher for the username and password of our authorized pages

Midterm exams

1st Midterm exam is held on the 18th of March, 2019. Exam starts at 17:30. We ask you to wait for the midterm exam in front of the Szent-Györgyi and Hevessy Lecture Halls.

Szent-Györgyi Albert Lecture Hall EM07-EM15 + FM
Hevessy György Lecture Hall EM01-EM06
1st ME W07 2019.03.18 17:30-19:00 SzALH
    2019.03.18 17:30-19:00 HGyLH
1st RE W08 2019.03.25 17:30-18:50 SzALH
2nd ME W12 2019.04.29 17:30-18:50 SzALH
    2019.04.29 17:30-19:00 HGyLH
1st RE W13 2019.05.06 17:30-18:50 SzALH
OR W14 2019.05.13 17:30- LR 

ME = midterm – exam; W07 = Week 07; SzALH = Szent-Györgyi Albert Lecture Hall; HGyLH = Hevesy Gyula Lecture Hall;  1st RE = 1st retake of the 1st midterm exam / RE = 1st retake of the 2nd midterm exam; OR = 2nd (oral) retake of the first and second midterm exams; LR = laboratory rooms

25 multiple choice type questions and 2 biochemistry problem sets are asked. Students may obtain 1 score for each correctly solved multiple choice questions. The both problem sets are evaluated by your own laboratory teachers (points: 0, 2, 3, 4, 5).  We calculate the sum of your scores and points of your midterm examinations and the tests are graded by the proposed limits of the table below:

Proposed limits for the marks of midterm are:

Sum of the grades and scores Grade of the midterm examination
0-18 1 (fail)
19-22 2 (pass)
23-26 3 (fair)
27-30 4 (good)
31-35 5 (excellent)

The grade for the midterm exam is 1 (fail), if (i) the sum of the scores and the points is 18, or less (ii) each of the problem sets are evaluated by 0.

Failed midterms might be retaken twice.

Students having failed the first retake might sit for the second retake in the 14th week of the semester. The second retake is an oral exam conducted by an examination committee. Students having failed the first retake of both midterms 1 and 2 will be examined in the material of both midterms at the same time. Passing both midterms is a prerequisite to acknowledgement of the semester.


For results of medical biochemistry competition  click link of page e-Lectures, e-Laboratory lessons, e-Seminars .

May 13, 2019 at 17:30, Szent-Györgyi Albert lecture hall for medical students, and at 17:40, Hevesy György lecture hall for the dentistry students.



Material: lectures, seminars and laboratory lessons of the fall and spring semesters of 2018/2019 and spring semester of the 2017/2018 academic year
Test: biochemistry problems and structures (max. 30 + 10) + 70 multiple choice type questions
Students reaching at least 75 % will be exempted from the examination by mark 5
Other exemptions are not possible

  • grade 3 or better at both midterms
  • registration for the subject matter of Medical Biochemistry 3 in the spring semester of 2018/2019 academic year
  • registration for the subject matter of Medical Biochemistry 2 in the fall semester of 2018/2019 academic year
  • registration for the subject matter of Medical Biochemistry 1 in the fall semester of 2017/2018  academic year

Registration: May 8-10, 2019

Topic list

Final examination

Course-outline: Medical Biochemistry 3

Spring semester of 2018/2019 academic year

Head of Deparment of Medical Biochemistry: Prof. Tretter, László

  • Subject title: Medical biochemistry 3
  • Faculty: Medicine
  • Code: AOKOBI463_3A
  • Credit: 5
Student office of Department of Medical Biochemistry
Budapest IX., Tűzoltó utca 37-47 H-1094; ROOM: 1.508
+36-1-459-1500#60061;  +36-20-666-60061
Office hours: Tuesday, Wednesday, Thursday – 10:00-12:00
Course-coordinator for medical biochemistry 1-2-3, dental biochemistry 1-2-3 students:
István Léránt PhD., +36-20-663-2267
Mr. Zsolt Ozsváth Mrs Vera Pichler
+36-20-666-0061 +36-20-666-0061
medical & dental biochemistry 3 medical & dental biochemistry 1
medical & dental biochemistry 2  

“English Secretariate”

Dentistry students Medical students
Mrs Borbála Hanek Adrienn Bácskai
+36-20-666-0479 +36-20-666-0072
Dental biochemistry 2-3 Medical biochemistry 2-3
Dental biochemistry 1 Éva Kiss
  Medical biochemistry 1


e-Lectures, e-Laboratory lessons, e-Seminars