Lectures
Lecturers: Beáta Törőcsik MD, PhD (BT); István Léránt (IL); prof. Kraszimir Kolev MD, PhD, DSc (KK); József Mandl MD, PhD, DSc (JM); Erzsébet Komorowicz MD, PhD (EK)
| Tuesday | 15:35-16:45 | Szent-Györgyi Albert lecture hall |
| Thursday | 09:20-10:30 | Szent-Györgyi Albert lecture hall |
| Week | Metabolism of carbohydrates | |
| 01 | 2018.09.11 | Carbohydrates. Digestion and absorption of carbohydrates, cellular glucose uptake, glucose transporters BT |
| 2018.09.13 | Glycolysis BT | |
| 02 | 2018.09.18 | Metabolism of fructose and galactose. Gluconeogenesis. Cori-cycle BT |
| 2018.09.20 | Regulation of glycolysis and gluconeogenesis. Oxidation of alcohol and carbohydrate metabolism BT | |
| 03 | 2018.09.25 | Metabolism of glycogen. Mobilization of glycogen in liver and muscle BT |
| 2018.09.27 | Blood glucose level and its regulation: hyperglycaemia. Insulin release, insulin receptors BT | |
| 04 | 2018.10.02 | Biochemistry of diabetes mellitus (DM) type I and type II DM BT |
| Biotransformation | ||
| 2018.10.04 | Characterization and classification of reactions in biotransformation. Phase I and Phase II reations. Clinical significance of induction JM | |
| 05 | 2018.10.09 | Role of biotransformation in drug metabolism and detoxification. Metabolism of ethanol and its pathobiochemical effects JM |
| Metabolism of lipids | ||
| 2018.10.11 | Metabolism of lipids – overview. Absorption of lipids. Metabolism of chylomicrons. (IL) | |
| 06 | 2018.10.16 | Mobilization of fatty acids in adipose tissue, its regulation. Transport on circulation. Free fatty acids, VLDL, IDL (IL) |
| 2018.10.18 | Oxidation of fatty acids. Ketone bodies. (IL) | |
| 07 | 2018.10.24 | Synthesis of fatty acids (IL) (Wednesday 16:30-17:40) |
| 2018.10.25 | Biosynthesis of triacylglycerol, phospholipids, their regulation (IL) | |
| Amino acids | ||
| 08 | 2018.10.30 | Nitrogen balance. Digestion of proteins. Function of proteases, their regulation. Absorption of amino acids, amino acid transporters (IL) |
| 09 | 2018.11.06 | Catabolism of amino acids. Elimination of ammonia, reactions of ornithine cycle. Its regulation (IL) |
| 2018.11.07 | Catabolism of amino acids. Catabolism of carbonic skeleton (IL) (Wednesday 16:30-17:40) | |
| 2018.11.08 | Catabolism of amino acids. Catabolism of carbonic skeleton. Role of vitamins in amino acid metabolism (IL) | |
| 10 | 2018.11.13 | Biosynthesis of nonessential amino acids and other amino acid derivatives (IL) |
| Metabolism of nucleotides; synthesis and degradation of heme | ||
| 2018.11.15 | Structure and function of nucleotides. The fate of diatary nucleotides. Formation and elimination of uric acid, its metabolic role in humans. Molecular basis of gout. KK | |
| 11 | 2018.11.20 | Synthesis and degradation of purine and pyrimidine nucleotides. Effects of cytostatic drugs on nucleotide metabolism. KK |
| 2018.11.22 | Biosynthesis and degradation of heme. Homeostasis of iron. KK | |
| Metabolism of cholesterol, cholesterol transport in circulation | ||
| 12 | 2018.11.27 | Metabolism of cholesterol, cholesterol transport in circulation KK |
| 2018.11.29 | Biosynthesis and metabolism of the bile acids, the importance of bile acids in lipid digestion. Cholesterol uptake and release by cells KK | |
| 13 | 2018.12.04 | Pathobiochemistry of atherosclerosis KK |
| Steroid hormones and eicosanoids | ||
| 2018.12.06 | Synthesis of steroidal hormones in adrenal cortex. Synthesis of glucocorticoids. Biochemical background of adrenal cortex layers. Synthesis of mineralocorticoids, its regulation, prereceptor specificity. Effect of cortisol, regulation of cortisol synthesis. Androgen production of adrenal cortex EK | |
| 14 | 2018.12.11 | Synthesis of sex hormones. Ovarian cyclic hormone production. Biosynthesis of progesterone and estradiol in placenta. Synthesis of testosterone in testis, formation and importance of dihydrotestosterone EK |
| 2018.12.13 | Eicosanoids: synthesis of prostaglandins, thromboxanes and leukotriens (cyclooxygenase and lipoxigense pathway) EK |
Lab. lessons
Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)
| 1. | 09.10_09.14 | Safety rules for work in the laboratory . Amidolytic activity of trypsin (Pr) |
| 2. | 09.17_09.21 | Competitive inhibition of succinate dehydrogenase (Pr) |
| 3. | 09.24_09.28 | Enzyme kinetics – computer simulation (S) |
| 4. | 10.01_10.05 | Lactic acidosis (S). |
| 5. | 10.08_10.12 | Allosteric regulation of pyruvate kinase (Pr) |
| 10.13 SAT | For groups: EM03, 05, 07, 13, 14, 15: Insulin signaltransduction (S) | |
| 6. | 10.15_10.19 | Fructose intolerance (S), McArdle’s disease (S) |
| 7. | 10.24_10.26 | Oxidative phosphorylation in mitochondria (Pr) |
| 8. | 10.29_MON | For groups: EM03, 05, 07, 13, 14, 15: Oxidative phosphorylation in mitochondria (Pr) |
| 10.30_10.31 | Insulin signaltransduction (S) | |
| 9. | 11.05_11.09 | Digestion of lipids (Pr) Substrate specificity of trypsin and chymotrypsin (Pr) |
| 11.10 SAT | For groups EM 01, 08, 09, 11: Insulin signaltransduction (S) | |
| 10. | 11.12_11.16 | Lipoprotein lipase (S); Carnitine deficiency (S) |
| 11. | 11.19_11.23 | Determination of serum cholesterol and triglyceride (Pr) |
| 12 | 11.26_11.30 | Hereditary hyperammonaemia (S) |
| 13. | 12.03_12.07 | Glutamate dehydrogenase (Pr) |
| 14. | 12.10_12.14 | Vit B12 deficiency (S); methylmalonic acidaemia .(S) |
Groups
Laboratory lessons and seminars are held at laboratory rooms of the Deparment (EOK-Building, Budapest IX., Tűzoltó utca 37-47. H-1094, 1st floor, passage ‘C’)
| Day | Time | Group | |
| Monday | 08:00-10:10 | EM03 | Kolev, K prof |
| 08:00-10:10 | EM05 | Tóth, E | |
| 08:00-10:10 | EM07 | Komorowicz, E | |
| Monday | 11:00-13:10 | EM14 | Kolev, K prof |
| 11:00-13:10 | EM15 | Törőcsik, B | |
| Monday | 13:40-15:50 | EM13 | Dóczy, J |
| Tuesday | 10:40:12:50 | EM02 | Müllner, N |
| 10:40:12:50 | EM04 | Léránt, I | |
| 10:40:12:50 | EM06 | Komáry, Zs | |
| 10:40:12:50 | EM10 | Chinopoulos, C | |
| 10:40:12:50 | EM12 | Mészáros, T | |
| Friday | 08:00-10:10 | EM01 | Bak, J |
| Friday | 10:40-12:50 | EM08 | Margittai, É |
| 10:40-12:50 | EM09 | Bartha, K | |
| 10:40-12:50 | EM11 | Törőcsik, B |
Recommended books
- Harper’s Illustrated Biochemistry (30th edition)
- Powerpoint files of lectures
- Consultation manual
- Students’ own note
Midterm exam
The oral retake exam is held on FRIDAY, (2018 Dec 14 – 15:00, 16:00, 16:30). Only failed students may come. Only registered student may sit for the exams. Students, who were ill at the time of retake exams, may sit for exams, if you bring your medical certificate.
Topic lists and condition for the oral retake exams
Oral retake exam
Registration for the exam:
| ME#2-Retake | Dec 5 | 16:45-18:05 |
- Midterm examination 1: Week 6. Oct 17, 2018 Wednesday 16:45-18:05 & 18:15-19:30 EOK Szent-Györgyi Albert Hall
- Midterm examination 1-retake: Week 8. Oct 31, 2018 Wednesday 16:45-18:05 EOK Szent-Györgyi Albert Hall
- Topic list – first midterm exam
- Midterm examination 2: Week 12. Nov 28, 2018 Wednesday 16:45-18:05 & 18:15-19:30 EOK Szent-Györgyi Albert Hall
- Midterm examination 2-retake: Week 13. Dec 05, 2018 Wednesday 16:45-18:05 EOK Szent-Györgyi Albert Hall
| ME#2.2 | Dec 5 |
16:45-18:05 | All groups |
Requirements
Competition
Date: Dec 12, 2018, 16:45 EOK-Building, Szent-Györgyi Albert Lecture Hall
Material: lectures, seminars and laboratory lessons of the fall semesters of 2018/2019 academic year.
Registration until 7th of December, 2018:
Students reaching at least 75 % will be exempted from the examination by mark 5. Other exemptions are not possible.
Conditition:
- grades 3 or better at both midterms
- registration for the subject matter of Medical Biochemistry 2 in the fall semester of 2018/2019 academic year
- registration for the subject matter of Medical Biochemistry 1 in the spring semester of 2017/2018 academic year
Registration: starts on the 1 Dec, 2018. Registration is closed on the 7th of December, 2018
DOWNLOADS
Subject matter: Medical Biochemistry 2
Fall semester of 2018/2019 academic year
Head of Deparment of Medical Biochemistry: Prof. Tretter, László
| Subject title: | Faculty |
Code: | Credit: |
| Medical biochemistry 2 | Medicine | AOKOBI463_2A | 5 |
- Head of Department of Medical Biochemistry: Tretter László MD, PhD, DSc
- Teaching secretary: Léránt István PhD +36-1-459 1500#60034; +36-20-663 2267
- Students Affairs Secretary: Mr. Zsolt Ozsváth EOK Building, 1st Floor, Passage ‘C’; +36-1-459 1500#60061
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