{"id":9540,"date":"2023-08-15T10:52:07","date_gmt":"2023-08-15T08:52:07","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=9540"},"modified":"2023-08-15T13:15:25","modified_gmt":"2023-08-15T11:15:25","slug":"a-scientific-reports-cimu-lapban-megjelent-a-dr-fekete-janos-tibor-kozremukodesevel-keszult-cikk","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/a-scientific-reports-cimu-lapban-megjelent-a-dr-fekete-janos-tibor-kozremukodesevel-keszult-cikk\/","title":{"rendered":"A Scientific Reports c\u00edm\u0171 lapban megjelent a Dr. Fekete J\u00e1nos Tibor k\u00f6zrem\u0171k\u00f6d\u00e9s\u00e9vel k\u00e9sz\u00fclt cikk"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9271 alignleft\" src=\"https:\/\/semmelweis.hu\/bioinformatika\/files\/2023\/06\/scientific-reports-280_174.png\" alt=\"\" width=\"280\" height=\"174\" \/>A neuroblaszt\u00f3ma a csecsem\u0151ket \u00e9s kisgyermekeket \u00e9rint\u0151 egyik legelterjedtebb daganatos megbeteged\u00e9s, amelynek kezel\u00e9s\u00e9ben gyakran alkalmaznak ciklofoszfamid ter\u00e1pi\u00e1t.<\/p>\n<p>A ciklofoszfamid bioaktiv\u00e1ci\u00f3s \u00e9s inaktiv\u00e1ci\u00f3s \u00fatvonal\u00e1ban a citokr\u00f3m P450 2B6 (CYP2B6) az els\u0151dleges kataliz\u00e1tor, a m\u00e1sodlagos enzim pedig a CYP2C19. A CYP metabolizmus hozz\u00e1j\u00e1rulhat a ciklofoszfamid nagyfok\u00fa farmakokinetikai variabilit\u00e1s\u00e1hoz, amely kedvez\u0151tlen ter\u00e1pia kimenetelhez \u00e9s klinikailag jelent\u0151s mell\u00e9khat\u00e1sok kialakul\u00e1s\u00e1hoz vezethet. A vizsg\u00e1lat c\u00e9lja az volt, hogy felt\u00e1rjuk a CYP2B6 \u00e9s CYP2C19 farmakogenetikai variabilit\u00e1s\u00e1nak szerep\u00e9t a ter\u00e1pi\u00e1s hat\u00e9konys\u00e1gban, valamint a ciklofoszfamid \u00e1ltal kiv\u00e1ltott mell\u00e9khat\u00e1sok megjelen\u00e9s\u00e9ben ciklofoszfamid ter\u00e1pia alatt \u00e1ll\u00f3 neuroblaszt\u00f3m\u00e1s gyermekekn\u00e9l.<\/p>\n<p>A cikk<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-38983-0\"> itt<\/a> olvashat\u00f3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A neuroblaszt\u00f3ma a csecsem\u0151ket \u00e9s kisgyermekeket \u00e9rint\u0151 egyik legelterjedtebb daganatos megbeteged\u00e9s, amelynek kezel\u00e9s\u00e9ben gyakran alkalmaznak ciklofoszfamid ter\u00e1pi\u00e1t. A ciklofoszfamid bioaktiv\u00e1ci\u00f3s \u00e9s inaktiv\u00e1ci\u00f3s \u00fatvonal\u00e1ban a citokr\u00f3m P450 2B6 (CYP2B6) az els\u0151dleges kataliz\u00e1tor, a m\u00e1sodlagos enzim pedig a CYP2C19. A CYP metabolizmus hozz\u00e1j\u00e1rulhat a ciklofoszfamid nagyfok\u00fa farmakokinetikai variabilit\u00e1s\u00e1hoz, amely kedvez\u0151tlen ter\u00e1pia kimenetelhez \u00e9s klinikailag jelent\u0151s mell\u00e9khat\u00e1sok kialakul\u00e1s\u00e1hoz &hellip;<\/p>\n","protected":false},"author":102018,"featured_media":9052,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-9540","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/102018"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=9540"}],"version-history":[{"count":3,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9540\/revisions"}],"predecessor-version":[{"id":9576,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9540\/revisions\/9576"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/9052"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=9540"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=9540"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=9540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}