{"id":9304,"date":"2023-08-04T11:52:03","date_gmt":"2023-08-04T09:52:03","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=9304"},"modified":"2023-08-04T11:52:03","modified_gmt":"2023-08-04T09:52:03","slug":"megjelent-dr-posta-mate-cikke-a-clinical-and-translational-science-cimu-lapban","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/megjelent-dr-posta-mate-cikke-a-clinical-and-translational-science-cimu-lapban\/","title":{"rendered":"Megjelent Dr. Posta M\u00e1t\u00e9 cikke a Clinical and Translational Science c\u00edm\u0171 lapban"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-9312 alignleft\" src=\"https:\/\/semmelweis.hu\/bioinformatika\/files\/2023\/06\/J-of-Clinical-and-Translatonal-Science_jcts_250_250.logo_.png\" alt=\"\" width=\"313\" height=\"313\" srcset=\"https:\/\/semmelweis.hu\/bioinformatika\/files\/2023\/06\/J-of-Clinical-and-Translatonal-Science_jcts_250_250.logo_.png 250w, https:\/\/semmelweis.hu\/bioinformatika\/files\/2023\/06\/J-of-Clinical-and-Translatonal-Science_jcts_250_250.logo_-150x150.png 150w\" sizes=\"auto, (max-width: 313px) 100vw, 313px\" \/>A hasny\u00e1lmirigyr\u00e1k tov\u00e1bbra is vezet\u0151 ok\u00e1t jelenti a daganatokkal \u00f6sszef\u00fcgg\u0151 hal\u00e1loz\u00e1soknak. Ahhoz, hogy megfelel\u0151 ter\u00e1pi\u00e1s \u00e9s prognosztikai eszk\u00f6z\u00f6ket fejleszthess\u00fcnk ki, elengedhetetlen a tumor molekul\u00e1ris elt\u00e9r\u00e9seinek \u00e1tfog\u00f3 felt\u00e9rk\u00e9pez\u00e9se.<\/p>\n<p>A tanulm\u00e1ny c\u00e9lja, hogy integr\u00e1lja a rendelkez\u00e9sre \u00e1ll\u00f3 g\u00e9nexpresszi\u00f3s adatokat, \u00e9s hogy felfedezze azokat a g\u00e9neket, amelyek expresszi\u00f3j\u00e1nak megv\u00e1ltoz\u00e1sa egyszerre kapcsol\u00f3dik a daganat patogenezis\u00e9hez \u00e9s a rosszabb t\u00fal\u00e9l\u00e9shez. A vizsg\u00e1latban \u00f6sszesen 16 adatb\u00e1zist kombin\u00e1ltak, \u00e9s 1640 hasny\u00e1lmirigy sz\u00f6veti mint\u00e1nak a g\u00e9nexpresszi\u00f3s mint\u00e1zat\u00e1t elemezt\u00e9k t\u00f6bb mint 20.000 g\u00e9nre. Ezek alapj\u00e1n sz\u00e1mos, a t\u00fal\u00e9l\u00e9st befoly\u00e1sol\u00f3 g\u00e9nt \u00edrtak le, azonban 7 olyan g\u00e9n ker\u00fclt azonos\u00edt\u00e1sra [<em>ANXA8<\/em>, <em>FAM83A<\/em>, <em>KRT6A<\/em>, <em>MET<\/em>, <em>MUC16<\/em>, <em>NT5E<\/em> \u00e9s <em>SLC2A1<\/em>] melyeknek a daganatos elv\u00e1ltoz\u00e1sban jelent\u0151sen megn\u0151 az expresszi\u00f3ja \u00e9s ezen g\u00e9nek fokozott kifejez\u0151d\u00e9se drasztikusan rontja a t\u00fal\u00e9l\u00e9st.<\/p>\n<p>Ezen eredm\u00e9nyek fontos l\u00e9p\u00e9st jelentenek a hasny\u00e1lmirigydaganat meg\u00e9rt\u00e9s\u00e9ben \u00e9s lehet\u0151v\u00e9 teszik olyan g\u00e9nter\u00e1pi\u00e1s c\u00e9lpontok azonos\u00edt\u00e1s\u00e1t, amelyek hat\u00e9konyabb kezel\u00e9st eredm\u00e9nyezhetnek a betegek sz\u00e1m\u00e1ra. A felfedezett g\u00e9nek feh\u00e9rjeterm\u00e9kei k\u00f6z\u00f6tt m\u00e1r folynak c\u00e9lzott ter\u00e1pi\u00e1s gy\u00f3gyszerek fejleszt\u00e9s\u00e9t c\u00e9lz\u00f3 kutat\u00e1sok, \u00edgy ez a tanulm\u00e1ny tov\u00e1bbi lend\u00fcletet ad a ter\u00e1pi\u00e1s c\u00e9lpontok kidolgoz\u00e1s\u00e1hoz.<\/p>\n<p>A teljes k\u00f6zlem\u00e9ny, melynek c\u00edme \u201eAnalysis of a large cohort of pancreatic cancer transcriptomic profiles to reveal the strongest prognostic factors \u201d<a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13563\" target=\"_blank\" rel=\"noopener\">\u00a0ide kattintva<\/a>\u00a0\u00e9rhet\u0151 el.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A hasny\u00e1lmirigyr\u00e1k tov\u00e1bbra is vezet\u0151 ok\u00e1t jelenti a daganatokkal \u00f6sszef\u00fcgg\u0151 hal\u00e1loz\u00e1soknak. Ahhoz, hogy megfelel\u0151 ter\u00e1pi\u00e1s \u00e9s prognosztikai eszk\u00f6z\u00f6ket fejleszthess\u00fcnk ki, elengedhetetlen a tumor molekul\u00e1ris elt\u00e9r\u00e9seinek \u00e1tfog\u00f3 felt\u00e9rk\u00e9pez\u00e9se. A tanulm\u00e1ny c\u00e9lja, hogy integr\u00e1lja a rendelkez\u00e9sre \u00e1ll\u00f3 g\u00e9nexpresszi\u00f3s adatokat, \u00e9s hogy felfedezze azokat a g\u00e9neket, amelyek expresszi\u00f3j\u00e1nak megv\u00e1ltoz\u00e1sa egyszerre kapcsol\u00f3dik a daganat patogenezis\u00e9hez \u00e9s a rosszabb t\u00fal\u00e9l\u00e9shez. &hellip;<\/p>\n","protected":false},"author":102018,"featured_media":9308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-9304","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/102018"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=9304"}],"version-history":[{"count":8,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9304\/revisions"}],"predecessor-version":[{"id":9316,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9304\/revisions\/9316"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/9308"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=9304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=9304"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=9304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}