{"id":9107,"date":"2023-04-21T11:02:31","date_gmt":"2023-04-21T09:02:31","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=9107"},"modified":"2023-04-27T09:48:53","modified_gmt":"2023-04-27T07:48:53","slug":"megjelent-dr-vizkeleti-laura-kozlemenye-a-cancers-folyoiratban","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/megjelent-dr-vizkeleti-laura-kozlemenye-a-cancers-folyoiratban\/","title":{"rendered":"Megjelent Dr. V\u00edzkelety Laura k\u00f6zlem\u00e9nye a melanoma kutat\u00e1sok eredm\u00e9nyeivel"},"content":{"rendered":"

\"\"A kutat\u00e1s az UV-induk\u00e1lt kut\u00e1n melan\u00f3m\u00e1k mintegy 20%-\u00e1t kitev\u0151 tripla vad alt\u00edpus genetikai h\u00e1tter\u00e9t vizsg\u00e1lja teljes genom szekven\u00e1l\u00e1ssal. A klasszikus vez\u00e9r g\u00e9nmut\u00e1ci\u00f3k, mint BRAF, NRAS \u00e9s KIT hi\u00e1nya \u00e9s a nagyfok\u00fa genetikai heterogenit\u00e1suk miatt a ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek sz\u00e1ma ezen t\u00edpusban meglehet\u0151sen korl\u00e1tozott. Siker\u00fclt azonos\u00edtani olyan, kor\u00e1bban m\u00e1r melanom\u00e1b\u00f3l vagy m\u00e1s r\u00e1kt\u00edpusokb\u00f3l ismert aktiv\u00e1l\u00f3 tirozin-kin\u00e1z mut\u00e1ci\u00f3kat, mint az NTRK1\/3, RET vagy VEGFR1 elt\u00e9r\u00e9sei. A felt\u00e1rt vez\u00e9rmut\u00e1ci\u00f3k t\u00f6bbs\u00e9ge a daganattal szembeni immunit\u00e1s, Ca++ \u00e9s BMP jel\u00e1tviteli \u00fatvonalakat \u00e9rintette. Ugyanakkor j\u00f3 p\u00e1r esetben tov\u00e1bbra sem mutathat\u00f3 ki vez\u00e9rmut\u00e1ci\u00f3 jelenl\u00e9te, mely egy nagyobb mintasz\u00e1mon t\u00f6rt\u00e9n\u0151 vizsg\u00e1lat tervez\u00e9s\u00e9t s\u00fcrgeti az \u201eutaz\u00f3\u201d mut\u00e1ci\u00f3k k\u00f6z\u00f6tt esetlegesen megb\u00fav\u00f3 \u00e9s jelent\u0151s\u00e9ggel b\u00edr\u00f3 g\u00e9nmut\u00e1ci\u00f3k felt\u00e1r\u00e1s\u00e1ra.<\/p>\n

A teljes k\u00f6zlem\u00e9ny, melynek c\u00edme \u201eThe Driverless Triple-Wild-Type (BRAF, RAS, KIT) Cutaneous Melanoma: Whole Genome Sequencing Discoveries\u201d ide kattintva<\/a> \u00e9rhet\u0151 el.<\/p>\n","protected":false},"excerpt":{"rendered":"

A kutat\u00e1s az UV-induk\u00e1lt kut\u00e1n melan\u00f3m\u00e1k mintegy 20%-\u00e1t kitev\u0151 tripla vad alt\u00edpus genetikai h\u00e1tter\u00e9t vizsg\u00e1lja teljes genom szekven\u00e1l\u00e1ssal. A klasszikus vez\u00e9r g\u00e9nmut\u00e1ci\u00f3k, mint BRAF, NRAS \u00e9s KIT hi\u00e1nya \u00e9s a nagyfok\u00fa genetikai heterogenit\u00e1suk miatt a ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek sz\u00e1ma ezen t\u00edpusban meglehet\u0151sen korl\u00e1tozott. Siker\u00fclt azonos\u00edtani olyan, kor\u00e1bban m\u00e1r melanom\u00e1b\u00f3l vagy m\u00e1s r\u00e1kt\u00edpusokb\u00f3l ismert aktiv\u00e1l\u00f3 tirozin-kin\u00e1z mut\u00e1ci\u00f3kat, …<\/p>\n","protected":false},"author":102018,"featured_media":9109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-9107","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/102018"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=9107"}],"version-history":[{"count":5,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9107\/revisions"}],"predecessor-version":[{"id":9127,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/9107\/revisions\/9127"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/9109"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=9107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=9107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=9107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}