{"id":8271,"date":"2022-06-14T09:05:38","date_gmt":"2022-06-14T07:05:38","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=8271"},"modified":"2022-06-14T16:34:06","modified_gmt":"2022-06-14T14:34:06","slug":"megjelent-kovacs-szonja-anna-cikke-a-journal-of-translational-medicine-folyoiratban","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/megjelent-kovacs-szonja-anna-cikke-a-journal-of-translational-medicine-folyoiratban\/","title":{"rendered":"Megjelent Kov\u00e1cs Szonja Anna cikke a Journal of Translational Medicine foly\u00f3iratban"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-7911 alignleft\" src=\"https:\/\/semmelweis.hu\/bioinformatika\/files\/2022\/02\/Kovacs_Szonja_Anna.jpg\" alt=\"\" width=\"242\" height=\"350\" \/><\/p>\n<p>Az immunter\u00e1pi\u00e1kra, ezen bel\u00fcl is az immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3szerekre (\u201echeckpoint g\u00e1tl\u00f3k\u201d), adott ter\u00e1pi\u00e1s v\u00e1lasz elk\u00e9peszt\u0151en kedvez\u0151 lehet, azonban ez csak a betegek eleny\u00e9sz\u0151en kis r\u00e9sz\u00e9re jellemz\u0151 (~10-30% el\u0151zetes biomarker vizsg\u00e1lat n\u00e9lk\u00fcl). A jelenlegi biomarkerek (pl. PD-L1 st\u00e1tusz, tumor mut\u00e1ci\u00f3s terhel\u00e9s (TMB)) nem el\u00e9g megb\u00edzhat\u00f3ak a ter\u00e1pi\u00e1b\u00f3l potenci\u00e1lisan hasznosul\u00f3 betegek pontos kiv\u00e1laszt\u00e1s\u00e1ra. Azonban a checkpoint g\u00e1tl\u00f3 kezel\u00e9sek g\u00e9nexpresszi\u00f3ra kifejtett hat\u00e1s\u00e1nak vizsg\u00e1lat\u00e1val lehet\u0151s\u00e9g\u00fcnk ny\u00edlik predikt\u00edv biomarkerek azonos\u00edt\u00e1s\u00e1ra, amely inform\u00e1ci\u00f3t szolg\u00e1ltathat az adott kezel\u00e9sre val\u00f3 fog\u00e9konys\u00e1g\u00e1r\u00f3l.<\/p>\n<p>A k\u00f6z\u00f6lt irodalmi \u00e1ttekint\u0151ben Kov\u00e1cs Szonja Anna, a Bioinformatika Tansz\u00e9k PhD hallgat\u00f3ja olyan tanulm\u00e1nyokat foglalta \u00f6ssze, amelyben anti-PD-1, anti-PD-L1 \u00e9s anti-CTLA-4 checkpoint inhibitorokkal kezelt betegeket vizsg\u00e1ltak. A cikkben 26 tanulm\u00e1nyb\u00f3l sz\u00e1rmaz\u00f3, mintegy 1836 beteg 2386 mint\u00e1j\u00e1hoz tartoz\u00f3, publikusan el\u00e9rhet\u0151 klinikai \u00e9s transzkriptomikai adat ismertet\u00e9se olvashat\u00f3.<\/p>\n<p>A tanulm\u00e1ny el\u0151seg\u00edtheti a gyorsabb \u00e9s \u00e1tl\u00e1that\u00f3bb adatel\u00e9r\u00e9s \u00e1ltal a predikt\u00edv biomarkerek vizsg\u00e1lat\u00e1t.<\/p>\n<p>Szonja Anna Kov\u00e1cs, Bal\u00e1zs Gy\u0151rffy (2022)<\/p>\n<p>Journal of Translational Medicine volume 20, Article number: 249 (2022)<\/p>\n<p>A cikk ide kattintva \u00e9rhet\u0151 el: <a href=\"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-022-03409-4\">https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-022-03409-4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Az immunter\u00e1pi\u00e1kra, ezen bel\u00fcl is az immunellen\u0151rz\u0151pont-g\u00e1tl\u00f3szerekre (\u201echeckpoint g\u00e1tl\u00f3k\u201d), adott ter\u00e1pi\u00e1s v\u00e1lasz elk\u00e9peszt\u0151en kedvez\u0151 lehet, azonban ez csak a betegek eleny\u00e9sz\u0151en kis r\u00e9sz\u00e9re jellemz\u0151 (~10-30% el\u0151zetes biomarker vizsg\u00e1lat n\u00e9lk\u00fcl). A jelenlegi biomarkerek (pl. PD-L1 st\u00e1tusz, tumor mut\u00e1ci\u00f3s terhel\u00e9s (TMB)) nem el\u00e9g megb\u00edzhat\u00f3ak a ter\u00e1pi\u00e1b\u00f3l potenci\u00e1lisan hasznosul\u00f3 betegek pontos kiv\u00e1laszt\u00e1s\u00e1ra. Azonban a checkpoint g\u00e1tl\u00f3 kezel\u00e9sek g\u00e9nexpresszi\u00f3ra &hellip;<\/p>\n","protected":false},"author":102018,"featured_media":8273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-8271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/8271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/102018"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=8271"}],"version-history":[{"count":3,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/8271\/revisions"}],"predecessor-version":[{"id":8277,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/8271\/revisions\/8277"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/8273"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=8271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=8271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=8271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}