{"id":8139,"date":"2022-04-14T14:59:11","date_gmt":"2022-04-14T12:59:11","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=8139"},"modified":"2022-05-26T10:44:16","modified_gmt":"2022-05-26T08:44:16","slug":"megjelent-muller-dalma-cikke-a-biochimica-et-biophysica-acta-reviews-on-cancer-folyoiratban","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/megjelent-muller-dalma-cikke-a-biochimica-et-biophysica-acta-reviews-on-cancer-folyoiratban\/","title":{"rendered":"Megjelent M\u00fcller Dalma cikke a Biochimica et Biophysica Acta Reviews on Cancer foly\u00f3iratban"},"content":{"rendered":"

\u00a0<\/p>\n

\"Muller_Dalma\"DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer.<\/strong><\/p>\n

Dalma M\u00fcller, Bal\u00e1zs Gy\u0151rffy (2022)<\/p>\n

Biochim Biophys Acta Rev Cancer, 188722.<\/p>\n

A cikk ide kattintva<\/a> \u00e9rhet\u0151 el<\/p>\n

 <\/p>\n

A kolorekt\u00e1lis tumor a negyedik leggyakoribb daganatt\u00edpus: a 2018-ban \u00fajonnan diagnosztiz\u00e1lt esetek sz\u00e1m\u00e1t t\u00f6bb mint 1,8 milli\u00f3ra, az elhal\u00e1loz\u00e1sok\u00e9t pedig 881 000-re becs\u00fclt\u00e9k. Az el\u0151fordul\u00e1s r\u00e1t\u00e1ja szempontj\u00e1b\u00f3l Magyarorsz\u00e1g vil\u00e1gszinten vezet\u0151 helyet foglal el. A tumorprogresszi\u00f3 sor\u00e1n epigenetikai \u00e9s genetikai v\u00e1ltoz\u00e1sok halmoz\u00f3dnak fel.<\/p>\n

Az adenokarcin\u00f3m\u00e1nak n\u00e9gy konszenzus molekul\u00e1ris alt\u00edpusa van. A k\u00fcl\u00f6nb\u00f6z\u0151 csoportokat olyan tulajdons\u00e1gok jellemzik, mint a CpG sziget metil\u00e1tor (CIMP), mikroszatellita instabilit\u00e1s (MSI) \u00e9s kromosz\u00f3ma instabilit\u00e1s (CIN) st\u00e1tusz, valamint bizonyos g\u00e9nek mut\u00e1ci\u00f3ja vagy magas expresszi\u00f3ja . \u00a0A transzform\u00e1ci\u00f3 \u00fatvonala \u00e9s egy\u00e9b k\u00fcl\u00f6nbs\u00e9gek ellen\u00e9re egys\u00e9gesen meghat\u00e1rozhat\u00f3ak diagnosztikus, prognosztikus \u00e9s predikt\u00edv biomarkerek, melyek k\u00f6z\u00f6tt szerepelnek DNS metil\u00e1ci\u00f3 alap\u00faak.<\/p>\n

A k\u00f6z\u00f6lt irodalmi \u00e1ttekint\u00e9sben M\u00fcller Dalma, a Bioinformatika Tansz\u00e9k PhD hallgat\u00f3ja ezeket az egyedi l\u00f3kuszokhoz kapcsol\u00f3d\u00f3 biomarkereket, illetve a potenci\u00e1lisan \u00faj biomarkerek felfedez\u00e9s\u00e9t \u00e9s in silico <\/em>valid\u00e1ci\u00f3j\u00e1t el\u0151seg\u00edt\u0151, genomszint\u0171 metil\u00e1ci\u00f3t vizsg\u00e1l\u00f3 tanulm\u00e1nyokat foglalta \u00f6ssze.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0 DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer. Dalma M\u00fcller, Bal\u00e1zs Gy\u0151rffy (2022) Biochim Biophys Acta Rev Cancer, 188722. A cikk ide kattintva<\/a> \u00e9rhet\u0151 el   A kolorekt\u00e1lis tumor a negyedik leggyakoribb daganatt\u00edpus: a 2018-ban \u00fajonnan diagnosztiz\u00e1lt esetek sz\u00e1m\u00e1t t\u00f6bb mint 1,8 milli\u00f3ra, az elhal\u00e1loz\u00e1sok\u00e9t pedig 881 000-re becs\u00fclt\u00e9k. Az el\u0151fordul\u00e1s r\u00e1t\u00e1ja szempontj\u00e1b\u00f3l Magyarorsz\u00e1g …<\/p>\n","protected":false},"author":102018,"featured_media":8234,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-8139","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/8139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/102018"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=8139"}],"version-history":[{"count":10,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/8139\/revisions"}],"predecessor-version":[{"id":8230,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/8139\/revisions\/8230"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/8234"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=8139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=8139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=8139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}