{"id":7436,"date":"2021-02-19T14:39:01","date_gmt":"2021-02-19T13:39:01","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=7436"},"modified":"2021-04-18T14:52:59","modified_gmt":"2021-04-18T12:52:59","slug":"different-mutations-in-sars-cov-2-associate-with-severe-and-mild-outcome-2","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/different-mutations-in-sars-cov-2-associate-with-severe-and-mild-outcome-2\/","title":{"rendered":"Dr. Nagy \u00c1d\u00e1m cikke az International Journal of Antimicrobial Agents foly\u00f3iratban"},"content":{"rendered":"
K\u00fcl\u00f6nb\u00f6z\u0151 koronav\u00edrus-mut\u00e1ci\u00f3k \u00f6sszef\u00fcgg\u00e9se a v\u00edrusfert\u0151z\u00e9s lefut\u00e1s\u00e1val<\/h5>\n

\"\"<\/a>A h\u00e9t, embert is megfert\u0151z\u0151 koronav\u00edrus-t\u00f6rzs k\u00f6z\u00fcl a legut\u00f3bb felfedezett SARS-CoV-2 felel\u0151s a 2019-es \u00e9v v\u00e9g\u00e9t\u0151l indul\u00f3 COVID-19 pand\u00e9mi\u00e1\u00e9rt. A SARS-CoV-2 v\u00edrus teljes genomja k\u00f6r\u00fclbel\u00fcl 29000 nukleotid hossz\u00fas\u00e1g\u00fa \u00e9s 25 v\u00edrusg\u00e9nt k\u00f3dol. Ezen v\u00edrusg\u00e9nekr\u0151l \u00e1t\u00edr\u00f3d\u00f3 feh\u00e9rj\u00e9k k\u00f6z\u00fcl a v\u00edrus szerkezeti fel\u00e9p\u00edt\u00e9s\u00e9\u00e9rt a burok (E\u2013envelope), a t\u00fcske (S\u2013Spike), membr\u00e1n (M\u2013Membrane) \u00e9s a nukleokapszid (N\u2013Nukleokapszid) feh\u00e9rj\u00e9k, funkcion\u00e1lis m\u0171k\u00f6d\u00e9s\u00e9\u00e9rt pedig az RNS-f\u00fcgg\u0151-RNS polimer\u00e1z, az exonukle\u00e1z \u00e9s a metiltranszfer\u00e1z feh\u00e9rj\u00e9k felelnek. Ezen funkcion\u00e1lis, struktur\u00e1lis feh\u00e9rj\u00e9ket \u00e9rint\u0151 mut\u00e1ci\u00f3k n\u00f6velhetik a v\u00edrus fert\u0151z\u0151k\u00e9pess\u00e9g\u00e9t, azaz a patogenit\u00e1s\u00e1t. Fontos azonban az is, hogy a v\u00edrus szerkezeti \u00e9s funkcion\u00e1lis feh\u00e9rj\u00e9i mellett, az \u00fagynevezett nem struktur\u00e1lis feh\u00e9rj\u00e9ket (NSP\u2013Non-structural proteins) \u00e9rint\u0151 mut\u00e1ci\u00f3knak is lehet szerep\u00fck a v\u00edrus patogenit\u00e1s\u00e1ban.<\/p>\n

A koronav\u00edrusok \u00e1ltal\u00e1ban stabil genommal rendelkeznek, amely az id\u0151 m\u00fal\u00e1s\u00e1val nagyon kev\u00e9ss\u00e9 v\u00e1ltozik. A SARS-CoV-2 kutat\u00e1s alapvet\u0151 k\u00e9rd\u00e9se, hogy a v\u00edrus id\u0151vel gyeng\u00fclhet-e vagy sem. A vizsg\u00e1lat sor\u00e1n az volt a c\u00e9lunk, hogy olyan v\u00edrusmut\u00e1ci\u00f3kat azonos\u00edtsunk, amelyek \u00f6sszef\u00fcgg\u00e9sbe hozhat\u00f3k a v\u00edrusfert\u0151z\u00e9s s\u00falyoss\u00e1g\u00e1val \u2013 mutatott r\u00e1 Nagy \u00c1d\u00e1m, a Bioinformatikai Tansz\u00e9k egyetemi tan\u00e1rseg\u00e9de. Az eredm\u00e9nyeink azt mutatj\u00e1k, sz\u00e1mos ilyen mut\u00e1ci\u00f3 van. A nukleokapszid feh\u00e9rje eset\u00e9ben azonos\u00edtottuk a legt\u00f6bb olyan mut\u00e1ci\u00f3t (P13L, S194L, R203K, G204R \u00e9s I292T), amelyek eset\u00e9n a betegs\u00e9g lefoly\u00e1sa s\u00falyosabb volt. Eredm\u00e9nyeink azt sugallj\u00e1k, hogy vannak olyan mut\u00e1ci\u00f3k, amelyek al\u00e1t\u00e1masztj\u00e1k e v\u00e1ltoz\u00e1sok lehet\u0151s\u00e9g\u00e9t, ez\u00e9rt es\u00e9ly van arra, hogy a j\u00f6v\u0151ben a betegs\u00e9g lefoly\u00e1sa elmozduljon az enyh\u00e9bb vagy a s\u00falyosabb betegkimenetel fel\u00e9.<\/p>\n

\n

Different mutations in SARS-CoV-2 associate with severe and mild outcome.
\n\u00c1d\u00e1m Nagy, S\u00e1ndor Pongor, Bal\u00e1zs Gy\u0151rffy (2020)
\nInt J Antimicrob Agents, 106272.
\nhttps:\/\/doi.org\/10.1016\/j.ijantimicag.2020.106272<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

K\u00fcl\u00f6nb\u00f6z\u0151 koronav\u00edrus-mut\u00e1ci\u00f3k \u00f6sszef\u00fcgg\u00e9se a v\u00edrusfert\u0151z\u00e9s lefut\u00e1s\u00e1val <\/a> A h\u00e9t, embert is megfert\u0151z\u0151 koronav\u00edrus-t\u00f6rzs k\u00f6z\u00fcl a legut\u00f3bb felfedezett SARS-CoV-2 felel\u0151s a 2019-es \u00e9v v\u00e9g\u00e9t\u0151l indul\u00f3 COVID-19 pand\u00e9mi\u00e1\u00e9rt. A SARS-CoV-2 v\u00edrus teljes genomja k\u00f6r\u00fclbel\u00fcl 29000 nukleotid hossz\u00fas\u00e1g\u00fa \u00e9s 25 v\u00edrusg\u00e9nt k\u00f3dol. Ezen v\u00edrusg\u00e9nekr\u0151l \u00e1t\u00edr\u00f3d\u00f3 feh\u00e9rj\u00e9k k\u00f6z\u00fcl a v\u00edrus szerkezeti fel\u00e9p\u00edt\u00e9s\u00e9\u00e9rt a burok (E\u2013envelope), a t\u00fcske (S\u2013Spike), membr\u00e1n (M\u2013Membrane) …<\/p>\n","protected":false},"author":101779,"featured_media":7439,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-7436","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/7436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/101779"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=7436"}],"version-history":[{"count":2,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/7436\/revisions"}],"predecessor-version":[{"id":7440,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/7436\/revisions\/7440"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/7439"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=7436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=7436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=7436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}