{"id":10359,"date":"2024-06-12T11:12:13","date_gmt":"2024-06-12T09:12:13","guid":{"rendered":"https:\/\/semmelweis.hu\/bioinformatika\/?p=10359"},"modified":"2024-06-12T11:12:13","modified_gmt":"2024-06-12T09:12:13","slug":"megjelent-dr-munkacsy-gyongyi-attekinto-kezirata-a-hipertermia-onkologiaban-valo-alkalmazasarol","status":"publish","type":"post","link":"https:\/\/semmelweis.hu\/bioinformatika\/megjelent-dr-munkacsy-gyongyi-attekinto-kezirata-a-hipertermia-onkologiaban-valo-alkalmazasarol\/","title":{"rendered":"Megjelent Dr. Munk\u00e1csy Gy\u00f6ngyi \u00e1ttekint\u0151 k\u00e9zirata a hipertermia onkol\u00f3gi\u00e1ban val\u00f3 alkalmaz\u00e1s\u00e1r\u00f3l"},"content":{"rendered":"<div dir=\"ltr\">\n<div dir=\"ltr\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10363 alignleft\" src=\"https:\/\/semmelweis.hu\/bioinformatika\/files\/2024\/06\/Integrative-cancer-Therapy.jpg\" alt=\"\" width=\"225\" height=\"225\" srcset=\"https:\/\/semmelweis.hu\/bioinformatika\/files\/2024\/06\/Integrative-cancer-Therapy.jpg 225w, https:\/\/semmelweis.hu\/bioinformatika\/files\/2024\/06\/Integrative-cancer-Therapy-150x150.jpg 150w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/>A hipertermia, vagyis a tumor h\u0151m\u00e9rs\u00e9klet\u00e9nek emel\u00e9se (\u226539 \u25e6C), az adjuv\u00e1ns tumorter\u00e1pia nagy \u00edg\u00e9ret\u00e9t hordozza mag\u00e1ban. Az \u00e1ttekint\u00e9s a hipertermia k\u00e9t kulcsfontoss\u00e1g\u00fa aspektus\u00e1t mutatja be: a molekul\u00e1ris \u00e9s sejtes hat\u00e1sait valamint az immunrendszerre gyakorolt hat\u00e1s\u00e1t.<br \/>\nA hipertermia jelent\u0151s hat\u00e1ssal b\u00edr a biol\u00f3giai folyamatokra. A megn\u00f6vekedett h\u0151m\u00e9rs\u00e9klet g\u00e1tolja a DNS-jav\u00edt\u00f3 enzimeket, \u00edgy a tumoros sejtek \u00e9rz\u00e9kenyebb\u00e9 v\u00e1lnak a kemoter\u00e1pi\u00e1ra \u00e9s a sug\u00e1rz\u00e1sra. A megemelkedett h\u0151m\u00e9rs\u00e9klet a sejtciklus le\u00e1ll\u00e1s\u00e1t is kiv\u00e1ltja, \u00e9s apoptotikus \u00fatvonalakat ind\u00edt el. A hipertermia m\u00f3dos\u00edtja tov\u00e1bb\u00e1 a h\u0151sokkfeh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t, amelyek l\u00e9tfontoss\u00e1g\u00fa szerepet j\u00e1tszanak a r\u00e1kter\u00e1pi\u00e1ban, t\u00f6bbek k\u00f6z\u00f6tt az immunv\u00e1laszok fokoz\u00e1s\u00e1ban.<br \/>\nA hipertermi\u00e1s kezel\u00e9sek jelent\u0151s hat\u00e1ssal b\u00edrnak a szervezet daganatokkal szembeni immunv\u00e1lasz\u00e1ra is, ami potenci\u00e1lisan jav\u00edthatja az \u00fan. immune checkpoint inhibitorok (ICI) hat\u00e9konys\u00e1g\u00e1t. Az enyhe sziszt\u00e9m\u00e1s hipertermia (39-41\u00b0C) l\u00e1zat imit\u00e1l, aktiv\u00e1lja az immunsejteket \u00e9s n\u00f6veli az anyagcsere sebess\u00e9g\u00e9t. Az 50\u00b0C feletti intenz\u00edv h\u0151 felszabad\u00edthatja a tumor antig\u00e9njeit, fokozva az immunreakci\u00f3kat. A fototermikus nanor\u00e9szecsk\u00e9k c\u00e9lzott meleg\u00edt\u00e9s \u00e9s gy\u00f3gyszeradagol\u00e1s c\u00e9lj\u00e1b\u00f3l t\u00f6rt\u00e9n\u0151 alkalmaz\u00e1sa szint\u00e9n m\u00f3dos\u00edthatja az immunv\u00e1laszt.<br \/>\nA hipertermia k\u00f6lts\u00e9ghat\u00e9kony \u00e9s j\u00f3l toler\u00e1lhat\u00f3 adjuv\u00e1ns ter\u00e1piak\u00e9nt jelenik meg, ha az immunter\u00e1pi\u00e1val kombin\u00e1lj\u00e1k. Ez az \u00e1ttekint\u00e9s \u00e9rt\u00e9kes forr\u00e1sul szolg\u00e1lhat az egy\u00e9nre szabott kezel\u00e9sek kiv\u00e1laszt\u00e1s\u00e1hoz \u00e9s a j\u00f6v\u0151beli vizsg\u00e1latok megtervez\u00e9s\u00e9hez.<\/div>\n<div dir=\"ltr\">\u00a0<\/div>\n<p>A k\u00e9zirat az Integrative Cancer Therapies nev\u0171, D1-es tudom\u00e1nyos foly\u00f3iratban jelent meg, mely <a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/15347354241242094\">itt olvashat\u00f3.<\/a><\/p>\n<\/div>\n<div>\u00a0<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A hipertermia, vagyis a tumor h\u0151m\u00e9rs\u00e9klet\u00e9nek emel\u00e9se (\u226539 \u25e6C), az adjuv\u00e1ns tumorter\u00e1pia nagy \u00edg\u00e9ret\u00e9t hordozza mag\u00e1ban. Az \u00e1ttekint\u00e9s a hipertermia k\u00e9t kulcsfontoss\u00e1g\u00fa aspektus\u00e1t mutatja be: a molekul\u00e1ris \u00e9s sejtes hat\u00e1sait valamint az immunrendszerre gyakorolt hat\u00e1s\u00e1t. A hipertermia jelent\u0151s hat\u00e1ssal b\u00edr a biol\u00f3giai folyamatokra. A megn\u00f6vekedett h\u0151m\u00e9rs\u00e9klet g\u00e1tolja a DNS-jav\u00edt\u00f3 enzimeket, \u00edgy a tumoros sejtek \u00e9rz\u00e9kenyebb\u00e9 &hellip;<\/p>\n","protected":false},"author":102018,"featured_media":10365,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-10359","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hirek"],"acf":[],"_links":{"self":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/10359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/users\/102018"}],"replies":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/comments?post=10359"}],"version-history":[{"count":4,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/10359\/revisions"}],"predecessor-version":[{"id":10364,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/posts\/10359\/revisions\/10364"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media\/10365"}],"wp:attachment":[{"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/media?parent=10359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/categories?post=10359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/semmelweis.hu\/bioinformatika\/wp-json\/wp\/v2\/tags?post=10359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}